Polarized dermoscopy enables visualization of linear shiny white structures in melanomas, thought to be due to the existence of fibrosis in the dermis. Our objective was to establish the existence of two types of linear shiny white structures and assess their association with different histological structures. We performed a cross-sectional study including all non-acral, non-facial melanomas from our hospital with linear shiny white structures. The outcome variable was the type of linear shiny white structures: shiny white streaks and white strands. We evaluated their association with explanatory variables that may affect the reflectance of melanomas and Breslow index. We used χ2 statistics and also calculated the sensitivity and specificity of each linear shiny white structure to predict those variables. We detected linear shiny white structures in 118 melanomas. Regarding shiny white streaks, we only found a statistically significant positive relationship with fibrosis in the papillary dermis. Regarding white strands, we found statistically significant and positive relationships with hyperkeratosis, Breslow index of 0.8 mm or more and acanthosis. Sensitivity and specificity study revealed that the presence of shiny white streaks was the most sensitive (81.7%) and specific (72.3%) for fibrosis in the papillary dermis, and presence of white strands was the most sensitive (91.1%) and specific (85.7%) for hyperkeratosis.
Melanoma , Skin Neoplasms , Cross-Sectional Studies , Dermoscopy , Humans , Retrospective Studies
No disponible
Humans , Male , Female , Child, Preschool , Child , Granuloma/diagnostic imaging , Granuloma/pathology , Face , Retrospective Studies , Ultrasonography
The aim of this prospective study in a phototherapy unit was to describe adverse events (AEs) associated with discontinuation of phototherapy in a clinical setting. A total of 872 included patients received 1,256 courses of phototherapy treatment: 76.9% narrow-band UVB (NBUVB); 9.6% systemic psoralen plus UVA (PUVA); 11.4% topical PUVA; and 2.1% UVA. Approximately a fifth of the treatments (n = 240, 19.1%) were associated with AEs, the most frequent of which was erythema (8.8%). Systemic PUVA had the highest rate of AEs (32.5%). Mycosis fungoides was the dermatosis with the highest rate of AE (36.9%). A total of 216 (17.2%) patients stopped treatment: 23.6% because of AEs (4.1% of all treatments). Treatment suspension due to AEs was associated with PUVA, both topical and systemic (p < 0.001), and diagnoses of mycosis fungoides (p <0.001), palmoplantar psoriasis (p = 0.002), hand eczema (p = 0.002) and pityriasis lichenoides (p = 0.01). In conclusion, one in every 5 patients receiving phototherapy had an AE, but few stopped treatment for this reason.
Erythema/etiology , Mycosis Fungoides/drug therapy , PUVA Therapy/adverse effects , Skin Neoplasms/drug therapy , Adult , Aged , Dermatitis, Phototoxic/etiology , Eczema/drug therapy , Female , Humans , Male , Middle Aged , Pain/etiology , Patient Dropouts , Pityriasis Lichenoides/drug therapy , Prospective Studies , Psoriasis/drug therapy
We report three cases of patients with pseudohypoparathyroidism or pseudopseudohypoparathyroidism. These diseases are considered GNAS inactivating mutation syndromes that are characterized by a diversity of alterations among which a particular phenotype and specific endocrine or ossification abnormalities may be found. These patients may present with hard cutaneous nodules, which can represent osteoma cutis. The presence of these lesions in pediatric patients should prompt the dermatologist's consideration of this group of diseases when reaching a diagnosis. A multidisciplinary team of pediatricians, endocrinologists, geneticists, and dermatologists should carefully evaluate these patients.
Pseudohypoparathyroidism/complications , Pseudohypoparathyroidism/diagnosis , Pseudopseudohypoparathyroidism/complications , Pseudopseudohypoparathyroidism/diagnosis , Skin Diseases/etiology , Adolescent , Child , Female , Humans , Male , Skin Diseases/diagnostic imaging , Skin Diseases/pathology
Anti-Bacterial Agents/adverse effects , Clindamycin/adverse effects , Hidradenitis Suppurativa/drug therapy , Medication Adherence/statistics & numerical data , Rifampin/adverse effects , Administration, Oral , Adult , Age Factors , Anti-Bacterial Agents/administration & dosage , Clindamycin/administration & dosage , Drug Therapy, Combination , Female , Humans , Male , Middle Aged , Retrospective Studies , Rifampin/administration & dosage , Smoking
Antifungal Agents/adverse effects , Dermatitis, Allergic Contact/etiology , Imidazoles/adverse effects , Nail Diseases/chemically induced , Administration, Cutaneous , Administration, Topical , Aged , Antifungal Agents/administration & dosage , Female , Foot Dermatoses/chemically induced , Hand Dermatoses/chemically induced , Humans , Imidazoles/administration & dosage , Male , Middle Aged , Patch Tests
Antifungal Agents/adverse effects , Dermatitis, Allergic Contact/etiology , Foot Dermatoses/chemically induced , Onychomycosis/drug therapy , Undecylenic Acids/adverse effects , Diagnostic Errors , Excipients/adverse effects , Female , Humans , Imidazoles/therapeutic use , Middle Aged , Nail Diseases/diagnosis , Onychomycosis/diagnosis , Solutions
