Sex-specific pleiotropic changes in emotional behavior and alcohol consumption in human α-synuclein A53T transgenic mice during early adulthood.

Point mutations in the α-synuclein coding gene may lead to the development of Parkinson's disease (PD). PD is often accompanied by other psychiatric conditions, such as anxiety, depression, and drug use disorders, which typically emerge in adulthood. Some of these point mutations, such as SNCA and A30T, have been linked to behavioral effects that are not commonly associated with PD, especially regarding alcohol consumption patterns. In this study, we investigated whether the familial PD point mutation A53T is associated with changes in alcohol consumption behavior and emotional states at ages not yet characterized by α-synuclein accumulation. The affective and alcohol-drinking phenotypes remained unaltered in female PDGF-hA53T-synuclein-transgenic (A53T) mice during both early and late adulthood. Brain region-specific activation of ceramide-producing enzymes, acid sphingomyelinase (ASM), and neutral sphingomyelinase (NSM), known for their neuroprotective properties, was observed during early adulthood but not in late adulthood. In males, the A53T mutation was linked to a reduction in alcohol consumption in both early and late adulthood. However, male A53T mice displayed increased anxiety- and depression-like behaviors during both early and late adulthood. Enhanced ASM activity in the dorsal mesencephalon and ventral hippocampus may potentially contribute to these adverse behavioral effects of the mutation in males during late adulthood. In summary, the A53T gene mutation was associated with diverse changes in emotional states and alcohol consumption behavior long before the onset of PD, and these effects varied by sex. These alterations in behavior may be linked to changes in brain ceramide metabolism.

Gouy phase of Bessel-Gaussian beams: theory vs. experiment.

It is well-known that the wave of a freely propagating Gaussian beam experiences an additional π phase shift compared to a plane wave. This phase shift, known as the Gouy phase, has significant consequences in, e.g., nonlinear optics, since the nonlinear processes require high peak intensity and phase matching of the focused beams. Hence, determining and controlling the Gouy phase is crucial in many fields of modern optics and photonics. Here, we develop an analytical model for the Gouy phase of long-range Bessel-Gaussian beams obtained by annihilating highly charged optical vortices. The model accounts for the influence of the relevant experimental parameters (topological charge, radius-to-width ratio of the initial ring-shaped beam, and focal length of the Fourier-transforming lens). We find an evolution of the Gouy phase varying nearly linearly with propagation distance and confirm this result experimentally.

Long-range quasi-non-diffracting Gauss-Bessel beams in a few-cycle laser field.

Many applications ranging from nonlinear optics to material processing would benefit from pulsed ultrashort (quasi-)non-diffracting Gauss-Bessel beams (GBBs). Here we demonstrate a straightforward yet efficient method for generating such zeroth- and first-order GBBs using a single reflective spatial light modulator. Even in the sub-8-fs range there are no noticeable consequences for the measured pulse duration. The only effect is a weak "coloring" of the outer-lying satellite rings of the beams due to the spectrum spanning over more than 300 nm. The obtained beams have diffraction half-angles below 40 µrad and reach propagation distances in excess of 1.5 m.

Zeroth- and first-order long range non-diffracting Gauss-Bessel beams generated by annihilating multiple-charged optical vortices.

We demonstrate an alternative approach for generating zeroth- and first-order long range non-diffracting Gauss-Bessel beams (GBBs). Starting from a Gaussian beam, the key point is the creation of a bright ring-shaped beam with a large radius-to-width ratio, which is subsequently Fourier-transformed by a thin lens. The phase profile required for creating zeroth-order GBBs is flat and helical for first-order GBBs with unit topological charge (TC). Both the ring-shaped beam and the required phase profile can be realized by creating highly charged optical vortices by a spatial light modulator and annihilating them by using a second modulator of the same type. The generated long-range GBBs are proven to have negligible transverse evolution up to 2 m and can be regarded as non-diffracting. The influences of the charge state of the TCs, the propagation distance behind the focusing lens, and the GBB profiles on the relative intensities of the peak/rings are discussed. The method is much more efficient as compared to this using annular slits in the back focal plane of lenses. Moreover, at large propagation distances the quality of the generated GBBs significantly surpasses this of GBBs created by low angle axicons. The developed analytical model reproduces the experimental data. The presented method is flexible, easily realizable by using a spatial light modulator, does not require any special optical elements and, thus, is accessible in many laboratories.