Prevalence and correlates of inappropriate use of benzodiazepines in Kosovo.

BACKGROUND: In post-war Kosovo, the magnitude of inappropriate use of benzodiazepines is unknown to date. OBJECTIVE: The aim of this study was to assess the prevalence and correlates of continuation of intake of benzodiazepines beyond prescription (referred to as "inappropriate use") in the adult population of Gjilan region in Kosovo. METHOD: A cross-sectional study was conducted in Gjilan region in 2015 including a representative sample of 780 individuals attending different pharmacies and reporting use of benzodiazepines (385 men and 395 women; age range 18-87 years; response rate: 90%). A structured questionnaire was administered to all participants inquiring about the use of benzodiazepines and socio-demographic characteristics. RESULTS: Overall, the prevalence of inappropriate use of benzodiazepines was 58%. In multivariable-adjusted models, inappropriate use of benzodiazepines was significantly associated with older age (OR 1.7, 95% CI 1.1-2.7), middle education (OR 1.8, 95% CI 1.2-2.7), daily use (OR 1.4, 95% CI 1.1-2.0) and addiction awareness (OR 2.7, 95% CI 2.0-3.8). Furthermore, there was evidence of a borderline relationship with rural residence (OR 1.2, 95% CI 0.9-1.7). CONCLUSION: Our study provides novel evidence about the prevalence and selected correlates of inappropriate use of benzodiazepines in Gjilan region of Kosovo. Health professionals and policymakers in Kosovo should be aware of the magnitude and determinants of drug misuse in this transitional society.

Prevalence and Correlates of Drug-drug Interactions in the Regional Hospital of Gjilan, Kosovo.

AIM: Our aim was to assess the prevalence and socioeconomic and clinical correlates of drug-drug interactions among the adult population of transitional Kosovo. METHODS: A cross-sectional study was conducted including a representative sample of 1921 patients aged ≥18 years (mean age: 57.8±11.2 years; 50.3% women; overall response: 96%) from the regional hospital of Gjilan, Kosovo, during 2011-2013. Potential drug-drug-interactions were assessed and clinical data as well as demographic and socioeconomic information were collected. Binary logistic regression was used to assess the correlates of drug-drug interactions. RESULTS: Upon multivariable adjustment for all the demographic and socioeconomic factors as well as the clinical characteristics, drug-drug interactions were positively and significantly related to older age (OR=2.1, 95%CI=1.3-2.8), a lower educational attainment (OR=1.4, 95%CI=1.1-1.9), a longer hospitalization period (OR=2.7, 95%CI=2.1-3.6), presence of three groups of diseases [infectious diseases (OR=1.7, 95%CI=1.3-2.4), cardiovascular diseases (OR=1.8, 95%CI=1.4-2.6), respiratory diseases (OR=1.6, 95%CI=1.2-2.5)], presence of comorbid conditions (OR=3.2, 95%CI=2.3-4.4) and an intake of at least four drugs (OR=5.9, 95%CI=4.6-7.1). CONCLUSIONS: Our study provides important evidence on the prevalence and socioeconomic and clinical correlates of drug-drug interactions among the hospitalized patients in the regional hospital of Gjilan, Kosovo. Findings from our study should raise the awareness of decision-makers and policy makers about the prevalence and determinants of drug-drug interactions in the adult population of post-war Kosovo.

Pathogenic microbiological flora recovered from ear, nose and throat specimens in a regional hospital in Kosovo.

BACKGROUND: to investigate the recovery of pathogenic bacteria, fungi and parasites isolated from ear, nose and throat specimens in large population group in a secondary health care institution. METHODS: retrospective study results of all microbiologic cultures submitted from the outpatient clinic of a large, secondary health care practice, for the time period January 2001 until December 2005 were identified from a microbiologic specimen database. The results from these cultures were entered into a database, tabulating site from which the culture was taken, from whom the material was sent and the type of organism recovered. RESULTS: from a total of 17,362 specimens, 88% results in the normal bacterial flora. Remaining 12% were pathological bacterial, fungal and parasite flora: 1218 from ear specimens, 376 from nose and. 474 from throat specimens. In 40% of cases material was sent by primary health care provider, in 52% of cases material was taken during systematic screening and only in about 8% the material was sent from an ENT specialist. the most frequent pathogens isolated from ear specimens are Staphylococcus saprophiticus and aureus, 24.6 and 17.7%, followed by Pseudomonas auriginosa in 13.2%; from nose specimens the most often isolated pathogenic bacteria is Staphylococcus aureus in 52.4%, Streptococcus spp. in 16% and Branhamella in 13% of nose specimens. From the throat specimens Staphylococcus aureus in 48.7%, Enterococcus in 13.3%, Streptococcus beta-haemolyticus gr. A in 11.8% and Streptococcus beta-haemolyticus gr. B in 8.4% of cases. CONCLUSIONS: Staphylococcus spp, Pseudomonas, Escherichia and Streptococcus spp. are leading pathogens from ear, nose and throat specimens, so further investigation on appropriate antibiotics use and bacterial resistance will be welcome.