Multiple paths to rumination within a network analytical framework.

Theories of rumination have proposed different psychological factors to place one at risk for repetitive negative thinking. A comprehensive empirical test that captures the most relevant contributors to rumination is lacking. Building on influential self-regulatory and metacognitive frameworks, we modeled how key constructs in this context relate to ruminative thinking. 498 participants completed online questionnaires including indicators of rumination, metacognition, promotion goal orientation, effortful control, and depression. We estimated regularized partial correlation networks to investigate unique associations between the different constructs and followed these analyses up with directed acyclic graphs to identify potential pathways towards rumination. Results demonstrated that: (1) both self-regulatory and metacognitive factors were directly linked to rumination, amongst these were (2) positive beliefs, negative beliefs about uncontrollability and harm, cognitive self-consciousness, depression, effortful control, perfectionism, and (lack of) cognitive confidence, and (3) we identified multiple directed pathways, suggesting three direct contributors to rumination while controlling for the influence of all other variables: diminished effortful control, positive beliefs, and cognitive self-consciousness. This study is the first to comprehensively assess metacognitive and self-regulatory frameworks of rumination in a data-driven manner. Our findings suggest that there are multiple pathways towards rumination, which should be incorporated in clinical case conceptualization of rumination and related disorders.

Platelet MAO activity and COMT Val158Met genotype interaction predicts visual working memory updating efficiency.

The exact mechanism how serotonergic and dopaminergic systems relate to one another in working memory (WM) updating is unknown. Platelet monoamine oxidase (MAO) has been used as a marker for central serotonergic capacity, and catechol-O-methyltransferase (COMT) as a marker for central dopaminergic capacity. This study aimed to describe the interaction of platelet MAO activity and COMT Val158Met genotype in visual working memory updating: the ability to replace old information with new within hundreds of milliseconds. Previous studies suggest that platelet MAO activity and COMT Val158Met genotype could have an interaction effect on working memory. However, there are no studies that have directly examined the interaction of these biomarkers in WM updating. We used a 2-back updating task with facial expressions and defined updating efficiency as response times for correct responses. 455 subjects from a population representative sample were included. Mixed models were used for data analysis with an aim to study the interaction of COMT Val158Met genotype (Val/Val, Val/Met and Met/Met) and the level of MAO activity (high vs low). Education, IQ, sex, simple reaction times, and overall updating accuracy were included as covariates. We found that the effect of COMT Val158Met on updating efficiency depends on the level of platelet MAO activity. Low MAO in contrast to high MAO was associated with an increase in updating efficiency in Val/Met but a decrease in Met/Met. The results are discussed in the context of serotonin and dopamine functions in brain regions related to WM. The findings support the view that serotonin modulates dopaminergic activation in updating and contribute to understanding the role of serotonin in PFC, top-down inhibitory signals, and its interactions with dopamine in WM processes.

Updating facial emotional expressions in working memory: Differentiating trait anxiety and depressiveness.

Individual differences in updating emotional facial expressions in working memory are not fully understood. Here we focused on the effects of high trait anxiety and high depressiveness in men and women on updating schematic emotional facial expressions (sad, angry, scheming, happy, neutral). A population representative sample of young adults was divided into four emotional disposition groups based on STAI-T and MADRS cut-offs: high anxiety (HA, n = 41), high depressiveness (HD, n = 31), high depressiveness & high anxiety (HAHD, n = 65) and control (CT, n = 155). Participants completed a 2-back task with schematic emotional faces, and valence/arousal ratings and verbal recognition tasks. A novel approach was used to separate encoding from retrieval. We found an interaction of emotional dispositions and emotional faces in updating accuracy. HD group made more errors than HA when encoding happy schematic faces. Other differences between emotional dispositions on updating measures were found but they were not specific to any emotional facial expression. Our findings suggest that there is a minor happy disadvantage in HD in contrast to HA which can be seen in lower accuracy for visual encoding of happy faces, but not in retrieval accuracy, the speed of updating, nor perception of emotional content in happy faces. These findings help to explain differences and similarities between high trait anxiety and high depressiveness in working memory and processing of facial expressions. The results are discussed in relation to prevalent theories of information processing in anxiety and depression.

Updating schematic emotional facial expressions in working memory: Response bias and sensitivity.

It is unclear if positive, negative, or neutral emotional expressions have an advantage in short-term recognition. Moreover, it is unclear from previous studies of working memory for emotional faces whether effects of emotions comprise response bias or sensitivity. The aim of this study was to compare how schematic emotional expressions (sad, angry, scheming, happy, and neutral) are discriminated and recognized in an updating task (2-back recognition) in a representative sample of birth cohort of young adults. Schematic facial expressions allow control of identity processing, which is separate from expression processing, and have been used extensively in attention research but not much, until now, in working memory research. We found that expressions with a U-curved mouth (i.e., upwardly curved), namely happy and scheming expressions, favoured a bias towards recognition (i.e., towards indicating that the probe and the stimulus in working memory are the same). Other effects of emotional expression were considerably smaller (1-2% of the variance explained)) compared to a large proportion of variance that was explained by the physical similarity of items being compared. We suggest that the nature of the stimuli plays a role in this. The present application of signal detection methodology with emotional, schematic faces in a working memory procedure requiring fast comparisons helps to resolve important contradictions that have emerged in the emotional perception literature.

Perception of emotion in facial stimuli: The interaction of ADRA2A and COMT genotypes, and sex.

Emotional facial stimuli are important social signals that are essential to be perceived and recognized in order to make appropriate decisions and responses in everyday communication. The ability to voluntarily guide attention to perceive and recognize emotions, and react to them varies largely across individuals, and has a strong genetic component (Friedman et al., 2008). Two key genetic variants of the catecholamine system that have been related to emotion perception and attention are the catechol-O-methyl transferase genetic variant (COMT Val158Met) and the α2A-receptor gene promoter polymorphism (ADRA2A C-1291G) accordingly. So far, the interaction of the two with sex in emotion perception has not been studied. Multilevel modeling method was applied to study how COMT Val158Met, ADRA2A C-1291G and sex are associated with measures of emotion perception in a large sample of young adults. Participants (n=506) completed emotion recognition and behavioral emotion detection tasks. It was found that COMT Val158Met genotype in combination with the ADRA2A C-1291G and sex predicts emotion detection, and perception of valence and arousal. In simple visual detection, the ADRA2A C-1291G G-allele leads to slower detection of a highly arousing face (scheming), which is modulated by each additional COMT Val158Met Met-allele and male sex predicting faster responses. The combination of G-allele, Met-allele and male sex also predicts higher perceived negativity in sad faces. No effects of C-1291G, Val158Met, and sex were found on verbal emotion recognition. Applying the findings to study the interplay between catecholamine-O-methyl transferase activity and α2A-receptors in emotion perception disorders (such as ADHD, autism and schizophrenia) in men and women would be the next step towards understanding individual differences in emotion perception.