An evaluation of the efficacy of a supplemental computer-based tutorial to enhance the informed consent process for cataract surgery: an exploratory randomized clinical study.

BACKGROUND: To assess whether informing patients with a computer-based tutorial in addition to standard informed consent influences the patient's attitude towards surgery and increases patient's knowledge. METHODS: In this prospective, exploratory, randomized clinical study, patients scheduled for their first eye cataract surgery were randomly allocated to two groups, receiving standard face-to-face informed consent (control group) or additionally using an interactive computer-based tool (CatInfo) containing an audiovisual presentation about cataract and its treatment (study group). Cataract-related knowledge and decisional confidence (decisional conflict scale (DCS)) were assessed as well as one-month postoperatively decisional regret (decision regret scale (DRS)) and willingness to exchange face-to-face discussion time for the use of such a tool. RESULTS: The study comprised 134 patients, 64 patients in the study group and 70 in the control group. Patients in the study group answered more questions correctly, 16.3 ± 2.0 (median 16.5, 11.0-19.0) versus 15.5 ± 1.9 (median 16.0, 8.0-19.0; p = 0.01). Patients showed a high decisional confidence with a study group mean DCS score of 92.4 ± 9.8 (median 96.9, 65.6-100) and control group score of 91.6 ± 10.9 (median 95.3, 43.3-100; p = 0.52). Mean DRS score in the study group was 2.5 ± 8.0 (median 0, 0-40) and 4.3 ± 12.5 (median 0, 0-75) in the control group (p = 0.14). Of study group patients 23 (67.6%) were willing to trade time, on average 158 ± 180 s (median 120 s, 45-900). Satisfaction with the tool was high with a mean of 9.1 ± 1.3 out of 10 (median 9.7, 5.0-10). CONCLUSIONS: Cataract-related knowledge was generally good, with slightly higher scores in the study group. In both groups, decisional confidence was high and regret after surgery was low. A tendency towards slightly higher decisional confidence and lower regret was found in the study group, although these differences were not statistically significant. Additional use of an interactive computer-based tool may prove useful in the informed consent process in a high-volume cataract outpatient setting. TRIAL REGISTRATION: ClinicalTrials.gov, NCT04975126. Retrospectively registered - July 23, 2021.

A Randomized Study of the Impact of a Corneal Pre-Cut During Cataract Surgery on Wound Architecture and Corneal Astigmatism.

INTRODUCTION: The aim of the current study was to assess the effect of a 600-µm corneal pre-cut on wound architecture and its impact on surgically induced astigmatism. The images were acquired intraoperatively and postoperatively with high-resolution spectral-domain optical coherence tomography (SD-OCT). METHODS: This study included patients scheduled for cataract surgery. Preoperatively, optical biometry and corneal topography were performed (IOL Master 500 and Atlas 9000, both Carl Zeiss Meditec AG, Germany). The first eye randomly received a 600-µm corneal pre-cut during cataract surgery, or a single-plane stab-incision and the second eye received the other incision technique. Incision architecture was assessed intraoperatively using a continuous intraoperative optical coherence tomography (iOCT) device (ReScan 700, Carl Zeiss Meditec AG, Germany) at three time points: after the incision, after irrigation/aspiration and after intraocular lens (IOL) implantation. Additionally, OCT (Spectralis, Heidelberg Engineering, Germany) measurements were performed 1 h, 1 week and 1 month postoperatively. RESULTS: Forty eight eyes of 24 patients were analysed. The pre-cut group and the stab-incision group had a significant decrease in wound thickness from the 1-h to the 1-week measurement (p = 0.022 and p = 0.001). Corneal astigmatism showed a vector difference from preoperatively to the 1-week measurement of 0.48 D (SD, ± 0.27) in the stab incision group and 0.49 D (SD, ± 0.24) in the stab incision group. No significant differences were found between the groups. CONCLUSION: To our knowledge, this was the first study which compared the wound alterations in pre-cut and stab-incision groups. TRIAL REGISTRATION: NCT02155270.

Effect of Air Tamponade on Postoperative Visual Acuity and Intraretinal Cystoid Changes after Peeling of Idiopathic Epiretinal Membranes in Pseudophakic Patients.

PURPOSE: Epiretinal membrane is a macular disorder leading to metamorphopsia and decreased visual acuity. The aim of the present study was to assess the possible effects of air tamponade, balanced salt solution (BSS), and combined phacoemulsification on functional and anatomical outcomes. PROCEDURES: This prospective exploratory analysis included 72 eyes with idiopathic epiretinal membranes, scheduled to undergo 23-G pars plana vitrectomy with membrane peeling. Air tamponade or BSS was used in all cases. Optical coherence tomography (OCT) imaging was performed intraoperatively, and follow-up including visual acuity testing and OCT measurements was conducted until 3 months postoperatively. RESULTS: Mean best-corrected visual acuity improved between +2.1 and +3.1 letters, and mean central subfield thickness of the macula decreased between -29.6 and -76 µm in the examined groups, without significant differences between the air tamponade and BSS groups. There was no significant difference in the presence of intraretinal cystoid changes between the groups. CONCLUSIONS: The use of air tamponade did not show any significant differences in the anatomical and functional postoperative results compared to BSS. Furthermore, phacovitrectomy did not result in significantly more intraretinal cystoid changes 3 months after surgery.

Evaluation of an intraoperative toric intraocular lens alignment system using an image-guided system.

PURPOSE: To evaluate an intraoperative toric intraocular lens (IOL) alignment system using a dedicated operating microscope with an image-guided system without preoperative corneal marking. SETTING: Vienna Institute for Research in Ocular Surgery, Department of Ophthalmology, Hanusch Hospital, Vienna, Austria. DESIGN: Prospective case series. METHODS: In this prospective study, a new operating microscope system was used for cataract surgery (toric IOL alignment system of the OPMI Lumera 700 microscope and CALLISTO eye software). This system allows toric IOL alignment by matching limbal vessels from a preoperative photograph with the live image of the microscope. The preoperative photograph was taken with IOLMaster 500, which included a "Reference Image Attachment" system (red-free image), and this was used to track and follow the eye during surgery. After surgery, rotational alignment was assessed and compared with the preoperative axis calculation. At 1 hour postoperatively, a retroilluminaton photograph was taken, and then rotational alignment was compared with the preoperative axis calculation to see the rotational stability. RESULTS: Fifty eyes of 50 patients were included. The feasibility of the intraoperative marking was high. Deviation between the postoperative (at the end of surgery in the operating room) and aimed IOL axes was 0.52 degrees ± 0.56 (SD). The deviation between 1 hour postoperatively and the aimed IOL axes was 5.10 ± 4.45 degrees. CONCLUSION: Intraoperative toric IOL alignment using an image-guided system was an accurate and fast procedure resulting in precise toric IOL alignment, and the system simplified the positioning of toric IOLs. There was a slight rotation of IOLs shortly after surgery (within the first hour).

Attaining the optimal flange for intrascleral intraocular lens fixation.

We describe a technique for making an optimal flange in intraocular lenses (IOLs) used for flanged intrascleral IOL fixation. The flange shape varies in poly(methyl methacrylate) (PMMA) haptics of different IOLs of different manufacturers. We identified the distance between the forceps grip of the haptic and the end of the haptic during heating with a cauter as a critical factor for the optimal flange shape in 5 PMMA haptics but not in 2 polyvinylidene fluoride haptics.

Enhanced Penetration for Axial Length Measurement of Eyes with Dense Cataracts Using Swept Source Optical Coherence Tomography: A Consecutive Observational Study.

INTRODUCTION: The aim of this study was to find cases in which the axial eye length could not be measured with partial coherence interferometry (PCI) technology and to assess if it could be measured using swept source optical coherence tomography (ss-OCT) technology. METHODS: All patients were measured at their pre-assessment visit 1 week prior to cataract surgery using conventional optical biometry (PCI technology, IOLMaster 500, Carl Zeiss Meditec AG, Jena, Germany). Patients in whom one or both eyes could not be measured using PCI technology were invited to participate in the study and to be measured with the ss-OCT (IOL Master 700, Carl Zeiss Meditec AG, Jena, Germany) device. RESULTS: Altogether, 1226 eyes of 613 patients were measured consecutively, and 78 eyes were not measured successfully with PCI technology. Among those with unsuccessfully measured eyes, 23 patients were willing to participate in the study, and two of those were also unsuccessfully measured with the ss-OCT device (8.7%, 2/23). However, 91.3% (21/23) of the eyes that were unsuccessfully scanned with PCI technology were measurable with the ss-OCT device. The estimated overall rate of unsuccessful scans with the ss-OCT device was 0.5% (6/1226) ([Formula: see text] < 0.01). CONCLUSION: ss-OCT technology significantly improves the rate of attainable axial eye length measurements, especially in eyes with posterior subcapsular cataracts, but also in eyes with dense nuclear cataracts, except for white cataracts.

Risk factors for postoperative intraretinal cystoid changes after peeling of idiopathic epiretinal membranes among patients randomized for balanced salt solution and air-tamponade.

PURPOSE: Epiretinal membranes (ERM) are macular disorders leading to loss of vision and metamorphopsia. Vitrectomy with membrane peeling displays the gold standard of care. Aim of this study was to assess risk factors for postoperative intraretinal cystoid changes in a study population randomized for balanced salt solution and air-tamponade at the end of surgery. METHODS: A prospective randomized study, including 69 eyes with idiopathic ERM. Standard 23-gauge three-port pars plana vitrectomy with membrane peeling, using intraoperative optical coherence tomography (OCT), was performed. Randomization for BSS and air-tamponade was performed prior to surgery. RESULTS: Best-corrected visual acuity improved from 32.9 letters to 45.1 letters 3 months after surgery. Presence of preoperative intraretinal cystoid changes was found to be the only risk factor for presence of postoperative intraretinal cystoid changes 3 months after surgery (p = 0.01; odds ratio: 8.0). Other possible risk factors such as combined phacoemulsification with 23G-ppv and membrane peeling (p = 0.16; odds ratio: 2.4), intraoperative subfoveal hyporeflective zones (p = 0.23; odds ratio: 2.6), age over 70 years (p = 0.29; odds ratio: 0.5) and air-tamponade (p = 0.59; odds ratio: 1.5) were not found to be significant. CONCLUSION: There is strong evidence that preoperative intraretinal cystoid changes lead to smaller benefit from surgery.

Internal limiting membrane flap transposition for surgical repair of macular holes in primary surgery and in persistent macular holes.

PURPOSE: Classical or temporal internal limiting membrane (ILM) flap transposition with air or gas tamponade are current trends with the potential to improve surgical results, especially in cases with large macular holes. METHODS: A prospective case series included patients with idiopathic macular holes or persistent macular holes after 23-G pars plana vitrectomy (PPV) and ILM peeling with gas tamponade. In all patients, 23-G PPV and ILM peeling with ILM flap transposition with gas tamponade and postoperative face-down position was performed. RESULTS: In 7 of 9 eyes, temporal ILM flap transposition combined with pedicle ILM flap could be successfully performed and macular holes were closed in all eyes after surgery. The remaining 2 eyes were converted to pedicle ILM flap transposition with macular hole closure after surgery. Three eyes were scheduled as pedicle ILM flap transposition due to previous ILM peeling. In 2 of these eyes, the macular hole could be closed with pedicle ILM flap transposition. In 3 eyes, free ILM flap transposition was performed and in 2 of these eyes macular hole could be closed after surgery, whereas in 1 eye a second surgery, performed as pedicle ILM flap transposition, was performed and led to successful macular hole closure. CONCLUSIONS: Use of ILM flaps in surgical repair of macular hole surgery is a new option of treatment with excellent results independent of the diameter of macular holes. For patients with persistent macular holes, pedicle ILM flap transposition or free ILM flap transposition are surgical options.

Diagnostic precision of a microscope-integrated intraoperative OCT device in patients with epiretinal membranes.

PURPOSE: Preoperative and postoperative optical coherence tomography (OCT) of macular pathologies can be regarded as the gold standard diagnostic technique, providing detailed information on the microstructures of the macula for planning the surgical procedure and comparing improvements after surgery in the follow-up period. Intraoperative use of OCT is a novel application to support surgeons during macular surgery. The aim of this study was to examine the diagnostic precision of a microscope-integrated intraoperative spectral-domain OCT (i-OCT) device and compare imaging results to a stand-alone spectral-domain OCT (SD-OCT) device. METHODS: This prospective study included 41 eyes of 41 patients scheduled for pars plana vitrectomy with membrane peeling due to an idiopathic epiretinal membrane (ERM). Intraoperative imaging with the i-OCT device was performed at the beginning of the surgery and compared to preoperative SD-OCT images. RESULTS: Preoperative and intraoperative SD-OCT evaluations showed high intraobserver and interobserver reproducibility for the presence of ERM, lamellar macular hole, and vitreomacular traction. For intraretinal cystoid changes, intraobserver and interobserver reproducibility for both OCTs was rather poor, mainly due to microcystic changes. CONCLUSIONS: Intraoperative spectral-domain OCT offers high reproducibility regarding the visibility of ERM, lamellar macular holes, and vitreomacular traction. Microcystic changes cause discrepancies in interpretation, often simply diagnosed as retinal thickening.

Does perfluoro-n-octane use in 23G vitrectomy for retinal detachment surgery affect the integrity of the ellipsoid zone?

PURPOSE: To examine the integrity of the ellipsoid zone after perfluoro-n-octane use for reattachment of the central retina in macula-off retinal detachment cases. METHODS: Intraoperative video documentation with microscope-integrated intraoperative spectral-domain optical coherence tomography (OCT) of 10 consecutive patients with macula-off retinal detachment, scheduled for primary vitrectomy for retinal detachment repair, was retrospectively examined for defects in the integrity of the ellipsoid zone due to perfluoro-n-octane use. RESULTS: Successful intraoperative visualization was possible in all cases, retinal detachment was reattached in all cases, but residual islands of subretinal fluid persisted directly after perfluoro-n-octane use in 80% of cases. These were resorbed in all cases in the postoperative OCTs. Disturbances in the integrity of the ellipsoid zone or intraoperative macular hole formation did not present in any of our cases. CONCLUSIONS: Perfluoro-n-octane use seems to be a safe procedure regarding integrity of the ellipsoid zone in cases scheduled for primary vitrectomy for retinal detachment repair.

Effect of a multimedia-assisted informed consent procedure on the information gain, satisfaction, and anxiety of cataract surgery patients.

PURPOSE: To assess whether a multimedia-assisted preoperative informed consent procedure has an effect on patients' knowledge concerning cataract surgery, satisfaction with the informed consent process, and reduction in anxiety levels. SETTING: Hietzing Hospital, Vienna, Austria. DESIGN: Prospective randomized controlled clinical trial. METHODS: Patients participated in an informed consent procedure for age-related cataract surgery that included the standard approach only (reading the information brochure and having a standardized face-to-face discussion) or supplemented with a computer-animated video. The main outcome was information retention assessed by a questionnaire. Further outcome measures used were the State-Trait Anxiety Inventory, the Visual Function-14 score, and an assessment of satisfaction. RESULTS: The study included 123 patients (64 in standard-only group; 59 in computer-animated video group). Both groups scored well on the questionnaire; however, patients who watched the video performed better (82% retention versus 72%) (P = .002). Scores tended to decrease with increasing age (r = -0.25, P = .005); however, this decrease was smaller in the group that watched the video. Both groups had elevated anxiety levels (means in video group: anxiety concerning the current situation [S-anxiety] = 63.8 ± 9.6 [SD], general tendency toward anxiety [T-anxiety] = 65.5 ± 7.9; means in control group: S-anxiety = 61.9 ± 10.3, T-anxiety = 66.2 ± 7.8). CONCLUSIONS: A high level of information retention was achieved using an informed consent procedure consisting of an information brochure and a standardized face-to-face discussion. A further increase in information retention was achieved, even with increasing patient age, by adding a multimedia presentation. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.