RESUMEN
Introduction. Endovaginal brachytherapy treatment dosimetry differences were studied using Ir-192 or Co-60 sources for postoperative endometrial cancer. Materials and methods. A prospective descriptive study was conducted. Thirty-six dosimetry plans of different patients were studied (15 by Ir-192 and 21 by Co-60). Variables studied included D2cc Rectum, D2cc Bladder, D2cc Sigmoid, dose percentage at point 0 (applicator surface on the top of the cylinder) and dose percentage at point 1 (5 mm deep on the top of the cylinder). A comparative analysis was performed of the values obtained from each variable between Ir-192 and Co-60 treatments. We compared average of each variables between Iridium and Cobalt by T Student for independent samples (SPSS 22). Results. here were no significant differences on using Ir-192 or Co-60 by variables, except for dose percentage at point 1 in which we detected significant differences (Table 1). Discussion. Brachytherapy treatment dosimetry plans are similar using Ir-192 or Co-60, except dose percentage at point 1. In the scientific literature, some differences exist and there are some advantages in using cobalt (AU)
No disponible
Asunto(s)
Humanos , Femenino , Neoplasias Endometriales/diagnóstico , Neoplasias Endometriales/terapia , Braquiterapia/métodos , Dosimetría/análisis , Iridio , Radioisótopos de Iridio/administración & dosificación , Periodo Posoperatorio , Estudios Prospectivos , Radioisótopos de Iridio/análisisRESUMEN
INTRODUCTION: Endovaginal brachytherapy treatment dosimetry differences were studied using Ir-192 or Co-60 sources for postoperative endometrial cancer. MATERIALS AND METHODS: A prospective descriptive study was conducted. Thirty-six dosimetry plans of different patients were studied (15 by Ir-192 and 21 by Co-60). Variables studied included D2cc Rectum, D2cc Bladder, D2cc Sigmoid, dose percentage at point 0 (applicator surface on the top of the cylinder) and dose percentage at point 1 (5 mm deep on the top of the cylinder). A comparative analysis was performed of the values obtained from each variable between Ir-192 and Co-60 treatments. We compared average of each variables between Iridium and Cobalt by T Student for independent samples (SPSS 22). RESULTS: There were no significant differences on using Ir-192 or Co-60 by variables, except for dose percentage at point 1 in which we detected significant differences (Table 1). Table 1 The results Variables Sources Iridium 192 Cobalt 60 D2cc Rectum (mean dose) [rank] 6.01 Gy [3.99-7.90] 5.28 Gy [3.87-6,34] D2cc Bladder (mean dose) [rank] 5.82 Gy [4.20-8.38] 5.05 Gy [2.23-6.95] D2cc Sigmoid (mean dose) [rank] 4.43 Gy [1.66-6.67] 2.33 Gy [0.60-4.28] Dose percentage at point 0a (mean) [rank] 210.74% [120.90-234.90] 204.75% [177.10-223] Dose percentage at point 1b (mean) [rank] 93.49% [87.30-100.60] 100.11% [96.70-102] aPoint 0: point to the applicator surface bPoint 1: point to 5 mm applicator surface DISCUSSION: Brachytherapy treatment dosimetry plans are similar using Ir-192 or Co-60, except dose percentage at point 1. In the scientific literature, some differences exist and there are some advantages in using cobalt.
Asunto(s)
Braquiterapia/métodos , Radioisótopos de Cobalto/uso terapéutico , Neoplasias Endometriales/radioterapia , Radioisótopos de Iridio/uso terapéutico , Órganos en Riesgo/efectos de la radiación , Cuidados Posoperatorios , Planificación de la Radioterapia Asistida por Computador , Neoplasias Endometriales/cirugía , Femenino , Estudios de Seguimiento , Humanos , Pronóstico , Estudios Prospectivos , Radiometría , Dosificación RadioterapéuticaRESUMEN
OBJECTIVE: To evaluate acute and chronic toxicity of chemoirradiation treatment (neoadjuvant, adjuvant and radical treatment) in patients diagnosed with cervix cancer. METHODS: From December 1999 to August 2007, 53 patients diagnosed with adenocarcinoma or squamous cell carcinoma of the uterine cervix received neoadjuvant, adjuvant or radical chemoirradiation. RESULTS: Acute gastrointestinal toxicity of grade 3 or more in 9 patients (17%) and haematological toxicity of grade 3 or more in 9 patients (17%). Chronic toxicity of grade 3 or more was shown in only 2 patients (4%). The most frequent toxicities were gastrointestinal toxicity and haematological toxicity. The most frequent chronic toxicities were gastrointestinal toxicity and vaginal toxicity. CONCLUSIONS: We report that the combined neoadjuvant, adjuvant or radical chemoirradiation treatment with weekly cisplatin chemotherapy (40 mg/m(2)/week) in patients diagnosed with cervix cancer is a well tolerated treatment and chronic and acute toxicity is low-grade. This treatment scheme has easy compliance.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Neoplasias del Cuello Uterino/terapia , Adenocarcinoma/tratamiento farmacológico , Adenocarcinoma/cirugía , Adenocarcinoma/terapia , Adulto , Anciano , Carcinoma de Células Escamosas/tratamiento farmacológico , Carcinoma de Células Escamosas/cirugía , Carcinoma de Células Escamosas/terapia , Terapia Combinada , Femenino , Estudios de Seguimiento , Humanos , Persona de Mediana Edad , Terapia Neoadyuvante , Radioterapia/efectos adversos , Estudios Retrospectivos , Neoplasias del Cuello Uterino/tratamiento farmacológico , Neoplasias del Cuello Uterino/cirugíaRESUMEN
OBJECTIVE: To evaluate acute and chronic toxicity of chemoirradiation treatment (neoadjuvant, adjuvant and radical treatment) in patients diagnosed with cervix cancer. METHODS: From December 1999 to August 2007, 53 patients diagnosed with adenocarcinoma or squamous cell carcinoma of the uterine cervix received neoadjuvant, adjuvant or radical chemoirradiation. RESULTS: Acute gastrointestinal toxicity of grade 3 or more in 9 patients (17%) and haematological toxicity of grade 3 or more in 9 patients (17%). Chronic toxicity of grade 3 or more was shown in only 2 patients (4%). The most frequent toxicities were gastrointestinal toxicity and haematological toxicity. The most frequent chronic toxicities were gastrointestinal toxicity and vaginal toxicity. CONCLUSIONS: We report that the combined neoadjuvant, adjuvant or radical chemoirradiation treatment with weekly cisplatin chemotherapy (40 mg/m(2)/week) in patients diagnosed with cervix cancer is a well tolerated treatment and chronic and acute toxicity is low-grade. This treatment scheme has easy compliance (AU)
No disponible
Asunto(s)
Humanos , Femenino , Adulto , Persona de Mediana Edad , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Radioterapia/efectos adversos , Adenocarcinoma/tratamiento farmacológico , Neoplasias del Cuello Uterino/tratamiento farmacológico , Adenocarcinoma/cirugía , Carcinoma de Células Escamosas/tratamiento farmacológico , Carcinoma de Células Escamosas/cirugía , Terapia Combinada , Estudios de Seguimiento , Estudios Retrospectivos , Terapia Neoadyuvante , Neoplasias del Cuello Uterino/cirugía , Cuello del Útero , Cuello del Útero/patologíaRESUMEN
Ectopic bone formation may occur after total hip arthroplasty, but fortunately most patients are asymptomatic. Both pre-operative and post-operative radiotherapy are effective in prevention of ectopic bone formation. In the few patients who needed re-operation, we found that re-irradiation is possible and safe. This case report presents our experience with single dose reirradiation of the hip in an attempt to prevent post-operative ectopic bone formation.
Asunto(s)
Artroplastia de Reemplazo de Cadera/efectos adversos , Osificación Heterotópica/prevención & control , Osificación Heterotópica/radioterapia , Anciano , Femenino , Humanos , Osificación Heterotópica/etiología , ReoperaciónRESUMEN
Ectopic bone formation may occur after total hip arthroplasty, but fortunately most patients are asymptomatic. Both pre-operative and post-operative radiotherapy are effective in prevention of ectopic bone formation. In the few patients who needed re-operation, we found that re-irradiation is possible and safe. This case report presents our experience with single dose reirradiation of the hip in an attempt to prevent post-operative ectopic bone formation (AU)
Asunto(s)
Humanos , Femenino , Anciano , Artroplastia de Reemplazo de Cadera/efectos adversos , Osificación Heterotópica/prevención & control , Osificación Heterotópica/radioterapia , Osificación Heterotópica/epidemiología , Osificación Heterotópica/etiología , Reoperación/métodos , ReoperaciónRESUMEN
Heterotopic ossification or ectopic bone formation represents a widely known complication after surgery involving joint spaces. Posttraumatic heterotopic ossification can be found at any site. The most common postsurgical site is the hip following total hip arthroplasty. This review explores the treatment options to prevent ectopic bone formation after major surgery of hip, especially, the role of radiotherapy (AU)