In this study, aiming at the problem of low strength and high creep caused by medium-low modulus flexible resin based on the formulation design idea of high-molecular-weight epoxy resin (E12)-reinforced flexible epoxy-terminated urethane resin (EUR), a flexible epoxy prepreg resin with high strength and low bending creep was prepared to be suitable for hot melt processing technology. Flexible EUR was synthesized by grafting flexible polyurethane segments onto the epoxy side chain by urethane bonding. By adjusting the ratio of E12 and EUR, the effects of different ratios of the two components on the mechanical properties and viscoelasticity of the resin were systematically studied with dicyandiamide as the latent curing system. Research has found that when the E12 content is between 20%wt and 40%wt, the resin system has the best coating viscosity at 65 °C to 85 °C. The molecular weight and the content of aromatic heterocyclic groups of the resin determine the strength and creep behavior of the resin. When the content of E12 in the system is less than 50%wt, modulus and strength increase linearly, but after more than 50%wt E12 content, the modulus is almost unchanged and the strength begins to decrease. By increasing the content of E12 in the resin, the creep behavior of the resin is greatly reduced. When the content of E12 increases to 50%wt, the bending creep is the lowest.
BACKGROUND: Mounting evidence suggest that there are an association between psoriasis and ulcerative colitis (UC), although the common pathogeneses are not fully understood. Our study aimed to find potential crucial genes in psoriasis and UC through machine learning and integrated bioinformatics. METHODS: The overlapping differentially expressed genes (DEGs) of the datasets GSE13355 and GSE87466 were identified. Then the functional enrichment analysis was performed. The overlapping genes in LASSO, SVM-RFE and key module in WGCNA were considered as potential crucial genes. The receiver operator characteristic (ROC) curve was used to estimate their diagnostic confidence. The CIBERSORT was conducted to evaluate immune cell infiltration. Finally, the datasets GSE30999 and GSE107499 were retrieved to validate. RESULTS: 112 overlapping DEGs were identified in psoriasis and UC and the functional enrichment analysis revealed they were closely related to the inflammatory and immune response. Eight genes, including S100A9, PI3, KYNU, WNT5A, SERPINB3, CHI3L2, ARNTL2, and SLAMF7, were ultimately identified as potential crucial genes. ROC curves showed they all had high confidence in the test and validation datasets. CIBERSORT analysis indicated there was a correlation between infiltrating immune cells and potential crucial genes. CONCLUSION: In our study, we focused on the comprehensive understanding of pathogeneses in psoriasis and UC. The identification of eight potential crucial genes may contribute to not only understanding the common mechanism, but also identifying occult UC in psoriasis patients, even serving as therapeutic targets in the future.
Chitinases , Colitis, Ulcerative , Humans , Colitis, Ulcerative/genetics , Machine Learning , Computational Biology
BACKGROUND: The negative experiences of intensive care unit (ICU) patients seriously affect their quality of life and survival outcomes. Thus, it is of great significance to evaluate the monitoring experience of ICU patients for the clinical improvement of their experiences and promote interventions. OBJECTIVES: The objective of this study was to investigate patients' experiences of ICU and to understand the sources of patient experience and influencing factors. METHODS: From November 2021 to September 2022, a cross-sectional survey was conducted with 600 inpatients from four grade A-III hospitals in western China. Data were collected using the Chinese version of the Intensive Care Experience Questionnaire. RESULTS: 585 valid questionnaires were collected, the response rate was 97.5%. ICU patients in western China scored below-the-average for their intensive care experience. Family monthly income, occupation types, medical payment method, type of ICU, ICU admission plan, ICU admission times, mechanical ventilation use, fertility status, analgesia, sedation, and Acute Physiology and Chronic Health Evaluation II scores are important factors influencing ICU patients' intensive care experience. CONCLUSIONS: Medical staff need to pay attention to patient experience, improve the awareness of patient stressors and influencing factors, design nursing programs conducive to patient-positive experience, and promote interventions to further improve the long-term prognosis of patients. The results of this study can also be used as a set of nursing-sensitive indicators for evaluating nursing structure, process, and outcomes.
Intensive Care Units , Quality of Life , Humans , Cross-Sectional Studies , Critical Care , China
Patients' Unplanned Extubation (UEX) is dangerous in the intensive care units (ICU), it is necessary to make early warning of UEX. However, the low fine-grained action of UEX and complexity of ICU environment make early warning a great challenging by using RGB video data. To address this issue, we propose a novel lightweight Spatial-Temporal Transformer (STformer) for early warning of patients' UEX action in the ICU. Specially, the SlowFast is used to extract patient's spatial-temporal features initially. Then, in order to improve the representation of features, we introduce spatial attention to enhance the spatial representation of fine-grained actions, and capture the long-term dependency of motions through temporal attention. Finally, a spatial-temporal joint attention is used to reconstruct and strengthen spatial and temporal information. Experiment results illustrate state-of-the-art performance of our STformer on ICU monitory datasets. While ensuring the accuracy of early warning, the computational complexity of STformer are also light.
Airway Extubation , Intensive Care Units , Humans , Electric Power Supplies
Long distance accumulators are widely used in underwater electro-hydraulic control systems. However, as the working depth increases, the underwater umbilical cable becomes longer. The actual physical properties of the gas in the accumulator change. These factors affect the charging characteristics of the accumulator. To address the above issues, a simulation model of the charging of the long distance accumulator under real operating conditions is developed. Among them, the real properties of the gas inside the accumulator were calculated using the Redlich-Kwong-Soave method. The coefficient of friction within the umbilical cable is based on the Reynolds number and relative roughness. The simulation data were compared with the experimental results in the South China Sea to verify the accuracy of the simulation model. The effects of key factors on the charging characteristics of the long distance accumulators were also analyzed. The results show that the simulation results are in good agreement with the experimental results. The law of accumulator charging was analyzed: the greater the pressure of the gas source, the smaller the accumulator charging time; the greater the working water depth, the shorter the accumulator charging time. The research provides guidance for the design of long distance accumulators.
BACKGROUND: Xerosis cutis in older adults is a geriatric public health issue that severely affects healthy aging, associated with adverse outcomes and increased nursing burden. Skin care plays a significant role in the management of xerosis cutis. AIM: To assess the pooled prevalence and interventions of xerosis cutis among older adults. METHODS: We searched ten databases systematically from inception to August 29, 2023. We estimated pooled prevalence of xerosis cutis using Stata 15.0. RESULTS: 28 articles were included in this review. The pooled prevalence of xerosis cutis was 53 %(95 %CI:36-69 %). We found the prevalence of xerosis cutis was highest in nursing homes and developed countries. The prevalence of xerosis cutis was similar in males and females. The prevalence of mild xerosis cutis and xerosis cutis at lower limbs was relatively high. Regular use of humectant-containing leave-on skin care products and structured skin care regimens were helpful in alleviating xerosis cutis. CONCLUSION: Older adults are at high risk for xerosis cutis. The research provides health professionals with a basic framework for the prevention and management of xerosis cutis.
Skin Diseases , Male , Female , Humans , Aged , Prevalence , Skin Diseases/epidemiology , Skin Diseases/therapy , Nursing Homes , Skin Care
Cinnamomum camphora, an essential woody plant in China, experienced a severe outbreak of trunk canker affecting an area of 540,000 square meters in the Xiaoshan District of Zhejiang province during the early summer of 2022. The observed symptoms included stem canker, dieback, twig blight, and extensive vascular discoloration, with an incidence rate ranging from 45% to 70%. To investigate the etiology of the disease, symptomatic plant samples were subjected to rigorous surface sterilization involving washing with running tap water, followed by surface sterilization using 75% ethanol. The samples were then rinsed twice with sterile distilled water, plated on potato dextrose agar (PDA) medium, and incubated at a temperature of 28°C. The isolated fungi exhibited characteristics consistent with the species Botryosphaeria dothidea. Fungal isolates displayed abundant white aerial mycelium, which darkened to grey after five to seven days, eventually giving rise to black pycnidia. Single hyphal tip cultures of putative two isolates were stored at the Agricultural Experiment Station of Zhejiang University. Conidia formed on pycnidia were one-celled, hyaline, aseptate, and fusiform, with dimensions of 18.34-27.12 µm x 3.77-6.84 µm (average 22.90 µm x 5.20 µm) (one hundred conidia were measured). To determine the fungal species, genomic DNA was extracted from individual isolates ZJUP0868, and subjected to DNA sequence analysis of four gene regions: the internal transcribed spacer (ITS) using the primer-pair ITS4 and ITS1 (White et al., 1990), the large subunit (LSU) gene with LR0R and LR5 (Rehner and Samuels, 1995), the small subunit (SSU) gene with SR1R and SR7 (Zoller et al., 1999), and the translation elongation factor 1-alpha (tef1) with EF1-983F and EF1-2218R (Rehner and Buckley, 2005). Furthermore, DNA sequence analysis of above four genes was performed. BLAST analysis indicated the highest nucleotide sequence identity with Botryosphaeria dothidea CBS 115476 reference sequence (ITS: 99.59%, KF766151; LSU: 99.88%, DQ377852; SSU: 100%, NG_062738; tef1: 98.93%, AY236898). Representative sequences of isolate ZJUP0868 from these regions were deposited in GenBank (ITS: Accession No. OR192838; LSU: Accession No:OR248147; SSU: Accession No:OR248174; tef1: Accession No. OR262053). A phylogenomic analysis was conducted to determine the phylogenetic position of Botryosphaeria dothidea in the family Botryosphaeriaceae. The combined morphological and molecular findings confirmed the identification of the pathogen as Botryosphaeria dothidea. Pathogenicity tests were conducted by stem inoculation of two-year-old Cinnamomum camphora baranches. Mycelial plugs (2-3 mm in diameter) from actively growing colonies of B. dothidea (PDA) were applied to bark of similar size on the middle point of the stems. Inoculated barks were wrapped with Parafilm, while control branches received sterile PDA plugs. Inoculated and control branches (7 each) were maintained in a greenhouse at 28°C. After two weeks, all inoculated plants exhibited dark vascular stem tissue, whereas the control plants remained healthy. B. dothidea was re-isolated from symptomatic tissues, thus fulfilling Koch's postulates. No symptoms were observed in the control branched, and B. dothidea was not re-isolated from their tissues. B. dothidea , the type species of Botryosphaeria (Botryosphaeriaceae, Botryosphaeriales), is commonly associated with cankers and dieback in woody plants. Previous reports have identified Botryosphaeria dothidea as a pathogen causing stem dieback and trunk canker on Glycine max (Chen et al., 2020), Camellia oleifera (Hao et al., 2022), and Gleditsia sinensis (Huang et al., 2020). Additionally, B. dothidea has been reported to cause leave wilt on various plant species in China, including Daimyo oak (Liu et al., 2023) and Cornus officinalis (Zhang et al., 2022). To the best of our knowledge, this is the first report of B. dothidea on C. camphora in China. This findings contribute to a better understanding of the pathogens affecting Cinnamomum camphora in the China.
Structural parameters play a decisive role in the performance of hydrocyclones for in situ natural gas hydrate (NGH) recovery and desanding. In this paper, the effects of key structural parameters on its performance were investigated by numerical simulations and experimental methods. The results show that the most influential factors are the spiral pitch of the spiral inlet, the vortex finder diameter, and the spigot diameter. The second most influential factors are the spiral turn number and the cone angle. Other parameters have the least influence. Specifically, the NGH recovery efficiency and pressure drop increase, but desanding efficiency decreases as d0/D and the cone angle increase. The NGH recovery efficiency and pressure drop decrease and desanding efficiency increases as ds/D increases. Therefore, it is necessary to choose a suitable value to balance the efficiency and pressure drop to improve the performance, for example, selecting the appropriate diameter ratio of the vortex finder and spigot. The above results can be used for the engineering design of in situ separators in marine hydrate mining and further realize in situ desanding, NGH recovery, and sand backfilling.
Because of its significant advantage of fast postoperative recovery, natural orifice specimen extraction surgery (NOSES) has attracted increasing attention worldwide. However, the NOSES in gastric cancer (GC) treatment still needs more clinical practice, especially for the rare anatomical anomaly. Situs inversus totalis (SIT) is a rare autosomal recessive anatomical anomaly with an incidence ranging between 1/8,000 and 1/25,000 births. We present a video of transvaginal specimen extraction following totally laparoscopic D2 distal gastrectomy performed in a 59-year-old woman known to have SIT. Preoperative investigations revealed that the patient had early GC at the antrum. A gastroscopy report from the local hospital showed signet-ring cell carcinoma. The preoperative computed tomography scan revealed irregular thickening of the gastric wall at the junction of the greater curvature and antrum without metastasis to the lymph nodes. In total, laparoscopic D2 distal gastrectomy was performed with transvaginal specimen extraction. Billroth II with Braun anastomosis was performed for reconstruction. The length of the operation was 240 min without intraoperative complications and with minimal blood loss of 50 ml. The patient was uneventfully discharged on postoperative Day 7. The final pathology confirmed signet-ring cell carcinoma confined to the mucosal muscle without metastasis in 16 lymph nodes. Transvaginal specimen extraction following totally laparoscopic D2 distal gastrectomy can be safely performed in patients with SIT and has similar surgical outcomes to usual laparoscopic gastrectomy.
BACKGROUND: The present study intended to establish a predictive nomogram for early relapse (ER) (<12 months) after autologous stem cell transplantation (ASCT) in the novel drug era for multiple myeloma (MM). PATIENTS AND METHODS: The nomogram was designed and constructed to a retrospective clinical data of newly diagnosed MM patients received novel agent induction therapy and subsequent ASCT at three centers in China from July 2007 to December 2018. The retrospective study was conducted among 294 patients in the training cohort and 126 in the validation cohort. The nomogram's predictive accuracy was evaluated by the concordance index, calibration curve and decision clinical curve. RESULTS: The study cohort included 420 newly diagnosed MM patients, and 100 (23.8%) were identified as having ER, including 74 in the training cohort and 26 in the validation cohort. According to the result of multivariate regression in the training cohort, the prognostic variables included in the nomogram were high-risk cytogenetics, LDH > UNL, and response less than very good partial response (VGPR) after ASCT. The calibration curve showed good fitness between the nomogram predictions and the actual observations and the nomogram was further validated by a clinical decision curve. The nomogram's C-index achieved 0.75 (95% CI, 0.70-0.80), which was higher than that of the Revised International Staging System (R-ISS) (0.62), ISS (0.59), and Durie-Salmon (DS) staging system (0.52). The discrimination ability of the nomogram in the validation cohort was superior to that of the other staging systems (C-index: 0.73 vs. R-ISS (0.54), ISS (0.55), and DS staging system (0.53)). DCA showed the prediction nomogram adds much more clinical utility. Different scores of the nomogram draw a distinction of OS. CONCLUSION: The present nomogram could serve as a feasible and accurate prediction of ER in novel drug induction transplantation-eligible MM patients, which could help modify the post-ASCT strategy for patients at high risk of ER.
Hematopoietic Stem Cell Transplantation , Multiple Myeloma , Humans , Prognosis , Multiple Myeloma/drug therapy , Nomograms , Retrospective Studies , Transplantation, Autologous , Stem Cell Transplantation , Recurrence
Our previous studies found that the H1-50 monoclonal antibody (mAb) of influenza A virus hemagglutinin (HA) cross-reacted with pancreatic tissue and islet ß-cells, and further studies showed that H1-50 mAb binds to prohibitin (PHB) protein of islet ß-cells. These suggest that there are heterophilic epitopes between influenza virus HA and pancreatic tissue, which may be involved in the pathogenesis of type 1 diabetes. To further investigate these heterophilic epitopes, we screened binding epitopes of H1-50 mAb using a phage 12-peptide library. DNA sequencing and comparative analysis were performed on specific positive phage clones, and the sequence of 12-peptide binding to H1-50 mAb was obtained. The binding epitopes of H1-50 mAb in influenza virus HA were determined by sequence analysis and experimental verification, and their distribution within the three-dimensional structure was assessed by PyMOL. The results showed that H1-50 mAb specifically binds to polypeptides (306-SLPFQNIHPITIGK-319) of influenza A virus HA, located in the stem of the HA protein. However, there is no specific binding sequence between H1-50 mAb and the PHB protein of islet ß-cells in the primary structure, and we speculate that the binding of H1-50 mAb to islet ß-cells may depend on the spatial conformation. The identification of the heterophilic epitopes of H1N1 influenza virus hemagglutinin provides a new perspective on type 1 diabetes that may be caused by influenza virus infection, which may contribute to the prevention and control of influenza.
Diabetes Mellitus, Type 1 , Influenza A Virus, H1N1 Subtype , Influenza A virus , Influenza, Human , Humans , Epitopes/chemistry , Epitopes/genetics , Hemagglutinins , Influenza A Virus, H1N1 Subtype/genetics , Influenza A virus/genetics , Hemagglutinin Glycoproteins, Influenza Virus/genetics , Antibodies, Viral , Antibodies, Monoclonal
To enhance the damping properties of nitrile butadiene rubber (NBR), the elastomer used was blended with chlorinated paraffin 52 (CP52) to prepare NBR/CP52 composites. The results showed that CP52 could significantly enhance the damping properties of NBR and shift the glass transition temperature (Tg) to lower temperatures. Molecular dynamics models of the CP52/NBR system were established, and the damping properties of the CP52-reinforced NBR were investigated using molecular dynamics (MD) simulations. Through the combination of MD simulations and the experimental results, the essential mechanism of the enhanced damping properties of the NBR was methodically expatiated and was ascribed to the Cl-CP-H····NC-NBR (type I) and CP-Cl····H-NBR-CN (type II) analogous hydrogen bonds formed between NBR and CP52. The higher the CP52 content, the higher the analogous hydrogen bond concentration, and the better the damping properties of the CP52/NBR composites. The experimental results were very consistent with the MD simulation results, meaning that the combination method can provide a new means to optimize the design of damping materials and broaden the application range of small polar molecules in the damping modification of polar rubber materials.
The inlet structure of hydrocyclones has great impact on performance. In this paper, the effects of spiral inlet geometric parameters on the flow field characteristics and separation performance were investigated by CFD. Numerical results show that the pitch has the largest influence, followed by the heads, the turns, and the steady flow cone. With the increase of the steady flow cone angle, the turbulence intensity increases. The efficiency, pressure drop, tangential velocity, sand volume fraction at the spigot, and natural gas hydrate (NGH) volume fraction at the vortex finder decrease, when the pitch increases. With the increase of the number of heads and turns, the efficiency, pressure drop, tangential velocity, the NGH volume fraction at the vortex finder, and the sand volume fraction at the spigot increase. The efficiency and pressure drop of hydrocyclones with the optimal parameters are 90% and 0.05 MPa, respectively. Therefore, the performance of the NGH hydrocyclone can be improved by increasing the inlet pitch and the number of spiral heads and inlet spiral turns. The results provide theoretical guidance for the engineering design of NGH in situ separators.
The construction of heterojunctions is considered to be an important means to promote efficient electron-hole separation in photocatalysts. However, photocatalysts have poor light absorption ability and a relatively small chance of capturing H+, and the stability needs to be improved. In this work, a non-precious metal co-catalyst Cu3P was introduced for the successful construction of p-n heterojunctions from NiO and CdS to promote charge separation while expanding the light absorption capacity and increasing the chance of H+ capture, thus enhancing the photocatalytic hydrogen precipitation activity and stability. The overall photocatalytic performance was improved by continuously optimizing the loading of NiO and Cu3P. Satisfyingly, using a 5 W LED lamp as the light source, the hydrogen evolution rate of the composite photocatalyst 15NC@Cu-10 in 10 vol% lactic acid solution is 15 612.0 µmol h-1 g-1, and the AQE reaches 10.4%. XPS analysis confirmed the direction and path of electron transfer. This synergistic strategy of co-catalyst modification of p-n heterojunctions provides a unique insight into the preparation of efficient and stable photocatalysts and also expands the applications of MOFs and their derivatives in the field of photocatalysis.
Immune checkpoint blockade has become a paradigm-shifting treatment modality to combat cancer, while conventional administration of immune checkpoint inhibitors, such as anti-PD-L1 antibody (α-PD-L1), often shows unsatisfactory immune responses and lead to severe immune-related adverse effects (irAEs). Herein, we develop a PD-L1 aptamer-based spherical nucleic acids (SNAs), which consists of oxaliplatin (OXA) encapsulated in a metal-organic framework nanoparticle core and a dense shell of aptPD-L1 (denoted as M@O-A). Upon light irradiation, this nanosystem enables concurrent photodynamic therapy (PDT), chemotherapy, and enhanced immunotherapy in one shot to inhibit both primary colorectal tumors and untreated distant tumors in mice. Notably, M@O-A shows scarcely any systemic immunotoxicity in a clinical irAEs-mimic transgenic mouse model. Collectively, this study presents a novel strategy for priming robust photo-immunotherapy against cancer with enhanced safety.
Metal-Organic Frameworks , Nanoparticles , Neoplasms , Photochemotherapy , Animals , Mice , Cell Line, Tumor , B7-H1 Antigen , Immunotherapy , Nanoparticles/therapeutic use , Neoplasms/drug therapy
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide and has a poor prognosis. Cuproptosis is a novel mode of cell death that has only recently been discovered. Considering the critical role of lncRNAs in liver cancer development, the aim of this study was to construct a prognostic signature based on cuproptosis-related lncRNAs (CRlncRNAs). We downloaded RNA-sequencing data and corresponding clinical information of patients with HCC from The Cancer Genome Atlas (TCGA) database. To verify the robustness of the model, we added an external validation set obtained from the Gene Expression Omnibus (GEO): GSE40144. In addition, we identified the cuproptosis-related genes (CRGs) based on previous reports. Pearson correlation analysis, univariate Cox regression, and least absolute shrinkage and selection operator (LASSO) Cox regression analysis were utilized to screen for genes associated with prognosis. On this basis, multivariate Cox regression and stepAIC were used to further construct and optimize the prognostic model. The simplified signature with the lowest Akaike information criterion (AIC) value was considered the prognostic signature. Seven different algorithms were used to perform immune infiltration analysis. The single-sample Gene Set Enrichment Analysis (ssGSEA) algorithm was utilized to find the difference in immune function between the high- and low-risk groups. Finally, in vitro experiments were performed by quantitative real-time PCR (qRT-PCR) analysis using HCC cell lines to validate the expression of prognostic genes. We identified 3 lncRNAs (CYTOR, LINC00205, and LINC01184) as independent risk factors for HCC. The receiver operating characteristic (ROC) curves calculated that the AUC at 1, 3, and 5 years reached 0.717, 0.633, and 0.607, respectively. The expression levels of 41 immune checkpoints differed significantly between the high- and low-risk groups, and there were significant differences in sensitivity to immunotherapy between the high- and low-risk groups. The risk model could also serve as a promising predictor of immunotherapeutic response, which has been verified by the TIDE algorithm (p < 0.001). Overall, we propose a signature related to CRlncRNAs that can be used to predict the prognosis of HCC patients, which was validated in external cohort and in vitro experiments.
Apoptosis , Carcinoma, Hepatocellular , Liver Neoplasms , RNA, Long Noncoding , Humans , Carcinoma, Hepatocellular/genetics , Liver Neoplasms/genetics , Prognosis , Risk Factors , RNA, Long Noncoding/genetics , Copper
The erosion of the valve core causes valve failure problems. Thus, a novel method to extend the erosion resistance of the valve was innovatively proposed, namely, nanosecond laser ablation micro-pits on the substrate surface and high velocity oxygen fuel (HVOF) spraying WC coating to extend the erosion resistance of the valve. The characterization and evaluation of the erosion resistance of the WC-sprayed coating after the pretreatment of the 3Cr13 substrate surface polishing/grit blasting/nanosecond laser ablation circular micro-dimple were conducted using the unit coupon erosion test of liquid-solid two-phase flow, followed by the test evaluation and analysis of the erosion resistance test of the WC coating after different pretreatments of the full-size valve core. Results showed that the micro-dimple pretreatment on the surface of the 3Cr13 substrate increased the contact area rate and bonding strength of the substrate and the WC coating. By taking erosion volume loss as the evaluation index, the erosion resistance of the micro-dimple pretreatment on the surface of the 3Cr13 substrate was increased by about 31.98% compared with that of the polishing pretreatment. Therefore, the new method of surface nanosecond laser texture pretreatment and HVOF-spraying WC coating can effectively improve the erosion resistance of the valve.
In view of the fact that the exposed catalytic active sites of single-metal MOFs cannot satisfy the efficient progress of the catalytic reaction, here we constructed a star-shaped bimetallic ZnCoMOF by introducing a Zn source by the partial ion exchange method and coprecipitation method. By controlling the quality of sodium hypophosphite, ZnCoMOF was subjected to different degrees of phosphating to optimize the experimental conditions. The introduction of the more electronegative P can attract more H+ to participate in the reduction reaction. The ZnCoMOF@CoP-5 S-scheme heterojunction was constructed in situ by generating CoP on the surface of ZnCoMOF under a PH3 reducing atmosphere, which exhibited excellent H2 evolution performance. This unique heterojunction effectively promotes the separation and transfer of e--h+ pairs, ensuring a strong redox capability. The best hydrogen-evolution performance of ZnCoMOF@CoP-5 under the EY sensitization system reaches 16â¯958 µmol h-1 g-1, which has significant advantages over the same type of materials and similar photocatalytic hydrogen-evolution work. Finally, the photocatalytic mechanism was demonstrated by an in situ XPS technique. Our work provides important ideas for the research of bimetallic MOFs in the field of photocatalytic hydrogen evolution.
Today, the IT departments of many healthcare organizations are suffering from data storage and network speed. Doctors diagnose patients to help them out, and this treatment process needs to be well managed. Clinical trial data are the main basis for judging the patient's condition in the medical process. With the rapid development of clinical laboratory technology in China, important achievements have been made in medicine. Clinical hospitals use a large number of different types of testing reagents and equipment, and the accuracy of testing data has become a key issue for testing results. The accuracy of testing data comes from the zero error of clinical testing, derived from the rigor and operational rigor of the testers in clinical testing. This article is dedicated to the quality control analysis and research based on mobile medical edge computing in clinical trials. This article introduces the relevant theories of mobile medical edge computing technology and quality control methods, with reference to the study on the general medical students' clinical competency in problem-solving, communication skills, procedure, history, and physical examination and critical and non-critical indicators in objective structured clinical examination (OSCE). In addition, a routine testing group and a quality control group for strengthening important aspects of medical testing were designed to conduct comparative experiments. Experiments have proved that the quality control group for strengthening the important links of medical testing has a higher index than the routine testing group in all aspects. Among them, the detection accuracy rate can reach up to 99.48%, which is of great significance for the improvement of the detection link of the patient's condition and the follow-up diagnosis and treatment link.
Students, Medical , Clinical Competence , Humans , Physical Examination , Quality Control
