1.
Bioorg Med Chem Lett
; 20(10): 3039-42, 2010 May 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20403696
RESUMEN
A series of C-2 pyrroloquinoline analogs designed to improve aqueous solubility were examined for herpesvirus polymerase and antiviral activity. Several analogs were identified that maintained the antiviral activity of the previous development candidate against HCMV, HSV-1 and VZV, but with significantly improved aqueous solubility.
Asunto(s)
Antivirales/química , Herpesviridae/enzimología , Inhibidores de la Síntesis del Ácido Nucleico , Pirroles/química , Quinolinas/química , Antivirales/síntesis química , Antivirales/farmacología , Citomegalovirus/efectos de los fármacos , ADN Polimerasa Dirigida por ADN/metabolismo , Herpesvirus Humano 1/efectos de los fármacos , Herpesvirus Humano 3/efectos de los fármacos , Humanos , Pirroles/síntesis química , Pirroles/farmacología , Quinolinas/síntesis química , Quinolinas/farmacología , Solubilidad , Relación Estructura-Actividad
2.
Bioorg Med Chem Lett
; 20(6): 1994-2000, 2010 Mar 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20167488
RESUMEN
Discovery efforts were focused on identifying a non-nucleoside antiviral for treating infections caused by human cytomegalovirus (HCMV) with equal or better potency and diminished toxicity compared to current therapeutics. This Letter describes the HCMV DNA polymerase inhibition and in vitro antiviral activity of various 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides.