Hydrogen sulfide regulates macrophage polarization and necroptosis to accelerate diabetic skin wound healing.

Hydrogen sulfide (H2S), recognized as the third gasotransmitter, plays a pivotal role in the pathophysiological processes of various diseases. Cystathionine γ-lyase (CSE) is the main enzyme for H2S production in the skin. However, effects and mechanisms of H2S in diabetic skin wound healing remain unclear. Our findings revealed a decrease in plasma H2S content in diabetic patients with skin wounds. CSE knockout (KO) diabetic mice resulted in delayed wound healing, reduced blood perfusion, and CD31 expression around the wounds. It also led to increased infiltration of inflammatory cells and M1-type macrophages, decreased collagen levels, α-smooth muscle actin (α-SMA), and proliferating cell nuclear antigen (PCNA) expression. Additionally, there were enhanced expressions of necroptosis related proteins, including receptor interacting protein kinase 1 (RIPK1), RIPK3 and mixed lineage kinase domain like protein (MLKL). In comparison, sodium hydrosulfide (NaHS), H2S donor, accelerated skin wound healing in leptin receptor deficiency (db/db) mice. This acceleration was accompanied by increased blood perfusion and CD31 expression, reduced infiltration of inflammatory cells and M1-type macrophages, elevated collagen levels, α-SMA, and PCNA expressions, and decreased necroptosis-related protein expressions together with nuclear factor-κB (NF-κB) p65 phosphorylation. In conclusion, H2S regulates macrophage polarization and necroptosis, contributing to the acceleration of diabetic skin wound healing. These findings offer a novel strategy for the treatment of diabetic skin wounds.

Adsorption of Congo red by fibrous xonotlite prepared from waste silicon residue.

Fibrous xonotlite was synthesized under the conditions of Na2SiO3 concentration of 0.05 mol·L-1, molar ratio of Si/Ca of 1:1, temperature of 220 °C and time of 9 h. It is worth pointing out that the Na2SiO3 solution as raw material was obtained from silicon residue through several procedures. The fibrous xonotlite exhibits excellent adsorption capacity for Congo red. 50 mL solution of Congo red with the concentrations of 100, 150 and 200 mg·L-1 can be almost completely adsorbed by 30 mg of fibrous xonotlite within 10 min, and the adsorption ratios are 94.05%, 95.50% and 94.14%. The Langmuir model describes the adsorption well, indicating the adsorption is monolayer. The adsorption kinetics follows the pseudo-second-order model. The calculated maximum adsorption capacity of fibrous xonotlite for Congo red is 574.71 mg·g-1 at room temperature. Fibrous xonotlite is a potential efficient adsorbent for Congo red owing to its rapid adsorption, high adsorption capacity and regeneration capacity.

Research on Urban Spatial Connection and Network Structure of Urban Agglomeration in Yangtze River Delta-Based on the Perspective of Information Flow.

Exploration of urban spatial connections and network structures of urban agglomeration in the Yangtze River Delta, as well as its influencing factors, is of great significance regarding optimization of the development pattern of the Yangtze River Delta urban agglomeration and promotion of regional high-quality development. Therefore, based on Baidu index data in 2015 and 2019, this paper first analyzes the spatiotemporal variation characteristics of information-flow connections in the Yangtze River Delta urban agglomeration. Then it uses social network analysis to explore the information-flow network structure in the Yangtze River Delta urban agglomeration, and finally explores the influencing factors of information-flow intensity in the Yangtze River Delta urban agglomeration. The main conclusions are as follows: (1) The total amount of information flow in the Yangtze River Delta urban agglomeration has had no obvious change, and the coverage of information flow in the central urban circle has expanded. (2) The network hierarchy presents a relatively stable "pyramid" distribution pattern, which tends to develop into a "spindle" pattern. (3) The overall network density of the Yangtze River Delta urban agglomeration is high and is increasing. The backbone network is a "triangle" structure. The central cities in the region are stable, and the subgroups are adjacent to each other geographically. (4) Gross Domestic Product, resident population of the region and the number of Internet broadband subscribers all have important effects on the total information flow, among which the number of Internet broadband subscribers has the greatest effect on the total information flow. In addition, urban functions and their positioning, urban events, history and culture, and other factors that are difficult to quantify also have a certain impact on the information-flow network among cities.

Fabrication of CIGSSe Thin Film Solar Cells with Colloidal Synthesized CuIn0.7Ga0.3S2 Nanocrystals.

Quaternary colloidal CuIn0.7Ga0.3S2 nanocrystals were synthesized by hot injection method using oleylamine as single solvent. The structure, morphology and optical absorption properties of assynthesized CuIn0.7Ga0.3S2 nanocrystals were characterized in detail using X-ray powder diffraction, transmission electron microscopy and UV-vis spectrometry. The as-fabricated CIGSSe thin film was obtained by spin-casting as-synthesized colloidal CuIn0.7Ga0.3S2 nanocrystals after selenization. The classical pn heterojunction CIGSSe/CdS thin film solar cells displayed the 6.18% power conversion efficiency under AM1.5G illumination.

Synthesis and photocatalytic degradation ability evaluation for rhodamine B of ZnO@SiO2 composite with flower-like structure.

ZnO@SiO2 composite with flower-like structure was successfully prepared with molar ratio of ZnO/SiO2 = 1:1 based on the optimized synthesizing parameters of spherical SiO2 and flower-like ZnO. SiO2 particles were coated on the flower-like ZnO to form a homogeneous film through the multidimensional polycondensation of Si(OH)4. The photocatalytic degradation ability of ZnO@SiO2 composite for rhodamine B (RhB) obtained at different ZnO/SiO2 molar ratio and the comparison to that of flower-like ZnO showed that ZnO@SiO2 composite with ZnO/SiO2 molar ratio of 1:1 displayed a relatively good photocatalytic degradation ability to degrade RhB, but it was weaker than that of flower-like ZnO. Twenty millilitres of RhB solution at a concentration of 15 mg·L-1 could be completely degraded by 300 mg flower-like ZnO powder within 3 h, while the degrading efficiency was only 82.5% by 300 mg ZnO@SiO2 composite. But ZnO@SiO2 composite showed a better photocatalytic activity than flower-like ZnO at a lower pH value of 4.5.