1.
Blood Transfus
; 22(3): 246-252, 2024 May.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38315531
Asunto(s)
Factor Plaquetario 4 , Púrpura Trombocitopénica Idiopática , Trombosis , Humanos , Trombosis/etiología , Trombosis/inmunología , Trombosis/sangre , Femenino , Púrpura Trombocitopénica Idiopática/inmunología , Púrpura Trombocitopénica Idiopática/sangre , Púrpura Trombocitopénica Idiopática/inducido químicamente , Masculino , Factor Plaquetario 4/inmunología , Persona de Mediana Edad , Adulto , Autoanticuerpos/sangre , Autoanticuerpos/inmunología , Anciano
2.
Transfus Apher Sci
; 60(1): 103010, 2021 Feb.
Artículo
en Inglés
| MEDLINE
| ID: mdl-33223471
RESUMEN
Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare condition mainly characterized by microangiopathic hemolytic anemia, thrombocytopenia, reported in approximately three cases per one million adults per year. Some reports describing co-occurrence of aTTP and other autoimmune disorders, as Graves' thyroiditis, are reported. To the best of our knowledge this is the first report describing co-occurrence of subacute thyroiditis and aTTP. The patient was refractory to conventional therapy with plasma exchange, steroids and rituximab but was successfully treated with the addition of caplacizumab, an anti-VWF bivalent variable-domain-only immunoglobulin fragment that inhibits interaction between VWF multimers and platelets.