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1.
Rev. bras. farmacogn ; 27(5): 587-591, Sept.-Oct. 2017. tab, graf
Artículo en Inglés | LILACS | ID: biblio-898707

RESUMEN

Abstract Herba Cistanche (Cistanche species) in Traditional Chinese Medicine is used for the treatment of several diseases and symptoms, to include pain. The objective of this study was to evaluate the antinociceptive effect of the hydroethanol extract of Cistanche salsa (C.A.Mey.) Beck, Orobanchaceae, stolons in animal models of pain. Chemical composition of Herba Cistanche was analyzed by HPLC-UV. Mice Swiss Webster (25-30 g, n = 6) were orally pre-treated with Herba Cistanche (10, 30 or 100 mg/kg) and evaluated in the formalin test and in the capsaicin- or glutamate-induced licking response. Kazakh Herba Cistanche is composed mainly by phenylpropanoid glycosides, from which echinacoside, acteoside and tubuloside B are the main constituents. When Herba Cistanche was administered to mice it had an effect in both phases of the formalin test (77% activity at 30 mg/kg for phase 1 and 62% activity at 100 mg/kg for phase 2) suggesting analgesic and anti-inflammatory properties. Kazakh Herba Cistanche was able to reduce the animals licking time after injection of glutamate (81% reduction at 30 mg/kg) and capsaicin (81% reduction at 100 mg/kg). We conclude that phenolics present in the hydroethanol extract of C. salsa could be responsible for its pharmacological profile. In order to source a good quality raw material for Traditional Chinese Medicine we recommended this Kazakh species to be standardized using echinacoside and acteoside as markers.

2.
Acta Pol Pharm ; 74(1): 31-40, 2017 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-29474759

RESUMEN

The review deals with analysis and classification of literature data on phamacognostic study (botanical characteristics, geographical distribution, chemical composition and use in medicine) of species of Motherwort genus (Leonums L.). The review unveils opportunities for comprehensive study and development of approaches to the standardization of raw materials of Turkistan motherwort (L. turkestanicus V.I. Krecz. & Kuprian). That will allow to expand the range of sources of herbal remedies raw materials in the framework of realization of the state program for import substitution.


Asunto(s)
Leonurus , Extractos Vegetales/farmacología , Animales , Humanos , Leonurus/química , Leonurus/clasificación , Farmacognosia , Extractos Vegetales/uso terapéutico
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