[Systemic coagulopathic distress syndrome in surgery: concept, pathogenesis, prophylaxis]. / Ponyatie sistemnogo koagulopaticheskogo distress-sindroma v khirurgii, ego patogenez i printsipy profilaktiki.

OBJECTIVE: The purpose of the study is to determine the correlation of changes in the humoral and tissue components of the hemostasis system with lipid metabolism in case of various urgent surgical diseases, on the basis of which the systemic coagulopathic distress syndrome can be used as the scientific basis for the definition of a new syndrome. MATERIAL AND METHODS: The work includes the results of experimental and clinical laboratory tests. Experiments on dogs: in the first group (n=18) destructive pancreatitis; in the second (n=18) - fecal peritonitis; in the third (n=15), acute obstructive intestinal obstruction; in the fourth (n=16) fecal peritonitis, in the postoperative period, Remaxol (15 ml/kg) was included in the therapy. The analysis of 55 patients with acute peritonitis, operated on for acute appendicitis, perforated gastric or duodenal ulcer, acute intestinal obstruction, acute destructive cholecystitis. In the study group (n=28), Remaxol is included in the postoperative therapy. The state of the humoral and tissue (in the experiment, the tissues of the liver, intestines, kidneys, heart, lungs, pancreas, in the clinic - tissues of the resected organs) components of the hemostasis system was evaluated, a number of lipid metabolism indicators were determined, etc. RESULTS: In the early periods of all investigated urgent diseases of the abdomen, pronounced changes in the system of both humoral and tissue components of the hemostasis system were revealed. The modification of the coagulation system is registered not only in the tissues of the lesion organs, but also in the target organs (system tissue hemocoagulation modifications). The research established one of the most important processes - the trigger of the hemostatic cascade reaction - is membrane-destabilizing (the source of tissue thromboplastin), which is determined by changes in the phospholipid composition of various organs tissues (involved in the pathological process or not in it). Changes in lipid metabolism are due to the activation of phospholipases and membrane lipid peroxidation in tissues. The factual material was the scientific basis for the establishment of a new syndrome. Systemic coagulopathic distress syndrome is a set of pathological processes of the body, the most important component of which is a violation of the phospholipid bilayer of blood cell membranes and organ cells due to oxidative and phospholipase induced phenomena, leading to a coagulopathic condition. It changes understanding of the prevention of thrombohemorrhagic complications, proving the effectiveness of complex therapy, including not only anticoagulants, but also drugs with membrane-stabilizing activity, in particular, Remaxol.

Proton tracks and the formation of pores in poly[diethylene glycol bis-(allyl carbonate)].

Modern dosimetry needs efficient detectors for registering light ions, especially light ions having energies of up to 10 MeV/amu. That is why this research pays attention to the development of materials for such a task. In this work, a CR-39 detector, which is the most efficient detector, was used. It was irradiated with low-energy protons. Using sensitive electrolytic etching and electron scanning microscopy, a complete analysis was carried out of the process of the formation of a pore starting from its opening to the final stage of its formation. The process of sequential track breakthroughs was observed. The data obtained on the shape of the pore and the parameters of its formation allow simulation of the process of etching. The etch rates and sensitivity of etching are determined. The influence of energy losses on the geometry of the pore is considered.

[A biological compatibility study of hydroxyapatite]. / Issledovanie biologicheskoi sovmestimosti gidroksiapatita.

The biological compatibility of coatings of subcutaneous implants was studied in rat experiments. The implants were coated with hydroxyapatite and hydroxyapatite modified by chloromethylsilanthrane (silamine). The coatings were found to inhibit lipid peroxidation and form the optimal ratio of connective tissue biopolymers in capsules forming round the implants. Both types of hydroxyapatites used were characterized by high biological compatibility.