We studied the state of antiviral defense in patients with severe course of herpetic infection of anogenital and labial localization and the frequency of its combination with other herpes virus infections. It was found that severe course of herpetic infection caused by herpes simplex virus occurs against the background of combined secondary immunodeficiency and its complication. We first demonstrated that severe course of the disease is associated with mixed viral infection.
Herpesviridae Infections/immunology , Immunologic Deficiency Syndromes/complications , Simplexvirus/metabolism , Comorbidity , Cytokines/blood , Cytokines/immunology , Female , Herpesviridae Infections/physiopathology , Humans , Immunocompromised Host , Immunoglobulins/metabolism , Immunologic Deficiency Syndromes/immunology , Male
AIM: To study antiviral defense in patients with severe anogenital and labial herpetic infection, prevalence of herpetic infection and possible combination with other strains. MATERIAL AND METHODS: The immune status (basic lymphocyte subpopulations, IgA, IgM, IgG, circulating immune complexes in blood serum, cytokines, interferon status, functional activity of neutrophils) was investigated in 102 patients with severe Herpex simplex infection (HSI). RESULTS: Marked deficiency and hyporeactivity of natural and/or specific cytotoxicity were found in 70% HSI patients with severe disease. CONCLUSION: Severe HSI runs in serious combined secondary immunodeficiency, its complications and is an active mixed viral infection.
Female Urogenital Diseases/virology , Herpes Simplex/drug therapy , Herpes Simplex/virology , Immunologic Factors/therapeutic use , Male Urogenital Diseases/virology , Adult , Female , Herpes Simplex/immunology , Humans , Immunoglobulin A/immunology , Immunoglobulin G/immunology , Immunoglobulin M/immunology , Male , Rectal Diseases/virology , Recurrence
