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BACKGROUND: Objective diagnostic approaches need to be tested to enhance the efficacy of depression detection. Non-invasive EEG-based identification represents a promising area. AIMS: The present EEG study addresses two central questions: 1) whether inner or overt speech condition result in higher diagnositc accuracy of depression detection; and 2) does the affective nature of the presented emotion words count in such diagnostic approach. METHODS: A matched case-control sample consisting of 10 depressed subjects and 10 healthy controls was assessed. An EEG headcap containing 64 electrodes measured neural responses to experimental cues presented in the form of 15 different words that belonged to three emotional categories: neutral, positive, and negative. 120 experimental cues was presented for every participant, each containing an "inner speech" and an "overt speech" segment. An EEGNet neural network was utilized. RESULTS: The highest diagnostic accuracy of the EEGNet model was observed in the case of the overt speech condition (i.e. 69.5%), while a an overall subject-wise accuracy of 80% was achieved by the model. Only a negligible difference in diagnostic accuracy could be found between aggregated emotion word categories, with the highest accuracy (i.e. 70.2%) associated with the presentation of positive emotion words. Model decision was primarily influenced by electrodes representing the regions of the left parietal, the left temporal lobe and the middle frontal areas. CONCLUSIONS: While the generalizability of our results is limited by the small sample size and potentially uncontrolled confounders, depression was associated with sensitive and presumably network-like aspects of these brain areas, potentially implying a higher level of emotion regulation that increases primarily in open communication.
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Outcome prediction in prolonged disorders of consciousness (DOC) remains challenging. This can result in either inappropriate withdrawal of treatment or unnecessary prolongation of treatment. Electroencephalography (EEG) is a cheap, portable, and non-invasive device with various opportunities for complex signal analysis. Computational EEG measures, such as EEG connectivity and network metrics, might be ideal candidates for the investigation of DOC, but their capacity in prognostication is still undisclosed. We conducted a meta-analysis aiming to compare the prognostic power of the widely used clinical scale, Coma Recovery Scale-Revised - CRS-R and EEG connectivity and network metrics. We found that the prognostic power of the CRS-R scale was moderate (AUC: 0.67 (0.60-0.75)), but EEG connectivity and network metrics predicted outcome with significantly (p = 0.0071) higher accuracy (AUC:0.78 (0.70-0.86)). We also estimated the prognostic capacity of EEG spectral power, which was not significantly (p = 0.3943) inferior to that of the EEG connectivity and graph-theory measures (AUC:0.75 (0.70-0.80)). Multivariate automated outcome prediction tools seemed to outperform clinical and EEG markers.
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BACKGROUND: The long-term availability of online Web services is of utmost importance to ensure reproducibility of analytical results. However, because of lack of maintenance following acceptance, many servers become unavailable after a short period of time. Our aim was to monitor the accessibility and the decay rate of published Web services as well as to determine the factors underlying trends changes. METHODS: We searched PubMed to identify publications containing Web server-related terms published between 1994 and 2017. Automatic and manual screening was used to check the status of each Web service. Kruskall-Wallis, Mann-Whitney and Chi-square tests were used to evaluate various parameters, including availability, accessibility, platform, origin of authors, citation, journal impact factor and publication year. RESULTS: We identified 3649 publications in 375 journals of which 2522 (69%) were currently active. Over 95% of sites were running in the first 2 years, but this rate dropped to 84% in the third year and gradually sank afterwards (P < 1e-16). The mean half-life of Web services is 10.39 years. Working Web services were published in journals with higher impact factors (P = 4.8e-04). Services published before the year 2000 received minimal attention. The citation of offline services was less than for those online (P = 0.022). The majority of Web services provide analytical tools, and the proportion of databases is slowly decreasing. Conclusions. Almost one-third of Web services published to date went out of service. We recommend continued support of Web-based services to increase the reproducibility of published results.