RESUMEN
The goal of this study was to identify host and tumour factors associated with postoperative pneumonia (PP) in a selected population of laryngeal cancer patients, treated by partial laryngectomy in 20 years at our Institution and to assess its potential prognostic impact. Clinical records of 416 consecutive patients were retrospectively reviewed. Tobacco consumption, body mass index (BMI), previous pulmonary disease, age, sex, preoperative blood gas analysis values, tumour stage and type of surgery were tested as potential risk factors for PP. Finally, the prognostic impact of these variables, including PP, in terms of disease-free and actuarial survival by Kaplan-Meier and Cox analyses were evaluated. PP developed in 73 patients (16.8%). We identified two groups of patients: 26 patients experienced an early PP within the first 7-9 days after surgery, whilst 44 experienced an ab ingestis PP following attempts of oral food intake restoration, three patients died for PP related sepsis. At multivariate Cox analysis, age older than 60 years and BMI greater than 30 were statistically associated with early PP; whereas male gender and laryngectomy with neck dissection were statistically related to a higher risk of ab ingestis PP. Interestingly, the occurrence of early PP was a negative independent prognostic factor for 5-years disease-free and actuarial survival (p=0.049 and p=0.001, respectively). The occurrence of early-onset pneumonia in laryngeal cancer patients selected for conservative laryngectomies is predictable and associated with poor clinical outcome.
Asunto(s)
Carcinoma de Células Escamosas/cirugía , Neoplasias Laríngeas/cirugía , Laringectomía/mortalidad , Neumonía/etiología , Complicaciones Posoperatorias/mortalidad , Adulto , Anciano , Carcinoma de Células Escamosas/mortalidad , Femenino , Humanos , Estimación de Kaplan-Meier , Neoplasias Laríngeas/mortalidad , Laringectomía/rehabilitación , Masculino , Persona de Mediana Edad , Neumonía/mortalidad , Medición de Riesgo , Factores de Tiempo , Adulto JovenAsunto(s)
Anticuerpos Antifosfolípidos/metabolismo , Síndrome Antifosfolípido/metabolismo , Oclusión de la Arteria Retiniana/metabolismo , Oclusión de la Vena Retiniana/metabolismo , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Oclusión de la Arteria Retiniana/complicaciones , Oclusión de la Vena Retiniana/complicaciones , Factores de RiesgoAsunto(s)
Anticolesterolemiantes/efectos adversos , Lovastatina/análogos & derivados , Polimiositis/inducido químicamente , Adulto , Humanos , Hipercolesterolemia/tratamiento farmacológico , Lovastatina/efectos adversos , Masculino , Metilprednisolona/administración & dosificación , Metilprednisolona/uso terapéutico , Polimiositis/tratamiento farmacológico , Polimiositis/inmunología , SimvastatinaRESUMEN
We report a single case of Weill-Marchesani syndrome, typically characterized by progressive joint stiffness, brachiymorphy, brachydactyly, and ectopia lentis. The clinical case appears particularly interesting as the patient also had primary osteoporosis, which until now has not been considered as a possible manifestation of Weill-Marchesani syndrome.
Asunto(s)
Enfermedades del Tejido Conjuntivo/complicaciones , Enanismo/complicaciones , Osteoporosis/etiología , Adulto , Biomarcadores/sangre , Densidad Ósea , Enfermedades Óseas Metabólicas/diagnóstico por imagen , Enfermedades Óseas Metabólicas/genética , Enfermedades Óseas Metabólicas/metabolismo , Enfermedades del Tejido Conjuntivo/genética , Enfermedades del Tejido Conjuntivo/metabolismo , Enfermedades del Tejido Conjuntivo/patología , Enanismo/genética , Enanismo/metabolismo , Enanismo/patología , Humanos , Masculino , Osteoporosis/metabolismo , Fenotipo , Radiografía , SíndromeAsunto(s)
Síndrome de Eosinofilia-Mialgia/tratamiento farmacológico , Anciano , Antiinflamatorios/uso terapéutico , Antiinflamatorios no Esteroideos/uso terapéutico , Síndrome de Eosinofilia-Mialgia/etiología , Síndrome de Eosinofilia-Mialgia/fisiopatología , Humanos , Indometacina/uso terapéutico , Masculino , Metilprednisolona/uso terapéuticoAsunto(s)
Antirreumáticos/efectos adversos , Artritis Reumatoide/tratamiento farmacológico , Erupciones por Medicamentos/etiología , Metotrexato/efectos adversos , Adulto , Artritis Reumatoide/complicaciones , Biopsia , Erupciones por Medicamentos/patología , Humanos , Inyecciones Intramusculares , MasculinoRESUMEN
It is well known that patients affected by rheumatic diseases may present specific pathological trends in personality structure, as has been extensively reported in literature. Our study was aimed at investigating several aspects of the personality traits of 20 patients with psoriatic arthropathy, compared with a group of 20 patients with rheumatoid arthritis. All patients were evaluated with appropriate rating scales assigned in auto and hetero-administration. The study results points to a personality trait disturbance in psoriatic arthritis patients, which can be clearly differentiated from the anxious habitus and/or reactive-depressive state observed in patients with rheumatoid arthritis.
Asunto(s)
Artritis Psoriásica/psicología , Artritis Reumatoide/psicología , Personalidad , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pruebas de PersonalidadRESUMEN
BACKGROUNDS: Various cardiac abnormalities have been described in patients with Behçet's disease. The number of reports remains small, but increasing awareness have widened the spectrum of manifestations. We report our evaluation of cardiac involvement in 15 patients affected by Behçet's disease, diagnosed according to the criteria for the International Study Group for Behçet's Disease. PATIENTS AND METHODS: All the patients have been examined by a clinical, biochemical and instrumental point of view. Six patients resulted to be affected by heart diseases, in particular by mitral valve prolapse; moreover one of them presented an unexpected dilatative cardiomyopathy. CONCLUSIONS: The authors affirm that the pathological heart features are not so uncommon as previously reported in literature, emphasizing the necessity of a constant evaluation for the cardiovascular system also in the asymptomatic patients.
Asunto(s)
Síndrome de Behçet/complicaciones , Cardiopatías/etiología , Adulto , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
This study was performed to evaluate the therapeutic efficacy and tolerability of glucosamine sulfate in patients with gonarthritis. During the 12-month study period, the signs and symptoms of the disease were evaluated, as well as the dosage of the urinary pyridinoline. In this trial, we demonstrated that glucosamine sulfate has a chondroprotective activity, which was significant after the first 3 months of therapy. Moreover, this study showed that the side effects due to glucosamine sulfate were mild to moderate and did not require discontinuation of the drug.
Asunto(s)
Aminoácidos/uso terapéutico , Amino Azúcares/uso terapéutico , Tolerancia a Medicamentos , Glucosamina/uso terapéutico , Osteoartritis/tratamiento farmacológico , Adulto , Anciano , Quimioterapia Combinada , Femenino , Humanos , Persona de Mediana Edad , Resultado del TratamientoAsunto(s)
Artritis Reactiva/diagnóstico , Bacteriemia/diagnóstico , Cardiomiopatía Restrictiva/diagnóstico , Infecciones Estafilocócicas/diagnóstico , Staphylococcus epidermidis , Adulto , Antiinflamatorios no Esteroideos/administración & dosificación , Artritis Reactiva/tratamiento farmacológico , Bacteriemia/tratamiento farmacológico , Cardiomiopatía Restrictiva/tratamiento farmacológico , Quimioterapia Combinada , Gentamicinas/administración & dosificación , Humanos , Masculino , Infecciones Estafilocócicas/tratamiento farmacológico , Staphylococcus epidermidis/efectos de los fármacosRESUMEN
In the literature many cases of Staphylococcus epidermidis (SE) complications are reported, but we have not found any reference about reactive arthritis secondary to SE. We report an unusual case of a patient with SE bacteriaemia, who developed elbow arthritis, asymmetrical sacroiliitis, keratoderma and restrictive cardiomyopathy. The clinical pictures, the instrumental and biochemical findings, in particular the positivity of HLA B27, allow us to set this case in the complex and heterogeneous chapter of reactive arthritis.
Asunto(s)
Artritis Reactiva/etiología , Bacteriemia/complicaciones , Antígeno HLA-B27/inmunología , Infecciones Estafilocócicas/complicaciones , Staphylococcus epidermidis/inmunología , Adulto , Artritis Reactiva/diagnóstico , Artritis Reactiva/tratamiento farmacológico , Artritis Reactiva/fisiopatología , Bacteriemia/diagnóstico , Bacteriemia/tratamiento farmacológico , Bacteriemia/fisiopatología , Cardiomiopatías/diagnóstico por imagen , Cardiomiopatías/etiología , Diagnóstico Diferencial , Ecocardiografía , Humanos , Queratodermia Palmoplantar/etiología , Queratodermia Palmoplantar/fisiopatología , Masculino , Articulación Sacroiliaca/fisiopatología , Infecciones Estafilocócicas/diagnóstico , Infecciones Estafilocócicas/tratamiento farmacológico , Infecciones Estafilocócicas/fisiopatología , Staphylococcus epidermidis/efectos de los fármacosAsunto(s)
Infecciones por Chlamydia/complicaciones , Chlamydia trachomatis/aislamiento & purificación , Pericarditis/complicaciones , Síndrome de Sjögren/complicaciones , Adulto , Infecciones por Chlamydia/diagnóstico , Infecciones por Chlamydia/tratamiento farmacológico , Infecciones por Chlamydia/fisiopatología , Diagnóstico Diferencial , Femenino , Humanos , Pericarditis/diagnóstico , Pericarditis/tratamiento farmacológico , Pericarditis/fisiopatología , Síndrome de Sjögren/diagnóstico , Síndrome de Sjögren/tratamiento farmacológico , Síndrome de Sjögren/fisiopatologíaRESUMEN
Nabumetone, a compound of the naphthylalkanone class, has shown considerable anti-inflammatory, analgesic and antipyretic effects, together with high systemic and organ-specific tolerability. Its reputation for tolerability has been increased by an in-vitro study evaluating the mature collagen metabolism's markers under nabumetone treatment, which shows that, nabumetone does not interfere with collagen synthesis. Therefore, unlike some nonsteroidal anti-inflammatory drugs, nabumetone might not be injurious to articular cartilage. This feature makes nabumetone even safer for long-term treatment of rheumatic and orthopaedic conditions.
Asunto(s)
Antiinflamatorios no Esteroideos/efectos adversos , Butanonas/efectos adversos , Cartílago Articular/efectos de los fármacos , Profármacos/efectos adversos , Enfermedades Reumáticas/tratamiento farmacológico , Adulto , Antiinflamatorios no Esteroideos/farmacocinética , Butanonas/farmacocinética , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Nabumetona , Proyectos Piloto , Profármacos/farmacocinética , Membrana Sinovial/efectos de los fármacos , Membrana Sinovial/metabolismoRESUMEN
Although in literature are not reported any cases of an association between palindromic rheumatism and idiopathic osteoporosis, the Authors describe two patients, to whom the above-mentioned diseases appeared and were diagnosed at the same time, suggesting a possible interrelationship.