Manifestaciones de trastornos musculoesqueléticos en moldeadores manuales metalúrgicos

Introducción: Los trastornos musculoesqueléticos en el contexto laboral metalúrgico repercuten negativamente desde la perspectiva personal, económica y social de los trabajadores. Objetivo: Identificar las manifestaciones de trastornos musculoesqueléticos en los moldeadores manuales metalúrgicos del área de fundición de la empresa Holmeca de la provincia Holguín, Cuba, en el período comprendido enero-marzo de 2021. Método: Se realizó un estudio observacional, no experimental de corte transversal en 19 moldeadores manuales metalúrgicos, en el que se incluyeron variables sociodemográficas, ubicación de zonas dolorosas, intensidad del dolor, tiempo de aparición y duración del trastorno. Se emplearon métodos teóricos, empíricos. Fue utilizado el Cuestionario Nórdico estandarizado de Kuorinka y la Escala Visual Analógica. El procesamiento de la información se llevó a cabo mediante la estadística descriptiva. Resultados: Se identificaron las zonas dolorosas y la prevalencia más alta de dolor musculoesqueléticos en: muñeca/mano (94,74 %), hombro (89,47 %), dorsal/lumbar (89,47 %) y codo/antebrazo (84,21 %). La intensidad del dolor fue determinada como intenso en el 36,84 % y moderado en el 42,11 % de los trabajadores; mientras que en el 21,05 % fue leve. El tiempo de padecimiento delos trastornos fue de 3-38 años,que aparecieron luego de 5 a 7 años de haber comenzado las labores en el área de estudio. Conclusiones: La prevalencia de manifestaciones de trastornos musculoesqueléticos en los moldeadores manuales metalúrgicos del área de fundición de la empresa Holmeca de Holguín es elevada. Se identifican en mano/muñeca, hombro, lumbar y codo/antebrazo, como las zonas anatómicas más afectadas en este grupo poblacional.

Introduction: Musculoskeletal disorders in the metallurgical work context have a negative impact from the personal, economic and social perspective of workers. Objective: To identify the manifestations of musculoskeletal disorders in metallurgical manual molders in the foundry area of the Holmeca company in the province of Holguín, Cuba, in the period from January to March 2021. Method: An observational, non-experimental study was carried out. cross-sectional study in 19 metallurgical manual shapers, which included sociodemographic variables, location of painful areas, pain intensity, time of onset and duration of the disorder. Theoretical and empirical methods were used. The standardized Kuorinka Nordic Questionnaire and the Visual Analog Scale were used. The information processing was carried out using descriptive statistics. Results: The painful areas and the highest prevalence of musculoskeletal pain were identified in: wrist/hand (94.74%), shoulder (89.47%), dorsal/lumbar (89.47%) and elbow/forearm (84.21%). The intensity of the pain was determined as intense in 36.84% and moderate in 42.11% of the workers; while in 21.05% it was mild. The duration of the disorders was 3-38 years, which appeared after 5 to 7 years after beginning work in the study area. Conclusions: The prevalence of manifestations of musculoskeletal disorders in metallurgical manual molders in the foundry area of the Holmeca company in Holguín is high. They are identified in the hand/wrist, shoulder, lumbar and elbow/forearm, as the anatomical areas most affected in this population group.

Introdução: As lesões osteomusculares no contexto do trabalho metalúrgico têm um impacto negativo na perspectiva pessoal, económica e social dos trabalhadores. Objetivo: Identificar as manifestações de distúrbios osteomusculares em moldadores manuais metalúrgicos da área de fundição da empresa Holmeca, na província de Holguín, Cuba, no período de janeiro a março de 2021. Método: Foi realizado um estudo observacional, não experimental. estudo transversal em 19 modeladores manuais metalúrgicos, que incluiu variáveis sociodemográficas, localização das áreas dolorosas, intensidade da dor, tempo de início e duração do distúrbio. Foram utilizados métodos teóricos e empíricos. Foram utilizados o Questionário Nórdico Kuorinka padronizado e a Escala Visual Analógica. O processamento das informações foi realizado por meio de estatística descritiva. Resultados: As áreas dolorosas e as maiores prevalências de dores musculoesqueléticas foram identificadas em: punho/mão (94,74%), ombro (89,47%), dorsal/lombar (89,47%) e cotovelo/antebraço (84,21%). A intensidade da dor foi determinada como intensa em 36,84% e moderada em 42,11% dos trabalhadores; enquanto em 21,05% foi leve. A duração dos distúrbios foi de 3 a 38 anos, surgindo após 5 a 7 anos após o início do trabalho na área de estudo. Conclusões: É elevada a prevalência de manifestações de distúrbios musculoesqueléticos em moldadores manuais metalúrgicos na área de fundição da empresa Holmeca em Holguín. São identificadas na mão/punho, ombro, lombar e cotovelo/antebraço, como as áreas anatômicas mais acometidas neste grupo populacional.

Masaje terapéutico para estudiantes universitarios con estrés

Introducción: El estrés psíquicoen los estudiantes universitarios de Licenciatura en Turismo puede provocar manifestaciones negativas en el orden psíquico, físico y social. Objetivo: Exponer la validez de un procedimiento de masaje terapéutico que contribuya a disminuir el estrés psíquico en los estudiantes de Licenciatura en Turismo en la Universidad de Holguín. Método: Se realizó una investigación cuantitativa, se utilizaron métodos teóricos y empíricos; para el procesamiento de los datos se utilizó la estadística matemática. Se seleccionaron 17 expertos para la valoración del procedimiento empleado, con una experiencia promedio de 17 años, la investigación fue de septiembre 2019 a julio 2022. Se seleccionó una muestra de82 estudiantes, a la cual se le aplicó un test antes y después de concluir el tratamiento con masaje terapéutico. Resultados: Mediante la observación a los estudiantes en los diferentes contextos de actuación y la revisión de las fuentes de información se evidenció resultados indicadores de estrés psíquico. En encuesta aplicada a los profesores, se demostró pocos conocimientos teóricos y metodológicos para la aplicación del masaje terapéutico para estudiantes universitarios con estrés psíquico. Conclusiones: El procedimiento elaborado para disminuir el estrés se aplicó y demuestra su efectividad en la salud y el bienestar de la muestra seleccionada.

Introduction: Psychological stress in university students studying Bachelor of Tourism can cause negative manifestations in the psychological, physical and social order. Objective: To present the validity of a therapeutic massage procedure that contributes to reducing psychological stress in Bachelor of Tourism students at the University of Holguín. Method: A quantitative research was carried out, theoretical and empirical methods were used.Mathematical statistics were used to process the data.17 experts were selected to evaluate the procedure used, with an average experience of 17 years. The research was from September 2019 to July 2022. A sample of 82 students was selected, to whom a pre-test was applied before treatment,with therapeutic massage, and a post-test at the end. Results: By observing the students in the different contexts of action and reviewing the sources of information, results indicative of psychological stress were evident.In a survey administered to teachers, little theoretical and methodological knowledge was demonstrated for the application of therapeutic massage for university students with psychological stress. Conclusions: The procedure developed to reduce stress was applied and demonstrate its effectiveness on the health and well-being of the selected sample.

Introdução: O estresse psicológico em estudantes universitários do Bacharelado em Turismo pode causar manifestações negativas de ordem psicológica, física e social. Objetivo: Apresentar a validade de um procedimento de massagem terapêutica que contribui para a redução do estresse psicológico em estudantes do Bacharelado em Turismo da Universidade de Holguín. Método: Foi realizada uma pesquisa quantitativa, foram utilizados métodos teóricos e empíricos.Estatística matemática foi usada para processar os dados.Para avaliar o procedimento utilizado foram selecionados 17 especialistas, com experiência média de 17 anos. A pesquisa ocorreu de setembro de 2019 a julho de 2022. Foi selecionada uma amostra de 82 estudantes, aos quais foi aplicado um pré-teste antes do tratamento com massagem terapêutica, e um pós-teste no final. Resultados: Ao observar os estudantes nos diferentes contextos de atuação e revisar as fontes de informação, ficaram evidentes resultados indicativos de estresse psicológico.Em pesquisa realizada com professores, foi demonstrado pouco conhecimento teórico e metodológico para a aplicação da massagem terapêutica em estudantes universitários com estresse psicológico. Conclusões: O procedimento desenvolvido para reduzir o estresse foi aplicado e demonstrou sua eficácia na saúde e no bem-estar da amostra selecionada.

IgA-Dominant Infection-Associated Glomerulonephritis Following SARS-CoV-2 Infection.

The renal involvement of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported. The etiology of kidney injury appears to be tubular, mainly due to the expression of angiotensin-converting enzyme 2, the key joint receptor for SARS-CoV-2; however, cases with glomerular implication have also been documented. The multifactorial origin of this renal involvement could include virus-mediated injury, cytokine storm, angiotensin II pathway activation, complement dysregulation, hyper-coagulation, and microangiopathy. We present the renal histological findings from a patient who developed acute kidney injury and de novo nephrotic syndrome, highly suggestive of acute IgA-dominant infection-associated glomerulonephritis (IgA-DIAGN) after SARS-CoV-2 infection, as evidenced by the presence of this virus detected in the renal tissue of the patient via immunohistochemistry assay. In summary, we document the first case of IgA-DIAGN associated to SARS-CoV-2. Thus, SARS-CoV-2 S may act as a super antigen driving the development of multisystem inflammatory syndrome as well as cytokine storm in patients affected by COVID-19, reaching the glomerulus and leading to the development of this novel IgA-DIAGN.

Urinary Klotho measured by ELISA as an early biomarker of acute kidney injury in patients after cardiac surgery or coronary angiography.

BACKGROUND: Acute kidney injury (AKI) is a common complication after cardiac surgery and percutaneous coronary interventions which markedly worsens prognosis. In recent years, new early biomarkers of AKI have been identified, but many important aspects still remain to be solved. Klotho is a pleiotropic protein that acts as a paracrine and endocrine factor in multiple organs. Reduced renal Klotho levels have been show in several animal models of AKI. No study has been published in which Klotho was tested in humans as an early marker of AKI. The aim of this work is to assess the usefulness of measuring urinary Klotho for the early diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing cardiac surgery or coronary angiography. METHODS: Urinary Klotho was measured 12 hours after intervention in 60 patients admitted to the Intensive Care Unit with acute coronary syndrome or heart failure secondary to coronary or valvular conditions, who underwent coronary angiography (30 patients) or cardiac bypass surgery or heart valve replacement (30 patients). The primary endpoint used was the onset of AKI according to the RIFLE classification system. Human Klotho levels were measured using an ELISA assay. RESULTS: We found no differences in urinary Klotho levels between AKI patients and those who did not develop AKI. Moreover, there was not significant correlation between urinary Klotho levels and the presence of AKI. CONCLUSION: Urinary Klotho measured by ELISA does not seem to be a good candidate to be used as an early biomarker of AKI.

Klotho urinario determinado por ELISA como biomarcador precoz de fracaso renal agudo en pacientes sometidos a cirugía cardiaca o angiografía coronaria / ELISA-measured urinary Klotho as an early biomarker of acute kidney failure in patients undergoing heart surgery or coronary angiography

Introducción y objetivos: El fracaso renal agudo (FRA) es una complicación frecuente tras la cirugía cardiaca y las intervenciones percutáneas coronarias cuya aparición empeora el pronóstico de manera marcada. En los últimos años se han identificado nuevos biomarcadores precoces de FRA, pero aún quedan muchos aspectos importantes por resolver. Klotho es una proteína pleiotrópica que actúa como un factor paracrino y endocrino en múltiples órganos. En diversos modelos animales de FRA se ha demostrado niveles disminuidos de Klotho renal. No se ha publicado ningún estudio en el que se haya probado Klotho como marcador precoz de FRA en humanos. El objetivo de este trabajo es investigar la utilidad de la determinación de Klotho en orina para el diagnóstico precoz del FRA en pacientes con síndrome coronario agudo ofallo cardiaco sometidos a cirugía cardiaca o angiografía coronaria. Métodos: Se midió Klotho urinario 12 horas tras la intervención en 60 pacientes ingresados en la unidad de cuidados intensivos por síndrome coronario agudo o fallo cardiaco secundarios a enfermedad coronaria o valvular y a los que se realizó angiografía coronaria (30 pacientes)o cirugía cardiaca de recambio valvular o bypass (30 pacientes). El criterio de valoración primario fue la aparición de FRA según la clasificación RIFLE. Los niveles de Klotho humano se midieron utilizando un ensayo ELISA. Resultados: No encontramos diferencias en los niveles de Klotho en orina entre los pacientes que desarrollaron FRA y aquellos que no. Además, no había correlación significativa entre niveles de klotho en orina y presencia de FRA. Conclusión: Klotho urinario medido por ELISA no parece ser un buen candidato para ser usado como biomarcador precoz de FRA (AU)

Introduction and objectives: Acute kidney injury (AKI) is a common complication after cardiacsurgery and percutaneous coronary interventions that markedly worsens prognosis. In the last years new early biomarkers for AKI have been identified, but many important aspects still remain to be solved. Klotho is a pleiotropic protein that acts as a paracrine and endocrine hormonal factor in multiple organs. Renal Klotho deficiency has been shown in several AKI animal models. No study has been published in which Klotho was tested in humans as an early biomarker of AKI. The aim of this study was to assess the usefulness of urinary determination of Klotho for the early detection of AKI in patients with acute coronary syndrome or heart failure undergoing cardiac surgery or coronary angiography. Methods: Urinary Klotho was measured 12 hours after intervention in 60 patients admitted to the Intensive Care Unit with acute coronary syndrome or heart failure due to coronary or valvular pathologies, who underwent coronary angiography (30 patients), or cardiac bypass surgery or heart valve replacement (30 patients). The endpoint used for evaluating our patients was the appearance of AKI, in keeping with the RIFLE classification system. Human Klotho levels were measured using an ELISA assay. Results: We found no differences in urinary Klotho levels between patients with AKI and those who did not develop AKI. Moreover, there was no significant correlation between urinary Klotho levels and AKI development. Conclusions: Urinary Klotho measured by ELISA does not seem to be a good candidate to be used as an early biomarker of AKI (AU)

Early biomarkers of acute kidney failure after heart angiography or heart surgery in patients with acute coronary syndrome or acute heart failure.

BACKGROUND: Acute kidney injury (AKI) is a common complication in cardiac surgery and coronary angiography, which worsens patients' prognosis. The diagnosis is based on the increase in serum creatinine, which is delayed. It is necessary to identify and validate new biomarkers that allow for early and effective interventions. AIMS: To assess the sensitivity and specificity of neutrophil gelatinase-associated lipocalin in urine (uNGAL), interleukin-18 (IL-18) in urine and cystatin C in serum for the early detection of AKI in patients with acute coronary syndrome or heart failure, and who underwent cardiac surgery or catheterization. METHODS: The study included 135 patients admitted to the intensive care unit for acute coronary syndrome or heart failure due to coronary or valvular pathology and who underwent coronary angiography or cardiac bypass surgery or valvular replacement. The biomarkers were determined 12 hours after surgery and serum creatinine was monitored during the next six days for the diagnosis of AKI. RESULTS: The area under the ROC curve (AUC) for NGAL was 0.983, and for cystatin C and IL-18 the AUCs were 0.869 and 0.727, respectively. At a cut-off of 31.9 ng/ml for uNGAL the sensitivity was 100% and the specificity was 91%. CONCLUSIONS: uNGAL is an early marker of AKI in patients with acute coronary syndrome or heart failure and undergoing cardiac surgery and coronary angiography, with a higher predictive value than cystatin C or IL-18.

New mutation in female patient with renal variant of Fabry disease and HIV.

We describe the case of a 27-year-old woman with a family history of Anderson-Fabry disease (AFD). Urinary sediment presented microhematuria and 0.9 g/24 hours proteinuria. The alpha-galactosidase A measurement in fibroblasts showed partial deficit of the enzyme, which was compatible with being a carrier of the illness. Renal biopsy gave evidence of kidney lesions from Fabry disease. Genetic study revealed mutation C52Y or Cys52Tyr, which has not been previously described and had also been detected in the father of the patient. During follow-up, the presence of hypergammaglobulinemia revealed an underlying HIV disease. She is now awaiting enzymatic substitution treatment.