1.
Nat Prod Res
; 20(12): 1129-35, 2006 Oct.
Article
En
| MEDLINE
| ID: mdl-17127667
A new sulfur-containing guanidino derivative, halichondria sulfonic acid (1) showing anti-HIV-1 activity, and halistanol trisulfate (2) with anti-tumor activity have been isolated from the marine sponge Halichondria rugosa Ridley & Dendy collected in the Chinese Southern Sea. The structure of 1 was elucidated by analysis of spectroscopic and crystal data.
Anti-HIV Agents/chemistry , Guanidines/chemistry , HIV-1/drug effects , Porifera/chemistry , Sterols/chemistry , Sulfonic Acids/chemistry , Animals , Anti-HIV Agents/isolation & purification , Anti-HIV Agents/toxicity , Cell Line , Cell Survival/drug effects , China , Crystallography, X-Ray , Enzyme-Linked Immunosorbent Assay , Guanidines/isolation & purification , Guanidines/toxicity , Inhibitory Concentration 50 , Molecular Structure , Oceans and Seas , Spectrophotometry, Infrared , Spectrum Analysis , Sterols/isolation & purification , Sterols/toxicity , Sulfonic Acids/isolation & purification , Sulfonic Acids/toxicity , Tetrazolium Salts , Thiazoles