Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans.

Ischemic skeletal muscle conditions are known to augment exercise-induced increases in blood pressure (BP). Aging is also a factor that enhances the pressor response to exercise. However, the effects of aging on the BP response to ischemic exercise remain unclear. We, therefore, tested the hypothesis that aging enhances the BP response to rhythmic handgrip (RHG) exercise during postexercise muscle ischemia (PEMI). We divided the normotensive participants without cardiovascular diseases into three age groups: young (n = 26; age, 18-28 years), middle-aged (n = 23; age, 35-59 years), and older adults (n = 23; age, 60-80 years). The participants performed RHG exercise with minimal effort for 1 min after rest with and without PEMI, which was induced by inflating a cuff on the upper arm just before the isometric handgrip exercise ended; the intensity was 30% of maximal voluntary contraction force. Under PEMI, the increase in diastolic BP (DBP) from rest to RHG exercise in the older adult group (Δ13 ± 2 mmHg) was significantly higher than that in the young (Δ5 ± 2 mmHg) and middle-aged groups (Δ6 ± 1 mmHg), despite there being no significant difference between the groups in the DBP response from rest to RHG exercise without PEMI. Importantly, based on multiple regression analysis, age remained a significant independent determinant of both the SBP and DBP responses to RHG exercise during PEMI (p < 0.01). These findings indicate that aging enhances the pressor response to ischemic rhythmic exercise.

A new method for evaluating joint position sense using oral instructions based on body schema.

[Purpose] This study investigated the efficacy of our independently developed method for measuring shoulder joint position sense using oral instructions based on body schema ("schema method") and investigated age-related changes. [Participants and Methods] Forty university students, 19 elderly individuals, and 16 elementary school students were included. Active shoulder abduction was measured in an upright sitting position. Target angles for position sense measurement were 45° of abduction (Target 45) and 90° of abduction (Target 90). The schema method consisted of indicating the target angles through oral instructions alone. The reproduction method and the imitation method were also used to measure angles. Abduction angle, absolute error, and variable error were calculated. [Results] A significant difference in abduction angle at Target 45 was observed between the schema method and the reproduction and imitation methods; no significant differences were observed at Target 90. No significant differences in variable error at Target 90 were observed among the three measurement methods. A significant difference in abduction angle was observed between university students and elderly individuals, and a significant difference in variable error was observed between elementary school students and elderly individuals. [Conclusion] Our body schema-based oral instruction method will be useful for evaluating joint position sense or proprioception.

Effects of moderate exercise on metabolic responses and respiratory exchange ratio (RER).

To counteract insulin resistance, it is necessary to increase the utilization rate of fatty acids in blood and adipose tissue. The aim of the present study was to determine the relation between metabolic responses and exercise duration from changes in the respiratory exchange ratio (RER). The mean RER during 30 minutes of moderate exercise (mean pulse 115 beats/min) was 0.89 +/- 0.02, indicating no major change. Significant changes were observed in the levels of plasma glucose (PG), plasma free fatty acid (FFA), and plasma immunoreactive insulin (IRI) before and after exercise, demonstrating a decrease in PG and IRI, and an increase in FFA levels. However, the RER value indicated that carbohydrate was the dominant metabolic substrate; therefore, prolonged or repetitive brief and mild to moderate exercise is necessary to increase the utilization of fatty acids.