In past studies conducted by our group, riparin I (rip I) isolated from the green fruit of Aniba riparia presented antianxiety effects in mice, while its analogs rip II and III showed anxiolytic and antidepressant-like actions. This time around, we investigated a possible antidepressant activity of rip I using the forced swimming test (FST) and tail suspension test (TST) as predictive tests for antidepressant activity in rodents. In addition, the involvement of the monoaminergic system in this effect was also assessed. rip I was acutely administered by intraperitoneal (i.p.) and oral (p.o) routes to male mice at doses of 25 and 50 mg/kg. Results showed that rip I at both tested doses and administration routes produced a significant decrease in immobility time in FST and TST. The pretreatment of mice with prazosin (1 mg/kg, i.p., an α1 -adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an α2 -adrenoceptor antagonist), SCH23390 (15 µg/kg, i.p., a dopamine D1 receptor antagonist), sulpiride (50 mg/kg, i.p., a dopamine D2 receptor antagonist), p-chlorophenylalanine (100 mg/kg, an inhibitor of serotonin synthesis) or ritanserin (4 mg/kg, a serotonin 5-HT2(A)/2(C) receptor antagonist) blocked the anti-immobility effects elicited by rip I (50 mg/kg, p.o.) in the FST. Taken together, results indicate that rip I produces significant antidepressant-like activity in the FST and TST, and this effect seems to be dependent on its interaction with noradrenergic, dopaminergic and serotonergic systems.
Antidepressive Agents/chemistry , Antidepressive Agents/pharmacology , Behavior, Animal/drug effects , Benzamides/pharmacology , Lauraceae/chemistry , Tyramine/pharmacology , Animals , Anti-Anxiety Agents/chemistry , Anti-Anxiety Agents/pharmacology , Dopamine/pharmacology , Hindlimb Suspension/methods , Male , Mice , Motor Activity/drug effects , Norepinephrine/pharmacology , Swimming , Tyramine/analogs & derivatives
Com a Política Nacional de Medicamentos, a assistência farmacêutica (AF) tornou-se parte integrante de um conjunto de práticas voltadas para a promoção, prevenção e recuperação de saúde, tendo o medicamento como principal insumo, porém contemplando atividades que extrapolam o simples abastecimento de medicamentos, compreendendo seleção, programação, aquisição, armazenamento, distribuição, prescrição, dispensação e uso. O presente estudo tem como objetivo realizar uma revisão integrativa da literatura no sentido de fornecer um documento de atualização e compilação de dados recentes acerca da gestão da AF do Brasil nos últimos anos. Para a busca dos artigos foram consultadas as bases de dados LILACS, SciELO e MEDLINE, com os descritores gestão da assistência farmacêutica e assistência farmacêutica e gestão. Os critérios de inclusão considerados foram: os artigos eletrônicos estarem disponíveis na íntegra, em língua portuguesa e que foram publicados no período compreendido entre 2006 e 2013. Para a coleta de dados dos artigos selecionados, foram utilizados os itens: ano, tipo de estudo, título e objetivo. Foram selecionados oito artigos científicos. Observou-se que, apesar de todos os trabalhos apresentarem objetivos diferentes dentro de uma mesma temática, todos trouxeram à tona um problema comum: a falta de estruturação adequada da AF no Brasil. Ficou evidenciado que a AF é ainda vista como um mero setor de fornecimento de medicamentos. Sugere-se, portanto, uma gestão voltada para atividades de natureza administrativa com AF voltada para o medicamento e usuário...
With the National Drug Policy, the pharmaceutical care (PC) has become an integral part of a set of practices for the promotion, prevention and health recovery, having the drug as the main ingredient, but contemplating activities that extrapolate the mere supply of drugs, including selection, programming, acquisition, storage, distribution, prescription, dispensing and use. This study has as an objective to carry out an integrative literature review in order to provide an updated document and compilation of recent data on the management of the PC in Brazil in recent years. For the search of articles were consulted the databases LILACS, SciELOand MEDLINE with the descriptors management of pharmaceutical care and pharmaceutical care and management. Inclusion criteria were: electronic articles are available in full in Portuguese and which were published in the period between 2006 and 2013. To collect the data of the selected articles, the following items were used: year, type of study, title and objective. Eight scientific articles were selected. It was observed that, despite all the articles have different objectives within the same theme, all brought to light a common problem: the lack of proper structuring of PC in Brazil. The study revealed that PC is still seen as a mere drug supply sector. Therefore, it is suggested the management focused on administrative activities with PC facing the drug and user...
Humans , Male , Female , Drug Storage , Health Information Systems , National Drug Policy , Pharmaceutical Services , Pharmaceutical Preparations/supply & distribution , Clinical Protocols , Health Management , Health Promotion , Health Services , Organization and Administration , Public Policy
