1.
Am J Hematol
; 82(3): 231-3, 2007 Mar.
Article
En
| MEDLINE
| ID: mdl-17022045
We describe an extremely rare case of megakaryocytic blast crisis as first presentation of chronic myeloid leukemia. The patient had a very high platelet count and developed an ischemic stroke with seizures. She was treated with hydroxyurea, platelet apheresis, ARA-C, and idarubicin in order to obtain a prompt reduction of thrombocytosis and then with imatinib 600 mg/die PO. The therapy induced a complete hematological remission with a resolution of neurological signs within 4 weeks.
Blast Crisis/pathology , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology , Megakaryocytes/pathology , Antineoplastic Agents/administration & dosage , Antineoplastic Agents/therapeutic use , Blast Crisis/complications , Blast Crisis/drug therapy , Female , Humans , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/complications , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy , Middle Aged , Seizures/etiology , Stroke/etiology , Treatment Outcome