RESUMEN
The sampling of study included 185 examined workers. Out of them 90 work at "Opitnii zavod Neftekhim" (67 females and 23 males) and 95--at "Kaustik" (64 females and 31 males) from various workshops of the given enterprises. To determine biochemical indicators samples of blood, saliva and urine were collected. The study was carried out in concordance with ethic principles of the Helsinki world medical association declaration, 2008 ed. with receiving written consent of patient to participate in study.
Asunto(s)
Industria Química , Hidrocarburos Aromáticos/efectos adversos , Enfermedades Profesionales/diagnóstico , Exposición Profesional/efectos adversos , Adulto , Antipirina/administración & dosificación , Antipirina/sangre , Biomarcadores/sangre , Biomarcadores/orina , Catalasa/sangre , Eritrocitos/química , Eritrocitos/metabolismo , Femenino , Glutatión/sangre , Gliceraldehído-3-Fosfato Deshidrogenasas/sangre , Hexoquinasa/sangre , Humanos , Isoniazida/administración & dosificación , Isoniazida/orina , Masculino , Persona de Mediana Edad , Enfermedades Profesionales/sangre , Enfermedades Profesionales/orina , Peroxidasa/sangre , Piruvato Quinasa/sangre , Saliva/química , ATPasa Intercambiadora de Sodio-Potasio/sangre , Compuestos de Sulfhidrilo/sangre , Superóxido Dismutasa/sangreRESUMEN
Based on analysis of materials provided by occupational safety department PC "UZEMiK" and JSC "Kauchuk", the authors evaluate contemporary work conditions and occupational morbidity in workers engaged into rubber, mechanical rubber and tyre industries.
Asunto(s)
Industrias , Enfermedades Profesionales , Salud Laboral/normas , Goma , Lugar de Trabajo/normas , Humanos , Morbilidad , Enfermedades Profesionales/epidemiología , Enfermedades Profesionales/etiología , Federación de RusiaRESUMEN
The article presents the results of studies concerning the effect of unfavorable factors of chemical nature on fluid of oral cavity among workers of the Ufa plant of elastomer materials, articles and structures. It is established that in persons contacting with chemical pollutants of manufacture of rubber and rubber technical production the indicators of chemiluminescence of saliva fluid are significantly expressed and depend on professional standing.
Asunto(s)
Luminiscencia , Boca/patología , Exposición Profesional , Humanos , Pronóstico , Goma/química , Goma/toxicidad , Saliva/química , Contaminación Química del AguaRESUMEN
The paper gives the results of a study of energy metabolism in the red blood cells of the workers from OAO "Salavatnefteorgsinthez" of petrochemical industry. The energy metabolism has been found to substantially change in the examinees in contact with a mixture of organic solvents and a mixture of chlorinated solvents under industrial conditions.
Asunto(s)
Contaminantes Ambientales/toxicidad , Eritrocitos/efectos de los fármacos , Hidrocarburos Clorados/toxicidad , Exposición Profesional/efectos adversos , Solventes/toxicidad , Nucleótidos de Adenina/sangre , Adenosina Trifosfatasas/sangre , Industria Química , Metabolismo Energético , Eritrocitos/metabolismo , Humanos , Fosfotransferasas (Aceptor de Grupo Alcohol)/sangreRESUMEN
The article deals with the data on morbidity with temporary disability among workers producing rubber and mechanical rubber articles in petrochemical industry. The leading place in the structure of morbidity is taken by the diseases of nervous and cardiovascular systems, liver, gastrointestinal tract, respiratory system and thyroid gland.
Asunto(s)
Industria Química , Evaluación de la Discapacidad , Enfermedades Profesionales/epidemiología , Adulto , Baskiria/epidemiología , Humanos , Persona de Mediana Edad , Morbilidad/tendencias , Enfermedades Profesionales/rehabilitación , Adulto JovenRESUMEN
The paper gives the results of studying the free radical oxidation-antioxidant defense (FRO-AOD) system in the blood, saliva, and urine of workers from the petrochemical industry OAO "Salavatnefteorgsintez". The FRO-AOD system has been ascertained to be considerably changed in the plasma, tear, and urine of persons contacting a mixture of petrol and Grade BP-1 solvent with organic solvents and aromatic hydrocarbons and a mixture of 1,2-dichloroethane with chlorinated hydrocarbons under industrial conditions.
Asunto(s)
Contaminantes Ocupacionales del Aire/toxicidad , Antioxidantes/metabolismo , Enzimas/análisis , Radicales Libres/análisis , Exposición Profesional/efectos adversos , Enzimas/sangre , Enzimas/orina , Femenino , Radicales Libres/sangre , Radicales Libres/orina , Humanos , Mediciones Luminiscentes , Masculino , Enfermedades Profesionales/inducido químicamente , Oxidación-Reducción , Medición de Riesgo , Saliva/químicaRESUMEN
The paper gives the results of studying the processes of free radical and microsomal oxidation, antioxidant defense, and energy and electrolyte metabolism in the workers of OAO "Salavatnefteorgsintez", one of the leading petrochemical plants in the Republic of Bashkortostan. The metabolic processes have been found to substantially change in the persons contacting a mixture of chlorinated and aromatic hydrocarbons under industrial conditions.
Asunto(s)
Contaminantes Ambientales/toxicidad , Exposición Profesional/efectos adversos , Contaminantes Ocupacionales del Aire/toxicidad , Antioxidantes/análisis , Industria Química , Metabolismo Energético , Radicales Libres/análisis , Humanos , Microsomas/metabolismo , Oxidación-Reducción , Petróleo , Equilibrio HidroelectrolíticoRESUMEN
The article covers results of studies concerning adenylic system state in RBC and tissues (lungs; liver, kidneys, heart, brain) of rats exposed to acute and chronic inhalation of chemical pollutants widely used in petrochemical and oil-processing industries. Findings are that the animals subjected to ecologic toxic agents have significantly decreased ATP level, ADP and AMF accumulation in tissues and RBC.
Asunto(s)
Nucleótidos de Adenina/metabolismo , Contaminantes Atmosféricos/efectos adversos , Hidrocarburos Aromáticos/efectos adversos , Hidrocarburos Clorados/efectos adversos , Solventes/efectos adversos , Adenosina Difosfato/metabolismo , Adenosina Monofosfato/metabolismo , Adenosina Trifosfato/metabolismo , Animales , Encéfalo/efectos de los fármacos , Encéfalo/metabolismo , Industria Procesadora y de Extracción , Corazón/efectos de los fármacos , Riñón/efectos de los fármacos , Riñón/metabolismo , Hígado/efectos de los fármacos , Hígado/metabolismo , Pulmón/efectos de los fármacos , Pulmón/metabolismo , Miocardio/metabolismo , RatasRESUMEN
The paper presents data on the antioxidative activity of blood, saliva, tear, and urine in petrochemical industry workers. The chemiluminescence values of plasma, saliva, tear, and urine were ascertained to be significantly higher in the persons contacting chemical pollutants.
Asunto(s)
Antioxidantes/metabolismo , Sangre/metabolismo , Mediciones Luminiscentes/métodos , Exposición Profesional/efectos adversos , Saliva/metabolismo , Orina , Adulto , Análisis Químico de la Sangre/métodos , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
The paper presents the results of studies of free radical oxidation (FRO) and antioxidant defense (AOD) in the blood, oral fluid, and urine of petrochemical industrial workers. The red blood cell, plasma, oral fluid, and urine values of FRO and AOD has been ascertained to be much pronounced in persons contacting chemical pollutants during production.
Asunto(s)
Antioxidantes/metabolismo , Radicales Libres/sangre , Radicales Libres/orina , Exposición Profesional/efectos adversos , Solventes/efectos adversos , Industria Química , Femenino , Humanos , Masculino , Oxidación-ReducciónRESUMEN
The authors present results obtained in a study of how rubber and technical rubber products influence acid and osmotic resistance of RBC in workers engaged into petrochemical industry. Findings are that the rubber and technical rubber products sensitize the RBC to osmotic and acidic lysis.
Asunto(s)
Ácidos , Industria Química/estadística & datos numéricos , Eritrocitos/fisiología , Enfermedades Profesionales/sangre , Enfermedades Profesionales/epidemiología , Petróleo , Goma , Humanos , Enfermedades Profesionales/diagnóstico , Presión Osmótica , Factores de TiempoRESUMEN
The article covers evaluation of health state in workers of main petrochemical workshops. Leading place in structure of transitory disablement morbidity in workers is occupied by cardiovascular and nervous disorders, diseases of liver, gastrointestinal tract and respiratory system.
Asunto(s)
Industria Química , Estado de Salud , Enfermedades Profesionales/epidemiología , Salud Laboral , Adulto , Evaluación de la Discapacidad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Morbilidad/tendencias , Factores de Riesgo , Federación de Rusia/epidemiología , Adulto JovenRESUMEN
The article deals with results of studies covering free radical oxidation and peroxidation in RBC, serum, saliva and urine of petrochemistry workers. Individuals exposed to chemical pollutants in production of rubber, tyre and mechanical rubber goods appeared to have considerably increased free radical oxidation parameters in RBC, serum, saliva and urine.
Asunto(s)
Industria Química , Depuradores de Radicales Libres/metabolismo , Peroxidación de Lípido/fisiología , Enfermedades Profesionales/metabolismo , Exposición Profesional/efectos adversos , Adulto , Eritrocitos/metabolismo , Femenino , Humanos , Masculino , Malondialdehído/metabolismo , Persona de Mediana Edad , Enfermedades Profesionales/etiología , Factores de Riesgo , Saliva/metabolismo , Espectrofotometría , Orina/químicaRESUMEN
Data on the impact exerted by industrial products, i.e. pyromellitic dianhydride, on the acidic and osmotic resistance of erythrocytes in workers are described. The influence of hazardous factors of the oil-and-chemical production was found to result in a changing erythrocytes' resistance (of workers) to the osmotic and acidic hemolytics with regard for a labor record and duration of contact with toxicants. The shifts in acidic and osmotic resistance can serve as an early marker of changes in the functional erythron's status in workers occupied under hazardous industrial factors.
Asunto(s)
Contaminantes Ocupacionales del Aire/efectos adversos , Eritrocitos/efectos de los fármacos , Ácido Clorhídrico/efectos adversos , Adulto , Femenino , Hemólisis , Humanos , Masculino , Persona de Mediana Edad , Presión Osmótica , PetróleoRESUMEN
The paper presents the results of studies of the amounts of diene conjugates, malonic dialdehyde, and Schiff's bases, which are molecular LPO products in the tissues of the lung, liver, kidney in animals exposed to 4-hour inhalation of cyclic hydrocarbons (pyromellitic dianhydride, durol, pseudocumene, and dioxane-1,4). Exposure to ecotoxicants at concentrations of 10 and 1 mg/m3 was found to result in the accumulation of initial, intermediate, and final molecular LPO products. These changes were recorded only after exposure to pseudocumene and dioxane vapors in a dose of 0.1 mg/m3 and after inhalation of dioxane-1,4 vapors in a dose of 0.01 mg/m3.
Asunto(s)
Hidrocarburos Cíclicos/toxicidad , Peroxidación de Lípido/efectos de los fármacos , Administración por Inhalación , Contaminantes Atmosféricos/toxicidad , Animales , Derivados del Benceno/toxicidad , Benzoatos/administración & dosificación , Benzoatos/toxicidad , Dioxanos/toxicidad , Hidrocarburos Cíclicos/administración & dosificación , Riñón/efectos de los fármacos , Riñón/metabolismo , Hígado/efectos de los fármacos , Hígado/metabolismo , Pulmón/efectos de los fármacos , Pulmón/metabolismo , Malondialdehído/metabolismo , Ratas , Bases de Schiff/metabolismo , Xenobióticos/farmacologíaRESUMEN
The authors' investigations show that red cells and tissues of animals exposed to a single 4-h inhalation of vapors of 1,2,4-trimethylbenzene in concentration 10 mg/m3 contained reduced amount of ATP, accumulated amounts of ADP, AMP in active inclusion of 32-P in the structure of these compounds. Activation of ATPase is accompanied with a rise of Na and P concentrations and fall in K, Mg and Ca ions concentrations. In blood plasm there were lower levels of Na and Ca and higher levels of K, Mg and P ions. In exposure to ecotoxicant in concentration 0.01-0.1 and 1.0 mg/m3 the changes were insignificant.
Asunto(s)
Nucleótidos de Adenina/metabolismo , Derivados del Benceno/toxicidad , Metabolismo Energético/efectos de los fármacos , Contaminantes Ambientales/toxicidad , Nucleótidos de Adenina/sangre , Adenosina Difosfato/sangre , Adenosina Difosfato/metabolismo , Adenosina Monofosfato/sangre , Adenosina Monofosfato/metabolismo , Adenosina Trifosfato/sangre , Adenosina Trifosfato/metabolismo , Administración por Inhalación , Animales , Eritrocitos/metabolismo , Riñón/metabolismo , Hígado/metabolismo , Pulmón/metabolismo , RatasRESUMEN
This paper gives data on the levels of cytochromes of B5, P450, P420, P450 + P420, on the rates of amidopyrinum N-demethylation and aniline n-hydroxylation in the tissues of the lung, liver, kidney of experimental rats upon acute and chronic (4-month) inhalation exposure to pseudocumol and durol at a concentration of 10 mg/m3. Acute and chronic inhalation exposures to the xenobiotics in this concentration result in activation of microsomal monooxygenases in the tissues of experimental rats in relation to the type of exposure.
Asunto(s)
Derivados del Benceno/toxicidad , Exposición por Inhalación , Microsomas/efectos de los fármacos , Animales , Citocromos/metabolismo , Hidroxilación , Riñón/efectos de los fármacos , Riñón/metabolismo , Hígado/efectos de los fármacos , Hígado/metabolismo , Pulmón/efectos de los fármacos , Pulmón/metabolismo , Metilación , Microsomas/enzimología , Microsomas Hepáticos/efectos de los fármacos , Microsomas Hepáticos/enzimología , Ratas , Factores de Tiempo , Xenobióticos/metabolismoRESUMEN
Disorders in erythrocyte energy metabolism, plasma and erythrocyte electrolyte metabolism, erythrocyte, plasma, and urinary free-radical oxidation, and in the urinary microsomal monoxigenase system were detected in workers engaged in oil-processing industry. All examinees were divided into 3 groups with different intensity of exposure to chemical pollutants: 1) workers having no contacts with chemicals (n = 21); 2) workers exposed to chemicals 2-3 times a week (n = 28, risk group); and 3) workers permanently exposed to chemicals for 3-5 years (n = 45). Control group consisted of 40 subjects occupationally not exposed to chemicals. The findings indicate marked changes in energy metabolism, free-radical and microsomal oxidation, and electrolyte metabolism in group 2 and more so in group 3.
Asunto(s)
Contaminantes Ocupacionales del Aire/efectos adversos , Electrólitos/sangre , Metabolismo Energético , Industria Procesadora y de Extracción , Microsomas/metabolismo , Interpretación Estadística de Datos , Femenino , Radicales Libres , Humanos , Peroxidación de Lípido , Masculino , Microsomas/enzimología , Oxidación-Reducción , Factores de TiempoRESUMEN
The influence of unfavourable factors of the industrial environment on electrolyte balance in the red blood cells and plasma of workers engaged in petroleum-refining industry was studied. All examinees were divided into 3 groups in terms of the exposure to chemical pollutants: 1) workers unexposed to chemical pollutants; 2) those exposed to them 2-3 times a week; 3) those exposed constantly during their work for 3-5 years. A control group included individuals who were not engaged in chemical industry. Groups 2 and 3 showed decreases in the levels of K, Mg, and Ca and increases in the concentrations of Na and P in the red blood cells and in those of K, Mg, and P in the plasma while plasma Na and Ca reduced.
Asunto(s)
Contaminantes Ocupacionales del Aire/efectos adversos , Electrólitos/sangre , Industria Procesadora y de Extracción , Petróleo , Adulto , Calcio/sangre , Femenino , Humanos , Magnesio/sangre , Masculino , Persona de Mediana Edad , Potasio/sangre , Sodio/sangre , Factores de TiempoRESUMEN
Free radical lipid peroxidation in erythrocytes, plasma, and urine was studied in workers engaged in oil processing industry. The examinees were divided into 3 groups with different intensity of exposure to chemical factors: 1) 21 workers without contacts with chemicals; 2) 28 workers handling chemicals 2-3 times a weeks (risk group); 3) 46 workers permanently exposed to chemicals for 3-5 years. Control group consisted of 40 workers occupationally not exposed to chemicals. Free radical lipid peroxidation in erythrocytes, plasma, and urine was intensified in groups 2 and more so in group 3.