Subjective, behavioral and neurobiological effects of cannabis and cannabinoids in social anxiety.

Social anxiety disorder (SAD) is a debilitating disorder, characterized by fear and anxiety in social situations. Evidence suggests that the levels of SAD are rising, in particularly after the COVID-19 pandemic. Serotonin and noradrenaline reuptake inhibitors and cognitive-behavioral therapy are effective treatments for SAD. Nevertheless, a significant number of patients do not respond well to these therapeutic options. During the last years, Cannabis and cannabinoid-containing products have been investigated for the treatment of different neuropsychiatric disorders. Nevertheless, their efficacy for the treatment of anxiety disorders is still a matter of debate. The purpose of this review was to investigate subjective, behavioral, and neurobiological effects of Cannabis and cannabinoids in social anxiety and SAD. A search in the PubMed database for articles published between the years of 2003-2023 was conducted. One hundred and seventeen (117) original studies were identified. After the exclusion criteria, eighteen (18) studies were selected. The studies investigated the effects of the cannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in patients or healthy volunteers submitted to tasks that assessed social anxiety. Results showed that CBD decreases social anxiety, producing an inverted U-shaped curve, with anxiety measurements being reduced at intermediate doses administered orally (300-600 mg), but not at lower or higher doses. THC either reduces (lower doses, 6-7.5 mg) or increases (higher doses) social anxiety measurements. CBD attenuates the anxiogenic effects of THC. The effects of THC and CBD in anxiety are associated to the modulation of fronto-limbic regions. Further clinical trials, conducted with male and female patients and larger cohorts are still necessary to consolidate these results.

Are Cytomorphogenetic Events Correlated with Oral Mucosal Lesions Induced by Crack Cocaine Use? A Systematic Review.

The aim of this systematic review was to answer the question of whether crack cocaine can induce cellular and molecular alterations and whether such alterations are somehow related to clinical lesions in the oral mucosa. The searches were undertaken in three electronic databases and conducted based on the PRISMA 2020 statement. Eleven studies published between 1994 and 2020 were analyzed. The quality of the included studies was assessed by two independent reviewers (TGP and DAR) through a confounder's categorization methodology, in which final ratings were attributed (strong, moderate or weak) for each study. From 11 studies included, 7 evaluated the cellular/molecular impact of the addiction in a total of 492 individuals and compared to a control (non-exposure) group (n = 472). The main tests used for cellular alteration were MN and AgNORs. Cells from crack cocaine groups exhibited increased proliferation and MN counting. Only four studies evaluated the prevalence of oral lesions. All of them showed that individuals exposed to crack cocaine presented an increased number of oral lesions. Most studies showed good quality. In conclusion, our results demonstrate that crack use may induce changes at the cellular and molecular level and also exhibit an increased number of oral lesions. However, a correlation between such changes and oral mucosa lesions still needs further investigation and elucidation through other clinical studies in humans.

Is micronucleus assay a suitable method for biomonitoring children exposed to X-ray? A systematic review with meta-analysis.

PURPOSE: The aim of this study was to evaluate if the micronucleus test using oral epithelial cells is a suitable biomarker for biomonitoring children exposed to X-ray. MATERIAL AND METHODS: A search was performed through the electronic databases PubMed/Medline, Scopus, and Web of Science, all studies published up to February 2022 that examined the relationship between exposure of children to radiographic examinations and micronucleus. RESULTS: A total of 17 full-text manuscripts were screened for eligibility. Only two studies found a difference in micronucleus labeling. On the other hand, all studies showed that X-ray was able to induce cellular death in oral mucosa cells. Following the parameters of the Effective Practices in Public Health Project (EPHPP), five manuscripts reached moderate and strong scores, and four studies were categorized as weak at final rating. In the meta-analysis, statistically significant difference was detected in micronucleated cells in children before and after radiographic examinations (SMD = 0.96, 95% CI, 0.07-1.84, p = .04), with τ2=1.09; χ2=53.37, and p < .001. CONCLUSION: Radiographic examinations in children can cause genotoxic and cytotoxic damage in the oral epithelium with a large effect size.

Cannabis sativa and Cannabidiol: A Therapeutic Strategy for the Treatment of Neurodegenerative Diseases?

This work is a literature review, presenting the current state of the use of cannabinoids on neurodegenerative diseases. The emphasis is on Parkinson's (PD) and Alzheimer's (AD) diseases, the two most prevalent neurological diseases. The review goes from Cannabis sativa and its hundreds of bioactive compounds to Δ9-tetrahydrocannabinol (THC) and mainly cannabidiol (CBD) and their interactions with the endocannabinoid receptors (CB1 and CB2). CBD molecular targets were also focused on to explain its neuroprotective action mechanism on neurodegenerative diseases. Although THC is the main psychoactive component of C. sativa, and it may induce transient psychosis-like symptoms, growing evidence suggests that CBD may have protective effects against the psychotomimetic effects of THC and therapeutic properties. Furthermore, a great number of recent works on the neuroprotective and anti-inflammatory CBD effects and its molecular targets are also reviewed. We analyzed CBD actions in preclinical and in clinical trials, conducted with PD and AD patients. Although the data on preclinical assays are more convincing, the same is not true with the clinical data. Despite the consensus among researchers on the potential of CBD as a neuroprotective agent, larger and well-designed randomized clinical trials will be necessary to gather conclusive results concerning the use of CBD as a therapeutic strategy for the treatment of diseases such as PD and AD.

Clozapine prevented social interaction deficits and reduced c-Fos immunoreactivity expression in several brain areas of rats exposed to acute restraint stress.

In the present study, we evaluate the effect of acute restraint stress (15 min) of male Wistar rats on social interaction measurements and c-Fos immunoreactivity (c-Fos-ir) expression, a marker of neuronal activity, in areas involved with the modulation of acute physical restraint in rats, i.e., the paraventricular nucleus of the hypothalamus (PVN), median raphe nucleus (MnR), medial prefrontal cortex (mPFC), cingulate prefrontal cortex (cPFC), nucleus accumbens (NaC), hippocampus (CA3), lateral septum (LS) and medial amygdala (MeA). We considered the hypothesis that restraint stress exposure could promote social withdrawal induced by the activation of the hypothalamic-pituitary-adrenocortical (HPA) axis, and increase c-Fos expression in these limbic forebrain areas investigated. In addition, we investigated whether pretreatment with the atypical antipsychotic clozapine (5 mg/kg; I.P.) could attenuate or block the effects of restraint on these responses. We found that restraint stress induced social withdrawal, and increased c-Fos-ir in these areas, demonstrating that a single 15 min session of physical restraint of rats effectively activated the HPA axis, representing an effective tool for the investigation of neuronal activity in brain regions sensitive to stress. Conversely, pretreatment with clozapine, prevented social withdrawal and reduced c-Fos expression. We suggest that treatment with clozapine exerted a preventive effect in the social interaction deficit, at least in part, by blocking the effect of restraint stress in brain regions that are known to regulate the HPA-axis, including the cerebral cortex, hippocampus, hypothalamus, septum and amygdala. Further experiments will be done to confirm this hypothesis.

High and fluctuating levels of ovarian hormones induce an anxiogenic effect, which can be modulated under stress conditions: Evidence from an assisted reproductive rodent model.

Elevated levels of endogenous ovarian hormones are conditions commonly experienced by women undergoing assisted reproductive technologies (ART). Additionally, infertility-associated stress and treatment routines are factors that together may have a highly negative impact on female emotionality, which can be aggravated when several cycles of ART are needed to attempt pregnancy. This study aimed to investigate the effect of high and fluctuating levels of gonadal hormones induced by repeated ovarian stimulation on the stress response in rodents. To mimic the context of ART, female rats were exposed to an unpredictable chronic mild stress (UCMS) paradigm for four weeks. During this time, three cycles of ovarian stimulation (superovulation) (150 IU/Kg of PMSG and 75 IU/Kg of hCG) were applied, with intervals of two estrous cycles between them. The rats were distributed into four groups: Repeated Superovulation/UCMS; Repeated Superovulation/No Stress; Saline/UCMS; and Saline/No Stress. Anxiety-like and depressive-like behaviors were evaluated in a light-dark transition box and by splash test, respectively. Corticosterone, estradiol, progesterone, and biometric parameters were assessed. Data were analyzed using a two-way Generalized Linear Model (GzLM). Our results showed that repeated ovarian stimulation exerts by itself an expressive anxiogenic effect. Surprisingly, when high and fluctuating levels of ovarian hormones were combined with chronic stress, anxiety-like behavior was no longer observed, and a depressive-like state was not detected. Our findings suggest that females subjected to emotional overload induced by repeated ovarian stimulation and chronic stress seem to trigger the elaboration of adaptive coping strategies.

Dimethoate induces genotoxicity as a result of oxidative stress: in vivo and in vitro studies.

Dimethoate ([O,O-dimethyl S-(N-methylcarbamoylmethyl) phosphorodithioate]) is an organophosphate insecticide and acaricide widely used for agricultural purposes. Genotoxicity refers to the ability of a chemical agent interact directly to DNA or act indirectly leading to DNA damage by affecting spindle apparatus or enzymes involved in DNA replication, thereby causing mutations. Taking into consideration the importance of genotoxicity induced by dimethoate, the purpose of this manuscript was to provide a mini review regarding genotoxicity induced by dimethoate as a result of oxidative stress. The present study was conducted on studies available in MEDLINE, PUBMED, EMBASE, and Google scholar for all kind of articles (all publications published until May, 2020) using the following key words: dimethoate, omethoate, DNA damage, genetic damage, oxidative stress, genotoxicity, mutation, and mutagenicity. The results showed that many studies were published in the scientific literature; the approach was clearly demonstrated in multiple tissues and organs, but few papers were designed in humans. In summary, new studies within the field are important for better understanding the pathobiological events of genotoxicity on human cells, particularly to explain what cells and/or tissues are more sensitive to genotoxic insult induced by dimethoate.

Genotoxicity, oxidative stress, and inflammatory response induced by crack-cocaine: relevance to carcinogenesis.

Crack-cocaine is a cocaine by-product widely consumed by general population in developing countries. The drug is low cost and is associated with more intense effects when compared to other illicit drugs. Genotoxicity, oxidative stress, and inflammatory response are considered crucial events in carcinogenesis, since they actively participate in the multistep process. The purpose of this paper was to provide a mini review regarding the relationship between carcinogenesis and genotoxicity, oxidative stress, and inflammation induced by crack-cocaine. The present study was conducted on search of the scientific literature from the published studies available in PubMed, MEDLINE, Scopus, and Google Scholar for all kind of articles (all publications to November 2020) using the following key words: crack-cocaine, DNA damage, genotoxicity, cellular death, cytotoxicity, mutation, oxidative stress, inflammation, and mutagenicity. The results showed that published papers available were almost all in vivo test system being conducted in humans or rodents. Crack-cocaine was able to induce genotoxicity and oxidative stress in mammalian cells. However, the role of inflammatory response after exposure to crack-cocaine was not conclusive so far. In summary, this study is consistent with the notion that crack-cocaine is a chemical carcinogen as a result of genotoxicity and oxidative stress induced in mammalian and non-mammalian cells.

A single ovarian stimulation, as performed in assisted reproductive technologies, can modulate the anxiety-like behavior and neuronal activation in stress-related brain areas in rats.

Infertility affects about 8 to 12% of couples of childbearing age around the world, and is recognized as a global public health issue by the WHO. From a psychosocial perspective, infertile individuals experience intense psychological distress, related to emotional disorders, which have repercussions on marital and social relationships. The symptoms persist even after seeking specialized treatment, such as assisted reproductive technologies (ART). While the stress impact of ART outcome has been comprehensively studied, the role of supraphysiological concentrations of gonadal hormones on stress response, remains to be elucidated. This study aimed to evaluate the effect of a single ovarian stimulation on the stress response in rats. To mimic the context of ART in rodents, female rats were submitted to the superovulation (150 UI/kg of PMSG and 75 UI/kg of hCG) and then to psychogenic stress (restraint stress for 30 min/day, repeated for three days). Anxiety-like behavior was evaluated in the elevated plus-maze, and neuronal activation in the stress-related brain areas assessed by Fos protein immunoreactivity. Corticosterone, estradiol, progesterone and corpora lutea were quantified. Data were analyzed using Generalized Linear Model (GzLM). Our findings indicate anxiolytic-like and protective effects of supraphysiological concentrations of gonadal hormones induced by a single ovarian stimulation on stress response. An activation of hypothalamus-pituitary-adrenal response inhibitory pathways, with participation of the prefrontal cortex, basomedial amygdala, lateral septum, medial preoptic area, dorsomedial and paraventricular hypothalamus, was detected.

Behavioral and neurobiological alterations induced by chronic use of crack cocaine.

Crack cocaine is the crystal form of cocaine and can be smoked, and rapidly absorbed, and, in part for this reason, is potently addictive. It is hypothesized that crack cocaine is able to induce important changes in different tissues and organs, and thus dramatically alter behavior. Nevertheless, which alterations in the central nervous system are related to its frequent use is still a matter of discussion. The present study is a literature review of articles published between the years 2008 and 2018 on the theme 'crack cocaine and brain' available in PUBMED, MEDLINE, EMBASE, and Google scholar databases. The results show that the use of crack cocaine induces important behavioral, neuroanatomical, and biochemical alterations. The main behavioral sequelae include cognitive and emotional changes, such as increased anxiety and depressive symptoms, attention and memory deficits, and hyperactivity. Among the neurobiological alterations are reductions in the activity of the prefrontal, anterior cingulate cortex, and nucleus accumbens. Molecular changes include decreases in neurotrophic factors and increases in oxidative stress and inflammatory cytokines, which may be responsible for the morphological alterations observed. It is also hypothesized that these neurobiological changes might explain the emotional and cognitive dysfunctions experienced by crack cocaine addicts.

Chronic intermittent ethanol administration differentially alters DeltaFosB immunoreactivity in cortical-limbic structures of rats with high and low alcohol preference.

BACKGROUND: The role of specific cerebral areas involved in alcohol use disorder, such as the amygdala, hippocampus and prefrontal cortex, has emerged as a subject of interest over recent years. Nevertheless, the role played by these regions is frequently confounded by different variables, among them are the patterns of alcohol consumption presented by the subjects. OBJECTIVES: The present study verified the effects of chronic voluntary ethanol intake (20 sessions) on DeltaFosB immunoreactivity (DeltaFosB-ir) in the amygdala, hippocampus and prefrontal cortex of rats showing high and low preference for ethanol. METHODS: DeltaFosB-ir induced by chronic voluntary ethanol intake with a two-bottle intermittent access to 20% ethanol model in male Wistar rats was measured. Three groups of animals were analyzed: control (n = 6), low preference (n = 8) and high preference (n = 8) for ethanol, the latter two categorized from their pattern of voluntary consumption of the alcohol solution. RESULTS: Ethanol intake in high-preference rats increased DeltaFosB-ir in the central amygdala, CA1 and CA3 regions of the hippocampus and decreased DeltaFosB-ir in the prelimbic cortex and anterior cingulate cortex. On the other hand, in low preference rats, chronic voluntary ethanol intake decreased DeltaFosB-ir in the medial amygdala, basolateral amygdala, dentate gyrus and anterior cingulate cortex. CONCLUSIONS: The present results suggest that different alcohol intake patterns are associated with a specific pattern of DeltaFosB-ir in brain structures that play a key role in controlling behavior and decision making, that is the amygdala, the hippocampus and the prefrontal cortex.

Behavioral and stereological analysis of the prefrontal cortex of rats submitted to chronic alcohol intake.

Alcohol consumption has been identified as a causal factor promoting changes in different molecular and cellular mechanisms resulting in neurodegeneration. This process is specific to certain brain regions and its effects on different areas of the brain can result in a variety of deleterious consequences. The prefrontal cortex (PFC) appears to be particularly sensitive to alcohol-induced neurodegeneration; this region is quite complex, as it is responsible for high order mental processes such as decision making. Thus, it is important to have precise and unbiased data of neuronal morphology parameters to understand the real effects of alcohol on the PFC. This study aimed to investigate alcohol-induced neurodegeneration in the PFC by utilizing behavioral and stereological methods. In the first phase of the study, we utilized eighteen animals, six controls and twelve alcohol-treated, that were submitted to voluntary chronic alcohol ingestion for four or eight weeks. Their brains were analyzed by design-based stereology methods to assess number and volume parameters regarding neuronal integrity in regions of the PFC (prelimbic - PL, infralimbic - IL and anterior cingulate - ACC). In the second phase of the study, six animals were utilized as controls and eight animals were submitted to the same alcohol ingestion protocol and to a behavioral decision-making test. In conclusion, our findings indicate that chronic alcohol consumption promotes a decrease in volume in the prelimbic and in the anterior cingulate, a decrease of mean neuronal volume in the anterior cingulate cortex and a decrease of total volume of neurons in the IL area. We did not observe changes in decision-making behavior in either of the two periods of alcohol intake. This shows that morphological changes occur in specific regions of the prefrontal cortex, a noble area of cognitive functions, induced by chronic alcohol consumption.

Role of polyphenols and nonpolyphenols against toxicity induced by fluoride: a comprehensive review.

Since its discovery as an antimicrobial agent, fluoride has been used in the control of dental caries. Many studies have shown that the chronic exposure of fluoride in high concentrations causes adverse effects in multiple organs; the use of bioactive compounds present in foods as a tool to mitigate the effects of fluoride could potentially be useful for populations in different parts of the world are exposed to fluoride in a chronic and systemic way. Thus, the aim of this comprehensive review is to present and discuss the published papers that focused on the use of polyphenols and nonpolyphenols that can mitigate the harmful activities promoted by fluoride exposure. Certainly, these data will contribute toward a better understanding of the role of food compounds in the pathological outcomes induced by fluoride. The new information will be added to that already available for regulatory purposes as a safe way to promote oral healthcare and prevent oral carcinogenesis.

Ansiedade e Qualidade de Vida entreEstudantes Universitários Ingressantes:Avaliação e Intervenção / Anxiety and Life Quality among Freshmen College Students:Evaluation and Intervention / Ansiedad e y Calidad de Vida Entre Estudiantes Universitariosde Primer Año: Evaluación y Intervención

O estudo avaliou ansiedade e qualidade de vida (QV) entre estudantes universitários ingressantes da área da saúde de uma universidade pública (estudo 1). Com base nos resultados, um programa de intervenção grupal foi desenvolvido (estudo 2). A intervenção consistiu de 8 sessões de 90 min. Em duas sessões foi utilizado um instrumento de biofeedback de variabilidade da frequência cardíaca. Os participantes foram avaliados pelo Inventário de Ansiedade Traço-Estado (IDATE) e pelo questionário que avalia qualidade de vida (QV) SF-36. As mulheres universitárias, independentemente do curso, apresentaram maior ansiedade e pior pontuação em diferentes domínios de mensuração da QV. Os homens do curso de educação física apresentaram melhores escores em diferentes domínios da QV. A intervenção reduziu significativamente a ansiedade e melhorou a saúde mental dos participantes. Estes dados reafirmam a importância do desenvolvimento de programas de intervenção psicoterápica na universidade.(AU)

The study evaluated anxiety and life quality (LQ) of undergraduate freshman students from health science courses of a public university (study 1). In light of the results, a group intervention study was performed (study 2). This intervention consisted of eight sessions, of 90 min each. In two of the sessions, a biofeedback training device, that monitors the variability of the heart rate, was employed. The subjects were evaluated before and after the intervention by the State-Trace Anxiety Inventory and by the Medical Outcomes Study 36 – Item short form health survey. Levels of anxiety were higher and LQ aspects were lower in female students, independently of the undergraduate course. Men from the course of Physical Education showed higher scores in different domains that measured LQ. The intervention significantly reduced levels of anxiety and improved mental health. These data reaffirm the importance of the development of psychotherapeutic programs by the university.(AU)

El estudio evaluó la ansiedad y calidad de vida (CV) entre los estudiantes universitarios de primer año de cursos de la salud en una universidad pública (estudio 1). Con base en los resultados, un programa de intervención grupal fue desarrollado (estudio 2). La intervención consistió en 8 sesiones de 90 min. En dos sesiones se utilizó un instrumento de retroalimentación biológica de la variabilidad del ritmo cardíaco. Los participantes fueron evaluados por el Inventario de Ansiedad Rasgo-Estado (STAI) y el cuestionario de evaluación de CV SF-36. Las mujeres universitarias, independientemente del curso, mostraron mayor ansiedad y peor puntuación en la CV. Hombres del curso de educación física mostraron puntuaciones más altas en diferentes ámbitos de la CV. La intervención redujo significativamente la ansiedad y mejoró la salud mental de los participantes. Estos datos reafirman la importancia del desarrollo de programas de intervención psicoterapéutica en la universidad.(AU)

O Emprego do Biofeedback como Estratégia deManejo do Estresse e da Ansiedade em Atletas: um Ensaio Clínico / Biofeedback Training as a Management Strategy for Stress and Anxietyin Athletes: A Clinical Study / La Retroalimentación Biológica como Estrategia de Gestión de Estrés yAnsiedad en Atletas: Un Ensayo Clínico

O objetivo desse estudo foi avaliar a eficácia do treinamento em biofeedback de variabilidade da frequência cardíaca na redução de sintomas de estresse e ansiedade em atletas. Método: Participaram do estudo atletas de uma equipe de handebol de uma cidade do estado de São Paulo. O software de biofeedbackutilizado foi o EmWave® Desktop PC e seus efeitos foram avaliados através dos instrumentos: Avaliação da Qualidade de Vida (WHOQOL – BREF), Inventário de Ansiedade de Beck (BAI), Inventário de Sintomas de Stress para Adultos de Lipp (ISSL) e Competitive State Anxiety Inventory (CSAI-2). Resultados e Conclusão: O treinamento em biofeedback promoveu melhora na qualidade de vida e redução do estresse e ansiedade competitiva dos atletas, o que sugere sua eficácia como recurso terapêutico nesta população.(AU)

The aim of this study was to evaluate the efficacy of a heart rate variability biofeedback-training device in reducing stress and anxiety levels in athletes. Method: Study participants where athletes of a handball team from a city of the state of São Paulo, Brazil. The biofeedback software used was EmWave® Desktop PC and its effects where assessed by the following instruments: The World Health Organization Quality of Life-BREF (WHOQOL – BREF), Beck Anxiety Inventory (BAI), Inventory of Stress Symptoms for Adults (ISSL), and Competitive State Anxiety Inventory (CSAI-2). Results and Conclusion: There was an improvement of quality of life and reduction of stress and competitive anxiety, suggesting the efficacy of biofeedback training as a therapeutic tool for athletes.(AU)

O emprego do biofeedback como estratégia de manejo do estresse e da ansiedade em atletas: um ensaio clínico / Biofeedback training as a management strategy for stress and anxiety in athletes: a clinical study / La retroalimentación biológica como estrategia de gestión de estrés y ansiedad en atletas: un ensayo clínico

O objetivo desse estudo foi avaliar a eficácia do treinamento em biofeedback de variabilidade da frequência cardíaca na redução de sintomas de estresse e ansiedade em atletas. Método: Participaram do estudo atletas de uma equipe de handebol de uma cidade do estado de São Paulo. O software de biofeedback utilizado foi o EmWave® Desktop PC e seus efeitos foram avaliados através dos instrumentos: Avaliação da Qualidade de Vida (WHOQOL – BREF), Inventário de Ansiedade de Beck (BAI), Inventário de Sintomas de Stress para Adultos de Lipp (ISSL) e Competitive State Anxiety Inventory (CSAI-2). Resultados e Conclusão: O treinamento em biofeedback promoveu melhora na qualidade de vida e redução do estresse e ansiedade competitiva dos atletas, o que sugere sua eficácia como recurso terapêutico nesta população.

The aim of this study was to evaluate the efficacy of a heart rate variability biofeedback-training device in reducing stress and anxiety levels in athletes. Method: Study participants where athletes of a handball team from a city of the state of São Paulo, Brazil. The biofeedback software used was EmWave® Desktop PC and its effects where assessed by the following instruments: The World Health Organization Quality of Life-BREF (WHOQOL – BREF), Beck Anxiety Inventory (BAI), Inventory of Stress Symptoms for Adults (ISSL), and Competitive State Anxiety Inventory (CSAI-2). Results and Conclusion: There was an improvement of quality of life and reduction of stress and competitive anxiety, suggesting the efficacy of biofeedback training as a therapeutic tool for athletes.

Biofeedback no tratamento de transtornos relacionados ao estresse e à ansiedade: uma revisão crítica / Biofeedback in the treatment of stress and anxiety-related disorders: a critical review / Biofeedback en el tratamiento de trastornos relacionados con el estrés y la ansiedad: una revisión crítica

O treinamento em biofeedback tem sido utilizado para o tratamento de diferentes quadros clínicos e para a prevenção/alívio de sintomas relacionados ao estresse/ansiedade. Este trabalho analisou a literatura de 2008 a 2012 sobre o tema “biofeedback, estresse e ansiedade” publicada nas bases MEDLINE, LILACS e Web of Sciences, utilizando como palavras-chave “biofeedback”, “anxiety”, “stress”, “psychology” e “biofeedback training”. Os resultados demonstram que técnicas de biofeedback são eficazes no manejo do estresse/ansiedade nas diferentes populações estudadas. Entretanto, todos os estudos encontrados foram realizados fora do Brasil, o que sugere que técnicas de biofeedback como ferramenta terapêutica não tem sido utilizadas no país, por algum motivo que merece ser melhor investigado.(AU)

Biofeedback training has been utilized for the treatment of different pathological conditions, in particular those related to stress/anxiety. This study reviews the scientific literature from 2008 to 2012 about the subject “biofeedback, stress and anxiety”, published in MEDLINE, LILACS and Web of Sciences, using as keywords “biofeedback”, “anxiety”, “stress”, “psychology” and “biofeedback training”. The results obtained showed that biofeedback training has been successfully employed as a therapeutic tool for the management of stress/anxiety in the different populations studied. Nevertheless, all of the studies found were performed outside Brazil, which suggests that biofeedback as a therapeutic tool has not been utilized in the country for some reason that deserves to be better investigated.(AU)

El entrenamiento con biofeedback se ha utilizado para el tratamiento de diferentes manifestaciones clínicas y para la prevención y alivio de síntomas relacionados con el estrés/ansiedad. Este estudio analizó la literatura desde 2008 hasta 2012 sobre el tema “biofeedback, estrés y ansiedad”, publicada en MEDLINE, LILACS y Web of Sciences, utilizando como palabras clave “biofeedback”, “anxiety”, “stress”, “psychology” y “biofeedback training”. Los resultados demuestran que técnicas de biofeedback son eficaces para el tratamiento del estrés y la ansiedad en diferentes poblaciones. Sin embargo, todos los estudios encontrados se realizaron fuera de Brasil, un indicador de que el biofeedback como herramienta terapéutica no ha sido utilizado en el país por una razón que debe investigarse más a fondo.(AU)

Biofeedback no tratamento de transtornos relacionados ao estresse e à ansiedade: uma revisão crítica / Biofeedback in the treatment of stress and anxiety-related disorders: a critical review / Biofeedback en el tratamiento de trastornos relacionados con el estrés y la ansiedad: una revisión crítica

O treinamento em biofeedback tem sido utilizado para o tratamento de diferentes quadros clínicos e para a prevenção/alívio de sintomas relacionados ao estresse/ansiedade. Este trabalho analisou a literatura de 2008 a 2012 sobre o tema “biofeedback, estresse e ansiedade” publicada nas bases MEDLINE, LILACS e Web of Sciences, utilizando como palavras-chave “biofeedback”, “anxiety”, “stress”, “psychology” e “biofeedback training”. Os resultados demonstram que técnicas de biofeedback são eficazes no manejo do estresse/ansiedade nas diferentes populações estudadas. Entretanto, todos os estudos encontrados foram realizados fora do Brasil, o que sugere que técnicas de biofeedback como ferramenta terapêutica não tem sido utilizadas no país, por algum motivo que merece ser melhor investigado.

Biofeedback training has been utilized for the treatment of different pathological conditions, in particular those related to stress/anxiety. This study reviews the scientific literature from 2008 to 2012 about the subject “biofeedback, stress and anxiety”, published in MEDLINE, LILACS and Web of Sciences, using as keywords “biofeedback”, “anxiety”, “stress”, “psychology” and “biofeedback training”. The results obtained showed that biofeedback training has been successfully employed as a therapeutic tool for the management of stress/anxiety in the different populations studied. Nevertheless, all of the studies found were performed outside Brazil, which suggests that biofeedback as a therapeutic tool has not been utilized in the country for some reason that deserves to be better investigated.

El entrenamiento con biofeedback se ha utilizado para el tratamiento de diferentes manifestaciones clínicas y para la prevención y alivio de síntomas relacionados con el estrés/ansiedad. Este estudio analizó la literatura desde 2008 hasta 2012 sobre el tema “biofeedback, estrés y ansiedad”, publicada en MEDLINE, LILACS y Web of Sciences, utilizando como palabras clave “biofeedback”, “anxiety”, “stress”, “psychology” y “biofeedback training”. Los resultados demuestran que técnicas de biofeedback son eficaces para el tratamiento del estrés y la ansiedad en diferentes poblaciones. Sin embargo, todos los estudios encontrados se realizaron fuera de Brasil, un indicador de que el biofeedback como herramienta terapéutica no ha sido utilizado en el país por una razón que debe investigarse más a fondo.

Freud, as neurociências e uma teoria da memória / Freud, neurosciences and a theory of memory / Freud, neurosciences et une théorie sur la mémoire / Freud, las neurociencias y una teoría de la memoria

Alguns estudos têm demonstrado que conceitos psicanalíticos e observações neurocientíficas recentes podem ser complementares, contribuindo para um melhor entendimento de determinados processos psicobiológicos. Esses estudos também sugerem a possibilidade de interpretação de conceitos psicanalíticos a partir de sua aproximação com as neurociências. O presente trabalho investiga possíveis relações entre uma teoria da memória proposta por Freud e concepções neurocientíficas que surgem a partir da segunda metade do século XX, com base em observações clínicas (o caso do paciente H. M.) e experimentais (o conceito de potenciação de longa duração, LTP). Primeiramente, são apresentadas as ideias de Freud sobre processos mnemônicos que fundamentam a construção de um "Eu", da obra Projeto para uma psicologia científica (1950/1976). Posteriormente, as principais observações que subsidiaram a construção de uma teoria neurobiológica sobre a memória são analisadas. Conclui-se que o modelo dinâmico adotado pela neurociência contemporânea encontra paralelos em conceitos freudianos do final do século XIX.(AU)

Previous evidences suggest that psychoanalytical concepts and recent neurobiological findings may complement each other, contributing to the better understanding of certain psychobiological processes. These evidences also indicate the possibility of interpretation of psychoanalytical concepts from a neurocientific perspective. This study investigates possible points of similarity between a theory of memory proposed by Freud and ideas formulated during the second half of the 20th century, on the basis of clinical (the case of patient H.M.) and experimental (the concept of Long Term Potentiation, LTP) findings. For that, at first, Freudian ideas regarding mnemonic processes underlying the construction of the Ego, found in the Project for a scientific psychology (1950/1976), are presented. Subsequently, studies which gave rise to a neurobiological theory of memory are analyzed. It is concluded that the dynamic model adopted by contemporary neuroscience shares important similarities with Freudian concepts proposed at the end of the 19th century.(AU)

Il y a études qui ont démontré que concepts psychanalytiques et les recherches neuroscientifiques peuvent être complémentaires et contribuent pour la compréhension de certains processus psicobiologiques. Ces études suggèrent aussi la possibilité d'interprétation des concepts psychanalytiques à partir de son rapprochement aux neurosciences. Cet article avalise les liens possibles entre une théorie sur la mémoire proposée par Freud et des conceptions neuroscientifiques de la seconde moitié du XXe siècle, basé sur observations cliniques (cas du patient HM) et expérimentales (concept de potentialisation à long terme, LTP). Premier seront présentées les idées de Freud sur des processus mnémoniques qui soutiennent la construction du Moi chez son ouvrage Esquisse d'une psychologie scientifique (1950/1976). Ensuite, seront analysées les études qui apportent la construction de une théorie neurobiologique sur la mémoire. On conclut que le modèle dynamique adoptée par la neuroscience présents similitudes à des concepts freudiens de la fin du XIXe siècle.(AU)

Estudios tienen demostrado que conceptos psicoanalíticos y descubiertas neurocientíficas recientes pueden ser complementarios, colaborando para la comprensión de ciertos procesos psicobiológicos. Estos estudios también sugieren la posibilidad de interpretación de los conceptos psicoanalíticos, a partir de su proximidad con las neurociencias. Este trabajo investiga relaciones entre una teoría acerca de la memoria propuesta por Freud y concepciones que surgen desde la segunda mitad del siglo XX, basándose en observaciones clínicas (caso del paciente H.M.) y experimentales (concepto de potenciación a largo plazo, LTP). Primero, se presentarán ideas de Freud acerca de los procesos mnemónicos que subyacen a la construcción de un Yo, contenidas en su Proyecto para una psicología científica (1950/1976). A seguir, se analizarán estudios que dieron subsidios para la construcción de una teoría neurobiológica de la memoria. Se concluye que el modelo dinámico adoptado por la neurociencia presenta similitudes con conceptos freudianos propuestos a finales del siglo XIX.(AU)