Using the developed "semiotic" classifier of laser correlation spectra of blood plasma the authors have carried out the verification of organism states of patients from the zone of Chernobyl accident, "Ural radiation trace" and collaborators from Sanct-Petersbourg Institute of Nuclear Physics. An analysis of results obtained using accidental selections which differed as to the character of radiation injury evidences for high informativeness of "semiotic" classifier of laser correlation spectra of blood plasma.
Nuclear Physics , Occupational Exposure , Plasma , Power Plants , Radioactive Hazard Release , Spectrum Analysis/methods , Humans , Lasers , Russia , Ukraine
Thymic serum activity (TSA) has been studied in 52 healthy subjects, 48 rheumatoid arthritis patients and 17 sufferers with systemic lupus erythematosus aged from 18 to 70. TSA was compared in patients under and over 40 years. In those under 40 TSA appeared significantly inhibited, while in older subjects it did not differ from age-matched control. No correlations were reported between TSA levels and clinical characteristics. Changes in TSA levels may be related both to low content of thymic hormones and formation of inactive complexes from thymic mediators with inhibitors.
Arthritis, Rheumatoid/blood , Lupus Erythematosus, Systemic/blood , Thymic Factor, Circulating/analysis , Adolescent , Adult , Aged , Chronic Disease , Humans , Middle Aged
UNLABELLED: The authors studied the levels of large- and medium molecular circulating immune complexes (CIC) and immunoglobulins of main classes (Ig) in 17 patients with systemic lupus erythematosus (SLE) and 47 patients with rheumatoid arthritis (RA). RESULTS: low molecular CIC increased in 35.2% of patients with SLE and in 42.5% with RA; patients with SLE showed a significant reduction of IgA in 80.4%. The IgA/IgM ratio was significantly reduced in SLE due to the above finding. The IgA level remained unchanged in RA.
Antigen-Antibody Complex/blood , Arthritis, Rheumatoid/immunology , Immunoglobulins/analysis , Lupus Erythematosus, Systemic/immunology , Adolescent , Adult , Aged , Chronic Disease , Humans , Middle Aged , Molecular Weight
The authors have analysed data from literature and their own results concerning multiparameter examination of the patients with rheumatoid arthritis. An effort has been made to establish a correlative relationship between changes in the following immunologic values: the level of rheumatoid factor, circulating immune complexes, antibodies to streptolysin-0 and immunoglobulin G; the number of T-lymphocytes and the quantity of natural cells of the killers and the hormone regulatory activity of thymus. Positive interdependence between the presence of rheumatoid factor and that of antibodies to streptolysin-0 as well as an increase in the content of circulating hormone complexes has been determined. In view of absence of one value which is strictly specific and compulsory for rheumatoid arthritis, it is only complex investigation that allows to describe the trends in changes of the immunologic state of the patient with rheumatoid arthritis.
Arthritis, Rheumatoid/immunology , Adult , Aged , Antigen-Antibody Complex/analysis , Antistreptolysin/analysis , Arthritis, Rheumatoid/diagnosis , Humans , Immunoglobulin G/analysis , Middle Aged , Prognosis , Rheumatoid Factor/analysis , T-Lymphocytes/immunology
Esophageal Neoplasms/immunology , Immunotherapy , Stomach Neoplasms/immunology , Thymus Extracts/therapeutic use , Thymus Hormones/blood , Adjuvants, Immunologic , Combined Modality Therapy , Esophageal Neoplasms/therapy , Humans , Postoperative Care , Stomach Neoplasms/therapy , Thymopoietins/therapeutic use , Thymus Hormones/deficiency
Lymphoproliferative Disorders/physiopathology , T-Lymphocytes/immunology , Thymus Gland/metabolism , Adolescent , Child , Child, Preschool , Humans , Infant , Mast Cells/drug effects , Mast Cells/immunology , Rosette Formation , T-Lymphocytes/drug effects , Thymic Factor, Circulating/analysis , Thymus Gland/immunology