[Squamous cell carcinoma arising in oral lichen planus : Report of two cases]. / Plattenepithelkarzinom auf dem Boden eines oralen Lichen planus : Bericht zweier Fälle.

Lichen planus is a chronic inflammatory, immunologically mediated mucocutaneous dermatosis. Lichen planus mucosae predominantly affects the oral cavity. Various trigger factors such as bacterial or viral infections, drugs or physical stimuli are discussed in the development of the disease. An association with human papillomavirus infections has also been described, but is not sufficiently proven. Lichen planus mucosae is considered as a premalignant condition, but the malignant transformation rate is low. The risk of malignant transformation is significantly increased in patients with oral lichen planus who smoke, drink alcohol or have hepatitis C. We describe two patients with locally advanced squamous cell carcinoma that developed on a longstanding oral lichen planus. Both cases were successfully treated with radical tumor resection, subsequent tissue reconstruction, and adjuvant radiation/radiochemotherapy.

Human Papillomavirus Type 16 Induced Squamous Cell Carcinoma (In situ) of the Toes.

is missing (Short communication).

[Atypical variant of hand-foot-mouth disease]. / Atypische Hand-Fuß-Mund-Krankheit.

An atypical variant of hand-foot-mouth disease (HFMD) has sporadically been reported in recent years, with outbreaks in Europe, Asia, the USA and South America. A new lineage of Coxsackie virus A6 has been identified as the causative agent, a virus-type belonging to the group of enteroviruses. HFMD is transmitted through droplet infection or through faecal-oral transmission. The disease may begin with a prodromal stage and is often accompanied by fever and malaise. Typical skin findings include a papular and vesiculobullous exanthema that might be accompanied by confluent blisters (bullae), crusting, and ulceration. In contrast to "classic" HFMD, predilection sites include the dorsal aspects of the hands and feet, forearms, lower legs, neck and trunk. Oral lesions may be present, but are less often seen compared to "classic" HFMD. The course of the disease is self-limiting, with complete resolution usually within 7-14 days after disease onset. The treatment of atypical HFMD is usually symptomatic. A diagnosis of atypical HFMD might be challenging due to the polymorphous presentation of the disease. This review describes a rarely reported but more frequently diagnosed viral condition.

[Frequent Skin Findings in Daily Routine of the General Practitioner]. / Häufige Hautbefunde in der Praxis.

Diseases of the skin are the cause of approximately one fifth of outpatient visits to general practitioners (GPs) in Germany. GPs are expected to be competent in both knowledge and skills required to manage dermatological diseases, but making the correct diagnosis can be challenging facing the broad clinical spectrum of dermatological disorders. Knowledge of morphological characteristics is essential in the accurate diagnosis of a dermatological condition and to ensure optimal patient care. The objective of this dossier is to provide an overview of common dermatological diseases in daily routine, with a focus on acute and chronic-inflammatory dermatoses. The most important dermatological diseases were sorted by three anatomic regions (face, trunk and lower leg), and an overview on the respective differential diagnoses is provided.