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1.
Behav Brain Res ; 187(1): 9-16, 2008 Feb 11.
Artículo en Inglés | MEDLINE | ID: mdl-17913255

RESUMEN

The onset of parental behavior has profound and enduring effects on behavior and neurobiology across a variety of species. In some cases, mere exposure to a foster neonate (and a subsequent parental response) can have similar effects. In the present experiment, we exposed adult male and female prairie voles (Microtus ochrogaster) to two foster pups for 20 min and quantified cell proliferation in the dentate gyrus of the hippocampus (DG), medial amygdala (MeA) and cortical amygdala (CorA). Prairie voles are highly social rodents that typically display biparental care and spontaneous parental care when exposed to foster pups. Comparisons were made between the animals that responded parentally or non-parentally towards the pups, as well as control conditions. Cell proliferation was assessed using injections of 5-bromo-2'-deoxyuridine (BrdU) and immunocytochemical localization of this marker. The phenotype of the cells was determined using double label immunofluoresence for BrdU and TuJ1 (a neuronal marker). An increase in cell proliferation in the DG was seen in animals exposed to pups. However, animals that responded non-parentally had a greater number of BrdU labeled cells in the DG compared to those that responded parentally. The majority of BrdU labeled cells co-expressed TuJ1 across all groups. These results demonstrate that exposure to a foster pup and the behavioral reaction to it (parental or non-parental) are associated with site-specific changes in cell proliferation.


Asunto(s)
Arvicolinae/fisiología , Hipocampo/citología , Neuronas/fisiología , Medio Social , Amígdala del Cerebelo/citología , Animales , Antimetabolitos , Bromodesoxiuridina , Proliferación Celular , Femenino , Técnica del Anticuerpo Fluorescente Indirecta , Alimentos , Inmunohistoquímica , Masculino , Padres , Fenotipo , Conducta Social , Fijación del Tejido
2.
Horm Behav ; 51(1): 54-61, 2007 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-17007856

RESUMEN

Stressful social conditions, such as isolation, that occur during sensitive developmental periods may alter present and future social behavior. Changes in the neuroendocrine mechanisms closely associated with affiliative behaviors and stress reactivity are likely to underlie these changes in behavior. In the present study, we assessed the effects of post-weaning social housing conditions on the neuropeptides arginine vasopressin (AVP) and oxytocin (OT), and components of the hypothalamic-pituitary-adrenal axis (corticotropin releasing factor: [CRF], and corticosterone: [CORT]) in the prairie vole (Microtus ochrogaster), a socially monogamous bi-parental rodent. Following weaning at 21 days of age, prairie voles were maintained in one of three housing conditions: social isolation (isolate), paired with a same sex sibling (sibling) or paired with a stranger (stranger) of the same sex and age. Housing conditions were maintained for either 4 or 21 days. Central CRF, AVP and OT immunoreactivity (ir) were quantified and circulating plasma CORT, AVP and OT were assayed. Isolated voles had higher CRF-ir in the paraventricular nucleus of the hypothalamus (PVN) compared with sibling and stranger housed voles. Plasma CORT was significantly higher in isolates. AVP-ir was significantly lower in the PVN of isolate females compared to either sibling females or stranger females. However, AVP-ir was significantly higher in the supraoptic nucleus (SON) of isolates compared to siblings. There were no differences in central OT-ir or plasma OT. These results identify neuroendocrine mechanisms which respond to isolation and potentially modulate behavior.


Asunto(s)
Arvicolinae/metabolismo , Química Encefálica , Corticosterona/análisis , Hormona Liberadora de Corticotropina/análisis , Aislamiento Social , Vasopresinas/análisis , Animales , Arvicolinae/sangre , Arvicolinae/psicología , Corticosterona/sangre , Hormona Liberadora de Corticotropina/sangre , Femenino , Masculino , Núcleo Hipotalámico Paraventricular/química , Núcleo Supraóptico/química , Vasopresinas/sangre
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