[Somnological status of women in late reproductive and perimenopausal periods during treatment of sleep disorders using partial light deprivation]. / Somnologicheskii status zhenshchin v pozdnem reproduktivnom i perimenopauzal'nom periodakh pri ispol'zovanii chastichnoi svetovoi deprivatsii v korrektsii narushenii sna.

AIM: To study the characteristics of somnological status in women in the late reproductive, pre- and postmenopausal periods before and after partial light deprivation. MATERIAL AND METHODS: One hundred and eighty-four women of menopausal age were included. A polysomnographic study of night sleep was performed and the excretion of the morning fraction of 6-sulfatoxymelatonin in the urine was measured before and after partial light deprivation in the light-saturated months of the year (from April to October) using optical lenses with a mineral photochromic coating. RESULTS AND CONCLUSIONS: The following characteristics of sleep for women with a neuro-vegetative form of menopausal syndrome are identified: the deterioration in the overall effectiveness of sleep, consisting in the increase of 'apnea-hypopnea sleep' in women in premenopause and menopause compared to women in late reproductive period, the increase in the duration of superficial stages of slow-wave sleep, the decrease in the duration of paradoxical sleep, the prevalence of slow-wave sleep in all sleep cycles, the decrease in the duration of paradoxical sleep, the increase in wakefulness in sleep, motor activity and desaturation during sleep that is accompanied by the decrease in the level of 6-sulfate-oxymelatonin in the morning urine compared to women in the late reproductive period. After the use of partial light deprivation, the parameters of the subjective assessment of sleep quality improved in the majority of women and polysomnographic patterns, including the significant increase in melatonin production, reached the normal levels.

[Mechanisms of forming and working reproductive dominant].

Spectral and coherent analyses of biolectrical brain activity in gestational dynamics and in early post-natal period has been made at 560 pregnant women and at 35 women during menstrual cycle. The encephalography (EEG) examination of 184 women participating in the program in vitro fertilization (IVF) has been carried out. According to the theory and the experiments, it can be concluded that the occurance of one-foetus pregnancy is accompanied by the forming ofgestational dominant-constellation of nervous centres. Its central chains are located in limbico- diencephal and neocortical structures. Neocortical representation is formed within frontal and central areas of the hemisphere, that is contralatteral to the placenta replacement. Some electrographical phenomena have been found out and they is experimently prove this ideas. It is supposed, that one of the ways of increasing of efficacy of the IVF methods is the investigation of the mechanisms of central-peripheral integration in women's reproductive system.

Restructuring of the thyroid gland in primary hypothyroidism under the influence of intermittent hypobaric hypoxia.

We studied the effect of intermittent hypobaric hypoxia on morphofunctional characteristics of the thyroid gland during experimental hypothyroidism. Functional activity of the thyroid gland increased in the early period of hypoxia. Morphofunctional parameters reached a constant level with increasing the duration of hypoxia to 7-15 days. A new functional level was characterized by increased activity and normal function of glandular cells.

[Spatiotemporal organization of bioelectrical brain activity during gestational dominanta].

Spectral and coherent analysis of biolectrical brain activity was performed in 560 pregnant women in gestational dynamics and in the early post-natal period. According to the theory and the experiments, it can be concluded that the occurrence of one-fetus pregnancy is accompanied by formation of gestational dominanta (constellation of nervous centers) with its central units in the limbicodiencephalic and neocortical structures. Neocortical representation is formed within the frontal and central areas of the hemisphere contralateral to location of the placenta. Electrographic evidence in support of these ideas was found.

Spectral and coherent characteristics of EEG in women during various phases of menstrual cycle.

EEG recording was performed in healthy women during various phases of menstrual cycle. Comparative study showed that the power spectrum of EEG a-waves in central and medio-temporal areas significantly decreases during ovulation. In the menstrual phase coherent characteristics of EEG alpha-waves increased in symmetrical occipital and intrahemispheric parieto-occipital areas.

[EEG characteristics of bioelectrical activity of the brain in women with normal and complicated pregnancy]. / Prostranstvenno-vremennaia organizatsiia bioélectricheskoi aktivnosti mozga zhenshchin pri normal'noi i oslozhnennoi beremennosti.

Spectrum and coherent EEG analysis has been made at 109 pregnant women during 35-36 weeks of gestation. It has been shown, that functional interhemispherical asymmetry of the brain is the sensible parameter of normal and complicated gestation. It has been found out that as for normal pregnancy prevailing activation in central and temple areas of the brain contralateral to the side of placenta placement in uterus is characteristic. The development of gestation complications accompanied by the inversion of interhemispherical asymmetry of EEG activation. It was pointed out that correlative relations of bioelectrical activity of the brain in women with normal gestation are the indicator of dominating of nervous centers of left hemisphere in the integrational process.

Characteristics of spontaneous bioelectrical activity of the brain in women with normal gestation and gestosis.

Pregnant women were examined during I, II, and III trimesters in order to detect EEG correlations of gestation dominant in health and threatened abortion. Single uncomplicated pregnancy was characterized by predominant activation in the central and temporal areas contralateral to the location of the placenta. Threatened abortion was associated with inversion of interhemispheric asymmetry of activation with respect to the placenta location.

[The electroencephalographic correlates of the intellectual abilities of adolescents]. / Elektroéntsefalograficheskie korreliaty intellektual'nykh sposobnostei podrostkov.

Analysis of correlation between intellectual faculties of schoolchildren and spatiotemporal organization of their brain electrical activity was carried out. The less intelligent teen-agers showed more expressed alpha-activity in the EEG of rest, higher level of EEG coherence, and insignificant restructuring of the rhythmical activity under conditions of "open eyes" as compared with the "closed eyes". In the resting EEG of highly intelligent teen-agers beta-frequencies were more expressed and desynchronization after opening the eyes was clearly detectable.

[The modelling of different forms of natural selection in cells of the ciliated epithelium in the frog Rana temporaria]. / Modelirovanie raznykh form estestvennogo otbora na kletkakh mertsatel'nogo épiteliia liagushki Rana temporaria.

By means of thermal and non-thermal selection of parental gametes in the frog Rana temporaria, the effects of normalizing and canalizing forms of natural selection have been reproduced on the ciliary epithelium of the progeny. It was shown that the heat resistance level of epithelial cells in the progeny is inherited from both parents.

[Effect of gutimine derivatives on the metamorphosis of Rana temporaria tadpoles]. / O vliianii proizvodnykh gutiminovogo riada na metamorfoz golovastikov Rana temporaria.

A one-time addition of gutimine (0.5 g/l), amtizol (0.2 g/l), and unithiol (0.25 g/l) to the medium at early stages of tadpole development was shown to inhibit metamorphosis only upon addition of unithiol. Repeated addition of gutimine, amtizol, and unithiol to the medium leads to reliable delay in metamorphosis. The delay is more pronounced at addition of the compounds to the medium at late stages of tadpole development (beginning at 40 stage). This suggests that the studied compounds may have anti-thyroid activity. All drugs under study induce the skin clearing.

[Effect of temperature and non-temperature selection of male parental gametes on the heat resistance of the ciliated epithelium in frog progeny]. / Vliianie temperaturnogo i netemperaturnogo otborov muzhskikh gamet roditelei na teploustoichivost' resnitchatogo épiteliia potomstva u liagushek.

Positive correlation was observed between the thermostability level of the parental sperm and that of the ciliary epithelium in the frog Rana temporaria. It is suggested that this correlation is realized by a special mechanism irrespective of the functional profile of the somatic cells.