INTRODUCTION: There is a complex interrelationship between gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) potentially promoting the occurrence and modulating severity of each other reciprocally. Presence of Barrett's esophagus (BE) is a defining factor for the diagnosis of GERD. While several studies investigated the potential impact of concomitant GERD on the presentation and course of EoE, little was known with regards to BE in EoE patients. METHODS: We analyzed prospectively collected clinical, endoscopic, and histological data from patients enrolled in the Swiss Eosinophilic Esophagitis Cohort Study (SEECS) regarding differences between EoE patients with (EoE/BE+) versus without BE (EoE/BE-) and determined the prevalence of BE in EoE patients. RESULTS: Among a total of 509 EoE patients included in our analysis, 24 (4.7%) had concomitant BE with a high male preponderance (EoE/BE+ 83.3% vs. EoE/BE- 74.4%). While there were no differences in dysphagia, odynophagia was significantly (12.5 vs. 3.1%, p = 0.047) more common in EoE/BE+ versus EoE/BE-. General well-being at last follow-up was significantly lower in EoE/BE+. Endoscopically, we observed an increased incidence of fixed rings in the proximal esophagus in EoE/BE+ (70.8 vs. 46.3% in EoE/BE-, p = 0.019) and a higher fraction of patients with a severe fibrosis in the proximal histological specimen (8.7 vs. 1.6% in EoE/BE, p = 0.017). CONCLUSION: Our study reveals that BE is twice as frequent in EoE patients compared to general population. Despite many similarities between EoE patients with and without BE, the finding of a more pronounced remodeling in EoE patients with Barrett is noteworthy.
Barrett Esophagus , Deglutition Disorders , Eosinophilic Esophagitis , Gastroesophageal Reflux , Humans , Male , Barrett Esophagus/complications , Barrett Esophagus/epidemiology , Barrett Esophagus/diagnosis , Eosinophilic Esophagitis/complications , Eosinophilic Esophagitis/epidemiology , Eosinophilic Esophagitis/diagnosis , Cohort Studies , Switzerland/epidemiology , Gastroesophageal Reflux/diagnosis , Deglutition Disorders/complications
Introdução: A atividade física está presente no dia a dia das pessoas, porém, não se observa esta prática regular pelas pessoas com deficiência. Objetivos: O estudo buscou verificar o nível de atividade física regular dos adultos com deficiência visual e sua associação com indicadores antropométricos relacionados à saúde (IndAnt). Métodos: 43 sujeitos (21 H e 22 M, 38,81 ± 11,22 anos) tiveram 17 medidas antropométricas mensuradas, utilizando a padronização ISAK, e calculadas. O nível de atividade física foi determinado utilizando o IPAQ versão curta. Resultados: Apenas alguns IndAnt (RCQ, INDICE C e % GORDURA) apresentaram associação com o nível de atividade física em mulheres (p = 0,031, p = 0,06 e p = 0,039, respectivamente). Conclusão: Foi encontrada pouca associação entre IndAnt e deficiência visual. Porém, isto pode ser explicado, em parte, por outros fatores que influenciam os indicadores antropométricos, como desequilíbrio entre a ingesta e o gasto calórico, e estes dados não foram coletados.
Introduction: The Physical activity is present in the people's daily lives; however, this habit isn't regular in disabled people. Objectives: The aim of this study wasto verify the level of regular physical activity of adults with visual impairmentand its association with health-related anthropometric measures (AntMea).Methods: 43 subjects (21 M and 22 W, 38.81 ± 11.22 years) had 17 anthropometricmeasures taken, using ISAK standardization, and calculated. The level of physicalactivity was determined using the IPAQ short version. Results: Only a fewAntMea (WHR, C INDEX and % FAT) had an association with the level of physical activity in women (p = 0.031, p = 0.06 and p = 0.039, respectively). Conclusion:There was little association between AntMea and visual impairment. However,this can be explained in part by other factors that influence the anthropometricmeasurements, such as imbalance between caloric intake and expenditure, and these data were not collected.
Humans , Male , Female , Adult , Middle Aged , Visually Impaired Persons , Body Weights and Measures , Cross-Sectional Studies
An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled telescoping of the two steps into a single efficient process, readily amenable to scaleup.
Aldehydes/chemical synthesis , Morpholines/chemical synthesis , Phenylethyl Alcohol/chemical synthesis , Antidepressive Agents/chemistry , Humans , Molecular Structure , Morpholines/chemistry , Phenylethyl Alcohol/analogs & derivatives , Phenylethyl Alcohol/chemistry , Stereoisomerism
O presente estudo é caracterizado como descritivo-exploratório e teve como objetivo geral verificar a relação entre a prática do Goalball e a orientação e mobilidade das pessoas com deficiência visual. Foram aplicados 79 questionários com os atletas de Goalball participantes da Copa Brasil de Goalball, no ano de 2007. A contribuição do Goalball na orientação e mobilidade, sob a perspectiva dos atletas, foi positiva, sendo de suma importância para o desenvolvimento motor e também para a reabilitação da pessoa com deficiência visual, pois desenvolve percepções sensório-motoras como audição e tato, além de aguçar a noção espacial e aumentar os níveis de concentração.
The present study is characterized as descriptiveexploratory and have theobjective to investigate the relationship between the practice of goalball andorientation and mobility for people with visual impairments. 79 questionnaireswere administered to goalball athletes participants of Goalball Brazil Cup, in2007. The contribution of goalball orientation and mobility from the perspective of the athletes was positive, which is extremely important for motor development and also for the rehabilitation of the person with visual impairments, because it develops motor sensory perceptions such as hearing and touching, as well asimproves the concept space and increase levels of concentration.
Humans , Male , Female , Adult , Mobility Limitation , Motor Activity , Visually Impaired Persons/rehabilitation
