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1.
Int J Neurosci ; 133(6): 642-647, 2023 Jun.
Article En | MEDLINE | ID: mdl-34275423

Rosette-forming glioneuronal tumor (RGNT) of the 4th ventricle is a newly described WHO grade I brain tumor included in recent WHO classification of CNS tumors. It is a biphasic tumor thought to originate from pluripotent progenitor cells of subependymal plate. Intra-operative diagnosis plays an important role, as complete surgical excision is the treatment of choice. We are reporting a case of RGNT in a 19 years-old young male emphasizing the intra-operative pathological pointers and their role in accurate diagnosis for the suitable surgical intervention.


Brain Neoplasms , Cerebral Ventricle Neoplasms , Male , Humans , Young Adult , Adult , Cerebral Ventricle Neoplasms/diagnostic imaging , Cerebral Ventricle Neoplasms/surgery , Fourth Ventricle/diagnostic imaging , Fourth Ventricle/surgery , Fourth Ventricle/pathology , Brain Neoplasms/diagnostic imaging , Brain Neoplasms/surgery , Cytological Techniques , Rosette Formation
2.
Eur J Ophthalmol ; 33(3): NP60-NP65, 2023 May.
Article En | MEDLINE | ID: mdl-35229680

INTRODUCTION: Rosai Dorfman disease (RDD) is a rare benign histiocytic proliferative disorder of lymph node sinuses. Langerhans cell histiocytosis (LCH) is a solitary or multisystem clonal proliferation of abnormal dendritic cells (Langerhans cells) with varied presentations. The co-occurrence of these two entities is quite rare. CASE DESCRIPTION: A six-year-old boy presented with multiple mass lesions in the neck since two years and a nodular lesion in right upper eyelid for the past 4 months. He was diagnosed with tubercular lymphadenitis 2 years back, and was given a course of anti-tubercular therapy (ATT) elsewhere. No improvement was seen. Fine needle aspiration cytology (FNAC) of the cervical lymph nodes revealed reactive lymphadenitis while lymph node biopsy showed features of RDD. Excision biopsy of the orbital mass showed features of both RDD and LCH. The patient was started on tablet prednisolone. Six months later, complete resolution of lymph node enlargement and remaining orbital mass was noted. Post operative contrast enhanced Magnetic Resonance Imaging of head and neck was normal. CONCLUSION: The coexistence of RDD and LCH may be a result of divergent differentiation from a common lineage or a de novo phenotypic evolution.


Histiocytosis, Langerhans-Cell , Histiocytosis, Sinus , Lymphadenitis , Male , Humans , Child , Histiocytosis, Sinus/diagnosis , Histiocytosis, Sinus/drug therapy , Histiocytosis, Sinus/complications , Histiocytosis, Langerhans-Cell/diagnosis , Histiocytosis, Langerhans-Cell/drug therapy , Histiocytosis, Langerhans-Cell/complications , Biopsy , Lymph Nodes/pathology , Lymphadenitis/complications , Lymphadenitis/pathology
3.
Case Rep Ophthalmol Med ; 2022: 3032246, 2022.
Article En | MEDLINE | ID: mdl-35368581

A middle-aged lady presented with a firm, nontender mass on the left upper lid and area behind the left ear following lid reconstruction with postauricular graft for cicatricial ectropion 11 months prior. She had a similar mass on the right shin. She was diagnosed as a case of multiple keloids. Intralesional injection of triamcinolone acetonide suspension and 5-Fluorouracil (5-FU) in the upper lid keloid resulted in ulceration of its surface. Surgical excision, injection of 5-FU in the keloid bed with temporal forehead flap reconstruction, was performed. Occurrence of inadvertent postoperative wound infection with Acinetobacter baumannii was treated with local dressing with colistimethate sodium. Adjuvant therapy with topical imiquimod cream 5% was given subsequently for 24 weeks with no recurrence of the lid keloid after 16 months. The patient was managed using a combination of conservative and surgical therapy and multidisciplinary team work and kept on a long term follow-up.

4.
BMC Cancer ; 22(1): 133, 2022 Feb 02.
Article En | MEDLINE | ID: mdl-35109816

BACKGROUND: Gonadotropin-releasing hormone (GnRH) receptor, a rhodopsin-like G-protein coupled receptor (GPCR) family member involved in GnRH signaling, is reported to be expressed in several tumors including glioblastoma multiforme (GBM), one of the most malignant and aggressive forms of primary brain tumors. However, the molecular targets associated with GnRH receptor are not well studied in GBM or in other cancers. The present study aims at investigating the effect of GnRH agonist (Gosarelin acetate) on cell proliferation and associated signaling pathways in GBM cell line, LN229. METHODS: LN229 cells were treated with different concentrations of GnRH agonist (10-10 M to 10-5 M) and the effect on cell proliferation was analyzed by cell count method. Further, total protein was extracted from control and GnRH agonist treated cells (with maximum reduction in cell proliferation) followed by trypsin digestion, labeling with iTRAQ reagents and LC-MS/MS analysis to identify differentially expressed proteins. Bioinformatic analysis was performed for annotation of proteins for the associated molecular function, altered pathways and network analysis using STRING database. RESULTS: The treatment with different concentrations of GnRH agonist showed a reduction in cell proliferation with a maximum reduction of 48.2% observed at 10-6 M. Quantitative proteomic analysis after GnRH agonist treatment (10-6 M) led to the identification of a total of 29 differentially expressed proteins with 1.3-fold change (23 upregulated, such as, kininogen-1 (KNG1), alpha-2-HS-glycoprotein (AHSG), alpha-fetoprotein (AFP), and 6 downregulated, such as integrator complex subunit 11 (CPSF3L), protein FRG1 (FRG1). Some of them are known [KNG1, AHSG, AFP] while others such as inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2), ITIH4, and LIM domain-containing protein 1 (LIMD1) are novel to GnRH signaling pathway. Protein-protein interaction analysis showed a direct interaction of KNG1, a hub molecule, with GnRH, GnRH receptor, EGFR and other interactors including ITIH2, ITIH4 and AHSG. Overexpression of KNG1 after GnRH agonist treatment was validated using Western blot analysis, while a significant inhibition of EGFR was observed after GnRH agonist treatment. CONCLUSIONS: The study suggests a possible link of GnRH signaling with EGFR signaling pathways likely via KNG1. KNG1 inhibitors may be investigated independently or in combination with GnRH agonist for therapeutic applications.


Brain Neoplasms/metabolism , Cell Proliferation/drug effects , Glioblastoma/metabolism , Gonadotropin-Releasing Hormone/biosynthesis , Receptors, LHRH/biosynthesis , Animals , Antineoplastic Agents, Hormonal/pharmacology , Brain Neoplasms/genetics , Brain Neoplasms/pathology , Cell Line, Tumor , Chromatography, Liquid , Computational Biology , Glioblastoma/genetics , Glioblastoma/pathology , Gonadotropin-Releasing Hormone/agonists , Gonadotropin-Releasing Hormone/genetics , Goserelin/pharmacology , Humans , Proteomics/methods , Receptors, LHRH/genetics , Signal Transduction/drug effects , Tandem Mass Spectrometry
5.
BMJ Case Rep ; 14(10)2021 Oct 07.
Article En | MEDLINE | ID: mdl-34620635

A 16-year-old woman presented with a painless, progressive, hard swelling in the left inferolateral orbital wall for the past 1 year. There was no diminution of vision or limitation of ocular motility. Imaging revealed an intraosseous, well-defined, expansile, soft tissue lesion in the inferolateral wall of the left orbit. A left anterior orbitotomy with complete surgical excision was performed. Histopathological evaluation of the specimen revealed fascicular pattern of spindle cells with a rich network of slit-like, branching blood vessels. Tumour cells exhibited smooth muscle actin and vimentin positivity but were negative for CD-34 and STAT-6. In absence of any systemic manifestation, a diagnosis of intraosseous solitary orbital myofibroma was made. The case highlights the importance of integrating clinical, radiological and histopathological features in overcoming the diagnostic challenge of differentiating myofibroma from other mesenchymal neoplasms. It also brings forth the importance of complete resection and curettage to prevent recurrence.


Myofibroma , Orbit , Adolescent , Female , Humans , Myofibroma/diagnostic imaging , Myofibroma/surgery , Neoplasm Recurrence, Local , Tomography, X-Ray Computed , Vimentin
7.
Nepal J Ophthalmol ; 13(24): 225-229, 2021 Jul.
Article En | MEDLINE | ID: mdl-35996789

INTRODUCTION: This case report describes 3 cases of unsuspected neoplasms in previously blind eyes, with recent onset pain. Cases and observations: Case 1: Female with pain, redness in the non-seeing right eye (R/E) for two months. R/E had total cataract, low intraocular pressure and a well-defined globular mass lesion at the posterior pole, seen on ultrasound. Enucleation with an implant was done. Histopathology clinched the diagnosis of choroidal melanoma. Case 2: A 20-year male, developed pain, redness in left eye (L/E) for two months. L/E was blind since childhood, secondary to trauma. The patient underwent enucleation and detailed histopathological examination and immunohistochemistry supported a diagnosis of ependymoma with vascular malformation. Case 3: A 24-year male with pain, redness in L/E for six months, with decrease in size of eyeball. L/E had low vision since childhood. On examination, L/E was phthisical with diffuse conjunctival congestion, band-shaped keratopathy, cataract, and neovascularization of iris. Imaging revealed a small distorted globe with highly reflective mass along the posterior pole. Histopathology of the enucleated specimen confirmed the diagnosis of choroidal osteoma, with gliosis of the adjacent RPE. CONCLUSION: In the management of a painful blind eye, it is extremely important to rule out an intraocular malignancy, particularly in patients with recent onset of pain.


Cataract , Choroid Neoplasms , Uveal Neoplasms , Blindness/diagnosis , Blindness/etiology , Child , Choroid Neoplasms/complications , Choroid Neoplasms/diagnosis , Choroid Neoplasms/surgery , Eye Enucleation , Female , Humans , Male , Pain
8.
Acta Medica (Hradec Kralove) ; 63(4): 198-201, 2020.
Article En | MEDLINE | ID: mdl-33355082

Pseudoxanthoma elasticum (PXE) is a rare hereditary disorder occurring due to metabolic defect in the liver and manifesting predominantly in the skin, eyes and arteries. It shows characteristic yellowish papules on the skin around the nape of neck along with looseness of skin over flexural surfaces. PXE shows marked phenotypic heterogeneity. Complications related to arterial wall and retinal Bruchs' membrane calcification occur later in life; early diagnosis therefore helps keep patient on follow up for development of the same. In Indian patients, classic skin changes may be missed clinically making histopathology pivotal in diagnosis and patient management.


Pseudoxanthoma Elasticum/genetics , Adolescent , Adult , Female , Humans , India , Male , Siblings
9.
Asian J Neurosurg ; 15(4): 1027-1030, 2020.
Article En | MEDLINE | ID: mdl-33708683

Central nervous system (CNS) germinomas often extend or disseminate into the ventricular and subarachnoid space. We present a case of primary CNS germinoma consisting mainly of meningeal dissemination, which is extremely unusual and must be kept in the differential diagnosis.

10.
Indian J Dermatol Venereol Leprol ; 85(5): 455-461, 2019.
Article En | MEDLINE | ID: mdl-31031313

BACKGROUND: Alopecia areata is an autoimmune disease that occurs as a result of the loss of the inherent immune privilege of the hair follicle. It has been recently demonstrated that the interferon-γ/interleukin-15 feedback loop that signals via the Janus kinase-signal transducer and activator of transcription pathway is critical to the breakdown of this immune privilege. AIMS: To evaluate the immunological distribution of CD4+ T-cells, CD8+ T-cells, phosphorylated signal transducer and activator of transcription 1 and study its relation with the clinical and histopathological findings of the disease. MATERIALS AND METHODS: A total of 30 patients of alopecia areata were included in the study. Following a detailed history and clinical examination, a scalp biopsy was performed. Histopathology was studied and immunohistochemistry was done to demonstrate the positivity and distribution of CD4+ T-cells, CD8+ T-cells and phosphorylated signal transducer and activator of transcription 1. RESULTS: The follicular count, number of anagen and terminal hair were found to be decreased, whereas the catagen, telogen and vellus hair were found to be increased in number. A peribulbar CD4+ T-cell infiltrate was seen in 70% cases, whereas a CD8+ T-cell infiltrate was seen in 83.3% cases. An intrabulbar CD4+ T-cell infiltrate was seen in 26.7% cases, whereas a CD8+ T-cell infiltrate was seen in 70% cases. Among the 25 hair follicles dermal papilla identified, 36.8% cases were found to be positive for phospho-signal transducer and activation of transcription-1. LIMITATIONS: The drawbacks of our study included a small sample size and the use of only vertical sectioning for the scalp biopsy samples. CONCLUSION: Phosphorylated signal transducer and activator of transcription 1 positivity as an indicator of signalling via the Janus kinase-1/2 pathway was seen in 36.8% of our cases highlighting the integral role of this pathway in the pathogenesis of alopecia areata.


Alopecia Areata/immunology , Alopecia Areata/pathology , Janus Kinase 1/physiology , Janus Kinase 2/physiology , Transcription, Genetic/physiology , Adolescent , Adult , CD4-Positive T-Lymphocytes/physiology , CD8-Positive T-Lymphocytes/physiology , Child , Child, Preschool , Cross-Sectional Studies , Female , Hair Follicle/immunology , Hair Follicle/pathology , Humans , Janus Kinases/physiology , Male , Middle Aged , Young Adult
11.
J Cancer Res Ther ; 15(Supplement): S159-S162, 2019 Mar.
Article En | MEDLINE | ID: mdl-30900639

Incidentally, detected upper urinary tract urothelial carcinoma is a rare entity. We report the case of a 70-year-old female patient who presented with flank pain, pyuria, fever, and a unilateral nonfunctioning kidney with nephrolithiasis and pyonephrosis on pyelography. Routine imaging failed to identify a mass lesion. In an Indian setting, the clinical differential of tuberculosis was considered likely. A nephrectomy was performed in view of the poor perfusion and functional status of the right kidney. Histopathological examination of the kidney showed a tumor of urothelial origin arising at the renal pelvis displaying extensive squamous metaplasia. Such a near total metaplastic change is rare and has hitherto been undescribed in the renal pelvis. Activation of pleuripotent urothelial stem cells in the setting of chronic irritation and inflammation may be the pathogenetic process behind such an occurrence.


Carcinoma, Squamous Cell/diagnosis , Carcinoma, Transitional Cell/diagnosis , Incidental Findings , Kidney Neoplasms/diagnosis , Pyonephrosis/surgery , Aged , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/surgery , Carcinoma, Transitional Cell/complications , Carcinoma, Transitional Cell/pathology , Carcinoma, Transitional Cell/surgery , Female , Humans , Kidney/diagnostic imaging , Kidney/pathology , Kidney/surgery , Kidney Neoplasms/complications , Kidney Neoplasms/pathology , Kidney Neoplasms/surgery , Nephrectomy , Pyonephrosis/diagnosis , Pyonephrosis/etiology , Radionuclide Imaging , Technetium Tc 99m Pentetate/administration & dosage , Ultrasonography
12.
J Neurol Surg A Cent Eur Neurosurg ; 80(1): 58-61, 2019 Jan.
Article En | MEDLINE | ID: mdl-29972855

Chondrosarcoma is a rare malignant tumor originating from cartilaginous tissue with a tendency to localize in the epiphysis of long and pelvic bones. Only 7% of all chondrosarcomas originate in the craniocervical region. Metastasis from intracranial chondrosarcoma is extremely rare with only two previously reported cases. We report on a young patient with intracranial chondrosarcoma who presented with extracranial metastasis 2 years after surgical excision of the primary lesion. Gross total excision combined with radiotherapy so far has led to a favorable outcome.


Brain Neoplasms/pathology , Chondrosarcoma, Mesenchymal/secondary , Head and Neck Neoplasms/secondary , Brain Neoplasms/diagnostic imaging , Brain Neoplasms/surgery , Chondrosarcoma, Mesenchymal/diagnostic imaging , Chondrosarcoma, Mesenchymal/surgery , Female , Head and Neck Neoplasms/diagnostic imaging , Head and Neck Neoplasms/surgery , Humans , Young Adult
13.
World Neurosurg ; 117: 344-349, 2018 Sep.
Article En | MEDLINE | ID: mdl-29966776

BACKGROUND: Lhermitte-Duclos disease is an extremely rare pathologic entity characterized by a cerebellar mass composed of enlarged cerebellar folia containing abnormal ganglion cells. This entity usually presents in young and middle-aged adults and rarely in children. There is no study in the literature analyzing the long-term clinical course of this disease to assess the behavior primarily because of its rarity. CASE DESCRIPTION: We present our experience with a 7-year-old patient of Lhermitte-Duclos disease who was followed up for 5 years and found to have progressed to bilateral World Health Organization grade IV medulloblastoma. This case denotes the malignant potential of this rare disorder. CONCLUSIONS: LDD is seen rarely and demands a high degree of suspicion in patients presenting with cerebellar mass and/or imaging characteristics. It is prudent to keep these patients in close follow-up for early detection of malignant transformation.


Cerebellar Neoplasms/physiopathology , Hamartoma Syndrome, Multiple/physiopathology , Medulloblastoma/physiopathology , Cerebellar Neoplasms/diagnostic imaging , Cerebellar Neoplasms/pathology , Cerebellar Neoplasms/therapy , Child , Disease Progression , Hamartoma Syndrome, Multiple/diagnostic imaging , Hamartoma Syndrome, Multiple/drug therapy , Humans , Male , Medulloblastoma/diagnostic imaging , Medulloblastoma/pathology , Medulloblastoma/therapy
14.
World Neurosurg ; 115: 41-43, 2018 Jul.
Article En | MEDLINE | ID: mdl-29653277

BACKGROUND: Vertebral artery dissection (VAD) is an important cause of stroke in young and a known complication of spinal manipulation procedures, although dissection following neck massage has rarely been reported in literature. Head and neck massage by improperly trained salon employees is very popular and widely practiced in developing countries like India. In the present report we present a case of VAD following neck massage. MATERIAL AND METHODS: We present an unusual case of VAD in a 30-year-old male patient following an episode of neck massage. He developed headache, nausea, vomiting, blurred vision, diplopia, dizziness, and ataxia following the procedure. Initial history and examination suggested that the patient's symptoms were vascular in origin. We also discuss a brief review of the pathology, diagnosis, symptomatology, treatment, prognosis, and occurrence of this rare entity. RESULTS: Computed tomography and magnetic resonance imaging of the brain revealed acute infarction of the left cerebellar hemisphere. Digital subtraction angiography showed narrowing and dilatation of the V3 segment of the left vertebral artery with narrowing of the V4 segment consistent with dissection, along with a cavernous segment aneurysm of the contralateral internal carotid artery. CONCLUSION: This report illustrates the potential hazards associated with neck massage. The vertebral arteries are at risk for dissection, which can lead to acute stroke. This case also suggests that careful history taking and awareness of the symptoms of VAD are necessary to diagnose this entity as timely diagnosis and treatment can prevent permanent disability or even death.


Neck/surgery , Stroke/surgery , Vertebral Artery Dissection/surgery , Vertebral Artery/surgery , Adult , Angiography, Digital Subtraction/methods , Humans , Magnetic Resonance Angiography/methods , Magnetic Resonance Imaging/methods , Male , Stroke/diagnosis , Vertebral Artery Dissection/complications , Vertebral Artery Dissection/diagnosis
15.
J Child Neurol ; 33(6): 428-431, 2018 05.
Article En | MEDLINE | ID: mdl-29577824

A 5-year-old Indian boy presented with subacute onset regression of milestones associated with seizures and spasticity. The symptoms started after an attack of measles. The magnetic resonance imaging (MRI) of the brain showed cavitating leukodystrophy with posterior predominance. Molecular analysis of the APOPT1 gene, a recently described gene associated with mitochondrial leukodystrophy, showed the patient to be homozygous for a 12.82-kilobase deletion, including coding exon 3. Deletion of exon 3 produces a frameshift, predicting the translation of a truncated protein (p.Glu121Valfs*4). The patient was started on mitochondrial cocktail regimen of thiamine, riboflavin, coenzyme Q and carnitine. Although he initially showed some improvement, he died 6 months after the onset of his illness.


Apoptosis Regulatory Proteins/genetics , Brain/diagnostic imaging , Leukoencephalopathies/diagnostic imaging , Leukoencephalopathies/genetics , Mitochondrial Proteins/genetics , Sequence Deletion , Child, Preschool , Diagnosis, Differential , Fatal Outcome , Frameshift Mutation , Humans , Leukoencephalopathies/therapy , Male
16.
Pan Afr Med J ; 31: 233, 2018.
Article En | MEDLINE | ID: mdl-31447990

Although nearly half of all schwannomas involve the head and neck region, nasal and paranasal sinus presentations are quite rarely seen. Cystic schwannoma, characterized by cyst formation lined by S-100 protein positive membrane-like structures is very uncommonly seen in sphenoid sinus with only a single previously reported case. Here we report a young patient of cystic schwannoma of the paranasal sinuses having epicenter in the sphenoid sinus. The tumor had caused extensive erosion of the skull base and paranasal sinuses and extended intracranially that radiologically mimicked as infected mucocele causing loss of vision. This case denotes the aggressive behavior of such uncommon tumors.


Neurilemmoma/diagnosis , Paranasal Sinus Neoplasms/diagnosis , Skull Base Neoplasms/diagnosis , Cavernous Sinus/pathology , Humans , Male , Mucocele/diagnosis , Neoplasm Invasiveness , Neurilemmoma/pathology , Paranasal Sinus Neoplasms/pathology , Skull Base Neoplasms/pathology , Sphenoid Sinus/pathology , Vision Disorders/etiology , Young Adult
17.
Pract Neurol ; 18(5): 382-388, 2018 Oct.
Article En | MEDLINE | ID: mdl-31091191

Peripheral neuropathy is a common reason for referral to neurology. Chronic acquired demyelinating neuropathies are an important and varied group with overlapping presentations, and may have an immune-mediated cause. Their correct diagnosis is important as they respond to different treatments; timely intervention can prevent irreversible axonal degeneration. We present a case that highlights the approach to an adult presenting with a chronic demyelinating neuropathy.


Castleman Disease/complications , Castleman Disease/diagnostic imaging , Muscle Weakness/complications , Muscle Weakness/diagnostic imaging , POEMS Syndrome/complications , POEMS Syndrome/diagnostic imaging , Diagnosis, Differential , Humans , Male , Middle Aged , Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/complications , Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/diagnostic imaging
18.
Indian J Med Paediatr Oncol ; 38(3): 387-390, 2017.
Article En | MEDLINE | ID: mdl-29200699

Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft tissue tumors commonly arising from nerve roots in the extremities with a predilection in neurofibromatosis (NF) patients. MPNSTs are known to behave aggressively, with worse prognosis in nonresectable cases, and a 5-year survival of about 52% and 15% in resectable and unresectable cases, respectively. Although cytological diagnosis in a known case of NF-1 is possible, however, in the absence of any associated syndrome in a sporadic case, it is very challenging to accurately diagnose this tumor. Till date, to the best of our knowledge, only three cases of epithelioid MPNST correctly diagnosed on cytological examination have been described. We are presenting another case of epithelioid MPNST in a 40-year-old patient with stigmata of NF-1 since childhood, diagnosed on fine-needle aspiration cytology from the left flank mass with subsequent histopathology from left inguinal lymph node metastasis.

19.
Rom J Morphol Embryol ; 58(3): 997-1001, 2017.
Article En | MEDLINE | ID: mdl-29250680

Ameloblastoma is an aggressive odontogenic tumor, which arises from odontogenic epithelium. Ameloblastomas can present in several clinical and histomorphological patterns. The granular cell variant accounts for only 3.5% to 5% of ameloblastomas. We have presented two cases of granular cell ameloblastoma (GCA) occurring in a 44-year-old and 50-year-old man, respectively. Case No. 1 on incisional biopsy was diagnosed as unicystic ameloblastoma (UA), which later after excisional biopsy was finally diagnosed as GCA owing to the features observed in excisional biopsied tissue. Case No. 2 on incisional biopsy showed darker and lighter stained cells arranged in small follicular pattern, and anastomosing cords. Meticulous immunohistochemistry, histochemical examination and careful literature search helped us to diagnose it as GCA. We have made an attempt to elucidate the diagnosis of GCA especially in cases of GCA with unusual granular component.


Ameloblastoma/diagnosis , Odontogenic Tumors/diagnosis , Adult , Ameloblastoma/pathology , Ameloblastoma/therapy , Humans , Male , Middle Aged , Odontogenic Tumors/pathology , Odontogenic Tumors/therapy
20.
J Pediatr Neurosci ; 12(2): 174-176, 2017.
Article En | MEDLINE | ID: mdl-28904580

Ovarian germ cell tumors (GCTs) are rare and affect mainly young girls and women. Two histological groups are distinguished: dysgerminomas and nondysgerminomatous tumors. These tumors have initial good responses to surgery and chemotherapy in 80% cases, but >75% of patients die due to complications of disease progression. There are very few case reports of mixed GCT with extradural spine metastases. We report a rare case of a 17-year-old girl who had undergone left salpingo-oophorectomy with omental and peritoneal biopsy for ovarian GCT with extradural spinal metastasis.

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