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ABSTRACT Introduction Attention to the physical health of female university students has been increasing in recent years, and scientifically formulating sports plans for this public, and enhancing their fitness, has become an important topic. Objective Explore the influences of long-term physical exercise on the physical fitness of female college students. Methods 240 female college students in a given city were selected as volunteers, and divided into a resistance exercise group, an aerobic exercise group, and a control group. The total intervention period was ten weeks, followed by the recollection of vital data and other relevant markers for statistical analysis. Results After ten weeks of exercise, the task performance of the resistance exercise group was improved; the task performance of the resistance exercise group was significantly superior to aerobic exercise and control. Conclusion It was observed that the task performance of the resistance exercise group and the aerobic exercise group were positively impacted, and the positive benefits of the two types of exercise were different. Level of evidence II; Therapeutic studies - investigating treatment outcomes.
RESUMO Introdução A atenção à saúde física das estudantes universitárias femininas é crescente nos últimos anos e formular cientificamente os planos esportivos desse público, potencializando as suas aptidões tornou-se um tópico importante. Objetivo Explorar as influências de exercícios físicos de longo prazo sobre a aptidão física das estudantes universitárias. Métodos Foram selecionadas 240 estudantes universitárias em uma determinada cidade como voluntárias, divididas em grupo de exercícios de resistência, exercícios aeróbicos e controle. O período total de intervenção foi de 10 semanas, seguido de nova coleta de dados vitais e outros marcadores relevantes para a análise estatística. Resultados Após 10 semanas de exercício, o desempenho de tarefa do grupo de exercício de resistência foi aprimorado; o desempenho de tarefa do grupo de exercício de resistência foi significativamente superior ao exercício aeróbico e controle. Conclusão Observou-se que ao desempenho de tarefas do grupo de exercício de resistência e do grupo de exercício aeróbico foi positivamente impactado, e os benefícios positivos dos dois tipos de exercício foram diferentes. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.
RESUMEN Introducción La atención a la salud física de las estudiantes universitarias está creciendo en los últimos años y formular científicamente los planes deportivos de este público, potenciando su aptitud física se ha convertido en un tema importante. Objetivo Explorar las influencias del ejercicio físico de larga duración en la aptitud física de las estudiantes universitarias. Métodos Se seleccionaron como voluntarias 240 estudiantes universitarias de una ciudad determinada, divididas en grupo de ejercicio de resistencia, grupo de ejercicio aeróbico y grupo de control. El periodo total de intervención fue de 10 semanas, seguido de una nueva recogida de datos vitales y otros marcadores relevantes para el análisis estadístico. Resultados Tras 10 semanas de ejercicio, el rendimiento en la tarea del grupo de ejercicio de resistencia mejoró; el rendimiento en la tarea del grupo de ejercicio de resistencia fue significativamente superior al ejercicio aeróbico y al control. Conclusión Se observó que el rendimiento en la tarea del grupo de ejercicio de resistencia y del grupo de ejercicio aeróbico tenía un impacto positivo, y que los beneficios positivos de los dos tipos de ejercicio eran diferentes. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.
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OBJECTIVE: To establish a reference nomogram for end-tidal CO corrected for ambient CO (ETCOc) levels in term and late-preterm Chinese newborns and then assess its efficacy to identify hemolytic hyperbilirubinemia. STUDY DESIGN: We conducted a prospective study by measuring concurrent ETCOc and total serum bilirubin (TSB) or transcutaneous bilirubin (TcB) levels collected postnatally at 12, 24, 48, 72, 96, and 120 hours of age. ETCOc at the 25th, 50th, 75th, and 95th percentiles at each epoch were used to construct the reference nomogram. We then explored the ability of predischarge ETCOc and TSB/TcB metrics to predict the development of hyperbilirubinemia requiring phototherapy in early postnatal period and jaundice readmission in late postnatal period. RESULTS: Our nomogram, based on 990 measurements from 455 infants who were not nonhemolytic, displayed a steady line within 3 postnatal days, followed by a subsequent decline. From a cohort of infants with a serial ETCOc measurements (n = 130) and those readmitted (n = 21), we found that ETCOc and TSB/TcB ≥75th percentile can identify most hemolytic hyperbilirubinemia between 12 and 72 hours after birth with an area under the curve (AUC) of 0.741. An ETCOc ≥1.7 ppm alone between 96 and 120 hours after birth can identify most hemolytic hyperbilirubinemia with an AUC of 0.816. In addition, 90.5% of readmitted infants had an ETCOc ≥75th percentile. CONCLUSIONS: An ETCOc reference nomogram during the first 5 postnatal days in nonhemolytic term and late-preterm newborns can be used to identify hemolytic hyperbilirubinemia requiring phototherapy in the early postnatal period and readmission in the late postnatal period.
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Monóxido de Carbono , Hiperbilirrubinemia Neonatal , Humanos , Recién Nacido , Monóxido de Carbono/análisis , Bilirrubina , Nomogramas , Estudios Prospectivos , Hiperbilirrubinemia , Hemólisis , China , Hiperbilirrubinemia Neonatal/diagnóstico , Tamizaje NeonatalRESUMEN
OBJECTIVES:: Esophageal leiomyoma is the most common benign tumor of the esophagus, and it originates from mesenchymal tissue. This study analyzed the clinicopathological characteristics of esophageal leiomyoma and aimed to evaluate the role of endoscopic ultrasonography in the diagnosis and treatment selection for these lesions. METHODS:: Two hundred and twenty-five patients who had suspected esophageal leiomyomas in endoscopic ultrasonography were enrolled at the Endoscopy Center of The First Affiliated Hospital, Zhejiang University from January 1st, 2009 to May 31th, 2015. The main outcomes included the demographic and morphological characteristics, symptoms, comparisons of diagnosis and treatment methods, adverse events, and prognosis. RESULTS:: One hundred and sixty-seven patients were diagnosed as having an esophageal leiomyoma by pathological examination. The mean patient age was 50.57±9.983 years. In total, 62.9% of the lesions originated from the muscularis mucosa, and the others originated from the muscularis propria. The median distance to the incisors was 30±12 cm. The median diameter was 0.72±0.99 cm. As determined by endoscopic ultrasonography, most existing leiomyomas were homogeneous, endophytic, and spherical. The leiomyomas from the muscularis mucosa were smaller than those from the muscularis propria and much closer to the incisors (p<0.05). SMA (smooth muscle antibody) (97.2%) and desmin (94.5%) were positive in the majority of patients. In terms of treatments, patients preferred endoscopic therapies, which led to less adverse events (e.g., intraoperative bleeding, local infection, pleural effusion) than surgical operations (p<0.05). The superficial leiomyomas presented less adverse events and better recovery (p<0.05) than deep leiomyomas. CONCLUSION:: Endoscopic ultrasonography has demonstrated high accuracy in the diagnosis of esophageal leiomyomas and provides great support in selecting treatments; however, EUS cannot completely avoid misdiagnosis, so combining it with other examinations may be a good strategy to solve this problem.
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Endosonografía/métodos , Neoplasias Esofágicas/diagnóstico por imagen , Leiomioma/diagnóstico por imagen , Mesenquimoma/diagnóstico por imagen , Adulto , Anciano , Exactitud de los Datos , Desmina/metabolismo , Resección Endoscópica de la Mucosa/métodos , Endosonografía/normas , Neoplasias Esofágicas/patología , Neoplasias Esofágicas/terapia , Femenino , Humanos , Leiomioma/patología , Leiomioma/terapia , Masculino , Mesenquimoma/patología , Mesenquimoma/terapia , Persona de Mediana Edad , Músculo Liso/metabolismo , Estudios Retrospectivos , Tomografía/métodosRESUMEN
OBJECTIVES: Esophageal leiomyoma is the most common benign tumor of the esophagus, and it originates from mesenchymal tissue. This study analyzed the clinicopathological characteristics of esophageal leiomyoma and aimed to evaluate the role of endoscopic ultrasonography in the diagnosis and treatment selection for these lesions. METHODS: Two hundred and twenty-five patients who had suspected esophageal leiomyomas in endoscopic ultrasonography were enrolled at the Endoscopy Center of The First Affiliated Hospital, Zhejiang University from January 1st, 2009 to May 31th, 2015. The main outcomes included the demographic and morphological characteristics, symptoms, comparisons of diagnosis and treatment methods, adverse events, and prognosis. RESULTS: One hundred and sixty-seven patients were diagnosed as having an esophageal leiomyoma by pathological examination. The mean patient age was 50.57±9.983 years. In total, 62.9% of the lesions originated from the muscularis mucosa, and the others originated from the muscularis propria. The median distance to the incisors was 30±12 cm. The median diameter was 0.72±0.99 cm. As determined by endoscopic ultrasonography, most existing leiomyomas were homogeneous, endophytic, and spherical. The leiomyomas from the muscularis mucosa were smaller than those from the muscularis propria and much closer to the incisors (p<0.05). SMA (smooth muscle antibody) (97.2%) and desmin (94.5%) were positive in the majority of patients. In terms of treatments, patients preferred endoscopic therapies, which led to less adverse events (e.g., intraoperative bleeding, local infection, pleural effusion) than surgical operations (p<0.05). The superficial leiomyomas presented less adverse events and better recovery (p<0.05) than deep leiomyomas. CONCLUSION: Endoscopic ultrasonography has demonstrated high accuracy in the diagnosis of esophageal leiomyomas and provides great support in selecting treatments; however, EUS cannot completely avoid misdiagnosis, so combining it with other examinations may be a good strategy to solve this problem.
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Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Anciano , Endosonografía/métodos , Neoplasias Esofágicas/diagnóstico por imagen , Leiomioma/diagnóstico por imagen , Mesenquimoma/diagnóstico por imagen , Exactitud de los Datos , Desmina/metabolismo , Resección Endoscópica de la Mucosa/métodos , Endosonografía/normas , Neoplasias Esofágicas/patología , Neoplasias Esofágicas/terapia , Leiomioma/patología , Leiomioma/terapia , Mesenquimoma/patología , Mesenquimoma/terapia , Músculo Liso/metabolismo , Estudios Retrospectivos , Tomografía/métodosRESUMEN
DREB1 of the AP2/ERF superfamily plays a key role in the regulation of plant response to low temperatures. In this study, a novel DREB1/CBF transcription factor, PnDREB1, was isolated from Iceland poppy (Papaver nudicaule), a plant adaptive to low temperature environments. It is homologous to the known DREB1s of Arabidopsis and other plant species. It also shares similar 3D structure, and conserved and functionally important motifs with DREB1s of Arabidopsis. The phylogenetic analysis indicated that the AP2 domain of PnDREB1 is similar to those of Glycine max, Medicago truncatula, and M. sativa. PnDREB1 is constitutively expressed in diverse tissues and is increased in roots. qPCR analyses indicated that PnDREB1 is significantly induced by freezing treatment as well as by abscissic acid. The expression levels induced by freezing treatment were higher in the variety with higher degree of freezing tolerance. These results suggested that PnDREB1 is a novel and functional DREB1 transcription factor involved in freezing response and possibly in other abiotic stresses. Furthermore, the freezing-induction could be suppressed by exogenous gibberellins acid, indicating that PnDREB1 might play some role in the GA signaling transduction pathway. This study provides a basis for better understanding the roles of DREB1 in adaption of Iceland poppy to low temperatures.