Understanding cancer patient cohorts in virtual reality environment for better clinical decisions: a usability study.

BACKGROUND: Visualising patient genomic data in a cohort with embedding data analytics models can provide relevant and sensible patient comparisons to assist a clinician with treatment decisions. As immersive technology is actively used around the medical world, there is a rising demand for an efficient environment that can effectively display genomic data visualisations on immersive devices such as a Virtual Reality (VR) environment. The VR technology will allow clinicians, biologists, and computer scientists to explore a cohort of individual patients within the 3D environment. However, demonstrating the feasibility of the VR prototype needs domain users' feedback for future user-centred design and a better cognitive model of human-computer interactions. There is limited research work for collecting and integrating domain knowledge into the prototype design. OBJECTIVE: A usability study for the VR prototype--Virtual Reality to Observe Oncology data Models (VROOM) was implemented. VROOM was designed based on a preliminary study among medical users. The goals of this usability study included establishing a baseline of user experience, validating user performance measures, and identifying potential design improvements that are to be addressed to improve efficiency, functionality, and end-user satisfaction. METHODS: The study was conducted with a group of domain users (10 males, 10 females) with portable VR devices and camera equipment. These domain users included medical users such as clinicians and genetic scientists and computing domain users such as bioinformatics and data analysts. Users were asked to complete routine tasks based on a clinical scenario. Sessions were recorded and analysed to identify potential areas for improvement to the data visual analytics projects in the VR environment. The one-hour usability study included learning VR interaction gestures, running visual analytics tool, and collecting before and after feedback. The feedback was analysed with different methods to measure effectiveness. The statistical method Mann-Whitney U test was used to analyse various task performances among the different participant groups, and multiple data visualisations were created to find insights from questionnaire answers. RESULTS: The usability study investigated the feasibility of using VR for genomic data analysis in domain users' daily work. From the feedback, 65% of the participants, especially clinicians (75% of them), indicated that the VR prototype is potentially helpful for domain users' daily work but needed more flexibility, such as allowing them to define their features for machine learning part, adding new patient data, and importing their datasets in a better way. We calculated the engaged time for each task and compared them among different user groups. Computing domain users spent 50% more time exploring the algorithms and datasets than medical domain users. Additionally, the medical domain users engaged in the data visual analytics parts (approximately 20%) longer than the computing domain users.

Virtual reality for the observation of oncology models (VROOM): immersive analytics for oncology patient cohorts.

The significant advancement of inexpensive and portable virtual reality (VR) and augmented reality devices has re-energised the research in the immersive analytics field. The immersive environment is different from a traditional 2D display used to analyse 3D data as it provides a unified environment that supports immersion in a 3D scene, gestural interaction, haptic feedback and spatial audio. Genomic data analysis has been used in oncology to understand better the relationship between genetic profile, cancer type, and treatment option. This paper proposes a novel immersive analytics tool for cancer patient cohorts in a virtual reality environment, virtual reality to observe oncology data models. We utilise immersive technologies to analyse the gene expression and clinical data of a cohort of cancer patients. Various machine learning algorithms and visualisation methods have also been deployed in VR to enhance the data interrogation process. This is supported with established 2D visual analytics and graphical methods in bioinformatics, such as scatter plots, descriptive statistical information, linear regression, box plot and heatmap into our visualisation. Our approach allows the clinician to interrogate the information that is familiar and meaningful to them while providing them immersive analytics capabilities to make new discoveries toward personalised medicine.

Interpretability of Machine Learning Solutions in Public Healthcare: The CRISP-ML Approach.

Public healthcare has a history of cautious adoption for artificial intelligence (AI) systems. The rapid growth of data collection and linking capabilities combined with the increasing diversity of the data-driven AI techniques, including machine learning (ML), has brought both ubiquitous opportunities for data analytics projects and increased demands for the regulation and accountability of the outcomes of these projects. As a result, the area of interpretability and explainability of ML is gaining significant research momentum. While there has been some progress in the development of ML methods, the methodological side has shown limited progress. This limits the practicality of using ML in the health domain: the issues with explaining the outcomes of ML algorithms to medical practitioners and policy makers in public health has been a recognized obstacle to the broader adoption of data science approaches in this domain. This study builds on the earlier work which introduced CRISP-ML, a methodology that determines the interpretability level required by stakeholders for a successful real-world solution and then helps in achieving it. CRISP-ML was built on the strengths of CRISP-DM, addressing the gaps in handling interpretability. Its application in the Public Healthcare sector follows its successful deployment in a number of recent real-world projects across several industries and fields, including credit risk, insurance, utilities, and sport. This study elaborates on the CRISP-ML methodology on the determination, measurement, and achievement of the necessary level of interpretability of ML solutions in the Public Healthcare sector. It demonstrates how CRISP-ML addressed the problems with data diversity, the unstructured nature of data, and relatively low linkage between diverse data sets in the healthcare domain. The characteristics of the case study, used in the study, are typical for healthcare data, and CRISP-ML managed to deliver on these issues, ensuring the required level of interpretability of the ML solutions discussed in the project. The approach used ensured that interpretability requirements were met, taking into account public healthcare specifics, regulatory requirements, project stakeholders, project objectives, and data characteristics. The study concludes with the three main directions for the development of the presented cross-industry standard process.

The new norm: Computer Science conferences respond to COVID-19.

The disruption from COVID-19 has been felt deeply across all walks of life. Similarly, academic conferences as one key pillar of dissemination and interaction around research and development have taken a hit. We analyse an interesting focal point as to how conferences in the area of Computer Science have reacted to this disruption with respect to their mode of offering and registration prices, and whether their response is contingent upon specific factors such as where the conference was to be hosted, its ranking, its publisher or its original scheduled date. To achieve this, we collected metadata associated with 170 conferences in the area of Computer Science and as a means of comparison; 25 Psychology conferences. We show that conferences in the area of Computer Science have demonstrated agility and resilience by progressing to an online mode due to COVID-19 (approximately 76% of Computer Science conferences moved to an online mode), many with no changes in their schedule, particularly those in North America and those with a higher ranking. Whilst registration fees have lowered by an average of 42% due to the onset of COVID-19, conferences still have to facilitate attendance on a large scale due to the logistics and costs involved. In conclusion, we discuss the implications of our findings and speculate what they mean for conferences, including those in Computer Science, in the post-COVID-19 world.

Passive RFID Localisation Framework in Smart Homes Healthcare Settings.

In recent years, Smart Homes have become a solution to benefit impaired individuals and elderly in their daily life settings. In healthcare applications, pervasive technologies have enabled the practicality of personal monitoring using Indoor positioning technologies. Radio-Frequency Identification (RFID) is a promising technology, which is useful for non-invasive tracking of activities of daily living. Many implementations have focused on using battery-enabled tags like in RFID active tags, which require frequent maintenance and they are costly. Other systems can use wearable sensors requiring individuals to wear tags which may be inappropriate for elders. Successful implementations of a tracking system are dependent on multiple considerations beyond the physical performance of the solution, such as affordability and human acceptance. This paper presents a localisation framework using passive RFID sensors. It aims to provide a low cost solution for subject location in Smart Homes healthcare.

Interactive Visualization for Patient-to-Patient Comparison.

A visual analysis approach and the developed supporting technology provide a comprehensive solution for analyzing large and complex integrated genomic and biomedical data. This paper presents a methodology that is implemented as an interactive visual analysis technology for extracting knowledge from complex genetic and clinical data and then visualizing it in a meaningful and interpretable way. By synergizing the domain knowledge into development and analysis processes, we have developed a comprehensive tool that supports a seamless patient-to-patient analysis, from an overview of the patient population in the similarity space to the detailed views of genes. The system consists of multiple components enabling the complete analysis process, including data mining, interactive visualization, analytical views, and gene comparison. We demonstrate our approach with medical scientists on a case study of childhood cancer patients on how they use the tool to confirm existing hypotheses and to discover new scientific insights.

Designing for healthy living: supporting reflectivity on interactions in healthcare.

The design of an efficient and effective healthcare services is part of the design for healthy living. Contemporary models of health rely on a deeper involvement of the patient in the decision-making through the steps of the health journey. In these methods, the quality of practitioner-patient interaction is central to the successful processes and patient participation. The quality of these interactions and the ability of both medical practitioners and patients to reflect on each session is part of the design strategies for healthy living. Interactions rely on extensive, effective and empowering communication between practitioner and patient. The purpose of this work is to address the recognition of this importance, evidenced from the broad and diverse communication training for practitioners, by enabling the capture of information about the quality of these interactions. Captured information has to be encoded in a way that enables computer reasoning with it, as well as delivered to patients and practitioners in ways that allow quick interpretation from respective sides. We present the mechanics of the development of a visual language and analysis system enabling visual reasoning about the quality of interactions. The visual knowledge representation is designed based on aspects of human movement. Such design is justified from the fact that human possess implicit knowledge about human movement. The paper presents KIA (Kinetic Inter-Acting) encoding system that is the foundation of the visual language and respective visual analysis method. KIA enables both humans and machines to utilise information about how interactions unfold, which is necessary for practitioner-patient interaction. The paper concludes with discussion of KIA approach and technology in terms of the implications for designing for healthy living.

Interactive visualisation with user perspective for biological data analysis.

With an astonishing amount of genomic data generated for processing in medical field, it is essential to provide an effective methodology for understanding, reasoning and supporting decision making of large information spaces. This paper presents an interactive interface that provides a mechanism to analyse large scale biological and clinical data. This aims to provide a much greater flexibility and control for the domain experts to interactively customise the visualisation according to their preferences.