[A comparative study of the pharmacokinetics and pharmacodynamics of bonnecor]. / Sravnitel'noe izuchenie farmakokinetiki i farmakodinamiki bonnekora.

The pharmacokinetics and pharmacodynamics of bonnecor were studied simultaneously in animals with experimental arrhythmia. It was shown that irrespective of the animal species and individual features of the drug elimination kinetics the level of bonnecor concentration correlated with the antiarrhythmic effect. The data on the excretion of bonnecor and its metabolites in the urine in the dog and man were obtained. The decrease of bioavailability at oral administration of bonnecor was demonstrated to be related to its intensive conversion in metabolite M-I.

[Atherosclerotic lesions of the coronary arteries in acute myocardial infarction: effects on myocardial contraction, disease course and prognosis]. / Ateroskleroticheskoe porazhenie koronarnykh arterii pri ostrom infarkte miokarda: vliianie na sokratitel'nuiu funktsiiu serdtsa, techenie i prognoz zabolevaniia.

Coronary arterial affection (CAA) is an objective indicator, closely related to cardiac contractility as well as clinical severity and immediate prognosis of myocardial infarction. The progress of CAA is associated with more pronounced disorders of cardiac contractility, higher rates of severe complications and less optimistic immediate prognosis. Long-term prognosis is not affected by the magnitude of CAA in postmyocardial-infarction patients.

[Nitroglycerin pharmacodynamics in myocardial infarct]. / Farmakodinamika nitroglitserina pri infarkte miokarda.

The experience of treating 2,500 patients with acute myocardial infarction enabled the authors to prove a diverse character of nitroglycerin effect: it exerts a positive inotropic action on the myocardium, improves elastic properties of the myocardium, normalizes energy balance of the myocardium, influences the system of the blood aggregate state through contractile elements of platelets producing a hypocoagulatory effect.

[Central hemodynamic characteristics of patients with acute myocardial infarct of the right ventricle]. / Osobennosti tsentral'noi gemodinamiki u bol'nykh ostrym infarktom miokarda pravogo zheludochka.

A study of central hemodynamic parameters and clinical patterns of acute right-ventricular myocardial infarction (ARVMI) is reported. Thirty-nine patients with acute inferior left-ventricular myocardial infarction were divided into 2 groups: 28 patients with electrocardiographic signs of ARVMI (group 1) and 11 patients showing no such signs (group 2). All patients were subjected to catheterization of the heart's right compartments, and their minute blood volumes were measured by thermodilution. Three patterns of ARVMI were identified on the basis of the mean pulmonary arterial blood pressure: hypo-normo- and hypertensive ones. All the three were associated with the development of prevailing right-ventricular insufficiency in group 1.

[Relation between the extent of the myocardial lesion and the state of the coronary bed in acute myocardial infarction]. / Zavisimost' mezhdu ob'emom porazheniia serdechnoi myshtsy i sostoianiem koronarnogo rusla pri ostrom infarkte miokarda.

The probability of combined lesion of both ventricles in acute myocardial infarction (AMI) is discussed. In cases of proximal stenosis or occlusion of the right coronary artery, both inferior and right-ventricular (RV) AMI may develop. ECG recordings from the V3R-V6R, V3RIII, V4RIII leads were used for the diagnosis of RV AMI. Elevated ST segment plus the formation of Q waves and a negative T wave in the recordings from these leads indicate RV AMI in the presence of inferior AMI. The extent of myocardial lesion, estimated on the basis of maximum plasma MB CPK activity, is greater in cases of inferior AMI with electrocardiographic signs of RV AMI, as compared to inferior AMI free of such signs.