Enhanced carbon dioxide drainage observed in digital rock under intermediate wetting conditions.

Carbon dioxide (CO 2 ) trapping in capillary networks of reservoir rocks is a pathway to long-term geological storage. At pore scale, CO 2 drainage displacement depends on injection pressure, temperature, and the rock's interaction with the surrounding fluids. Modeling this interaction requires adequate representations of both capillary volume and surface. For the lack of scalable representations, however, the prediction of a rock's CO 2 storage potential has been challenging. Here, we report how to represent a rock's pore space by statistically sampled capillary networks (ssCN) that preserve morphological rock characteristics. We have used the ssCN method to simulate CO 2 drainage within a representative sandstone sample at reservoir pressures and temperatures, exploring intermediate- and CO 2 -wet conditions. This wetting regime is often neglected, despite evidence of plausibility. By raising pressure and temperature we observe increasing CO 2 penetration within the capillary network. For contact angles approaching 90 ∘ , the CO 2 saturation exhibits a pronounced maximum reaching 80 % of the accessible pore volume. This is about twice as high as the saturation values reported previously. For enabling validation of our results and a broader application of our methodology, we have made available the rock tomography data, the digital rock computational workflows, and the ssCN models used in this study.

El bullying: una mirada desde los niños y las niñas / Bullying: A scope from boys and girls / Bullying: Um olhar de meninos e meninas

(analítico) Se presentan los resultados sobre cómo se comprende y se asume el bullying, en tanto problema escolar y social, desde la perspectiva infantil. Para ello, se realizó una investigación cualitativa, hermenéutico-comprensiva, con grupos focales mediados por títeres o videos, producción gráfica y narración de historias. Los participantes fueron 626 estudiantes de 5 a 7 años. La comprensión transitó por elementos congruentes con la teoría, como exclusión, acoso verbal, afectación de pertenencias y una nueva tipología: falta de solidaridad. En cuanto a las experiencias, precisan las burlas, el acoso físico y el hurto, asociadas al contexto familiar o a ninguna, estas últimas por la confluencia del espacio escolar y la familia en un mismo lugar en tiempos de educación remota. En cuanto a la solución, está apela a figuras de autoridad, familiares, asumir actitudes reconciliadoras o al juego.

(analytical) The paper presents the results on how bullying, as scholar and social problem, is understood and assumed from the child's perspective. Therefore, a qualitative, hermeneutic-comprehensive research was carried out and focus groups were done by means of moppets and videos, graphic production, and storytelling. The participants were 626 students from 5 to 7 years old. The understanding went through elements consistent with the theory, such as exclusion, verbal harassment, affectation of be-longings and a new typology, lack of solidarity. Regarding the experiences, they specify teasing, physical harassment, theft, associated with the family context or none, the latter due to the confluence of the school space and the family in the same place in times of remote education. As for the solution, it is appealing to authority figures, relatives, assuming reconciliatory attitudes and playing.

(analítico) O artigo apresenta os resultados sobre como o bullying, como um problema social e escolar, é compreendido e assumido na perspectiva da criança. Para isso, realizou-se uma investigação qualitativa, hermenêutica-compreensiva e grupos focais mediados por fantoches ou vídeos, produção gráfica e contação de histórias; os participantes foram 626 alunos de 5 a 7 anos. O entendimento passou por elementos condizentes com a teoria, como exclusão, assédio verbal, afetação de pertences e uma nova tipologia, falta de solidariedade. Quanto às vivências, especificam provocações, assédios físicos, furtos, associados ao contexto familiar ou nenhum, este último devido à confluência do espaço escolar e da família no mesmo local em tempos de educação a distância. Quanto à solução, é apelar a figuras de autoridade, familiares, assumindo atitudes de conciliação e brincadeiras.

Una mirada a la Educación Superior Inclusiva en Latinoamérica / A Look at Inclusive Higher Education in Latin America

Resumen: Esta revisión tuvo como objetivo reconocer las investigaciones y las experiencias que surgen en las Instituciones Educativas Superiores en relación con la diversi dad e inclusión. Los resultado exhortan a revisar y trascender los enfoques que actualmente rigen el diseño de los procesos educativos en la Educación Supe rior, especialmente, aquellos dirigidos al restablecimiento de derechos a las po blaciones vulnerables, en aras de fortalecer la educación inclusiva y garantizar el derecho constitucional a una educación con calidad que dignifique y permita la participación plena de estos colectivos, reflejándose en una implementación de programas que posibiliten la inclusión educativa en las Universidades.

Abstract: The objective of this review was to recognize the research and experiences that arise in Higher Education Institutions in relation to diversity and inclusion. The results urge to review and to transcend the approaches that currently govern the design of educational processes in Higher Education, especially those aimed at restoring the rights of vulnerable populations in order to strengthen inclusive education and to guarantee the constitutional right to a quality education that dignifies and allows the full participation of these groups, reflected in the im plementation of programs that enable educational inclusion in Universities.

Mutual Information between EDA and EEG in Multiple Cognitive Tasks and Sleep Deprivation Conditions.

Sleep deprivation, a widespread phenomenon that affects one-third of normal American adults, induces adverse changes in physical and cognitive performance, which in turn increases the occurrence of accidents. Sleep deprivation is known to increase resting blood pressure and decrease muscle sympathetic nerve activity. Monitoring changes in the interplay between the central and autonomic sympathetic nervous system can be a potential indicator of human's readiness to perform tasks that involve a certain level of cognitive load (e.g., driving). The electroencephalogram (EEG) is the standard to assess the brain's activity. The electrodermal activity (EDA) is a reflection of the general state of arousal regulated by the activation of the sympathetic nervous system through sweat gland stimulation. In this work, we calculated the mutual information between EDA and EEG recordings in order to consider linear and non-linear interactions and provide an insight of the relationship between brain activity and peripheral autonomic sympathetic activity. We analyzed EEG and EDA data from ten participants performing four cognitive tasks every two hours during 24 h (12 trials). We decomposed EEG data into delta, theta, alpha, beta, and gamma spectral components, and EDA into tonic and phasic components. The results demonstrate high values of mutual information between the EDA and delta component of EEG, mainly in working memory tasks. Additionally, we found an increase in the theta component of EEG in the presence of fatigue caused by sleep deprivation, the alpha component in tasks demanding inhibition and attention, and the delta component in working memory tasks. In terms of the location of brain activity, most of the tasks report high mutual information in frontal regions in the initial trials, with a trend to decrease and become uniform for all the nine analyzed EEG channels as a consequence of the sleep deprivation effect. Our results evidence the interplay between central and sympathetic nervous activity and can be used to mitigate the consequences of sleep deprivation.

The administration of Alda-1, an activator of ALDH2, inhibits relapse-like ethanol intake in female alcohol-preferring UChB rats.

AIMS: Alcohol relapse is a main limitation for the treatment of alcohol use disorders. Previous studies have shown that Alda-1, a pharmacological activator of ALDH2, inhibits both acquisition and chronic ethanol intake in rats; however, its effects on relapse-like ethanol intake are unknown. The aim of this study was to assess the effect of Alda-1 on post-deprivation and reaccess relapse-like ethanol intake in alcohol-preferring UChB rats. We also aimed to assess the possible mechanisms associated with the effects of Alda-1 by measuring the levels of glutamate transporter (GLT-1), oxidative stress and neuroinflammation markers in different regions of the mesocorticolimbic system. MAIN METHODS: In Experiment I, UChB female rats were exposed for 100 days to voluntary ethanol intake followed by 2-weeks of ethanol withdrawal and 1 week of ethanol reaccess. Alda-1 (25 mg/kg, intragastric, i.g) or vehicle was administered daily for 14 days during the withdrawal/re-access period. Experiment II was similar to Experiment I, but after the withdrawal period, ethanol re-access was not allowed, and Alda-1 was administered during the last week of withdrawal. At the end of both experiments, the levels of GLT-1, oxidative stress (GSH, MDA), and neuroinflammation markers (GFAP, Iba-1) were assessed in nucleus accumbens and/or hippocampus. KEY FINDINGS: The results showed that Alda-1 administration markedly blocked (90 %, p < 0.001) relapse-like ethanol intake in UChB rats. Alda-1 increased Iba-1 reactivity (microglial marker) in the NAc of ethanol-deprived rats. Alda-1 administration did not influence the levels of GLT-1, oxidative stress markers (MDA, GSH) or GFAP reactivity in the mesocorticolimbic system. SIGNIFICANCE: These preclinical findings support the use of activators of ALDH2, such as Alda-1, as a potential pharmacological strategy in the treatment of alcohol relapse.

Afianzamiento de las habilidades argumentativas de jóvenes universitarios noveles en Envigado

(analítico) Este artículo presenta los resultados de una investigación postdoctoral cuyo objetivo fue afianzar las habilidades argumentativas de jóvenes universitarios del primer semestre de una facultad en Envigado (Colombia), dados los bajos niveles identificados en semestres anteriores. Para ello, se realizó una investigación cualitativa, hermenéutico-comprensiva, apoyada en herramientas de estadística descriptiva. Se hicieron pruebas de entrada y salida a los participantes. Se diseñaron seis talleres a partir de los resultados de la prueba de entrada. Cada taller requería de un entregable. La intervención se realizó bajo el marco de la lingüística textual, el análisis crítico del discurso y la argumentación pragmadialéctica. Aquellos que participaron activamente en los talleres propuestos afianzaron sus habilidades argumentativas considerablemente y, según las participantes entrevistadas, reconocen su utilidad en tareas académicas y en la participación ciudadana.

(analytical) This paper presents the results of a postdoctoral research whose objective was to strengthen young university firstyear students' argumentative skills in a school in Envigado (Colombia), because of the low levels identified in prior semesters. Therefore, qualitative hermeneutics-comprehensive research supported in descriptive statistics was done. Entry and exit tests to participants were carried out. 6 workshops were designed based on the entry test results. Each workshop required a class product. Intervention was proposed from text linguistic, critical discourse analysis and pragma-dialectic argumentation. Those students who participated actively in the workshops significantly strengthened their argumentative skills and, as some interviewees mentioned, they recognized these skills use in academic tasks and citizenship participation.

(analítico) Este artigo apresenta os resultados de uma pesquisa de pósdoutorado cujo objetivo foi fortalecer as habilidades argumentativas de jovens universitários do primeiro semestre de uma faculdade de Envigado (Colombia), dados os baixos níveis identificados nos semestres anteriores. Para isso, foi realizada uma pesquisa qualitativa, hermenêutica-abrangente, apoiada em ferramentas estatísticas descritivas. Os participantes foram testados para entrada e saída. 6 workshops foram concebidos com base nos resultados do teste de admissão. Cada workshop exigia uma entrega. A intervenção foi realizada no quadro da linguística textual, da análise crítica do discurso e da argumentação pragmadialética. Aqueles que participaram ativamente das oficinas propostas fortaleceram consideravelmente suas habilidades argumentativas e, segundo os entrevistados, reconhecem sua utilidade nas tarefas acadêmicas e na participação cidadã.

Revisión de las tendencias teóricas e investigativas en el campo de la Psicología de la Actividad Física y del Deporte en Iberoamérica / Review of theoretical and research trends in the field of Psychology of Physical Activity and Sports in Ibero-American

Resumen Introducción: Las tendencias teóricas e investigativas refieren propuestas y contemplaciones de los fenómenos sociales que se desarrollan en el campo de la psicología de la actividad física y del deporte, las cuales permiten tener otras perspectivas y formas de interactuar en el contexto. Objetivo: Revisión de las tendencias teóricas e investigativas en el campo de la Psicología de la Actividad Física y del Deporte en Iberoamérica. Método: La investigación fue cualitativa, hermenéutico-comprensiva. La unidad de análisis se conformó de 20 artículos de revistas iberoamericanas indexadas en Scopus en los años 2016 y 2017. Su selección se hizo a partir de los descriptores Deporte y Actividad Física. La búsqueda se realizó en el título, el resumen y las palabras clave. Para su análisis, se empleó una rúbrica, la cual permitió sistematizar la información bibliométrica del artículo, sus autores y textos citados y las palabras clave. Resultados: Se identificaron los puntos de encuentro y las apuestas teóricas presentes en dichos artículos, agrupadas en trece categorías. Conclusiones: Resulta significativa la presencia de categorías generales de la psicología como motivación, relacionamiento, habilidades para la vida e intereses de intervención dentro de aspectos tan disciplinarios como la Actividad Física y la Psicología del Deporte.

Abstract Introduction: Theoretical and investigative tendencies refer to proposals and contemplations of the social phenomena that are developed in the field of psychology of physical activity and sport, which allow to have other perspectives and ways of interacting in the context. Objective: Review of theoretical and research trends in the field of Psychology of Physical Activity and Sports in Ibero-American. Method: The research was qualitative, hermeneutic-comprehensive. The analysis unit consisted of 20 articles of Ibero-American journals indexed in Scopus in 2016 and 2017. Their selection was made from two descriptors Sport and Physical Activity. The search was carried out in the title, the summary and the keywords. For its analysis, a rubric was used, which allowed systematizing the bibliometric information of the article, its authors and cited texts and the keywords. Results: The agreement points and theoretical bets present in these articles were identified, grouped into thirteen categories. Conclusions: It is significant the presence of general categories of psychology such as motivation, relationship, life skills and intervention interests in such disciplinary aspects as Physical Activity and Sports Psychology.

Vaccine Hesitancy Against SARS-CoV-2 in Health Personnel of Northeastern Mexico and Its Determinants.

With the emergence of effective vaccines against SARS-CoV-2, the need to find the determinants for its correct distribution is created, with health personnel being an essential group where coverage must be ensured. MATERIALS AND METHODS: A cross-sectional study was conducted through an electronic survey that was distributed to health personnel in the state of Nuevo Leon, Mexico. Potential determinants for vaccine hesitancy were covered including their intention to be vaccinated against SARS-CoV-2. RESULTS: A total of 543 responses were collected from health professionals, which 30 (5.5%) of the subjects stated that they would reject SARS-CoV-2 vaccination. How well informed the subjects were was the most determining factor, where misinformation related to vaccination and COVID-19 was the most important cause of vaccine rejection. CONCLUSION: The implementation of educational strategies for health personnel are required.

Estrategias pedagógicas de literacidad: experiencia significativa en una Institución Educativa de Boyacá / Literacy pedagogical strategies: A meaningful experience in a Boyacá´s School (Colombia) / Estratégias pedagógicas de alfabetização: experiência significativa em uma Instituição de Ensino de Boyacá

Resumen (analítico): Este artículo presenta los resultados obtenidos en una investigación acción educativa de tipo cualitativo, realizada en una Institución Educativa Técnica rural en un municipio de Boyacá (Colombia), donde se realizó una intervención a partir de estrategias pedagógicas para fortalecer los niveles de literacidad, teniendo en cuenta el aprendizaje significativo en su diseño dado al bajo nivel de dichos estudiantes. El soporte teórico de la investigación fue la literacidad como desarrollo de competencias en comprensión y producción escritural en contexto. La unidad de análisis fue observación directa a 6 participantes, sus respectivas pruebas de entrada y salida y 5 talleres pedagógicos. Con los resultados logrados en la investigación se evidencian avances en la mayoría de las variables evaluadas; sin embargo, al valorar los resultados finales, algunos alumnos aún presentan dificultades.

Abstract (analytical): This paper shows the results obtained in a qualitative, educative action research carried out in a rural Technical Educational Institution in Boyacá Department (Colombia), where an intervention was made from pedagogical strategies to strengthen literacy levels, taking into account students´ meaningful learning in their design due to its students´ low level. The theoretical support of the research was literacy as the development of competences in comprehension and written production in context. The analysis unit was a direct observation to 6 participants, their entry and exit tests and 5 pedagogical workshops. With the results obtained in the research, progress is evidenced in most of the evaluated variables; however, some students still presenting difficulties when the final results are assessed.

Resumo (analítico): Este artigo apresenta os resultados obtidos em uma pesquisa de ação educativa do tipo qualitativa realizada em uma Instituição de Ensino Técnico rural em um município de Boyáca (Colômbia), onde foi feita uma intervenção a partir de estratégias pedagógicas para fortalecer os níveis de alfabetização, levando em consideração o aprendizado significativo em sua desenho dado o baixo nível de tais alunos. O suporte teórico da pesquisa foi a alfabetização como o desenvolvimento de competências em compreensão e produção de escrituras em contexto. A unidade de análise foi observação direta para 6 participantes, seus respectivos testes de entrada e saída e 5 workshops pedagógicas. Com os resultados obtidos na pesquisa, evidencia-se progresso na maioria das variáveis avaliadas; no entanto, ao avaliar os resultados finais, alguns alunos ainda têm dificuldades.

An agent-based model of the fission yeast cell cycle.

The objective of this paper is to develop a computational model of the fission yeast (Schizosaccharomyces pombe) cell cycle using agent-based modeling (ABM), to study the sequence of states of the proteins and time of the cell cycle phases, under the action of proteins that regulate its cell cycle. The model relies only on the conceptual model of the yeast cell cycle regulatory network, where each protein has been represented as an agent with a property called activity that represents its biological function and a stochastic Brownian movement. The results indicate that the simulated phase time did have similar results in comparison with other models using mathematical approaches. Similarly, the correct sequence of states was achieved, and the model was run under different initial states to understand its emergent behaviors. The cell reached the G1 stationary state 94% of the times when running the model under biological initial conditions and 87% of the times when running the model through all the different combinations of initial states. Such results imply that the cell was capable to fix toward the biological expected phenomena. These results show that ABM is a suitable technique to study protein-protein interactions without using, often unavailable, kinetic parameters, or differential equations. This model sets as a base for further studies that involve the cell cycle of the fission yeast, with a special attention to studies and development of drug treatments for specific types of cancer.

Niveles de literacidad en jóvenes universitarios: entrevistas cualitativas y análisis sociolingüístico / Literacy levels in University Students: Qualitative Interviews and Sociolinguistic Analysis / Níveis de literacidade em jovens universitários: entrevistas qualitativas e análise sociolinguística

Resumen (descriptivo): Se presentan algunos hallazgos emanados de la investigación denominada "Análisis sociolingüístico de los niveles de literacidad en jóvenes de la Institución Universitaria de Envigado", realizada por uno de los autores, para optar al título de "Doctor en Ciencias Sociales, Niñez y Juventud" de la Universidad de Manizales-Cinde. Pretende ser una contribución en una doble dirección. Por una parte, denunciar que es común que los jóvenes comiencen sus estudios universitarios con unos niveles de literacidad extremadamente bajos, lo que exige unos esfuerzos especializados en el proceso de enseñanza/aprendizaje de esta población. Por otra, aportar a los aspectos metodológicos, al examinar las posibilidades que ofrece el análisis sociolingüístico de las entrevistas en la investigación empírica. El diseño de la investigación incluyó una intervención académica realizada a una muestra experimental compuesta por 21 estudiantes que ingresaban a la universidad a los cuales se les pidió que diligenciaran una encuesta elemental de perfil sociocultural. Esto se complementó con 5 entrevistas cualitativas. Se concluye que el contexto biográfico desde la infancia y las instituciones involucradas como la familia y la escuela son preponderantes en la adquisición de las competencias en comprensión lectora, producción escritural y apropiación discursiva.

Abstract (descriptive): Findings from a research study on sociolinguistic analysis of the literacy levels of students from the University of Envigado are presented in this article, which is based on one of the author's thesis for a Doctorate in Social Science, Childhood and Youth at University of Manizales-Cinde. This paper aims to make two distinct contributions to this field. On one hand, it highlights that it is common that young students start their university studies with extremely low literacy levels, which requires specialized efforts in the learning/teaching process of this population. On the other hand, the study provides some interesting methodological aspects, examining the possibilities offered by a sociolinguistic analysis of interviews in empirical research. The research design included an academic intervention, which was carried out with an experimental sample consisting of by 21 students who were in their first semester of an undergraduate degree. These students filled out a basic sociocultural profile survey, which was complemented with 5 qualitative interviews. In conclusion, the study identifies that a student's biographical context since infancy and the institutions involved in their lives, such as family and school, are prevailing factors in the acquisition of reading comprehension and writing production competencies and discursive appropriation.

Resumo (descritivo): São apresentados alguns achados que fazem parte da pesquisa chamada de "Análise sociolinguística dos níveis de literacidade em jovens da Institución Universitaria de Envigado", realizada por um dos autores, para a obtenção do título de "Doutorado em ciências sociais, infância e juventude" da Universidade de Manizales-Cinde. O trabalho visa ser uma contribuição em dupla direção. No primeiro lugar, visa expor o fato de ser comum para os jovens o começo do ensino universitário com níveis de literacidade extremamente baixos, o que exige esforços especiais no processo de ensino/aprendizado para essa população. Alem disso, a pesquisa aporta aspectos metodológicos, ao examinar as possibilidades oferecidas pela análise sociolinguística nas entrevistas da pesquisa empírica. O projeto de investigação incluiu uma intervenção acadêmica feita com uma amostra experimental de 21 estudantes que entraram na universidade para a qual foram convidados, que deve processar uma pesquisa elementar de perfil sociocultural. Esta foi complementada por cinco entrevistas qualitativas. Concluiu-se que o contexto biográfico desde a infância e instituições envolvidas neste contexto como a família e a escola são preponderantes na aquisição de competências em compreensão de leitura, produção literária e apropriação discursiva.

Stages of Change for Mammography Among Mexican Women and a Decisional Balance Comparison Across Countries.

An analysis of the adoption of secondary preventive behaviors is significant in regions with disparities in mammography use and breast cancer survival. Therefore, we determined the cognitive factors and the degree to which they differentiate stages of change in mammography among Mexican women. We also compared the decisional balance performance at Mexico, Switzerland, South Korea, and the USA. A cross-sectional study was designed for women in the stages of precontemplation (n = 240), contemplation (n = 243), action (n = 205), maintenance (n = 311), and relapse (n = 348). We only considered those ≥40 years with no cancer history. We measured the pros, cons, and self-efficacy, among other components. The decisional balance was estimated, and the result was transformed into T-scores. Odds ratios (OR) and 95% confidence intervals (CI) were estimated with multinomial logistic regression using precontemplation as the reference group. The decisional balance distinguished stages partially: in contemplation, the OR was 1.26 (95%CI 1.08, 1.47) and in maintenance, 1.34 (95%CI 1.13, 1.59); in action and relapse, the statistical significance was marginal (p < 0.10). The decisional balance T-score performance registered variations among countries. Additionally, the effect of self-efficacy progressively ascended from contemplation to action and maintenance (OR = 1.29 [95%CI 1.05, 1.58], 1.53 [95%CI 1.20, 1.96], and 2.48 [95%CI 1.82, 3.39], respectively). Furthermore, risk perception and severity did not have an effect on stages of change among Mexican women. Recognition of what provokes action in a population is a key factor in the efficacy of screening programs. Variations among countries highlight the necessity for importance of investigating cognitive determinants for mammography in specific areas.

Relación maestro - alcance del logro: Una mirada a los procesos de enseñanza en la escuela

El presente artículo tiene como objetivo contribuir a la reflexión sobre las prácticas pedagógicas y didácticas orientadas al alcance del logro académico que los docentes desarrollan en el escenario educativo de la escuela. Del mismo modo, observar si los ambientes de aprendizaje se encuentran direccionados a potenciar los saberes previos, la construcción de planteamientos y posiciones que permiten comprender desde una posición crítica las condiciones del contexto de desenvolvimiento de las y los educandos. Y por último, reconocer los cambios que deben asimilar los docentes en una sociedad que paulatinamente exige nuevos conocimientos y competencias. Por tanto, es una invitación a repensar las acciones pedagógicas, los procesos de enseñanza aprendizaje, las didácticas en las que se apoyan los docentes para orientar el alcance del logro académico de las y los educandos.

This article aims to contribute to the reflection on pedagogical and didactic practices oriented to the scope of academic achievement and teachers developed in the educational setting for the school. In the same way see if learning environments are directed to enhance the knowledge previous to the construction of approaches and positions that allow to understand from a position criticized conditions in the context of unfolding of the learners. And finally to recognize the changes that must be gradually assimilate the teachers in a society that requires new knowledge and skills. Therefore, it is an invitation to rethink the pedagogical actions, teaching-learning processes, and the didactics that support teachers to guide to achieve the academic achievement of the students.

Este artigo pretende contribuir para a reflexão sobre as práticas pedagógicas e didáticas destinadas a alcançar o desempenho acadêmico que os professores desenvolvem cenário educacional na escola. Da mesma forma, observar se os ambientes de aprendizagem são direcionados para aumentar o conhecimento prévio, a construção de abordagens e posições que permitam a compreensão de um condições de contexto posição crítica e desenvolvimento dos alunos. E, finalmente, reconhecer as mudanças que os professores deveriam assimilar em uma sociedade que exige gradualmente novos conhecimentos e habilidades. Portanto, é um convite a repensar os processos de ações, de ensino e aprendizagem pedagógicas, ensinando nas quais os professores são suportados para orientar o alcance e desempenho acadêmico dos estudantes.

Análisis sociolingüístico de literacidad en jóvenes de la Institución Universitaria de Envigado

Introducción. Este artículo se desprende de la tesis doctoral Análisis sociolingüístico de los niveles de literacidad en jóvenes de la Institución Universitaria de Envigado (IUE). Por ello, tiene en cuenta variables como estrato social, edad, sexo y nivel educativo de los padres, factores que influyen sobre los niveles de literacidad de los estudiantes. Objetivo. Describir tales niveles y su correlación con los factores sociolingüísticos previamente señalados. Materiales y métodos. Para ello, se realizaron dos pruebas (una inicial y otra final) a dos grupos de primer semestre (Psicología 2010-II y Derecho 2011-II). Además, los participantes diligenciaron una encuesta sociocultural. Resultados. Los resultados en la prueba final indican que ambos grupos mejoraron, pero de manera desigual. El grupo de Psicología obtuvo resultados más significativos que el de Derecho. Conclusiones. Hay variables sociales que afectan el desarrollo de competencias en comprensión lectora y producción escritural; no obstante, estas probablemente puedan ser subsanadas a través de un curso dirigido desde la lingüística textual, el análisis crítico del discurso y la argumentación pragmadialéctica.

Introduction. This article is derived from the PhD thesis Análisis sociolingüístico de los niveles de literacidad en jóvenes de la Institución Universitaria de Envigado (IUE). Therefore, it takes into account variables such as social stratum, age, sex and educative level of the parents, given the fact that these factors affect the literacy levels of students. Objective. Describe such levels and their correlation with the sociolinguistic factors previously mentioned. Materials and methods. Two tests were performed, one at the beginning and another at the end, in two first semester groups (Psychology 2010-II and Law 2011-II). The participants also answered a sociocultural survey. Results. The results of the test performed at the end indicate that both groups improved, but in an uneven way. The group from psychology had more significant results that from Law. Conclusions. There are social variables that affect the development of reading comprehension and written production competencies. Nevertheless, they can be remedied by means of a special course proposed from textual linguistics, the critical analysis of speech and the pragma-dialectical argumentation.

Introdução. Este artículo se desprende da tese doutoral Análise sociolinguístico dos níveis de literacidade em jovens da Instituição Universitária de Envigado (IUE). Por isso, tenha em conta variáveis como estrato social, idade, sexo e nível educativo dos pais, fatores que influem sobre os níveis de literacidade dos estudantes. Objetivo. Descrever tais níveis e sua correlação com os fatores sociolinguísticos previamente mostrados. Materiais e métodos. Para isso, se realizaram duas provas (uma inicial e outra final) a dos grupos de primeiro semestre (Psicologia 2010-II e Direito 2011-II). Ademais, os participantes preencheram uma enquete sociocultural. Resultados. Os resultados na prova final indicam que ambos grupos melhoraram, mas de maneira desigual. O grupo de Psicologia obteve resultados mais significativos do que o de Direito. Conclusões. Há variáveis sociais que afetam o desenvolvimento de competências em compreensão leitora e produção escritural; embora, estas provavelmente possam ser corrigidas através de um curso dirigido desde a linguística textual, a análise crítica do discurso e a argumentação pragma-dialéctica.

Synthesis and antitumor evaluation of 6-aryl-substituted benzo[j]phenanthridine- and benzo[g]pyrimido[4,5-c]isoquinolinequinones.

A variety of novel 6-arylsubstituted benzo[j]phenanthridine- and benzo[g]-pyrimido[4,5-c]isoquinolinequinones were synthesized from 1,4-naphthoquinone, aryl-aldehydes and enaminones via a two-step synthetic approach. The cytotoxic activity of the aminoquinone derivatives was evaluated in vitro against one normal cell line (MRC-5 lung fibroblasts) and three human cancer cell lines (AGS human gastric adenocarcinoma; SK-MES-1 human lung cancer cells, and J82 human bladder carcinoma) in 72-h drug exposure assays using the MTT colorimetric method. Structure-activity relationships within the series of angular quinones reveal that the insertion of pyrrol-2-yl and furan-2-yl groups at the 6-position is more significant for the increase of the potency and selectivity index of the pharmacophores.

Inhibition of human topoisomerase I and activation of caspase-3 by aza-angucyclinones and arylaminopyrimido[4,5-c]isoquinoline-7,10-quinones.

Cancer is the second cause of death in the world after cardiovascular diseases. Cancer cells acquire capacities not present in normal cells, such as self-sufficiency, resistance to antiproliferative stimuli, evasion of apoptosis, unlimited replication, invasiveness and metastasis. Consequently, it is of major interest to explore and develop molecules with anticancer activity directed to specific targets. In this study, we aimed to evaluate two series of polycyclic quinones: aza-angucyclinone and arylaminopyrimido[4,5-c]isoquinoline-7,10-quinones, in their capacity to inhibit human topoisomerase I (TOP1) and to trigger apoptosis through activation of caspase-3. We evaluated the capacity of the two series of polycyclic quinones to inhibit TOP1, using a DNA supercoiled relaxation assay and their capacity to induce apoptosis through the activation of caspase-3 in HL60 cells. Both series of quinones inhibited TOP1 activity over 50%. When we evaluated the pro-apoptotic capacity of both series of quinones, at therapeutically relevant concentrations, the arylaminoquinones ADPA-1CC (methyl 7-(4-methoxyphenyl)amino-1,3-dimethyl-5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylate), P4 (9-phenylamino-3,4-dihydrophenanthridine-1,7,10(2H)-trione) and the aza-angucyclinone OH-6H (8-hydroxy-2,4-dimethyl-2H,4H-benzo[g]pyrimido[4,5-c]isoquinoline-1,3,7,12-tetraone) increased the caspase-3 activity by approximately 2-fold over the control. The series of the arylaminoquinones and aza-angucyclinones showed differential antiproliferative capacity. We further identified a group of them that showed antiproliferative capacity possibly through inhibition of TOP1 and by activation of caspase-3. This group of molecules may represent a potential pharmacological tool in the treatment against cancer.

Aminopyrimidoisoquinolinequinone (APIQ) redox cycling is potentiated by ascorbate and induces oxidative stress leading to necrotic-like cancer cell death.

Several phenylaminopyrimidoisoquinolinequinones (APIQs) were tested for their cytotoxicity against different cancer cell lines (K562, T24, HepG2) in the presence or absence of ascorbate. Ascorbate enhanced the toxic effects of quinones with first half-wave potential E(I) (1/2) values in the range of -480 to -660 mV. Phenylaminoquinones that were unsubstituted at position 6 exhibited greater cytotoxic activity than did their 6-methyl-substituted analogues. Two groups of compounds were further selected, namely 8-10 and 20-22, to study the cellular mechanisms involved in quinone cytotoxicity. Indeed, these compounds have the same range of redox potentials but differed considerably in their capacity to induce cell death. In the presence of ascorbate, the cell demise induced by compounds 8-10 was not caspase-3 dependent, as shown by the lack of activation of caspase-3 and the absence of cleaved PARP fragments. In addition, an index of ER stress (eIF2α phosphorylation) was activated by these compounds. Quinones 8-10 decreased the cellular capacity to reduce MTT dye and caused marked ATP depletion. Taken together, our results show that ascorbate enhances quinone redox-cycling and leads to ROS formation that inhibits cell proliferation and provokes caspase-independent cell death. Interestingly, we also observed that quinone 8 had a rather selective effect given that freshly isolated peripheral blood leukocytes from human healthy donors were more resistant than human leukemia K562 cells.

Studies on quinones. Part 46. Synthesis and in vitro antitumor evaluation of aminopyrimidoisoquinolinequinones.

In the search of structure-activity relationship studies and to explore the antitumor effect associated with the pyrimidoisoquinolinequinone scaffold, several diversily substituted 8-aminopyrimido[4,5-c]isoquinolinequinones were regioselectively synthesized. Variation in the structure of the nitrogen substituent bonded to the 8-position of the pyrimidoisoquinolinequinone system led to a set of alkylamino-, phenylamino- and alkyphenylamino derivatives. The cytotoxic activity of the aminoquinone derivatives was evaluated in vitro using the MTT colorimetric method against one normal cell line (MRC-5 lung fibroblasts) and four human cancer cell lines (AGS human gastric adenocarcinoma; SK-MES-1 human lung cancer cells, and J82 human bladder carcinoma; HL-60 human leukemia) in 72-h drug exposure assays. Among the series, five compounds exhibited interesting antitumor activity against AGS human gastric adenocarcinoma and human lung cancer cells. The SAR studies revealed that both the nature of the nitrogen substituent into the quinone ring and the methyl group at the 6-position play key roles in the antitumor activity.

Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones.

A series of 8-phenylaminopyrimido[4,5-c]isoquinoline-7,10-quinone derivatives were prepared by regioselective amination reaction of pyrimido[4,5-c]isoquinoline-7,10-quinones with arylamines in the presence of a Lewis acid catalyst. Preliminary evaluation of the members of the series against cancer cell lines and assays of activation of their cytotoxic activity on K562 cells with ascorbic acid are reported.