RESUMEN
The effect of on Changes in dielectric parameters of the skin (modulus of complex dielectric permittivity |e| and dielectric loss tangent tgd) were studied on rats with local surface contact cooling followed by treatment with various cream formulations. Addition of antioxidant superoxide dismutase (SOD) to the cream significantly prevented the shifts in these parameters, which attested to less pronounced changes in the water balance in SOD-treated skin. Application of SOD during the early terms after cooling accelerated wound healing. Histological examination performed on posttraumatic day 60 revealed better integrity of the skin structures (hair follicle, sweat and sebaceous gland), which indicates ability of SOD to prevent and ameliorate the degree of cold-induced damage in the skin.
Asunto(s)
Piel/efectos de los fármacos , Piel/metabolismo , Superóxido Dismutasa/farmacología , Animales , Congelación de Extremidades/inducido químicamente , Congelación de Extremidades/tratamiento farmacológico , Congelación de Extremidades/metabolismo , Masculino , Ratas , Superóxido Dismutasa/administración & dosificación , Cicatrización de Heridas/efectos de los fármacosRESUMEN
The molecular weights of collagen and hyaluronic acid solutions after their incubation with collagenase and hyaluronidase were evaluated by capillary viscosimetry. The results indicate high amylolytic activity of collagenase and the absence of proteolytic activity in hyaluronidase in an in vitro system.