In-hospital psychoeducation for family caregivers of Nigerian children with cancer (The RESCUE Study).

OBJECTIVES: High levels of caregiver burden (CB) are experienced by informal caregivers of pediatric patients with cancer. There is increasing evidence highlighting the extent of CB across sub-Saharan African countries, although there remains lack of interventions that target improvements in their experience. This study aimed to determine the impact of a structured psychoeducation program on caregivers' outcomes relating to preparedness to provide care, burden of caregiving, and quality of life (QoL). METHODS: This quasi-experimental (pre-and-posttest) design, involved family caregivers of children on admission for cancer treatment in 4 Nigerian tertiary hospitals. Eligible participants received 2 structured, psychoeducational training sessions delivered by a multidisciplinary oncology team, focusing on the management of patients' condition, spiritual care, self-care, and support. RESULTS: Subjects were mainly female (79.5%) and mostly mothers to children undergoing cancer treatment (74.7%). Commonest cancer type was acute lymphoblastic leukemia (23.9%) with evidence of metastatic disease found in 9.6% of children. Significant improvements were observed between pre- and posttest for unmet needs (z = -9.3; p < 0.001), preparedness for caregiving in palliative care (PCPC) (z = -7.0; p < 0.001), and overall QoL (z = -7.3; p < 0.001). A significant reduction in CB was also reported (z = -8.7; p < 0.001). SIGNIFICANCE OF RESULTS: This psychoeducational intervention (PEI) resulted in significant improvements in unmet needs, CB and significant improvements in PCPC. However, a reduction in QoL of the family caregivers was also observed. Findings from this study should encourage the use of well-crafted PEIs, delivered within hospital settings to promote improvements in outcomes for informal caregivers of hospitalized children suffering from cancer, in an African context. Further intervention development is required to better understand intervention components influencing changes in outcomes, while exploring feasibility testing and adaptation to similar settings in Nigeria and within Africa.

Prevalence and factors associated with depression among medical students in Nigeria.

BACKGROUND: Depression among medical students has been partly attributed to the nature of medical education, and may lead to poor academic and professional adjustment. The objectives of the study were to assess the prevalence of depression and its relationship to socio-demographic and clinical risk factors among medical students of Bayero University in Kano, Nigeria. METHODOLOGY: A descriptive cross-sectional study was performed. Two hundred and seventy-nine medical students were selected using a multi-stage sampling technique. The respondents were given a self-reporting questionnaire, which included sociodemographic details and 3-item Oslo Social Support Rating Scale. Depression was assessed using the Mini-International Neuropsychiatric Interview (7.0). RESULTS: The prevalence of depression among medical students was 15.1%. Depression was more in females, <22 years, those at the lower level of study, poor social support, family history of depression and history of depression. After logistic regression, only being female (P = 0.008) and history of depression (P = 0.007) differentiated medical students with depression from those with no depression with odds ratio (OR) of 2.88 (95% confidence interval [CI] = [1.31, 6.33]) and OR of 2.79 (95% CI = [1.33, 5.84]), respectively. There was no association between depression and poor financial state (P = 0.175), self-reported academic performance (P = 0.719) and use of psychoactive substances (P = 0.311). CONCLUSION: Depression is an important condition among medical students in Nigeria. There is a need to help students with mental health challenges by providing preventive measures, early identification and treatment mechanisms in medical schools in the country.

Comparison of impulsivity, aggression and suicidality between prisoners in Nigeria who have committed homicide and those who have not.

Most studies of prisoners, the nature of their offending and any related characteristics have been conducted in rich Western countries. In Nigeria, prison conditions differ in many important respects, key among them that prisoners share large communal spaces much of the time-up to 50 men sleeping in the same space as well as spending the day together. Our aim was to compare levels of impulsivity, aggression and suicide-related behaviours between prisoners in one prison in Nigeria who had committed a homicide and those who had not, allowing for socio-demographic factors. A case-control study design was employed with 102 homicide and an equal number of non-homicide offenders. Each participant was interviewed using the Abbreviated Barratt Impulsiveness Scale for impulsivity, the Modified Overt Aggression Scale for aggression, the MINI International Neuropsychiatric Interview (Module C) for suicide-related behaviours, and a questionnaire for ascertaining socio-demographic characteristics. On bivariate analysis, motor impulsivity was higher among homicide offenders (p = .014) while non-planning was higher among non-homicide offenders (p = .006), but this relationship was affected by demographic variables. Physical aggression levels did not distinguish the two groups, but homicide offenders were less likely to record property-directed and auto-aggressive behaviours (p < .05). By contrast, on average, scores for suicide-related behaviours were lower among the homicide offenders (p = .001), with non-homicide offenders showing a mean score in the high-risk category (13.25; SD, 1.25). As motor impulsivity significantly differentiated the groups, this may be an important measure to add to any risk assessment battery when there are concerns about homicidal behaviours. In this sample, history of interpersonal aggression did not distinguish the groups. People with indications of self-harm or suicide-related behaviours may be at less risk of violence to others, but care should be taken in interpreting this finding as it is not entirely consistent with other findings.

Self-limiting Atypical Antipsychotics-induced Edema: Clinical Cases and Systematic Review.

A number of atypical antipsychotics have been associated with peripheral edema. The exact cause is not known. We report two cases of olanzapine-induced edema and a brief review of atypical antipsychotic-induced edema, possible risk factors, etiology, and clinical features. The recommendation is given on different methods of managing this side effect.