RESUMEN
This study was aimed to assess the diagnostic value of laboratory markers of endothelial lesions in patients with unstable angina (UA). Plasma levels of CRP, homocysteine, endothelin-1 (ET1), and pregnancy-associated plasma protein (pAPP-A) were measured by an ultrasensitive method in 51 patients. They were followed up for 4 months to evaluate the clinical picture of CHD and dynamics of laboratory parameters. The hospitalized patients with UA had elevated baseline levels of CRP (5.02+-3.35 mg/ml) during the entire study period. PAPP-A and homocysteine levels were significantly decreased (p<0.05 and p<0.0 respectively). Patients with deteriorated clinical picture of CHD had significantly elevated ET1 levels (p<0.05) both on day 1 and 4 months later It is concluded that ET1 levels increase in patients with UA and severe prognostically unfavourable CHD.
Asunto(s)
Angina Inestable/sangre , Angina Inestable/diagnóstico , Endotelina-1/sangre , Endotelio Vascular/metabolismo , Angina Inestable/tratamiento farmacológico , Angina Inestable/fisiopatología , Inhibidores de la Enzima Convertidora de Angiotensina/uso terapéutico , Biomarcadores/sangre , Endotelio Vascular/efectos de los fármacos , Endotelio Vascular/fisiopatología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Pronóstico , Factores de Riesgo , Índice de Severidad de la Enfermedad , Estadística como Asunto , Factores de TiempoAsunto(s)
Prótesis Vascular , Vasos Coronarios/cirugía , Infarto del Miocardio/terapia , Angioplastia Coronaria con Balón , Prótesis Vascular/métodos , Terapia Combinada , Electrocardiografía , Humanos , Masculino , Persona de Mediana Edad , Infarto del Miocardio/diagnóstico , Cuidados Posoperatorios , Complicaciones Posoperatorias , Terapia TrombolíticaRESUMEN
The results of examination of 74 patients aged 33 to 65 years with intramural myocardial infarction (MI) are analyzed. It is established that as compared to patients with transmural MI, this group of patients showed recurrent attacks of angina pectoris and MI more frequently (during treatment at hospital). In addition, the exercise test in such patients was positive more often either (the data are statistically significant). The symptomatology of intramural MI is determined by the fact that the area of blood supply to tht subtotally stenosed infarction-dependent vessel is considerably larger as compared to the area of injury as a result of which the preserved myocardium experiences severe hypoxia. It is advised that in complicated intramural MI, angiography of the venous arteries may be carried out. Moreover, provided there are indications, endovascular or surgical revascularization of the myocardium may be considered.