RESUMEN
Arylsulfonyl group-bearing α,ß-unsaturated enol esters were readily assembled via the Cs2CO3-mediated union of 2-bromoallyl sulfones and cinnamic acids. The overall transformation is equivalent to an sp2 carbon-oxygen coupling reaction, and therefore constitutes a formal vinylic substitution. Several of the products display promising levels of antiproliferative activities higher than that of the anticancer drug carboplatin. Thiophenol reacted with 2-bromoallyl sulfones under identical conditions to afford α-thiophenyl-α'-tosyl acetone via an apparent aerial oxidation.
Asunto(s)
Antineoplásicos , Proliferación Celular , Ésteres , Antineoplásicos/farmacología , Antineoplásicos/síntesis química , Antineoplásicos/química , Ésteres/química , Ésteres/farmacología , Ésteres/síntesis química , Humanos , Proliferación Celular/efectos de los fármacos , Línea Celular Tumoral , Ensayos de Selección de Medicamentos Antitumorales , Estructura Molecular , Sulfonas/química , Sulfonas/farmacología , Sulfonas/síntesis química , Relación Estructura-Actividad , Compuestos de Vinilo/química , Compuestos de Vinilo/farmacología , Compuestos de Vinilo/síntesis químicaRESUMEN
Benzannulation reactions involve construction of a benzene ring from acyclic precursors. This class of reactions offer a versatile and often superior alternative to aromatic substitution for construction of substituted arenes. Selected pioneering and recent reports of various benzannulation reactions are categorised and discussed in this review.