OBJECTIVE: To determine the effectiveness of TENS at relieving pain and improving physical function as compared to placebo TENS, and to determine its safety, in patients with knee osteoarthritis. METHODS: Multi-centre, parallel, 1:1 randomized, double-blind, placebo-controlled clinical trial conducted in six outpatient clinics in Switzerland. We included 220 participants with knee osteoarthritis recruited between October 15, 2012, and October 15, 2014. Patients were randomized to 3 weeks of treatment with TENS (n = 108) or placebo TENS (n = 112). Our pre-specified primary endpoint was knee pain at the end of 3-weeks treatment assessed with the WOMAC pain subscale. Secondary outcome measures included WOMAC physical function subscale and safety outcomes. RESULTS: There was no difference between TENS and placebo TENS in WOMAC pain at the end of treatment (mean difference -0.06; 95%CI -0.41 to 0.29; P = 0.74), nor throughout the trial duration (P = 0.98). Subgroup analyses did not indicate an interaction between patient/treatment characteristics and treatment effect on WOMAC pain at the end of treatment (P-interaction ≥0.22). The occurrence of adverse events was similar across groups, with 10.4% and 10.6% of patients reporting events in the TENS and placebo TENS groups, respectively (P = 0.95). No relevant differences were observed in secondary outcomes. CONCLUSIONS: TENS does not improve knee osteoarthritis pain when compared to placebo TENS. Therapists should consider other potentially more effective treatment modalities to decrease knee osteoarthritis pain and facilitate strengthening and aerobic exercise. Our findings are conclusive and further trials comparing TENS and placebo TENS in this patient population are not necessary.
Arthralgia/physiopathology , Arthralgia/therapy , Osteoarthritis, Knee/physiopathology , Osteoarthritis, Knee/therapy , Pain Management/methods , Transcutaneous Electric Nerve Stimulation/methods , Aged , Double-Blind Method , Female , Humans , Male , Middle Aged , Pain Measurement , Surveys and Questionnaires
In contrast to multifollicular IVF, follicular flushing seems to increase the efficacy of monofollicular IVF treatments such as natural cycle IVF (NC-IVF). However, because follicular flushing causes loss of granulosa cells, it might negatively affect luteal phase length and endocrine function of the luteal body. A prospective cohort Phase II study was performed in 24 women undergoing NC-IVF. Women underwent a reference cycle with human chorionic gonadotrophin-induced ovulation without follicle aspiration and analysis of the length of the luteal phase and luteal concentrations of progesterone and oestradiol. In addition, they underwent a NC-IVF cycle which was performed identically but follicles were aspirated and flushed three times. The luteal phase was shorter in 29.2%, equal in 16.7% and longer in 50.0% of cases following flushing of the follicles. Overall, neither difference in luteal phase length was significant [median duration (interquartile range) in reference cycle: 13 (12; 14.5), IVF (flushing) cycle: 14 (12.5; 14.5), median difference (95% CI): 0.5 (-0.5 to 1.5)] nor median progesterone and oestradiol concentrations. In conclusion, follicular flushing in NC-IVF affects neither the length of the luteal phase nor the luteal phase concentrations of progesterone and oestradiol, questioning the need for luteal phase supplementation.
Estradiol/blood , Luteal Phase/metabolism , Oocyte Retrieval/methods , Ovarian Follicle/surgery , Progesterone/blood , Adult , Female , Fertilization in Vitro/methods , Humans , Luteal Phase/physiology , Time Factors
Materials and methods: A random sample of 439 patients charts, corresponding to 3 percent of all consultations during 1994, were analyzed. The results were compared with consultations during 1998, analyzed in a previous study. Results: During 1994, patients were older, came alone to the emergency wards and consulted during the night with greater frequency than during 1988. In both years psychosis were the main cause of consultation. Compared to 1988, during 1994 there was an increase in the frequency of affective disorders (16 and 12 percent of all consultations respectively) and substance abuse (15 and 3 percent respectively). Conclusions: The increase in consultations due to affective disorders and substance abuse in 1994 is in accordance with changes in the epidemiological profile of psychiatric disorders in Santiago
Humans , Male , Female , Adolescent , Adult , Middle Aged , Mental Disorders/epidemiology , Emergency Services, Psychiatric/statistics & numerical data , Health Services Needs and Demand/statistics & numerical data
No existen suficientes sobre la realidad de la atención psiquiátrica en nuestro país y por tal motivo se realiza una revisión de los as
Humans , Mental Health , Mental Health Services/supply & distribution , Mental Health Services/statistics & numerical data
