Asunto(s)
Inhibidores de la Enzima Convertidora de Angiotensina/farmacología , Antihipertensivos/farmacología , Arteria Braquial/efectos de los fármacos , Endotelio Vascular/efectos de los fármacos , Hipertensión/tratamiento farmacológico , Isquemia Miocárdica/tratamiento farmacológico , Perindopril/farmacología , Inhibidores de la Enzima Convertidora de Angiotensina/administración & dosificación , Inhibidores de la Enzima Convertidora de Angiotensina/uso terapéutico , Antihipertensivos/administración & dosificación , Antihipertensivos/uso terapéutico , Velocidad del Flujo Sanguíneo , Arteria Braquial/fisiología , Cromatografía Líquida de Alta Presión , Interpretación Estadística de Datos , Endotelinas/sangre , Endotelio Vascular/fisiología , Epoprostenol/sangre , Femenino , Humanos , Hipertensión/fisiopatología , Masculino , Isquemia Miocárdica/fisiopatología , Óxido Nítrico/sangre , Perindopril/administración & dosificación , Perindopril/uso terapéutico , Tromboxanos/sangre , Factores de Tiempo , VasodilataciónRESUMEN
AIM: To elucidate relationship between hereditary and environmental factors in development of target organ damage in hypertension. MATERIAL AND METHODS: The state of myocardium, central nervous system, blood vessels (including funduscopic examination) was assessed in 64 pairs of mono- and dizygous hypertensive twins (mean age 57.2+/-3.2 years) and clinical and genetic analysis of qualitative and quantitative signs was carried out. RESULTS: Hypertensive twins had similar qualitative features of target organs involvement irrespective of duration of hypertension. Concordance of signs of target organ damage in homozygous twins was more than twice higher than that of same signs in dizygous twin pairs. Left ventricular myocardial mass and intima-media thickness were mainly determined by hereditary factors. Their contribution into overall phenotypic variability of a sign exceeded 70%.
Asunto(s)
Enfermedades en Gemelos , Hipertensión/genética , Monitoreo Ambulatorio de la Presión Arterial , Vasos Sanguíneos/diagnóstico por imagen , Vasos Sanguíneos/patología , Arteria Carótida Común/diagnóstico por imagen , Arteria Carótida Común/patología , Enfermedades del Sistema Nervioso Central/complicaciones , Enfermedades en Gemelos/diagnóstico , Ecocardiografía , Ambiente , Femenino , Humanos , Hipertensión/complicaciones , Hipertensión/diagnóstico , Hipertensión/etiología , Hipertensión/patología , Hipertrofia Ventricular Izquierda/diagnóstico , Hipertrofia Ventricular Izquierda/diagnóstico por imagen , Hipertrofia Ventricular Izquierda/genética , Masculino , Persona de Mediana Edad , Fenotipo , Factores de Tiempo , Gemelos Dicigóticos , Gemelos MonocigóticosRESUMEN
Twenty four hour blood pressure monitoring was carried out in 64 sex concordant pairs of monozygotic and dizygotic hypertensive twins (mean age 52.7-/+3.2 years). Clinico-genetic analysis of quantitative parameters showed that during day awake time systolic, diastolic, and mean blood pressures were mainly determined by environmental factors while pulse pressure and heart rate were predominantly affected by genetic factors. Formation of parameters of variability of blood pressure and its biphasic rhythm were under the influence of random (intrafamily) environmental factors.
Asunto(s)
Ritmo Circadiano , Ambiente , Hipertensión/epidemiología , Hipertensión/genética , Gemelos/genética , Adulto , Humanos , Masculino , Índice de Severidad de la EnfermedadRESUMEN
Morbidity among the Moscow population receiving medical care at clinical hospital No. 85 and among workers, particularly those occupationally exposed to harmful factors, has been studied using an original system of automated processing of medical statistical information. The structure and incidence of the major groups of diseases has been studied in comparison with the mean data for Moscow. Total morbidity of adults and adolescents in 1998 was 1408/1000, which is close to the level for the whole Moscow (1396/1000). Morbidity among men was 1249/1000, which is lower than among women (1595/1000), while the incidence of diseases with temporary disability, primary invalidity, and mortality are higher among men. Population health is better in a relatively closed and socially protected population attached to a single institution in Moscow than in Russia in general; specifically, the incidence of infectious diseases and injuries is lower.