1.
Chem Commun (Camb)
; 53(77): 10656-10659, 2017 Sep 26.
Artículo
en Inglés
| MEDLINE
| ID: mdl-28905052
RESUMEN
Macrocyclic peptides have promising therapeutic potential but the scaling up of their chemical synthesis is challenging. The cyanobactin macrocyclase PatGmac is an efficient tool for production but is limited to substrates containing 6-11 amino acids and at least one thiazoline or proline. Here we report a new cyanobactin macrocyclase that can cyclize longer peptide substrates and those not containing proline/thiazoline and thus allows exploring a wider chemical diversity.