Investigation of the reliability and validity of the Turkish version of the Comprehensive Coordination Scale in patients with Parkinson's disease.

OBJECTIVE: The Comprehensive Coordination Scale (CCS) is a valid, reliable scale for evaluating motor coordination, described as the ability to produce context-dependent movements of multiple body parts in both spatial and temporal domains in patients with chronic stroke. The aim of this study was to develop a Turkish version of the CCS that can be used to evaluate coordination in Parkinson's disease patients and to test its validity and reliability. METHODS: Thirty-four patients with Parkinson's disease (18 females, 16 males) with a mean age of 67.55± 10.93 years were included. The 9-Hole Peg Test (9 HPT), Timed Up and Go Test (TUG), Berg Balance Scale (BBS), Functional Reach Test (FRT), and Modified Hoehn and Yahr (H&Y) were administered to the patients. RESULTS: In the correlation analysis for convergent validity, the CCS-TR showed a moderate negative correlation with both the 9 HPT and the TUG test (r=-0.684 and -0.641, respectively). There were also moderate positive correlations observed between the CCS-TR and the FRT and BBS (r=0.607 and 0.657, respectively). The total CCS-TR had excellent intrarater reliability (ICC=0.99; 95 % CI: 0.98-0.99) and interrater reliability (ICC=0.90; 95 % CI: 0.81-0.95). The CCS-TR subscales had excellent intrarater reliability (ICC: range 0.98 from 0.99). For intrarater agreement, the ICC was 0.99, and for interrater agreement, the ICC was 0.90 (excellent agreement). CONCLUSION: The results of the present study indicate that the Turkish version of the CCS is a reliable and valid coordination scale that can be used in patients with Parkinson's disease.

Effect of nusinersen treatment on quality of life and motor function in adult patients with spinal muscular atrophy.

The aim of this study was to assess the effect of 4 loading doses of nusinersen on motor function and quality of life (QoL) in adult patients with spinal muscular atrophy (SMA). Twenty-one adult patients with genetically confirmed SMA who were treated with 4 loading doses of nusinersen were included in this study. All patients were evaluated with the Medical Research Council (MRC) scale, the Hammersmith Functional Motor Scale Expanded (HFMSE), and the Short Form Survey-36 (SF-36) at baseline (V1) and before the first nusinersen maintenance treatment, which was at the 15th month of treatment (V2). The SF-36 score was compared between the patients and 35 age-matched healthy controls. Of the twenty-one patients with a median age of 36 years, 10 were nonambulatory, and 11 were ambulatory. The physical component score and the mental component score of the SF-36 were significantly lower in the SMA patient group at baseline than in the healthy group. The median HFMSE scores significantly improved at V2 in both ambulatory and nonambulatory SMA patients (p < 0.05). The median MRC score significantly increased at V2 in the ambulatory SMA patient group (p = 0.04) but not in the nonambulatory SMA patient group (p = 0.19). There was a significant improvement in physical QoL in all the SMA patients at V2 (p = 0.02), but there was no significant improvement in mental QoL (p = 0.15). The loading nusinersen treatment significantly improved motor function scores, muscle strength, and physical QoL.

Permanent pain and brachial plexus injury after coronary bypass grafting: Case report and reviwing the literature.

Neurological complications of cardiac surgery is known for almost a century. Brachial plexus injury after coronary artery bypass grafting is not a rare complication, but the frequency of reporting is less because these are temporary and often symptoms requiring treatment. in a few cases peripheral neuropathy findings are permanent and causes of disability. Diagnosis is based on symptoms, imaging and electrophysiological studies and it is important that both treatments for both medical and legal liability. Here in 63-year-old male patient was diagnosed brachial plexus injury lasting neuropathic pain the left upper limb after uneventful coronary artery bypass surgery presented and causes and consequences were discussed with literature.