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1.
Knee Surg Sports Traumatol Arthrosc ; 31(10): 4566-4574, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-37386197

RESUMEN

PURPOSE: Recurrent anterior shoulder instability caused by critical bone loss of the glenoid is a challenging condition for shoulder surgeons. The purpose of this prospective multicenter trial was to compare the arthroscopic transfer of the coracoid process (Latarjet procedure) with the arthroscopic reconstruction of the glenoid using iliac crest autografts. METHODS: A prospective multi-center trial was performed in nine orthopaedic centres in Austria, Germany and Switzerland between July 2015 and August 2021. Patients were prospectively enrolled and received either an arthroscopic Latarjet procedure or an arthroscopic iliac crest graft transfer. Standardized follow-up after 6 months and mimimum 24 months included range of motion, Western Ontario stability index (WOSI), Rowe score and subjective shoulder value (SSV). All complications were recorded. RESULTS: 177 patients (group Latarjet procedure: n = 110, group iliac crest graft: n = 67) were included in the study. WOSI (n.s.), SSV (n.s.) and Rowe score (n.s.) showed no difference at final follow-up. 10 complications were seen in group Latarjet procedure and 5 in group iliac crest graft; the frequency of complications did not differ between the two groups (n.s.). CONCLUSION: The arthrosopic Latarjet procedure and arthroscopic iliac crest graft transfer lead to comparable results regarding clinical scores, frequency of recurrent dislocations and complication rates. LEVEL OF EVIDENCE: Level II.


Asunto(s)
Inestabilidad de la Articulación , Luxación del Hombro , Articulación del Hombro , Humanos , Articulación del Hombro/cirugía , Luxación del Hombro/cirugía , Autoinjertos , Estudios Prospectivos , Hombro , Inestabilidad de la Articulación/cirugía , Inestabilidad de la Articulación/etiología , Ilion/trasplante , Artroscopía/métodos , Recurrencia
2.
Orthopadie (Heidelb) ; 52(2): 153-158, 2023 Feb.
Artículo en Alemán | MEDLINE | ID: mdl-36656335

RESUMEN

Shoulder arthrodesis and resection arthroplasty can be used as salvage procedures to treat severe complications after shoulder prosthesis failure. for both procedures, the indication and patient selection must be very strict. Shoulder arthrodesis after prosthesis failure can be indicated in young patients in case of chronic neuromuscular dysfunction. Filling the bony defect with either autologous or allogenic material and osteosynthetic primary stability are decisive for a good functional outcome. Aftercare comprises immobilization for 12 weeks and physical load is increased thereafter, depending on the sufficiency of bony consolidation. Resection arthroplasty after shoulder prosthesis failure is mostly reserved for multimorbid patients in case of a chronic infection. Thorough debridement and adequate systemic antibiotic treatment are crucial to achieve bacterial eradication.


Asunto(s)
Artrodesis , Artroplastía de Reemplazo de Hombro , Articulación del Hombro , Humanos , Artroplastia , Falla de Prótesis , Articulación del Hombro/cirugía
3.
Orthopadie (Heidelb) ; 52(2): 122-130, 2023 Feb.
Artículo en Alemán | MEDLINE | ID: mdl-36651970

RESUMEN

Glenoid implantation in revision arthroplasty of the shoulder remains a technical challenge in the case of severe bone loss. Metal glenoid augmentation and patient-specific glenoid implants represent new treatment options with great potential. Virtual planning techniques allow a differentiated evaluation of the extent of the bone loss and the planning of different augmentation options. Although not clearly defined so far, a patient-specific implant can be indicated if adequate fixation of the base plate in the native bone appears questionable. The planning is carried out with the support of the prostheses manufacturer and the stability is simulated using finite element analysis. A high level of primary stability is achieved by an optimized fitting of the implant into the bony defect. The short-term results are promising. However, in the absence of long-term results and limited options in case of revision, the use of a custom-made glenoid warrants a strict indication.


Asunto(s)
Miembros Artificiales , Enfermedades Óseas Metabólicas , Articulación del Hombro , Humanos , Articulación del Hombro/diagnóstico por imagen , Artroplastia , Escápula/cirugía , Enfermedades Óseas Metabólicas/cirugía
4.
Arch Orthop Trauma Surg ; 143(7): 4221-4227, 2023 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-36472639

RESUMEN

INTRODUCTION: Amputations of the upper extremity are rare but present a life-altering event that is accompanied with considerable restrictions for the affected patients. Even with functional prosthesis, tasks of the amputated limb are usually transferred to the unaffected arm which could result in complaints of the unaffected shoulder in the mid and long term. We therefore aimed to investigate musculoskeletal pain and morphological degenerative changes of the shoulder following a contralateral amputation. MATERIALS AND METHODS: We included all patients with a major amputation treated at our institution with a minimum of three years since the amputation. All patients received an MRI of both shoulders and were investigated using validated scores for the upper extremity and physical activity (SSV, ASES, DASH, GPAQ, SF-36). Results of the MRIs were investigated for morphological changes by two blinded investigators comparing the side of the amputation and the unharmed upper extremity and results were correlated to the time since amputation and their physical activity. RESULTS: A total of 20 patients with a mean age of 56 ± 19.9 years (range, 23-82 years) could be included in the study. The mean time since the amputation was 26.3 ± 19 years (range, 3-73 years). On the unharmed upper extremity, the mean SSV was 61.9 ± 24.6, the mean ASES-Score 54.5 ± 20.3, the Constant-score of 63.7 ± 40.4 and a DASH-score of 47.6 ± 23.8. The MRI of the unharmed shoulder showed significant more full-thickness rotator cuff tears and joint effusion compared to the side of the amputation. Significant differences in the degree of a glenohumeral arthritis, AC-joint arthritis, or partial rotator cuff tears could not be found between shoulders. CONCLUSION: Amputations of the upper extremity are associated with a high disability of the unharmed upper extremity and more full thickness rotator cuff tears compared to the side of the amputation. However, the small number of patients and rotator cuff injuries should be kept in mind when interpreting the data. LEVEL OF EVIDENCE: IV (retrospective case series).


Asunto(s)
Artritis , Lesiones del Manguito de los Rotadores , Humanos , Adulto , Persona de Mediana Edad , Anciano , Hombro , Manguito de los Rotadores/cirugía , Estudios Retrospectivos , Incidencia , Lesiones del Manguito de los Rotadores/cirugía , Amputación Quirúrgica , Resultado del Tratamiento , Artroscopía/métodos , Rango del Movimiento Articular
5.
Arch Orthop Trauma Surg ; 142(10): 2727-2738, 2022 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-34338888

RESUMEN

INTRODUCTION: There is little data available on non-operative treatment of anterior glenoid rim fractures (GRF). Nothing is known about fracture size and displacement in comparison to clinical outcomes and instability in a mainly middle-aged patient population. The aim of this study was to demonstrate the results of non-operative treatment in anterior glenoid rim fractures with the special focus on potential instability/recurrence. METHODS: The inclusion criteria were non-operatively treated anterior GRF of at least ≥ 5 mm width using the age- and gender-matched Constant/Murley score (a.-/g.-CMS) and the Western Ontario Instability Index (WOSI). Radiographic parameters (fracture morphology, displacement, major tuberosity fractures and Hill-Sachs lesion using initial CT and radiographs) and the proportion of the fractured glenoid were detected (2D-CT-circle-method) and osteoarthritis (A.P. and axial radiographs) was classified according to Samilson/Prieto. Proportion of fractured glenoid and medial displacement were correlated with the recurrence rate and the clinical scores. RESULTS: N = 36 patients could be followed-up after a mean of 4.4 years [12-140 month, average age: 58 (± 13, 33-86) years]. The a.-/g.-CMS was 93 (± 11, 61-100) points, and the WOSI was 81% (± 22%, 35-100%) on average. The mean intraarticular displacement was 4 mm (± 3 mm; 0-14 mm). The 2D-circle-method showed a mean glenoid fracture involvement of 21% (± 11, 10-52%). Two cases of frozen shoulders and one case with biceps pathology were associated with the trauma. Within the followed-up patient group re-instability has occurred in n = 2 patients (6%) within the first two weeks after trauma. Osteoarthritis was found in n = 11 cases. There was no correlation between the scores and the fracture size/displacement [(a.-/g.-CMS vs. displacement: r = - 0.08; p = 0.6; vs. size: r = - 0.29; p = 0.2); (WOSI vs. displacement: r = - 0.14; p = 0.4; vs. size: r = - 0.37; p = 0.06)], but very large (≥ 21%) fractures with displacement ≥ 4 mm showed slightly worse results without significant difference (a.-/g.-CMS p = 0.2; WOSI p = 0.2). The apprehension test was negative in all patients at final follow-up. CONCLUSION: Non-operative treatment of anterior GRF was associated with overall good results within a mainly middle-aged larger patient group. Re-instability is rare and is not associated with fragment size but can occur in the first weeks after trauma. Size and dislocation of the fracture is not a criterion for the prognosis of potential instability. LEVEL OF EVIDENCE: Level IV, retrospective case series.


Asunto(s)
Fracturas Óseas , Inestabilidad de la Articulación , Osteoartritis , Luxación del Hombro , Articulación del Hombro , Artroscopía/métodos , Fracturas Óseas/patología , Humanos , Inestabilidad de la Articulación/etiología , Inestabilidad de la Articulación/patología , Inestabilidad de la Articulación/terapia , Persona de Mediana Edad , Recurrencia , Estudios Retrospectivos , Luxación del Hombro/cirugía , Articulación del Hombro/cirugía
6.
J Orthop ; 25: 107-111, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33994707

RESUMEN

PURPOSE: Use of a relatively larger glenosphere with some larger overhang helps to minimize posterior impingement and some degree of glenoid lateralization is also beneficial in reverse shoulder arthroplasty (RSA). The optimal amounts of inferior overhang and lateralization are not agreed upon. The purpose of this in-vitro biomechanical study is to analyze the effect of glenosphere size and glenoid lateralization on deltoid load, focusing on differences in its three distinct heads. METHODS: Reverse shoulder arthroplasty (DeltaXtend, Fa. Depuy/Synthes) was performed on six cadaveric specimens. The load on each head of the deltoid muscle (spinalis, acromialis, and clavicularis) was measured indirectly by transferring deformation (µm/m) via strain gauges (Fa. Vishay) with stepwise lateralization: +0 mm (subgroup I), +5 mm (subgroup II), +10 mm (subgroup III). Each scenario was done with a 38 mm (group A) and a 42 mm (group B) glenosphere. RESULTS: In group A as well in group B, the mean measured deformation in the respective titanium omega increased with lateralization in the clavicular (AI: 119.6 µm/m, AIII: 307.3 µm/m; BI: 173.3 µm/m, BIII: 358.5 µm/m), in the spinal (AI: 85.3 µm/m, AIII: 188.5 µm/m; BI: 138.8 µm/m, BIII 261.2 µm/m) and in the acromial head (AI: 340.5 µm/µ; AIII: 454.2 µm/m; BI: 388.5 µm/m, BIII: 538.8 µm/m). A significant difference between the subgroups in the spinal (p = .048) and clavicular heads (p = .028) was found. The use of a 42 mm glenosphere increased significantly the load in each segment. CONCLUSION: Lateralization and glenosphere size increased significantly deltoid muscle loading, especially in the clavicular head. According to these in-vitro data, the high variability in the amount of lateralization influences the soft-tissue balance in reverse shoulder arthroplasty. LEVEL OF EVIDENCE: Basic science study.

7.
Arch Orthop Trauma Surg ; 141(9): 1615-1624, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-33877448

RESUMEN

INTRODUCTION: Radial head fractures account for the majority of bony elbow injuries. The individual treatment options have been described in detail. In some cases, however, an unusual concomitant injury occurs, which can significantly impede primary osteosynthesis and healing. This concomitant injury can be an interposing cartilaginous capitellar fragment. METHODS: This retrospective study describes four cases of trapped cartilage fragments of the capitellum that compromised primary osteosynthesis or primary conservative healing of a radial head fracture. Radiological imaging, function and pain level are presented pre- and postoperatively (mean follow-up 9.25 months). RESULTS: None of the four cases showed preoperative evidence of an incarcerated cartilage fragment of the capitellum. They all showed limited elbow range of motion. CT examinations were performed in all cases. In each case, the cartilage fragment was first sighted upon surgery, subsequently removed and the fractures treated with ORIF. Mean follow-up was of 9.25 months. All fractures healed, with excellent function and low pain scores. CONCLUSIONS: This study presents rare cases of a trapped humeral cartilage fragment in radial head fractures. Radiological imaging including CT scans cannot reliably detect this concomitant injury. Therefore, this problem becomes apparent and treatable only during surgery. A high degree of suspicion is necessary especially in patients with minimally displaced fractures associated with limited elbow motion and a gap at the fracture site as treating these injuries conservatively may lead to poor outcome.


Asunto(s)
Articulación del Codo , Fracturas del Radio , Adulto , Anciano , Cartílago , Articulación del Codo/diagnóstico por imagen , Articulación del Codo/cirugía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Radio (Anatomía) , Fracturas del Radio/diagnóstico por imagen , Fracturas del Radio/cirugía , Estudios Retrospectivos
8.
Knee Surg Sports Traumatol Arthrosc ; 29(12): 4188-4197, 2021 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-33688978

RESUMEN

PURPOSE: The aim of this study was to analyze the outcomes of anatomical repair and ligament bracing for Schenck III and IV knee dislocation (KD). METHODS: The results of 27 patients (15 and 12 cases of Schenck III and IV KD, respectively) after a mean follow-up of 18.1 ± 12.1 months (range 6-45 months) were retrospectively reviewed. Twenty-two patients suffered high-kinetic-energy accidents, whereas five patients suffered ultralow-velocity (ULV) trauma due to obesity. The outcome measures were the Lysholm score, Hospital for Special Surgery (HSS) knee score, Knee Society Score (KSS), Knee Injury and Osteoarthritis Outcome Score (KOOS) and Short Form 36 (SF-36) score. A kinematic 3D gait analysis with five walking trials was performed to compare the patients and healthy controls. RESULTS: The mean KSS, HSS score, Lysholm score, and KOOS were 77.4 ± 14.4, 84.6 ± 11.2, 81.5 ± 10.4, and 67.3 ± 16.8, respectively. No intra- or postoperative complications occurred. The mean range of motion deficiency compared to the healthy side was 24.4 ± 18.5°. Ten patients had first-degree residual laxity of the anterior cruciate ligament; 12 and 2 patients had first- and second-degree residual laxity of the collateral ligament, respectively. Five patients underwent additional arthroscopic arthrolysis due to arthrofibrosis at an average of 6.2 ± 1.9 months (range 4-9 months) after the initial surgery. The 3D gait analysis showed no major differences in joint stability or movement between the patients and healthy controls. Only the ULV trauma patients had significantly lower outcome scores and showed larger kinematic deviations in joint movement during the gait analysis. CONCLUSION: Anatomical repair with ligament bracing is a suitable surgical procedure in the treatment of KD and provides evidence in clinical practice with the benefit of early, definitive repair and preservation of the native ligaments. Patients reach acceptable subjective and objective functional outcomes, including mainly normalized gait patterns during short-term follow-up, with only minor changes in kinematics and spatial-temporal characteristics. Obese patients who suffered ULV trauma showed significantly inferior outcomes with larger deviations in joint kinematics. LEVEL OF EVIDENCE: Level III.


Asunto(s)
Lesiones del Ligamento Cruzado Anterior , Luxación de la Rodilla , Ligamento Cruzado Anterior , Lesiones del Ligamento Cruzado Anterior/cirugía , Fenómenos Biomecánicos , Estudios de Seguimiento , Humanos , Luxación de la Rodilla/cirugía , Articulación de la Rodilla/cirugía , Estudios Retrospectivos , Resultado del Tratamiento
9.
BMC Musculoskelet Disord ; 22(1): 284, 2021 Mar 18.
Artículo en Inglés | MEDLINE | ID: mdl-33736621

RESUMEN

AIM: The correction accuracy of the Taylor Spatial Frame (TSF) fixator depends considerably on the precise determination of the mounting parameters (MP). Incorrect parameters result in secondary deformities that require subsequent corrections. Different techniques have been described to improve the precision of MP measurement, although exact calculation is reportedly impossible radiologically. The aim of this study was to investigate the accuracy of intraoperative and postoperative radiographic measurement methods compared to direct MP measurement from TSF bone mounting. METHODS: A tibial Sawbone® model was established with different origins and reference ring positions. First, reference MPs for each origin were measured directly on the frame and bone using a calibrated, digital vernier calliper. In total 150 MPs measured with three different radiographic measurement techniques were compared to the reference MPs: digital radiographic measurements were performed using soft-copy PACS images without (method A) and with (method B) calibration and calibrated image intensifier images (method C). RESULTS: MPs measured from a non-calibrated X-ray image (method A) showed the highest variance compared to the reference MPs. A greater distance between the origin and the reference ring corresponded to less accurate MP measurements with method A. However, the MPs measured from calibrated X-ray images (method B) and calibrated image intensifier images (method C) were intercomparable (p = 0.226) and showed only minor differences compared to the reference values but significant differences to method A (p < 0,001). CONCLUSION: The results demonstrate that MPs can be accurately measured with radiographic techniques when using calibration markers and a software calibration tool, thus minimizing the source of error and improving the quality of correction.


Asunto(s)
Fijadores Externos , Tibia , Humanos , Cuidados Posoperatorios , Intensificación de Imagen Radiográfica , Radiografía , Tibia/diagnóstico por imagen
10.
Injury ; 52(6): 1606-1613, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-33436268

RESUMEN

INTRODUCTION: Segmental tibia defects remain challenging for orthopedic surgeons to treat. The aim of this study was to demonstrate bone-related and functional outcomes after treatment of complex tibial bone defects using Ilizarov bone transport with a modified intramedullary cable transportation system (CTS). PATIENTS AND METHODS: We conducted a single-center, retrospective study including all 42 patients treated for tibial bone loss via Ilizarov bone transport with CTS between 2005 and 2018. Bone-related and functional results were evaluated according to the Association for the Study and Application of Methods of Ilizarov (ASAMI) scoring system. Complication and failure rates were determined by the patients' medical files. RESULTS: Patients had a mean age of 45.5 ± 15.1 years. The mean bone defect size was 7.7 ± 3.4 cm, the average nonunion scoring system (NUSS) score was 59 ± 9.5 points, and the mean follow-up was 40.8 ± 24.4 months (range, 13-139 months). Complete bone and soft tissue healing occurred in 32/42 patients (76.2%). These patients had excellent (10), good (17), fair (2), and poor (3) results based on the ASAMI functional score. Regarding bone stock, 19 patients had excellent, 10 good, and 3 fair results. In total, 37 minor complications and 62 major complications occurred during the study. In 7 patients, bone and soft tissue healing occurred after CTS failure with either an induced membrane technique or classic bone transport; 3 patients underwent lower leg amputation. Patients with treatment failure were significantly older (57.6 vs. 41.8 years; p = 0.003). Charlson score and treatment failure had a positive correlation (Spearman's rho 0.43; p = 0.004). CONCLUSION: Bone transport using both intramedullary CTS and Ilizarov ring fixation is viable for treating patients with bone loss of the tibia and complex infection or soft tissue conditions. However, a high number of complications and surgical revisions are associated with the treatment of this severe clinical entity and should be taken into account.


Asunto(s)
Técnica de Ilizarov , Fracturas de la Tibia , Adulto , Fijadores Externos , Humanos , Persona de Mediana Edad , Estudios Retrospectivos , Tibia/diagnóstico por imagen , Tibia/cirugía , Fracturas de la Tibia/diagnóstico por imagen , Fracturas de la Tibia/cirugía , Resultado del Tratamiento
11.
Arch Orthop Trauma Surg ; 141(9): 1509-1515, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-33044707

RESUMEN

INTRODUCTION: Among the few techniques described for the treatment of coronoid fractures, osteosynthesis techniques include screw osteosynthesis from anterior to posterior (AP) or from posterior to anterior (PA) and plate osteosynthesis. The aim of this study was to test the biomechanical stability of screw osteosynthesis and plate osteosynthesis using anatomical plates in coronoid process fractures. MATERIALS AND METHODS: On a total of 25 biomechanical synthetical ulnae, a coronoid shear fracture including 70% of the coronoid height was simulated. Osteosynthesis was then performed using two 2.7 mm screws from anterior, posterior and with use of three different anatomical plates of the coronoid process. For the biomechanical testing, axial load was applied to the fragment with 1000 cycles from 5 to 250 N, load to failure and load at 100 µm displacement. Displacements were measured using a point-based three-dimensional motion analysis system. RESULTS: Osteosynthesis using the PA-screw showed significant more displacement during cyclic loading compared with all other osteosyntheses (0.99 mm), whereas AP-screw showed the smallest displacement (0.10 mm) during cyclic loading. The PA-screw technique showed a significant lower load to failure compared to all other osteosynthesis with the highest load in AP-screw osteosynthesis. The load for 100 µm displacement was the smallest in PA-screw with a significant difference to the AP-screw and one plate osteosynthesis. CONCLUSION: Osteosynthesis of large coronoid shear fractures with two small-fragment screws from anterior allows stable fixation that is not inferior to anterior plate osteosynthesis and might be an alternative in specific fracture types. Posterior screw fixation was found as the weakest fixation method. LEVEL OF EVIDENCE: Basic science study.


Asunto(s)
Tornillos Óseos , Fracturas del Cúbito , Fenómenos Biomecánicos , Fijación Interna de Fracturas , Humanos , Cúbito
12.
Eur J Orthop Surg Traumatol ; 31(4): 755-762, 2021 May.
Artículo en Inglés | MEDLINE | ID: mdl-33179139

RESUMEN

BACKGROUND: Nonunion after medial opening-wedge high tibial osteotomy (OWHTO) is a rare but serious complication with very limited data regarding its treatment. The aim of this study was to analyze the healing rate after operative treatment of nonunion after OWHTO. METHODS: We performed a single-center, retrospective study that included 14 patients with nonunion after OWHTO between 2010 and 2018. The treatment for all patients consisted of local debridement and cancellous bone grafting at the osteotomy gap. Revision osteosynthesis due to a loss of correction/loosening of the locking screws or plates was performed in 5 patients. In 7 patients, lateral hinge fractures were treated with additional lateral plating. Union was confirmed using the modified "Radiographic Union Score for Tibial fractures". Outcome measure was the Lysholm Knee Score at final follow-up. RESULTS: The mean age of the patients included in our study was 48.4 ± 6.7 years. Three patients were female (21.4%). The mean follow-up period was 20.8 ± 12.8 months. Union was achieved in 12/14 patients (85.7%) after a mean of 6 months (range, 3-13). The mean Lysholm Knee Score at the final follow-up was 83.2 ± 11.6. Two patients did not reach definitive union during the follow-up. In one patient, an infection of the nonunion following bone grafting was successfully treated with a two-stage procedure. Two patients needed additional cancellous bone grafting 6 and 8 months after the first revision surgery. All patients showed pain-free full weight bearing after union was achieved. CONCLUSIONS: Nonunions after OWHTO can generally be treated successfully with cancellous bone grafting. For patients who have loss of correction, loosening of the osteosynthetic material or fracture of the lateral hinge, an additional revision or additive osteosynthesis may be required. LEVEL OF EVIDENCE: Grade III.


Asunto(s)
Osteoartritis de la Rodilla , Fracturas de la Tibia , Placas Óseas , Femenino , Humanos , Recién Nacido , Osteoartritis de la Rodilla/diagnóstico por imagen , Osteoartritis de la Rodilla/cirugía , Osteotomía , Estudios Retrospectivos , Tibia/cirugía , Fracturas de la Tibia/diagnóstico por imagen , Fracturas de la Tibia/cirugía
13.
J Cell Mol Med ; 24(20): 11814-11827, 2020 10.
Artículo en Inglés | MEDLINE | ID: mdl-32885592

RESUMEN

Mesenchymal stromal cells are promising candidates for regenerative applications upon treatment of bone defects. Bone marrow-derived stromal cells (BMSCs) are limited by yield and donor morbidity but show superior osteogenic capacity compared to adipose-derived stromal cells (ASCs), which are highly abundant and easy to harvest. The underlying reasons for this difference on a proteomic level have not been studied yet. Human ASCs and BMSCs were characterized by FACS analysis and tri-lineage differentiation, followed by an intraindividual comparative proteomic analysis upon osteogenic differentiation. Results of the proteomic analysis were followed by functional pathway analysis. 29 patients were included with a total of 58 specimen analysed. In these, out of 5148 identified proteins 2095 could be quantified in >80% of samples of both cell types, 427 in >80% of ASCs only and 102 in >80% of BMSCs only. 281 proteins were differentially regulated with a fold change of >1.5 of which 204 were higher abundant in BMSCs and 77 in ASCs. Integrin cell surface interactions were the most overrepresented pathway with 5 integrins being among the proteins with highest fold change. Integrin 11a, a known key protein for osteogenesis, could be identified as strongly up-regulated in BMSC confirmed by Western blotting. The integrin expression profile is one of the key distinctive features of osteogenic differentiated BMSCs and ASCs. Thus, they represent a promising target for modifications of ASCs aiming to improve their osteogenic capacity and approximate them to that of BMSCs.


Asunto(s)
Tejido Adiposo/citología , Diferenciación Celular , Células Madre Mesenquimatosas/citología , Células Madre Mesenquimatosas/metabolismo , Osteogénesis , Proteómica , Adulto , Hueso Esponjoso/citología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Proteoma/metabolismo , Grasa Subcutánea/citología
14.
J Shoulder Elbow Surg ; 29(7): 1479-1483, 2020 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-32197807

RESUMEN

BACKGROUND: This study presents a new technique for assembling an all-suture anchor from existing medical products. The biomechanical characteristics of this self-made anchor (SMA) are compared with those of an industrially manufactured all-suture anchor. METHODS: The SMAs were made from established medical products (FiberWire #2 and 2-mm FiberTape; Arthrex, Naples, FL, USA). Pretesting was performed in biphasic polyurethane foam blocks. In the next step, 10 SMAs and 10 industrially made anchors (IMAs; 1.8-mm double-loaded Y-Knot Flex all-suture anchor; ConMed Linvatec, Largo, FL, USA) were applied with an insertion tool and tested in fresh porcine femora using a servohydraulic testing system, with a preload of 10 N and a displacement rate of 12.5 mm/s. Pullout strength and failure mode were recorded. RESULTS: The mean load at failure in the foam blocks was 459 ± 124 N in the SMA group and 538 ± 83 N in the IMA group. In porcine bone, failure occurred at 461 ± 102 N in the SMA group and 431 ± 135 N in the IMA group. The differences in pullout strength between the 2 types of anchor were not statistically significant, either in the foam blocks (P = .17) or in porcine bone (P = .62). CONCLUSION: A handmade all-suture anchor using 2 high-strength sutures woven into a 2-mm strip of high-strength tape did not show statistically different failure loads in polyurethane foam or in porcine metaphyseal bone in comparison with a commercially produced double-loaded all-suture anchor. The principal mode of failure in porcine bone in both groups was anchor pullout.


Asunto(s)
Fémur/cirugía , Procedimientos Ortopédicos/instrumentación , Anclas para Sutura , Suturas , Animales , Fenómenos Biomecánicos , Ensayo de Materiales , Modelos Anatómicos , Modelos Animales , Poliuretanos , Técnicas de Sutura , Porcinos , Resistencia a la Tracción
15.
Oper Orthop Traumatol ; 32(1): 35-46, 2020 Feb.
Artículo en Alemán | MEDLINE | ID: mdl-31940051

RESUMEN

OBJECTIVE: The aim of surgical treatment is reconstruction of the coronoid process' bony anatomy. INDICATIONS: Large shear fractures of the coronoid process (Regan-Morrey type II-III, O'Driscoll "tip" subtype 2 and "basal" subtype 1-2) and fractures of the anteromedial facet (O'Driscoll "anteromedial" subtype 1-3) can occur isolated or as part of the "terrible triad" injuries to the elbow. Due to the resulting instability of these injuries, surgical reconstruction is generally indicated. CONTRAINDICATIONS: In case of major accompanying soft tissue injuries to the elbow or an elbow infection, primary operative treatment using anatomical plate osteosynthesis is contraindicated. SURGICAL TECHNIQUE: Plate osteosynthesis of the coronoid process is performed through a medial approach (Hotchkiss or M. flexor carpi ulnaris split). After repositioning of the fracture fragments, a preformed anatomical plate can be fixed to the coronoid process. POSTOPERATIVE MANAGEMENT: The arm is immobilized in an over-the-elbow cast until the wounds are dried. Afterwards, the elbow should preferably be treated functionally without varus or valgus stress. RESULTS: Between January 2015 and July 2018, a total of 11 patients underwent osteosynthesis of the coronoid using anatomically preformed plate osteosynthesis. After a mean follow-up of 10.7 months, the mean Mayo Elbow Performance Score showed an excellent result with 78.89 points. The Quick Disabilities of Arm, Shoulder and Hand (Q-DASH) score showed a median of 18.64 points with a mean functional arc of 118°.


Asunto(s)
Placas Óseas , Articulación del Codo , Fijación Interna de Fracturas , Fracturas del Cúbito , Fijación Interna de Fracturas/métodos , Humanos , Rango del Movimiento Articular , Resultado del Tratamiento , Cúbito , Fracturas del Cúbito/cirugía
16.
BMC Musculoskelet Disord ; 21(1): 38, 2020 Jan 18.
Artículo en Inglés | MEDLINE | ID: mdl-31954400

RESUMEN

BACKGROUND: Septic arthritis of the elbow joint is a rare condition. Limited data is available on infections of the elbow joint following trauma or prior surgery on this joint. The aim of this study was to describe the etiology, comorbidities, bacterial spectrum and therapy of secondary purulent elbow infections. METHODS: Patients treated in our hospital were selected through retrospective chart review between 2006 and 2015. We included all patients with an empyema of the elbow after a trauma or surgical intervention on this joint. 30 patients between 26 and 82 years (mean: 52.47) were included. RESULTS: Seven patients (23.3%) were female, 23 (76.7%) male. 22 patients (73.3%) had a history of trauma, eight (26.7%) had prior elective surgeries on their elbow. Between one and 25 surgeries (mean: 5.77) were necessary for treatment. In nine patients, debridement and synovectomy were sufficient, eight patients (26.7%) received resection of the elbow joint. One patient was treated with a chronic fistula. In 18 patients (60%), cultures of aspiration/intraoperative swabs were positive for Staphylococcus aureus, four of these were methicillin-resistant. Four patients (13.3%) had positive cultures for Staphylococcus epidermidis, in five patients (16.7%) no bacteria could be cultured. CONCLUSIONS: Secondary infections of the elbow joint are a rare disease with potentially severe courses, requiring aggressive surgical treatment and possibly severely impacting elbow function. Staphylococcus aureus was the most common bacteria in secondary infections and should be addressed by empiric antibiotic treatment when no suspicion for other participating organisms is present.


Asunto(s)
Antibacterianos/uso terapéutico , Coinfección/terapia , Desbridamiento/métodos , Articulación del Codo/microbiología , Infecciones Estafilocócicas/terapia , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Coinfección/diagnóstico , Articulación del Codo/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Infecciones Estafilocócicas/diagnóstico , Staphylococcus aureus/aislamiento & purificación , Staphylococcus epidermidis/aislamiento & purificación , Adulto Joven
17.
Z Orthop Unfall ; 158(1): 58-74, 2020 Feb.
Artículo en Inglés, Alemán | MEDLINE | ID: mdl-31533167

RESUMEN

BACKGROUND: Knee joint infections with pronounced joint destruction, soft tissue and bone involvement are serious diseases in which not only the joint but also the entire extremity are directly endangered. What results can be achieved with the Ilizarov external fixator for septic knee arthrodesis? PATIENTS AND METHODS: Between 2005 and 2017, 13 patients (4 women and 9 men, mean age 46 years) with acute joint and concomitant bone and soft-tissue infections were treated with Ilizarov knee joint arthrodesis. In addition to demographic data, the time spent in the fixator, major and minor complications were retrospectively evaluated. RESULTS: The average time spent in the Ilizarov external fixator was 27 weeks (min. 13, max. 68). Arthrodesis and infection repair were primarily achieved in 12 out of 13 patients. In one patient, a delayed healing of the arthrodesis zone could be cured by iliac crest bone grafting, so that eventually a bony knee arthrodesis was achieved in all patients. Pin infects as a minor complication during the time spent in the fixator were common and could be treated by stab incision and antibiotics. Major complications occurred in 3 cases (2 femoral fractures peri-implant, 1 nonunion in the arthrodesis area), which were treated by dilatation of the Ilizarov external fixator and finally plate osteosynthesis or by resection of the pseudarthrosis and iliac crest bone grafting. CONCLUSION: The knee joint arthrodesis with the Ilizarov external fixator is a salvage procedure for limb preservation in fulminant knee joint and concomitant soft tissue infections. The advantages lie in the possibility of osteosynthesis in the acute infection and/or chronic osteomyelitis and the direct full load capacity. Disadvantages are long and complicated treatment times in the fixator with limited patient comfort.


Asunto(s)
Artrodesis , Fijadores Externos , Femenino , Fijación Interna de Fracturas , Humanos , Articulación de la Rodilla , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Resultado del Tratamiento
18.
Eur J Trauma Emerg Surg ; 46(5): 1167-1173, 2020 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-30747274

RESUMEN

PURPOSE: To analyze the differences in outcomes between primary and secondary definitive osteosynthesis for fractures of the lower leg with concomitant acute compartment syndrome (ACS). METHODS: From our trauma database, we identified a total of 107 patients with 126 fractures of AO/OTA type 41-44 and 120 ACS from January 01, 2001 to December 31, 2015 who were treated with primary or secondary definitive osteosynthesis after concomitant fasciotomy. RESULTS: Seventy-one patients with 77 fractures of AO/OTA classification type 41-44 suffering ACS received primary definitive osteosynthesis at the time of compartmental incision (POCI) and were compared to 36 patients with 49 fractures of AO/OTA type 41-44 and ACS, who received secondary definitive osteosynthesis after compartmental incision and soft tissue coverage (SOCI). Patients with POCI had a significantly shorter length of hospital stay with significantly fewer necessary surgeries to achieve definitive fracture treatment and soft tissue closure than SOCI patients (p ≤ 0.001). The overall rate of infections in both groups was 13%, without any difference between POCI and SOCI. CONCLUSIONS: POCI for AO/OTA fractures type 41-44 with ACS is a safe and effective procedure without increasing the infection rate compared to a gradual treatment (SOCI). However, the possible selection bias due to the retrospective study design needs to be considered.


Asunto(s)
Síndromes Compartimentales/cirugía , Fasciotomía , Fijación Interna de Fracturas/métodos , Fracturas Óseas/cirugía , Traumatismos de la Pierna/cirugía , Adulto , Síndromes Compartimentales/etiología , Femenino , Fracturas Óseas/complicaciones , Humanos , Traumatismos de la Pierna/complicaciones , Tiempo de Internación/estadística & datos numéricos , Masculino
19.
J Clin Orthop Trauma ; 10(2): 406-413, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30828216

RESUMEN

INTRODUCTION: Infections of the sternoclavicular joint (SCJ) account for less than 1% of all joint infections. There are no standardized diagnostic and therapeutic algorithms defined in literature. This study intended to report the risk factors, the bacterial spectrum, the extent and localization and the clinical outcome of SCJ infections. PATIENTS AND METHODS: We retrospectively reviewed the medical charts of 13 patients (8 men, five women, mean age 37.6 years) with SCJ infections between Januray 1st 2008 and October 30th 2015 for clinical parameters and radiological studies. All patients were interviewed during their follow-up along with clinical examination and assessing the Disabilities of the Arm, Shoulder and Hand questionnaire (DASH). RESULTS: Nine patients presented with local chest pain and swelling; in 4 patients, the prevalent symptom was pain without local signs of inflammation. Full blood count revealed a mean leukocytosis of 15 × 109 L and a mean CRP of 21.0 mg/dl. Approximately 61.5% reported known diabetes mellitus. 10 patients presented an involvement of surrounding structures. All patients received a preoperativ CT scan. Each patient was treated via SCJ resection without intraoperative complications. Primary wound closure was possible in all cases. The mean follow-up was 95 days. Wound culture revealed Staphylococcus aureus in all patients. Pathological examination affirmed acute osteomyelitis in 7 patients. Four patients required the intensive care of which 2 patients died from septic shock. Recurrent infection was encountered in 3 patients who underwent revision surgery. Mean DASH Score was 18.7. CONCLUSION: CT should be routinely obtained to recognize the possible extends to the surrounding structures. SCJ resection can result in satisfactory clinical results and should be considered in cases of extended infections including the surrounding structures. Empiric antibiotic coverage should contain cephalosporin or extended-spectrum penicillin. Inappropriate or less-invasive surgical procedures may cause recurrencent infections, especially in cases of osteomyelitis.

20.
Eur J Orthop Surg Traumatol ; 29(6): 1347-1353, 2019 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-30900018

RESUMEN

BACKGROUND: Acute bilateral patellar tendon rupture is a rare occurrence, especially in young patients in the absence of comorbidities. We describe a case of bilateral patellar tendon re-rupture in a young patient without predisposing factors. Further, we explain a technique for autograft augmented patellar tendon repair with bidirectional fixation using an ipsilateral semitendinosus graft in transosseous patellar and tibia bone tunnels. CASE PRESENTATION: We present the case of a 40-year-old healthy worker with bilateral acute on chronic patellar tendon rupture maintained following initial trauma and Krackow repair 2 years ago. He underwent bilateral reconstruction using semitendinosus autograft. At 1 year postoperatively, he has maintained the full range of motion and strength without re-rupture. CONCLUSION: This is the first case describing a new fixation technique after bilateral patellar tendon re-rupture. The use of semitendinosus autograft for reconstruction of the patellar tendon after re-rupture is a viable and effective option.


Asunto(s)
Tendones Isquiotibiales/trasplante , Articulación de la Rodilla , Ligamento Rotuliano , Complicaciones Posoperatorias , Traumatismos de los Tendones , Transferencia Tendinosa/métodos , Adulto , Artralgia/diagnóstico , Artralgia/etiología , Humanos , Articulación de la Rodilla/diagnóstico por imagen , Articulación de la Rodilla/fisiopatología , Imagen por Resonancia Magnética/métodos , Masculino , Ligamento Rotuliano/diagnóstico por imagen , Ligamento Rotuliano/lesiones , Ligamento Rotuliano/cirugía , Complicaciones Posoperatorias/patología , Complicaciones Posoperatorias/fisiopatología , Complicaciones Posoperatorias/cirugía , Radiografía/métodos , Rango del Movimiento Articular , Procedimientos de Cirugía Plástica , Recurrencia , Reoperación/métodos , Traumatismos de los Tendones/diagnóstico , Traumatismos de los Tendones/cirugía , Resultado del Tratamiento
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