Ambulatory Blood Pressure Characteristics of Patients with Alzheimer's Disease: A Multicenter Study from China.

BACKGROUND: Previous studies revealed that abnormal blood pressure (BP) plays an important role in the pathogenesis of Alzheimer's disease (AD). However, little is known about the ambulatory BP characteristics of AD in the mild or severe stage. OBJECTIVE: We explored the ambulatory BP characteristics of AD in the mild or severe stage. METHODS: In the present study, 106 AD patients (42.5%male, average age 81.6 years) were enrolled from three centers in China. Clinal BP measurements at the supine and standing positions, neurological evaluations, and the 24 h ambulatory BP monitoring were performed. RESULTS: In the 106 AD patients, 49.2%, 36.8%, and 70%of patients had 24 h, daytime, and nighttime systolic hypertension, respectively, while 19.8%, 29.2%, and 5.7%had 24 h, daytime, and nighttime diastolic hypotension. The prevalence of the reduced and reverse dipping pattern was 34.0%and 48.1%for systolic BP and 32.1%and 45.3%for diastolic BP, respectively. The daytime diastolic BP was significantly correlated with cognitive performance. After adjustment for age, sex, and body mass index, only daytime diastolic BP was associated with remarkable cognitive deterioration (p≤0.008). Further, AD patients in the severe stage had significantly lower levels of the 24 h, daytime, and nighttime diastolic BP, compared with those in the mild stage. CONCLUSION: In general, AD patients were featured with high nighttime systolic BP, low daytime diastolic BP, and abnormal circadian BP rhythm of reduced and reverse dipping. The diastolic BP, especially daytime diastolic BP, was adversely correlated with the cognitive deterioration in AD.

Child body mass index in four cities of East China compared to Western references.

BACKGROUND: The rising trends in child obesity worldwide are poorly documented in China. AIM: The present study compared the distribution of body mass index (BMI) by age in children from four cities in East China with Western references. SUBJECTS AND METHODS: 94 370 boys and 90 048 girls aged 0-19 years from Shanghai, Jinan, Xuzhou and Hefei were measured in 1999-2004 for length/height and weight. The LMS method was used to construct BMI centiles for each city. Shanghai children aged 0-6 years in 1986 and US and UK BMI references were used for comparison. RESULTS: The median BMI curves for the four cities differed in shape from those for the USA and UK. Chinese boys were fatter than US boys in early to mid-childhood but less so in adolescence, and US boys were fatter at age 18. Within China the adiposity rebound was earlier in boys than girls. Shanghai children were appreciably fatter in 2000 than in 1986, and boys more so than girls. CONCLUSIONS: The roots of child obesity lie in early life, particularly in boys, and are linked to economic development, which has important implications for both the aetiology of child obesity and the health of current and future Chinese children.