[Relationships between body composition and hematological parameters in long-living patients with coronary artery disease.]

The study objective to investigate hematological parameters and determine the relationships between these indicators and body composition in centenarians with coronary artery disease. This work is a cross-sectional study, which enrolled 239 patients over 90 years old hospitalized with a diagnosis of coronary artery disease; most of them (67,8%) were women. The age of the patients ranged from 90 to 106 years, averaging 92,8 (±2,5) years. Body composition was analyzed by dual energy X-ray absorptiometry. Anemia was detected in 108 (45,2%) patients, while a significant direct correlation was found between the hemoglobin level and all indicators of bone mineral density (p=0,004-0,00002). Patients with osteoporosis had lower levels of hemoglobin (p=0,002) and blood iron (p=0,02). Direct correlations were established between the hemoglobin level and lean tissue mass (p=0,06-0,003). Patients with obesity had higher levels of hemoglobin (p=0,007), erythrocytes (p=0,03), leukocytes (p=0,04), lymphocytes (p=0,01) and monocytes (p=0,05). A direct correlation was registered between the platelets count and fat tissue mass (p=0,04-0,00006) along with an inverse correlation between platelets and lean tissue (p=0,001-0,0004). The study results indicate significant relationships between the parameters of body composition and hematological indicators.

[Glomerular filtration rate in centenarians with coronary artery disease.]

The study objective was to compare the CKD-EPI, MDRD, BIS1, and Cockroft-Gault equations for calculating GFR, and analyze the various relationships between the glomerular filtration rate and clinical and laboratory parameters in long-living patients with coronary artery disease (CAD). A cross-sectional study of 270 patients from 90 to 106 years old, hospitalized with CAD diagnosis, was performed. The mean estimated GFR according to CKD-EPI was 51,4±14,2 ml/min, MDRD - 50,9±13,4, BIS1 - 38,4±7,7, Cockroft-Gault - 40,6±12,6 ml/min. Only 75 patients (27.8%) had CKD-EPI eGFR greater than or equal to 60 ml/min. The most common stage of chronic kidney disease was stage 3A, while stage CKD 5 did not occur at all. CKD staging results calculated using the MDRD and CKD-EPI equations were similar. However, when using the BIS1 equation, eGFR of more than 60 ml/min was not observed in any patient, and the vast majority of patients (64,1%) had stage 3B CKD. At high creatinine levels, there were no considerable differences between eGFR according to different equations, while at low and medium creatinine values, there were significant differences in eGFR, assessed using the CKD-EPI and MDRD equations on the one hand and BIS1 and Cockroft-Gault on the other. The maximum differences reached 21 ml/min.

[Tumor necrosis factor alfa in very elderly patients with coronary artery disease.]

The results of a study of the concentration of TNF-α as well as the relationship of this cytokine with a number of pathological conditions in very elderly patients with coronary artery disease compared with the control group of patients without CAD are presented in the article. The average group concentration of TNF-α reached 9,2+4,7 pg/ml (from 3,9 to 31,9 pg/ml) with normal TNF-α values of less than 8,1 pg/ml. An increase in the level of TNF-α was detected in 54,6% of patients. In patients with coronary artery disease the average concentration of TNF-α reached 10+4,9 pg/ml, while in the group of patients without CAD - 6,1+1,8 pg/ml (р=0,000001). TNF-α content was higher in patients with chronic heart failure (р=0,002) and with hyperuricemia (р=0,000006). The correlation analysis revealed a significant positive correlation between the level of TNF-α and uric acid (р<0,000001), between the concentration of TNF-α and the content of ß-Cross Laps (degradation products of type I collagen) (р=0,0001), as well as serum creatinine (р=0,002) and urea (p=0,00004) levels. In addition, a negative correlation was found between the values of TNF-α and high-density lipoprotein cholesterol concentration (р=0,00005), as well as leptin level (h=0,01). A decrease in the concentration of TNF-а was observed with increasing age of the patients (р=0,006).

[Bone mineral density in long-living patients with coronary artery disease.]

The results of cross-sectional study aimed to investigate bone mineral density (BMD) in 202 patients over 90 years old with coronary artery disease are presented in this atricle. Normal BMD indices in the lumbar spine were observed in 40,9%, osteoporosis - in 26,9%, osteopenia - in 32,2% of patients. Normal BMD indices in the proximal femur were observed in 21,3%, osteoporosis - in 39,9%, and osteopenia - in 38,8% of patients. A negative correlation between the severity of frailty, assessed using the questionnaire «Age is not a hindrance¼, and indicators of BMD (r=0,26; р=0,01) was found. A positive correlation was found between BMD indices and functional abilities of patients assessed using the Barthel index (r=0,44; p=0,000002) and the IADL scale (r=0,36; p=0,00008). Fractures in history were observed in 27,6% of patients.

[Lipid Blood Profile in Old Patients With Ischemic Heart Disease].

PURPOSE: to assess prevalence of dyslipidemia in patients with ischemic heart disease (IHD) older than 75 years as well as to evaluate possible associations between serum lipids and various cardiovascular and other diseases in these patients. METHODS: We enrolled in this cross sectional study 555 hospitalized IHD patients aged 75-98 years (mean age 86.8 years, 74.5 % women). Levels of lipids (total cholesterol [TC], triglycerides [TG], low and high-density lipoprotein cholesterol [LDLC, HDLC]) were measured by enzyme method on the biochemistry analyzer Konelab 60i. RESULTS: Elevated TC; hypertriglyceridemia and elevated LDLC were observed in 13.3, 10.4 and 26.3 % of patients, respectively. In the majority of patients severity of dyslipidemia was mild. With increasing age serum levels of TC and LDLC decreased. Negative correlation between TC level and patient's age was significant (r= -0.13; p=0.001). Mean TC level was 5.43, 5.0 and 4.7 mmol / l in patients aged.

[The feasibility of the application of cryotherapy and radonotherapy for the treatment of the patients presenting with osteoarthritis].

Osteoarthritis (OA) is currently considered to be one of the most widespread diseases. Its main clinical symptoms include pain and dysfunction of joints. In the present review of the foreign and domestic literature, the questions of pathogenesis and risk factors underlying the development of osteoarthritis are discussed. The understanding of OA pathogenesis have altered essentially in the recent years which made necessary the search for the novel approaches to the treatment of this pathology. According to the modern views of OA origin and progression, its therapy should be based on the application of the combination of medicamentous and non-medicamentous modalities including, in particular, collective and individual activities focused on the implementation of the programs of therapeutic physical training as an obligatory component of ОА prophylaxis and treatment. The present review gives evidence of the feasibility of the application of the methods of cryotherapy and radonotherapy for the management of the patients suffering from osteoarthritis. It is emphasized that many recent publications report extensive investigations of the clinical and pathogenetic aspects of the application of these methods for the combined regenerative treatment of the patients presenting with gonarthrosis. The influence of cryotherapy and radonotherapy on the neuroendocrine and immune systems is discussed with special reference to the possibility of regulation of the metabolic processes and retardation of inflammation. It is concluded that the introduction of the above methods into the compulsory individual program for the regenerative treatment of patients presenting with osteoarthritis is pathologically substantiated since it greatly contributes to the reduction of pain and retardation of the progress of the disease. The main pharmaceutical preparations for the OA treatment remain to be slow-acting symptomatic medicines possessed of the chondro-protective effect.

Glomerular lesion and increased cytokine gene expression in renal tissue in patients with decompensated nephrotic syndrome due to chronic GvHD.

The nephrotic syndrome is a rare complication of allogeneic stem cell transplantation (alloHSCT). We present two cases of nephrotic syndrome during chronic graft-versus-host disease (GvHD) involving altered cytokine gene expression in renal tissue. A patient with acute lymphatic leukemia demonstrated nephrotic syndrome due to minimal change disease as a marker of chronic GvHD. A patient with acute lymphoblastic leukemia suffered from severe nephrotic syndrome due to membranous glomerulopathy. In the two presented cases of GvHD-linked nephrotic syndrome, increased cytokine gene expression [tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta), interferon gamma (IFN-gamma), interleukin 2 (IL-2), IL-6, and IL-10] assessed using semiquantitative evaluation with reverse transcriptase polymerase chain reaction (RT-PCR) in situ on renal biopsy was observed.

[Luminescent control of the functional condition of Vallisneria spiralis L. treated by microwave irradiation].

The influence of microwave emission on the Vallisneria spiralis L. photoluminescence (PL) is studied. It is found that the irradiation leads to degradation of all the luminescence spectrum bands. It is shown that the influence on the chlorophyll PL at 715-735 and 800 nm is not limited by accompanied temperature effect. The degradation of PL has a temperature threshold at the thermal treatment. The 725 nm luminescence band of chlorophyll is shifted to short waves at both the irradiation and thermal treatment. The shift dependence from the irradiation dose and temperature is non-monotonous.

Band offsets and photocurrent spectroscopy of Si/Ge heterostructures with quantum dots.

Raman and lateral photoconductivity spectra of self-assembled SiGe nanoislands were studied with a height of ∼2 nm and a base of ∼20 nm formed at a temperature of 500 °C. It was estimated that the value of elastic deformation (ε(xx)) was -0.022 (ε(zz) = 0.017), while the germanium content in the islands (x) was 0.66. The obtained values of x and ε were used to calculate band offsets at the interfaces and the energy of interband transitions of structures under study. It was shown that the minimal energy of photocurrent observation is 0.52 eV, which is below the bandgap of the QDs under study. The first photocurrent component which began to contribute at 0.52 eV and had a peak at 0.68 eV is explained by optical transitions of electrons from the QD HH localized states of the valence band to the conduction band Δ(2) valley of the surrounding silicon matrix in which tensile strains are present. The second component with limiting energy of 0.73 eV can be caused by interband electron transitions from the HH valence band of the QDs to the Δ(4) valley of the QD conduction band.

[Vascular mechanisms of disorders of rheological properties of the blood in patients with myocardial infarction]. / Sosudistye mekhanizmy narusheniia reologicheskikh svoistv krovi u bo'lnykh infarktom miokarda.

The contribution made by vascular factors to impairment of blood rheological properties was demonstrated on the basis of examination of 65 apparently healthy persons by using a vascular occlusion test. The vascular endothelium showed a decrease in fibrinolytic, anticoagulant, antiaggregatory activities. The new term "hemorheological tolerance to vascular occlusion" was proposed to use. A number of quantitative and qualitative indices for normal hemorheological tolerance were identified. The paper provides data on the frequency of particular mechanisms responsible for its decrease. It also emphasizes that the knowledge of the mechanisms of vascular impairments makes it possible to choose a combined drug therapy for myocardial infarction in a differential fashion.