RESUMEN
We report a case of a 3-year-old girl with generalized pustular psoriasis (GPP) and a compound heterozygous mutation within the IL36 receptor antagonist (IL36RN) gene at c.28C>T and c.115+6T>C, who was successfully treated using secukinumab monotherapy. The first dose of secukinumab (150 mg) was administered subcutaneously, followed by 75 mg of secukinumab subcutaneously once weekly for 4 weeks and then 75 mg every 4 weeks. The total course of treatment was 4 months, with a total of 8 doses. A PASI score of 75 and 100 was achieved at weeks 1 and 2, respectively, and maintained for 11 months of follow-up, without disease recurrence or adverse events.
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Interleucinas , Psoriasis , Anticuerpos Monoclonales Humanizados , Preescolar , Femenino , Humanos , Interleucinas/genética , Mutación , Psoriasis/tratamiento farmacológico , Resultado del TratamientoRESUMEN
Background: Condylomata acuminata (CA) are a common sexually transmitted disease. The recurrence rate of condyloma acuminatum using traditional treatments is higher than that of applying photodynamic therapy, and a variety of adverse reactions after treatment. At the same time, different parts of condyloma acuminatum after treatment recurrence rate is also different, especially for intra anal-rectal warts.Objective: To evaluate whether using photodynamic therapy (PDT) can effectively reduce recurrence of condylomata acuminata for intra anal-rectal warts.Methods: After the confirmation of the diagnosis of intra anal-rectal warts, the patients were treated with PDT with 5-aminolevulinic acid hydrochloride (ALA). PDT was performed with irradiation of 18-36 J/cm2 at an irradiance of 20-40 mW/cm2 with light-emitting diode (LED) light energy, wavelength 635 nm. We used a special PDT light equipment for intra anal-rectal area warts. PDT was repeated once every week for 4 weeks.Results: After PDT, the complete clearance rate was 76.1% (35 of 46 patients). At the end of the 12 weeks followed, recurrence occurred in five cases. We recorded pain in all 46 patients and the average visual analog scale (VAS) pain score was 6.96 ± 1.41 points.Conclusion: The treatment with PDT is effective in reducing the high rate of recurrence for intra anal-rectal warts. Pain is still a great challenge for the therapy.
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Ácido Aminolevulínico/uso terapéutico , Condiloma Acuminado/tratamiento farmacológico , Fármacos Fotosensibilizantes/uso terapéutico , Adolescente , Adulto , Anciano , Humanos , Luz , Masculino , Persona de Mediana Edad , Fotoquimioterapia , Recurrencia , Adulto JovenRESUMEN
This corrects the article DOI: 10.1038/ncomms7793.
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Infecciones por Chlamydia/terapia , Chlamydia trachomatis , Consenso , Femenino , Humanos , MasculinoRESUMEN
Doxycycline is the preferred recommended second-line treatment for the treatment of early syphilis. Recent reports showed a declining efficacy trend of doxycycline in treatment of early syphilis. The aim of our study was to assess the serological response to the treatment for early syphilis with doxycycline compared with benzathine penicillin G and evaluate whether doxycycline is still an effective agent for the treatment of early syphilis. A record-based retrospective study was conducted. Patients were diagnosed with early syphilis in an sexually transmitted disease (STD) clinic from January 1, 2008 to December 31, 2014. They were treated with a single dose of benzathine penicillin G 2.4MU or oral doxycycline 100 mg twice daily for 14 days. Pearson's chi-squared test was used for data analysis. 601 cases were included in the final study sample: 105 (17.5%) patients received a 14-day course of doxycycline (doxycycline group), and 496 (82.5%) patients received single-dose benzathine penicillin G (BPG group). The serological responses at 6 months and 12 months after treatment were compared. No statistically significant differences were found between the two groups at 6 months (69.52% vs. 75.00%, P=0.245), and at 12 months (92.38% vs. 96.17%, P=0.115). Doxycycline is still an effective agent for the treatment of early syphilis.
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Antibacterianos/uso terapéutico , Doxiciclina/uso terapéutico , Penicilina G Benzatina/uso terapéutico , Sífilis/tratamiento farmacológico , Adolescente , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Adulto JovenAsunto(s)
Genes Bacterianos , Tipificación Molecular/métodos , Sífilis/microbiología , Treponema pallidum/genética , China/epidemiología , ADN Bacteriano , Femenino , Variación Genética , Genitales/microbiología , Humanos , Masculino , Polimorfismo de Longitud del Fragmento de Restricción , Análisis de Secuencia de ADN , Sífilis/epidemiología , Treponema pallidum/clasificación , Treponema pallidum/aislamiento & purificaciónAsunto(s)
Transferencia de Gen Horizontal , Genes Bacterianos , Mutación Puntual , ARN Ribosómico 16S/genética , Resistencia a la Tetraciclina , Treponema pallidum/genética , Humanos , Reacción en Cadena de la Polimerasa , Análisis de Secuencia de ADN , Sífilis/microbiología , Treponema pallidum/aislamiento & purificaciónAsunto(s)
Ácido Aminolevulínico/administración & dosificación , Condiloma Acuminado/tratamiento farmacológico , Fotoquimioterapia/métodos , Fármacos Fotosensibilizantes/administración & dosificación , Enfermedades Uretrales/tratamiento farmacológico , Administración Tópica , Adolescente , Adulto , Anciano , Condiloma Acuminado/diagnóstico , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Recurrencia , Medición de Riesgo , Índice de Severidad de la Enfermedad , Resultado del Tratamiento , Enfermedades Uretrales/diagnóstico , Adulto JovenRESUMEN
The epidemiology of syphilis among older adults in China has not been well studied. We studied changes over time in the prevalence of syphilis among older adults in Shandong, China to inform a syphilis intervention program in order to develop management strategies. We retrospectively reviewed passive surveillance data of syphilis among older adults in Shandong, China during 2008-2013, reported by clinicians in medical facilities. The data included the stage of syphilis, age of patient and gender by year. The prevalences for first, second, latent and overall syphilis by age among adults aged ≥60 years in Shandong were 0.92, 0.70, 2.37 and 3.92 cases per 100,000 population in 2008 and 2.66, 1.99, 9.11 and 13.95 cases per 100,000 population in 2013; giving average yearly increases of 23.66%, 23.24%, 30.90% and 28.90%, respectively. The reported overall prevalence of syphilis among those aged ≥80 years was greater than the general population (8.25 vs 4.38 cases per 100,000 population in 2008; 21.99 vs 13.95 cases per 100,000 population in 2013). The prevalence of syphilis is increasing in the study population. Age appropriate interventions are needed to reduce the prevalence of syphilis in the study population.
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Sífilis/epidemiología , Distribución por Edad , Anciano , Anciano de 80 o más Años , China/epidemiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Vigilancia de la Población , Prevalencia , Estudios Retrospectivos , Distribución por SexoRESUMEN
Genome-wide association studies (GWASs) have reproducibly associated â¼40 susceptibility loci with psoriasis. However, the missing heritability is evident and the contributions of coding variants have not yet been systematically evaluated. Here, we present a large-scale whole-exome array analysis for psoriasis consisting of 42,760 individuals. We discover 16 SNPs within 15 new genes/loci associated with psoriasis, including C1orf141, ZNF683, TMC6, AIM2, IL1RL1, CASR, SON, ZFYVE16, MTHFR, CCDC129, ZNF143, AP5B1, SYNE2, IFNGR2 and 3q26.2-q27 (P<5.00 × 10(-08)). In addition, we also replicate four known susceptibility loci TNIP1, NFKBIA, IL12B and LCE3D-LCE3E. These susceptibility variants identified in the current study collectively account for 1.9% of the psoriasis heritability. The variant within AIM2 is predicted to impact protein structure. Our findings increase the number of genetic risk factors for psoriasis and highlight new and plausible biological pathways in psoriasis.
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Pueblo Asiatico/genética , Psoriasis/genética , Proteínas Adaptadoras del Transporte Vesicular/genética , Adolescente , Adulto , Estudios de Casos y Controles , Proteínas Ricas en Prolina del Estrato Córneo/genética , Proteínas de Unión al ADN/genética , Exoma/genética , Femenino , Predisposición Genética a la Enfermedad , Humanos , Proteínas I-kappa B/genética , Proteína 1 Similar al Receptor de Interleucina-1 , Subunidad p40 de la Interleucina-12/genética , Péptidos y Proteínas de Señalización Intracelular/genética , Masculino , Proteínas de la Membrana/genética , Metilenotetrahidrofolato Reductasa (NADPH2)/genética , Proteínas de Microfilamentos/genética , Persona de Mediana Edad , Antígenos de Histocompatibilidad Menor , Inhibidor NF-kappaB alfa , Proteínas del Tejido Nervioso/genética , Proteínas Nucleares/genética , Polimorfismo de Nucleótido Simple , Receptores Sensibles al Calcio/genética , Receptores de Superficie Celular/genética , Receptores de Interferón/genética , Serina Endopeptidasas/genética , Transactivadores/genética , Adulto JovenRESUMEN
Genome-wide association studies (GWAS) have led to the discovery of several susceptibility loci for leprosy with robust evidence, providing biological insight into the role of host genetic factors in mycobacterial infection. However, the identified loci only partially explain disease heritability, and additional genetic risk factors remain to be discovered. We performed a 3-stage GWAS of leprosy in the Chinese population using 8,313 cases and 16,017 controls. Besides confirming all previously published loci, we discovered six new susceptibility loci, and further gene prioritization analysis of these loci implicated BATF3, CCDC88B and CIITA-SOCS1 as new susceptibility genes for leprosy. A systematic evaluation of pleiotropic effects demonstrated a high tendency for leprosy susceptibility loci to show association with autoimmunity and inflammatory diseases. Further analysis suggests that molecular sensing of infection might have a similar pathogenic role across these diseases, whereas immune responses have discordant roles in infectious and inflammatory diseases.