RESUMEN
Background Replicating a total shoulder arthroplasty in laboratory is a difficult task due to complex geometry of the structures and degrees of freedom of the joint. Implanted joint shoulders have been investigated using numerical tools, but models developed lack of experimental validation. The objective of this study was to develop a finite element model that replicated correctly an experimental simulator of an implanted joint shoulder based on the comparison of measured and calculated strains. The methods used include a non-cemented Anatomical Comprehensive© Total Shoulder System that was implanted in 4th generation composite bones. The finite element model designed replicates adequately the experimental model. Both models included the most important muscles of shoulder abduction and the same boundary conditions (loads, fixation, and interface conditions). Strain gauge rosettes were used to measure strain responses on the shoulder in 90° abduction. The results of linear regression analysis between numerical and experimental results present a high correlation coefficient of 0.945 and a root-mean-square-error of 35 µÎµ, suggesting adequate agreement between the experimental and the numerical models. Small strains were obtained and changes in load distribution from posterior to anterior region were observed. As conclusion we can say that the experiments allowed good replication of the finite element model, and the use of strain gauges is suitable for numerical-experimental validation of bone joints.
Asunto(s)
Articulación del Hombro , Fenómenos Biomecánicos , Análisis de Elementos Finitos , Prótesis e Implantes , Hombro/cirugía , Articulación del Hombro/cirugíaRESUMEN
Hereditary angioedema (HAE) is a rare autosomal dominant disease due to C1 esterase inhibitor deficiency (C1-INH). The disease is characterized by subcutaneous and submucosal edema in the absence of urticaria due to the accumulation of bradykinin. This descriptive study aimed to evaluate the clinical characteristics of patients with a confirmed diagnosis of HAE referred to our Outpatient Clinic between December 2009 and November 2017. Fifty-one patients (38 F, 13 M) with a mean age of 32 years (range: 7-70 y) were included. Family history of HAE was reported in 70% (36/51) of the cases; 33/46 patients became symptomatic by 18 years of age. The median time between onset of symptoms and diagnosis was 13 years (3 mo-50 y). The most frequent triggering factors for attacks were stress (74.4%), trauma (56.4%), and hormonal variations (56%). The main symptoms were subcutaneous edema in 93.5% (43/46) of patients, gastrointestinal symptoms in 84.8% (39/46), and obstruction in the upper airways in 34.8% (16/46). Hospitalization occurred in 65.2%, of whom 13.3% had to be transferred to the Intensive Care Unit. Prophylactic treatment was instituted in 87% (40/46) of patients, and 56.5% (26/46) required additional treatment to control attacks. Owing to our data collection over a period of 8 years, a significant number of patients were identified by this HAE reference center. Despite early recognition and prophylactic treatment, a high percentage of patients were hospitalized. HAE is still diagnosed late, reinforcing the need for more reference centers specialized in diagnosis and educational projects for health professionals.
Asunto(s)
Proteína Inhibidora del Complemento C1/análisis , Angioedema Hereditario Tipos I y II/sangre , Angioedema Hereditario Tipos I y II/etiología , Adolescente , Adulto , Edad de Inicio , Anciano , Antifibrinolíticos/uso terapéutico , Niño , Antagonistas de Estrógenos/uso terapéutico , Femenino , Angioedema Hereditario Tipos I y II/tratamiento farmacológico , Angioedema Hereditario Tipos I y II/prevención & control , Hospitalización , Humanos , Masculino , Persona de Mediana Edad , Nefelometría y Turbidimetría/métodos , Profilaxis Posexposición/métodos , Factores Desencadenantes , Trauma Psicológico/complicaciones , Factores de Riesgo , Estrés Psicológico/complicaciones , Resultado del Tratamiento , Adulto JovenRESUMEN
Eucalyptus plantations can be affected by species of defoliating caterpillars. The integrated management of this group primarily involves a monitoring system, natural enemies, and biological products. Alternative control methods, including the use of conventional light traps, have not been adopted, mostly because of their low efficiency. Therefore, a more efficient light trap model was developed. The new model allowed the capture of 3.6 times as many insects as the conventional model, with a 261% gain in control efficiency. The use of this new model represents another integrated management alternative for lepidopteran pests of eucalyptus plantations and other cultured plants.
Asunto(s)
Eucalyptus , Control de Insectos/instrumentación , Control de Insectos/métodos , Insectos , Luz , Animales , Femenino , MasculinoRESUMEN
Hereditary angioedema (HAE) is a rare autosomal dominant disease due to C1 esterase inhibitor deficiency (C1-INH). The disease is characterized by subcutaneous and submucosal edema in the absence of urticaria due to the accumulation of bradykinin. This descriptive study aimed to evaluate the clinical characteristics of patients with a confirmed diagnosis of HAE referred to our Outpatient Clinic between December 2009 and November 2017. Fifty-one patients (38 F, 13 M) with a mean age of 32 years (range: 7-70 y) were included. Family history of HAE was reported in 70% (36/51) of the cases; 33/46 patients became symptomatic by 18 years of age. The median time between onset of symptoms and diagnosis was 13 years (3 mo-50 y). The most frequent triggering factors for attacks were stress (74.4%), trauma (56.4%), and hormonal variations (56%). The main symptoms were subcutaneous edema in 93.5% (43/46) of patients, gastrointestinal symptoms in 84.8% (39/46), and obstruction in the upper airways in 34.8% (16/46). Hospitalization occurred in 65.2%, of whom 13.3% had to be transferred to the Intensive Care Unit. Prophylactic treatment was instituted in 87% (40/46) of patients, and 56.5% (26/46) required additional treatment to control attacks. Owing to our data collection over a period of 8 years, a significant number of patients were identified by this HAE reference center. Despite early recognition and prophylactic treatment, a high percentage of patients were hospitalized. HAE is still diagnosed late, reinforcing the need for more reference centers specialized in diagnosis and educational projects for health professionals.
Asunto(s)
Humanos , Masculino , Femenino , Niño , Adolescente , Adulto , Persona de Mediana Edad , Anciano , Adulto Joven , Proteína Inhibidora del Complemento C1/análisis , Angioedema Hereditario Tipos I y II/etiología , Angioedema Hereditario Tipos I y II/sangre , Estrés Psicológico/complicaciones , Factores Desencadenantes , Factores de Riesgo , Resultado del Tratamiento , Edad de Inicio , Antagonistas de Estrógenos/uso terapéutico , Angioedema Hereditario Tipos I y II/prevención & control , Angioedema Hereditario Tipos I y II/tratamiento farmacológico , Profilaxis Posexposición/métodos , Trauma Psicológico/complicaciones , Hospitalización , Antifibrinolíticos/uso terapéutico , Nefelometría y Turbidimetría/métodosRESUMEN
The traditional beef production in the South of Portugal is based on a discontinuous growth (DG) system that requires lower external inputs and could enhance meat quality and financial returns to cattle producers. This system allows farmers to take advantage of the bull's compensatory growth when the pasture is abundant and finishes the cattle on concentrates for 2 to 3 months before slaughter. The fast gain rate before slaughter could be a valuable strategy to improve tenderness and to reduce its inconsistency in beef production. Therefore, the aim of this study was to evaluate the effects of production system (continuous growth (CG) v. DG) on longissimus thoracis muscle properties from Alentejana bulls. In total, 40 Alentejana male calves were allocated to two distinct feeding regimes: in the CG system, animals were fed concentrate plus hay and slaughtered at 18 months of age, whereas in the DG system, animals were fed on hay until 15 months of age and then fed the same diet provided to the CG group until 24 months of age. The DG system had a positive impact on meat tenderness (P<0.001) and global acceptability (P<0.001). DG bulls had greater fibre cross-sectional area (CSA) of glycolytic fibres (P<0.05) and relative area of the muscle (RA) occupied by type IIX fibres (P<0.01) and greater levels of α-actinin (P<0.05) and myosin light chain 2 (P<0.01) proteins, and pH24h (P<0.01) than CG bulls. The latter had greater CSA of type I (P<0.05) and type IIA (P<0.01) and greater RA of type IIA (P<0.05) and oxidative (P<0.05) than CG bulls. The compensatory growth production system had a positive impact on meat tenderness and global acceptability, overcoming the negative effects of slaughter of the bulls at a later age. The DG beef system could be a worthwhile strategy of beef production in Mediterranean areas due to the low-quality pasture in summer.
Asunto(s)
Fibras Musculares Esqueléticas/fisiología , Carne Roja/normas , Crianza de Animales Domésticos/economía , Fenómenos Fisiológicos Nutricionales de los Animales , Animales , Cruzamiento , Bovinos/genética , Bovinos/crecimiento & desarrollo , Dieta/veterinaria , Glucólisis , Masculino , Proteínas Musculares/metabolismo , Portugal , ProteolisisRESUMEN
BACKGROUND: Diabetes is known as a major cause of morbidity and mortality worldwide. Portugal is known as the European country with the highest prevalence of this disease. While diabetes prevalence data is updated annually in Portugal, the General Practitioner's (GP) Sentinel Network represents the only data source on diabetes incidence. This study describes the trends in Diabetes incidence, between 1992 and 2015, and estimate projections for the future incidence rates in Portugal until 2024. METHODS: An ecological time-series study was conducted using data from GP Sentinel Network between 1992 and 2015. Family doctors reported all new cases of Diabetes in their patients' lists. Annual trends were estimated through Poisson regression models as well as the future incidence rates (until 2024), sex and age group stratified. Incidence rate projections were adjusted to the distribution of the resident Portuguese population given Statistics Portugal projections. RESULTS: The average increase in Diabetes incidence rate was in total 4.29% (CI95% 3.80-4.80) per year under study. Until 1998-2000, the annual incidence rate was higher in women, and from 1998-2000 to 2013-2015 turn out to be higher in men. The incidence rate projected for 2022-2024 was 972.77/10(5) inhabitants in total, and 846.74/10(5) and 1114.42/10(5), respectively, in women and men. CONCLUSIONS: This is the first study in Portugal to estimate diabetes incidence rate projections. The disturbing reported projections seem realistic if things continue as in the past. Actually, effective public health policies will need to be undertaken to minimize this alarming future scenario.
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Diabetes Mellitus/epidemiología , Medicina General/tendencias , Adolescente , Adulto , Distribución por Edad , Anciano , Niño , Preescolar , Bases de Datos Factuales , Diabetes Mellitus/diagnóstico , Femenino , Predicción , Humanos , Incidencia , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Portugal/epidemiología , Distribución por Sexo , Factores de Tiempo , Adulto JovenRESUMEN
The aim of this study was to evaluate the carcass and meat characteristics of eight muscles from bulls with distinct growth paths. A total of 40 Alentejana male calves were allocated to two distinct feeding regimes. In the continuous growth (CG) system, the animals were fed concentrates plus hay and were slaughtered at 18 months of age. On the other hand, in the discontinuous growth (DG) system, the animals were fed hay until 15 months of age; the cattle were then fed the same diet provided to the CG group from 15 to 24 months of age. The DG reduced hot carcass weight, fatness and dressing %, but the proportions of fat, bone and muscle tissues in the leg were not affected. In contrast, there was a positive impact of compensatory growth on supraspinatus, triceps brachii, semitendinosus, biceps femoris muscle tenderness, overcoming the negative effects of age at slaughter. The reasons for such improvement in meat tenderness were not related to intra-muscular fat content or myofibrillar protein degradation values. An association between tenderness and muscle collagen properties was not established. The results indicate that the compensatory growth has a muscle-dependent effect.
Asunto(s)
Bovinos/crecimiento & desarrollo , Dieta/veterinaria , Métodos de Alimentación/veterinaria , Carne/normas , Músculo Esquelético/fisiología , Factores de Edad , Animales , Peso Corporal/fisiología , Métodos de Alimentación/normas , Masculino , Carne/análisis , Músculo Esquelético/metabolismoRESUMEN
Experimental studies have been made to study and validate the biomechanics of the pair femur/acetabulum considering both structures without the presence of cartilage. The main goal of this study was to validate a numerical model of the intact hip. Numerical and experimental models of the hip joint were developed with respect to the anatomical restrictions. Both iliac and femur bones were replicated based on composite replicas. Additionally, a thin layer of silicon rubber was used for the cartilage. A three-dimensional finite element model was developed and the boundary conditions of the models were applied according to the natural physiological constrains of the joint. The loads used in both models were used just for comparison purposes. The biomechanical behaviour of the models was assessed considering the maximum and minimum principal bone strains and von Mises stress. We analysed specific biomechanical parameters in the interior of the acetabular cavity and on femur's surface head to determine the role of the cartilage of the hip joint within the load transfer mechanism. The results of the study show that the stress observed in acetabular cavity was 8.3 to 9.2 MPa. When the cartilage is considered in the joint model, the absolute values of the maximum and minimum peak strains on the femur's head surface decrease simultaneously, and the strains are more uniformly distributed on both femur and iliac surfaces. With cartilage, the cortex strains increase in the medial side of the femur. We prove that finite element models of the intact hip joint can faithfully reproduce experimental models with a small difference of 7%.
Asunto(s)
Acetábulo/fisiología , Cartílago/fisiología , Cabeza Femoral/fisiología , Articulación de la Cadera/fisiología , Modelos Biológicos , Fenómenos Biomecánicos , Análisis de Elementos Finitos , HumanosRESUMEN
A 3D finite element model of an in vitro implanted mandible was analysed. The load point was placed on the condyle in three positions (inside the mouth, centred and outside) to simulate different contact points between the mandible condyle and the temporal bone. The strain fields in the condyle were assessed and detailed around the surgical screws. The temporomandibular implant studied here was modelled on a commercial device that uses four screws to fix it in vivo in a very similar position. The boundary conditions of the numerical model simulated a load on the incisors with a 15 mm mouth aperture. The same contact loads were applied to the two condyles. Numerical results were successfully obtained for the three different contact points: the inside contact produced lower strains on the condyle. The first screw created a critical strain distribution in the bone, just under the screw. The study shows that centred and inside contact induces lower strain distributions. This suggests that spherical condyle geometry should be applied in order to reduce the strains in fixation. As the top screw was observed to play the most critical role, the third screw is in fact unnecessary, since the lower strain distribution suggests that it will be loosened.
Asunto(s)
Tornillos Óseos , Prótesis Articulares , Mandíbula/fisiopatología , Cóndilo Mandibular , Diseño de Prótesis , Articulación Temporomandibular , Fenómenos Biomecánicos , Fuerza de la Mordida , Simulación por Computador , Diseño Asistido por Computadora , Módulo de Elasticidad , Análisis de Elementos Finitos , Humanos , Imagenología Tridimensional/métodos , Incisivo/fisiología , Mandíbula/cirugía , Cóndilo Mandibular/fisiopatología , Modelos Anatómicos , Modelos Biológicos , Estrés Mecánico , Propiedades de Superficie , Hueso Temporal/fisiopatología , Hueso Temporal/cirugíaRESUMEN
Virtual design gives flexibility to explore constructive solutions or structures. It enables analysis that would often be impossible even if expensive real prototypes were available. Simulations using finite element models allow access to the stress and strain tensor or to the deformation tensor within an implant or a tissue which is impossible experimentally, even in vitro. This study is based on two numerical models of temporomandibular joint (TMJ) implants, comparing two bone-implant connections: an external connection performed with surgical screws (commercial model) and an internal connection carried out by penetration into the intramedullary space. The finite element models were constructed based on a cadaveric mandible and considering the five principal muscles in action. Strain distributions into the surrounding bone tissue are analysed and in both models they show significant differences at the external surface of the mandible in displacements. However, while the intramedullary fixation increases strains in the cancellous tissue, the study shows that strain distribution is mainly influenced by the number and distribution of screws in commercial solution.
Asunto(s)
Artroplastia de Reemplazo/métodos , Clavos Ortopédicos , Tornillos Óseos , Análisis de Elementos Finitos , Prótesis Articulares , Cóndilo Mandibular , Diseño de Prótesis , Articulación Temporomandibular/cirugía , Artroplastia de Reemplazo/instrumentación , Fenómenos Biomecánicos , Cadáver , Simulación por Computador , Diseño Asistido por Computadora , Humanos , Masculino , Mandíbula/fisiología , Mandíbula/cirugía , Músculo Masetero/fisiología , Persona de Mediana Edad , Músculos Pterigoideos/fisiología , Estrés Mecánico , Músculo Temporal/fisiología , Articulación Temporomandibular/fisiología , Tomografía Computarizada por Rayos X/métodos , Interfaz Usuario-ComputadorRESUMEN
BACKGROUND: The press-fit hip acetabular prosthesis implantation can cause crack formation in the thin regions surrounding the acetabular. As a consequence the presence of cracks in this region can lead to poor fixation and fibrous tissue formation. METHODS: Numerical and experimental models of commercial press-fit hip replacements were developed to compare the behavior between the intact and implanted joints. Numerical models with an artificial crack and without crack were considered. The iliac and the femur were created through 3D geometry acquisition based on composite human replicas and 3D-Finite Element models were generated. FINDINGS: The mechanical behavior was assessed numerically and experimentally considering the principal strains. The comparison between Finite Element model predictions and experimental measurements revealed a maximum difference of 9%. Similar distribution of the principal strains around the acetabular cavity was obtained for the intact and implanted models. When comparing the Von Mises stresses, it is possible to observe that the intact model is the one that presents the highest stress values in the entire acetabular cavity surface. INTERPRETATION: The crack in the posterior side changes significantly the principal strain distribution, suggesting bone loss after hip replacement. Relatively to micromotions, these were higher on the superior side of the acetabular cavity and can change the implant stability and bone ingrowth.
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Acetábulo/lesiones , Acetábulo/fisiopatología , Artroplastia de Reemplazo de Cadera/efectos adversos , Artroplastia de Reemplazo de Cadera/métodos , Modelos Anatómicos , Acetábulo/patología , Fenómenos Biomecánicos , Cadáver , Fibrosis/etiología , Análisis de Elementos Finitos , Prótesis de Cadera , Humanos , Movimiento (Física) , Diseño de Prótesis , Estrés MecánicoRESUMEN
BACKGROUND: Bone loss and subsequent defects are often encountered in revision total knee arthroplasty. In particular, when the cortical rim of proximal tibia is breached, the surgical decision on the reconstructive options to be taken is challenging due to the variety of defects and the lack of data from clinical or experimental studies that can support it. The purpose of this study is to assess how different reconstructive techniques, when applied to an identical defect and bone condition, can be associated to dissimilar longevity of the revision procedure, and the role of a stem in this longevity. METHODS: Proximal cortex strains and implant stability were measured in ten reconstructive techniques replicated with synthetic tibiae. The cancellous bone strains under each construct were assessed with finite element models which were validated against experimental strains. FINDINGS: The measured strains and stability showed that the proximal cortex is not immune to the different reconstructive techniques when applied to an identical defect. The largest cancellous strain differences between modular and non-modular techniques indicate a distinct risk between reconstructive techniques, associated to the supporting capacity of cancellous bone at long term. INTERPRETATION: The main finding of the present study is the observation that modular augments increases, on a long term basis, the potential risk of bone resorption relative to the non-modular techniques. In addition, the use of a press-fit stem in the scope of non-modular techniques can lead to improved stability and load transfer, which can contribute positively to the life expectancy of these techniques.
Asunto(s)
Artroplastia de Reemplazo de Rodilla/métodos , Análisis de Elementos Finitos , Modelos Biológicos , Procedimientos de Cirugía Plástica/métodos , Tibia/cirugía , Fenómenos Biomecánicos , Humanos , Técnicas In Vitro , Prótesis de la Rodilla , Diseño de Prótesis , Ajuste de Prótesis , Reoperación , Estrés Mecánico , Tibia/fisiopatologíaRESUMEN
PURPOSE: Revision total knee arthroplasty presents numerous technical challenges, with lower patient outcomes compared with those obtained in primary surgery. Extended stems have been used in revision total knee arthroplasty to improve component alignment and fixation. Hybrid fixation with cemented tibial tray and press-fit stem has shown good results. One of the disadvantages of this technique is pain related to the presence of a cementless diaphyseal engaging stem, often designated as end-of-stem pain. Patients with this pain have reported a decrease in overall satisfaction, as well as demonstrate a lower clinical outcome score. Clinical findings suggest that stem material and design are important factors in the development of end-of-stem pain. Therefore, a question can be raised: can a novel press-fit stem concept minimize bone strain changes at the stem tip? The hypothesis here considered lies upon the fact, that if periosteal cortex strain changes are minimized at the stem tip comparatively to the intact situation, the risk of end-of-stem pain might be minimized. SCOPE: This pre-clinical study was accomplished using synthetic tibiae to experimentally predict the periosteal cortex strains at the proximal and stem tip regions, with a commercial press-fit stem and a new stem concept. CONCLUSIONS: The results demonstrated that the new stem concept has the ability to minimize strain changes induced by the stem tip at the distal periosteal cortex and consequently, at the periosteal layer of bone tissue, which is highly pain sensitive, probably contributing to the reduction of the risk of end-of-stem pain.
Asunto(s)
Artroplastia de Reemplazo de Rodilla/métodos , Prótesis de la Rodilla , Modelos Teóricos , Dolor Postoperatorio/prevención & control , Dolor/cirugía , Reoperación , Tibia/cirugía , Fenómenos Biomecánicos , Diáfisis/cirugía , Humanos , Diseño de PrótesisRESUMEN
PURPOSE: It has been hypothesized that femoral notching in total knee arthroplasties weakens the cortex of the femur, which can predispose to femoral fractures in the postoperative period. Some authors suggest that patients who sustain inadvertent notching should have additional protection in the postoperative period, and consideration should be given to the use of prophylactic femoral stems. In this case, a question can be raised: Is the use of femoral stem in an anterior femoral notching an effective way to reduce the fracture risk? We hypothesized that for a larger notch, the use of a femoral stem does not decrease considerably the stress-riser at the notch edge, and the use of stem is not enough to reduce the risk of fracture. METHODS: In the present in vitro study, twelve synthetic femurs were selected and used for the experiments under two load scenarios. Femoral components with and without femoral stems were implanted in femurs with different notch sizes to predict experimentally the strain levels at the notch edge with the use of fiber Bragg gratings and at notch region with strain gauges. RESULTS: Despite the global strain reduction in stemmed condition, at the notch edge, the strain behavior was dissimilar for the different notch depths. For notch depths lower than 5 mm, the use of stem reduces the strain level at the notch edge to values below the intact femur condition, while for depths greater or equal to 5 mm, the strain levels at the notch edge were higher than the intact femur condition with values ranging from +10 to +189%. CONCLUSIONS: The present study suggests the use of a prophylactic stem for notch depths greater than 5 mm. For notch depths below 5 mm, the fracture risk due to strain increase at the notch edge seems to be low in the stemless condition.
Asunto(s)
Artroplastia de Reemplazo de Rodilla/métodos , Fracturas Periprotésicas/prevención & control , Humanos , Prótesis de la Rodilla , Ensayo de Materiales , Diseño de Prótesis , Medición de Riesgo , Estrés Mecánico , Torsión MecánicaRESUMEN
Taguchi technique is a powerful method of solving engineering problems in order to improve the performance of a process and to enhance the productivity. The methodology for the design of the experiment is proposed in order to find the best parameters for better experimental results with less number of experiments as possible. In this study, Taguchi technique was applied to optimize the compression moulding cycle for processing the Acetabular cup prototype. For the design of the experiments, three main factors such as processing temperature, pressure and the time of compaction were identified which directly influence the quality of the final product. For each factor three levels were considered and an orthogonal array L9 was associated. With the L9 orthogonal array, a total of 9 trial experiments have been performed and the optimum parameters were identified. An experimental test was performed in order to validate the founded conditions. The optimized conditions encountered were: processing temperature of 160 degrees C, processing pressure of 1000 psi and the compaction time of 90 s. With these optimized parameters, the acetabular cup prototypes were processed for nanocomposites having ultra-high molecular weight (UHMWPE) reinforced with different volume fractions of carbon nanotubes (CNTs) in the range of 0.2 to 2.0 vol.%.
RESUMEN
Computer-aided technologies have allowed new 3D modelling capabilities and engineering analyses based on experimental and numerical simulation. It has enormous potential for product development, such as biomedical instrumentation and implants. However, due to the complex shapes of anatomical structures, the accuracy of these technologies plays an important key role for adequate and accurate finite element analysis (FEA). The objective of this study was to determine the influence of the geometry variability between two digital models of a human model of the mandible. Two different shape acquisition techniques, CT scan and 3D laser scan, were assessed. A total of 130 points were controlled and the deviations between the measured points of the physical and 3D virtual models were assessed. The results of the FEA study showed a relative difference of 20% for the maximum displacement and 10% for the maximum strain between the two geometries.