[Novel functional stress test (stochastic) and perspectives of its application]. / Novaia funktsional'naia nagruzochnaia (stokhasticheskaia) proba i perspektivy ee primeneniia.

AIM: To assess advantages of a stochastic functional stress test during which workloads change according to law of random numbers. METHOD: Results of stochastic tests and standard stress tests with stepwise increments of workloads were compared in 45 healthy subjects and 90 patients with ischemic heart disease (45 with angina pectoris, 45 after myocardial infarction). RESULTS: Compared with standard tests stochastic test was characterized by shorter times of achievement of ischemic threshold and higher double product. Sensitivity and specificity of stochastic test were significantly better than those of standard stress test. The difference between results of two tests can be explained by increased information content of the stochastic test.

[Some results and perspectives of heart failure research]. / Nekotorye itogi i perspektivy issledovanii serdechnoi nedostatochnosti.

Heart failure is a frequent often in the practice of a cardiologist but data on its actual incidence are inconsistent. This can be explained by variations in methodological approaches. Screening studies require simple easily obtainable and safe techniques capable to characterize activity of a patient. Their results should be compatible with widely accepted NYHA classification. Six minute walking test is one of possible solutions. Its results agree with NYHA classes, peak oxygen consumption and prognosis of survival. For improvement of accuracy of estimation of physical working capacity it is important to consider body mass. This can be achieved by a simple portable device constructed by the authors. To assess sufficiency of circulation during testing it is advisable to determine the load at which decorreleation between dynamics of effort and that of physiological parameters is revealed. Basing on the above considerations the authors suggest to define heart failure as a condition when decorrelation of physiological functions causes deterioration of perfusion and worsening of quality of life.

[Transesophageal cardiac pacemakers]. / Chrespishchevodnye élektrokardiostimuliatory.

Based on over 10-year experience in developing, clinically testing, and using a great deal of different models of transesophageal pacemakers, the paper presents a concept of a present-day pacemaker. It reviews the production and experimental models of these apparatuses currently available in Russia.

[Effect of axoplasmic transport blocking and denervation on the activity and isomolecular spectra of some dehydrogenases in rat muscles]. / Vliianie blokirovaniia aksoplazmaticheskogo transporta i denervatsii na aktivnost' i izomolekuliarnye spektry nekotorykh degidrogenaz v myshtsakh krys.

Changes in the total activity and in the activity of isoenzyme forms of lactate dehydrogenase (EC 1.1.1.27), malate dehydrogenase (EC 1.1.1.37) and glucose-6-phosphate dehydrogenase (EC 1.1.1.49) are found in rat musculus gastrocnemius two weeks after blocking axoplasmic transport evoked by the application of 0.05 M colchicine solution to the ischiatic nerve. They are identical to those observed in surgical denervation. The changes in the isomolecular forms of the enzyme permit considering that the cell metabolism is affected by the axoplasmatic transport.

[Effect of axoplasmic flow blockade on enzymic activities and components of the rat muscle adenylate system]. / Vliianie blokady aksoplazmaticheskogo toka na fermentativnye aktivnosti i komponenty adenilovoi sistemy myshts krys.

Proteolytic aspartate and alanine aminotransferase, beta-D-galactosidase, N-acetyl-beta-D-glucosaminidase activities, contents of phosphocreatine, AMP + IMP, ADP, ATP were studied in the rat musculi gastrocnemius after denervation and blockade of axoplasmic flow, the latter being caused by 0.05 M colchicin solution applied to the sciatic nerve. Two weeks after denervation and the axoflow disturbance all the indices (except the N-acetyl-beta-D-glucoseaminidase activity) showed uniform changes. A month following the colchicin blockade the phosphocreatine and adenylates contents became normal. A conclusion is made on significance of the axoplasmic flow as a factor performing the trophic function of the nervous system.

[Changes in the protein content and their amino acid makeup in the muscles in feeding rats corn with an increased lysine content]. / Zminy vmistu bilkiv ta ikh aminokyslotnoho skladu u m'iazakh pry hodivli shchuriv kukurudzoiu z pidvyshchenym vmistom lizynu

The biochemical indexes of the rat muscles were studied as affected by maize with a higher content of lysin. It is shown that a month after an increase in the body weight and mass of muscles are more pronounced in the rats which were fed maize with a higher content of lysin. The latter, evidently, is due to an increase in the content of sarcoplasmatic proteins, RNA, as well as macroergic compounds, ATP and creatine phosphate, in the muscle of the animals under experiment. The qualitive composition of muscles proteins changes in these animals. A rated gain in essential amino acids is observed as compared to the control group. Hence the feeding of the maize with a higher content of lysin to animals may increase the feed value of meat products.