THE STUDY OF VDR FOKI RS2228570 SNP IN AUTOIMMUNE THYROIDITIS.

Autoimmune thyroid disease (AITD) is a common organ-specific autoimmune disease. A strong influence of genetic and epigenetic modifications has been demonstrated to take part in the development and progression of autoimmune thyroid diseases. The linkage between the Vitamin D receptor (VDR) polymorphism and several autoimmune disorders, including the AITD. In this article, we aim to investigate the Frequency of VDR Fokl (rs2228570) genotypes (CC, CT, TT) and alleles (C,T) in autoimmune thyroiditis. The investigation of VDR Fokl (rs2228570) was conducted on 150 samples (control (75 healthy women) and diseased women (75 diseased with autoimmune thyroiditis)) patients from the Adjara (Georgia) Population. It also examined some clinical and laboratory characteristics of the study population. Autoimmune thyroiditis's disease was diagnosed by measuring blood antibodies, determining the level of thyroperoxidase, and conducting an ultrasound examination. Anti-TPO and TSH were studied using the ELISA method. The genomic DNA was extracted from the peripheral blood. The polymerase chain reaction was evaluated to examine the VDR Fokl rs2228570 SNP polymorphism. According to VDR Fokl (rs2228570) genotypes (CC; CT, TT) frequency, in the control group, the Frequency of CC-genotype is 48%, CT-heterozygous genotype is 29.33%, and TT-genotype is 22.67%; in the diseased population, the Frequency of CC-genotype is 57.33%, CT-genotype is 34.67%, and TT-genotype is 8%. According to VDR Fokl (rs2228570) alleles (C, T), the Frequency of the C-allele is high, and the Frequency of the T-allele is low in both populations. The Frequency of the CC and CT genotypes of VDR Fokl (rs2228570) is high in the population with autoimmune thyroiditis compared to the control group; the TT genotype is relatively low in the population suffering from autoimmune thyroiditis; According to VDR Fokl (rs2228570) alleles (C, T), the Frequency of C-allele is high both population.

[THE ROLE AND PLACE OF VIRTUAL CT COLONOSCOPY IN COMPLEX RADIOLOGICAL DIAGNOSIS OF COLON DISEASES].

Nowadays CT colonoscopy is one of the basic methods for colon disease diagnostic. In Georgia mentioned method is used rarely despite of its high diagnostic potential. The current research aims to populate CT colonoscopy to be widely used in diagnostic as well as preventive healthcare, develop radiological semiotics of colon specifications and pathology changes. The research have been carried out in Batumi Referral Hospital. During the clinical researches patient's complains were gathered in details , also there was considered life , medical history and clinical research data. Following instrumental methods were used: CT colonoscopy, fibrocolonoscopy, irrigography-irrigoscopy, ultrasound research of colon. Computer Tomography researches was carried out on "General Electric" (USA) 16 layer CT scanner with 1.2 mm step by following phases: definition of research indication, preparation of intestine, insufflation, getting image, working on image and interpretation. In all cases intenstine was filled up with common air by manually method. According to 224 patients examination results in colon growing anomalies diagnostic CT colonoscopy responsivity is 98,0%, specificity 100%, diagnostic accuracy 98,2%, diverticulosis diagnostic 92,3%, 95,1%, 92,7%, and accordingly polyps in diagnostic: 87,3%, 85,6%, 85,9%. According to the gained results we can make conclusion, that CT colonoscopy is a reliable, high informational and minimally invasive diagnostic method to discover pathological disorder in colon wall and early stage cancer.

[Our experience of treatment inguinal hernia].

Inguinal hernia is the most common of all of all hernia surgical procedures. Surgery has generally been recommended for all inguinal hernias. The original method of reconstruction of the transverse fascia in patients with inguinal hernia was introduced. Treatment results in 1200 patients with inguinal hernias were analyzed and 558 (46,5%) cases of right-side inguinal hernia, 426 (35,5 %) - left-side inguinal hernia, 96 (8%) - both-sided inguinal hernia, 78 (6,5%) - recurrent inguinal hernias, 42 (3,5%) - multiple recurrent hernias, 608 (51%) - oblique inguinal hernia, 452 (38%) - straight inguinal hernia, 52 (4%) - oblique and straighten duct inguinal hernia, 51 (4%) - combined inguinal hernia (oblique and straight ) on one side, 29 (2%) - combined inguinal hernia (oblique on one side and straight on the other side), 777 (65%) - free inguinal hernia were revealed. Transversal fascia by prolen mesh technique is pathogenetically relevant and has shown good results.

[Treatment of abdominal hernias by cellular endoprosthesis].

Abdominal hernias are the most common conditions requiring surgery. The objectives of abdominal hernial repair are to minimize recurrence of the disease. The prosthetic hernioplasty, which was introduced by Stoppa and Rives, became one of the widely accepted. Long-term results of the surgical treatment using new modification of Rives-Stoppa technique were presented. The medical records were reviewed of 143 patients who underwent hernial repair. The decrease of complications such as infections, seromas, and hematomas, and tissue inflammation were reported. This technique is safe with a low risk of complications and a low rate of recurrence.

[Analysis of the situation of some urgent surgical services during the reform period in health care system in Adjara].

The reform that started in 1995 in health care system still is in progress in our country. It is necessary to evaluate the advantages and disadvantages of past period in order to achieving the objectives. For this aim we used the statistical facts gathered during the reforms and according to those data we tried to analyse the existing situation of urgent surgical service. We describe the main problems that would be the best way to solve them in the future. The results show that the urgent surgical help in a hospital still has enough reserve for optimization and reorganization, but it is clear, that for field working improvement there is necessity of the appropriate reformation of institutional organization, financing, program maintaining and human resources.