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Circular dichroism spectroscopy is a key probe of the structural and optical properties of chiral materials, however, commercial circular dichroism spectrometers are large, prohibitively expensive and rarely offer environmental control of the sample under test. Using Fresnel rhombs as inexpensive broadband quarter-wave plates, we demonstrate two novel, low-cost (<£2000) and portable imaging systems controlled by our own bespoke open-source control software which are capable of spatially mapping the circular dichroism of chiral solid state films. By coupling these imaging systems with a temperature controlled stage, we show that we can rapidly identify the thermal processing conditions required to maximise circular dichroism in chiral solid state films by measuring circular dichroism in situ during thermal annealing of a sample under test. The accuracy and spatial resolution of these circular dichroism imagers are cross-compared against our previous studies using an existing circular dichroism imaging system at the Diamond Light Source and are shown to be in good agreement, with a sensitivity down to 250 mdeg and a spatial resolution of 100 µm.
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Increased gut permeability is implicated in the initiation and extent of the cytokine inflammatory response associated with exertional heat stroke (EHS). The primary objective of this study was to determine if a five amino acid oral rehydration solution (5AAS), specifically designed for the protection of the gastrointestinal lining, would prolong time to EHS, maintain gut function and dampen the systemic inflammatory response (SIR) measured during EHS recovery. Male C57/BL6J mice instrumented with radiotelemetry were gavaged with 150 µL of 5AAS or H2 O, and ≈12 h later were either exposed to an EHS protocol where mice exercised in a 37.5°C environmental chamber to a self-limiting maximum core temperature (Tc,max) or performed the exercise control (EXC) protocol (25°C). 5AAS pretreatment attenuated hypothermia depth and length (p < 0.005), which are indicators of EHS severity during recovery, without any effect on physical performance or thermoregulatory responses in the heat as determined by percent body weight lost (≈9%), max speed (≈6 m/min), distance (≈700 m), time to Tc,max (≈160 min), thermal area (≈550°Câmin), and Tc,max (42.2°C). EHS groups treated with 5AAS showed a significant decrease in gut transepithelial conductance, decreased paracellular permeability, increased villus height, increased electrolyte absorption and changes in tight junction protein expression pattern suggestive of improved barrier integrity (p < 0.05). No differences were witnessed between EHS groups in acute phase response markers of liver, circulating SIR markers, or indicators of organ damage during recovery. These results suggest that a 5AAS improves Tc regulation during EHS recovery through maintaining mucosal function and integrity.
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Golpe de Calor , Hipotermia , Ratones , Masculino , Animales , Hipotermia/metabolismo , Golpe de Calor/prevención & control , Citocinas/metabolismo , Mucosa Intestinal/metabolismo , Aminoácidos/metabolismoRESUMEN
[This corrects the article DOI: 10.1039/D2TC01224C.].
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Circularly polarised light will revolutionise emerging technologies, including encrypted light-based communications, quantum computing, bioimaging and multi-channel data processing. In order to make use of these remarkable opportunities, high performance photodetectors that can accurately differentiate between left- and right-handed circularly polarised light are desperately needed. Whilst this potential has resulted in considerable research interest in chiral materials and circularly polarised photodetecting devices, their translation into real-world technologies is limited by non-standardised reporting and testing protocols. This mini-review provides an accessible introduction into the working principles of circularly polarised photodetectors and a comprehensive overview of the performance metrics of state-of-the-art devices. We propose a rigorous device characterisation procedure that will allow for standardised evaluation of novel devices, which we hope will accelerate research and investment in this area.
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BACKGROUND: Dual-task interference is a concern when users attempt to use head mounted displays (HMD) while performing seated manual control tasks. Auditory warnings of information displayed on the HMD may or may not assist users while multi-tasking. OBJECTIVE: In this study, we investigated the dual-task interference of words, to be remembered later, presented on a HMD and motor control in a manual tracking task. The word presentations were warned or not warned with auditory signals and the impact of audio warnings were examined. METHODS: Participants were required to perform five tasks: (1) a compensatory tracking task performed alone, (2) a word memory task performed alone, (3) a tracking and word memory task, (4) a word memory task with words preceded by audial signals, and (5) a tracking and word memory task with words preceded by audial signals. In addition, in the dual-tasks, half of the word presentations were paired with directions changes in the tracking task to test for immediate perceptual interference. RESULTS: There were significant dual task costs for both mean tracking error and later word recall. Additionally, participants took significantly longer to respond to motion changes paired with word presentations than motion changes not paired with word presentations. However, the impact of auditory warnings on tracking performance was nuanced. CONCLUSION: Even with an in field of view transparent HMD momentary and sustained cognitive dual-task interference remains. Reaction times are affected most in the worst case scenario, when task critical events occur at the same time as a text message. APPLICATION: The use of HMDs in time critical manual control tasks (such as operating machinery) should be limited. The use of audial warnings to alert operators to information displayed on an HMD requires further research; it may disrupt appropriate or natural task ordering.
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Gafas Inteligentes , Presentación de Datos , Humanos , Movimiento (Física) , Tiempo de Reacción , Análisis y Desempeño de TareasRESUMEN
BACKGROUND: Oncology patients have frequent venipunctures, which causes scarring, making subsequent draws difficult and painful. Novel blood collection systems may decrease discomfort in patients experiencing repeat blood draws. METHODS: Oncology outpatients (nâ =â 101; criteria excluded 12) were recruited to determine their preference for either of two blood collection systems, the 23-gauge standard BD Vacutainer Push Button Blood Collection Set (Standard Push Button system) or the 25-gauge BD Vacutainer UltraTouch Push Button Blood Collection Set (UltraTouch Push Button system). Subjects received two blinded, randomized blood draws, one with each device and just one device for each arm. Subjects subsequently rated their blinded preference for blood collection system. Specimen quality was assessed for each device with measurements for plasma hemoglobin (Shimadzu UV-1800 spectrophotometer, Shimadzu), lactate dehydrogenase, and potassium (Vitros 4600/5600 analyzer, Ortho Diagnostics). RESULTS: Preference for the 25-gauge UltraTouch Push Button system over the 23-gauge Standard Push Button system was significant (UltraTouch, n = 51; Standard n = 30; no preference, n = 8; P = 0.0196). Regarding sample quality, the 25-gauge UltraTouch Push Button system had significantly lower plasma hemoglobin (average 5.34 mg/dL) vs the 23-gauge Standard Push Button system (9.37 mg/dL; P < 0.0001); serum lactate dehydrogenase and potassium differences were not statistically significant. CONCLUSION: Subjects in an oncology clinic preferred phlebotomy with the 25-gauge UltraTouch Push Button system, and samples using this device had less hemolysis as assessed by plasma hemoglobin.
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Recolección de Muestras de Sangre , Flebotomía , Instituciones de Atención Ambulatoria , Hemoglobinas/análisis , Humanos , L-Lactato Deshidrogenasa , PotasioRESUMEN
AIMS: While the SARS-CoV-2 pandemic may be contained through vaccination, transfusion of convalescent plasma (CCP) from individuals who recovered from COVID-19 (CCP) is considered an alternative treatment. We investigate if CCP transfusion in patients with severe respiratory failure increases plasma titres of SARS-CoV-2 antibodies and improves clinical outcomes. METHODS: Patients with COVID-19 (n=34) were consented for CCP transfusion and serial blood draws pretransfusion and post-transfusion. Plasma SARS-CoV-2 antireceptor binding domain (RBD) IgG and IgM titres were measured by ELISA serially, and compared with serial plasma titre levels from control patients (n=68). The primary outcome was survival at 30 days, and secondary outcomes were length of ventilator and/or extracorporeal membrane oxygenation (ECMO) support, length of stay (LOS) in the hospital and in the intensive care unit (ICU). Outcomes were compared with matched control patients (n=34). Kinetics of antibodies and clinical outcomes were compared using LOess regression and ORs, respectively. RESULTS: Prior to CCP transfusion, 74% of patients were anti-RBD seropositive for IgG (median 1:3200), and 81% were anti-RBD IgM seropositive (median 1:320), while 16% were seronegative. The kinetics of antibody titres in CCP recipients were similar to controls. CCP recipients presented with similar survival, duration on ventilatory and/or ECMO support, as well as ICU and hospital LOS compared with controls. CONCLUSIONS: CCP transfusion did not increase the kinetics of SARS-CoV2 antibodies and did not result in improved clinical outcomes in patients with COVID-19 with severe respiratory failure, suggesting that CCP may not be indicated in this category of patients.
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COVID-19 , Insuficiencia Respiratoria , Anticuerpos Antivirales , Formación de Anticuerpos , Transfusión de Componentes Sanguíneos , COVID-19/terapia , Humanos , Inmunización Pasiva , Inmunoglobulina G , Inmunoglobulina M , Plasma , ARN Viral , Insuficiencia Respiratoria/terapia , SARS-CoV-2 , Sueroterapia para COVID-19RESUMEN
BACKGROUND: Anti-SARS-CoV-2 serological responses may have a vital role in controlling the spread of the disease. However, the comparative performance of automated serological assays has not been determined in susceptible patients with significant comorbidities. METHODS: In this study, we used large numbers of samples from patients who were negative (n = 2030) or positive (n = 112) for COVID-19 to compare the performance of 4 serological assay platforms: Siemens Healthineers Atellica IM Analyzer, Siemens Healthineers Dimension EXL Systems, Abbott ARCHITECT, and Roche cobas. RESULTS: All 4 serology assay platforms exhibited comparable negative percentage of agreement with negative COVID-19 status ranging from 99.2% to 99.7% and positive percentage of agreement from 84.8% to 87.5% with positive real-time reverse transcriptase PCR results. Of the 2142 total samples, only 38 samples (1.8%) yielded discordant results on one or more platforms. However, only 1.1% (23/2030) of results from the COVID-19-negative cohort were discordant. whereas discordance was 10-fold higher for the COVID-19-positive cohort, at 11.3% (15/112). Of the total 38 discordant results, 34 were discordant on only one platform. CONCLUSIONS: Serology assay performance was comparable across the 4 platforms assessed in a large population of patients who were COVID-19 negative with relevant comorbidities. The pattern of discordance shows that samples were discordant on a single assay platform, and the discordance rate was 10-fold higher in the population that was COVID-19 positive.
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Anticuerpos Antivirales/sangre , Bioensayo/estadística & datos numéricos , Prueba Serológica para COVID-19 , COVID-19/diagnóstico , SARS-CoV-2/inmunología , Anciano , Anticuerpos Antivirales/inmunología , Bioensayo/métodos , COVID-19/sangre , COVID-19/epidemiología , COVID-19/virología , Estudios de Cohortes , Femenino , Humanos , Masculino , Estados Unidos/epidemiologíaRESUMEN
Solubilized fullerene derivatives have revolutionized the development of organic photovoltaic devices, acting as excellent electron acceptors. The addition of solubilizing addends to the fullerene cage results in a large number of isomers, which are generally employed as isomeric mixtures. Moreover, a significant number of these isomers are chiral, which further adds to the isomeric complexity. The opportunities presented by single-isomer, and particularly single-enantiomer, fullerenes in organic electronic materials and devices are poorly understood however. Here, ten pairs of enantiomers are separated from the 19 structural isomers of bis[60]phenyl-C61-butyric acid methyl ester, using them to elucidate important chiroptical relationships and demonstrating their application to a circularly polarized light (CPL)-detecting device. Larger chiroptical responses are found, occurring through the inherent chirality of the fullerene. When used in a single-enantiomer organic field-effect transistor, the potential to discriminate CPL with a fast light response time and with a very high photocurrent dissymmetry factor (gph = 1.27 ± 0.06) is demonstrated. This study thus provides key strategies to design fullerenes with large chiroptical responses for use as chiral components of organic electronic devices. It is anticipated that this data will position chiral fullerenes as an exciting material class for the growing field of chiral electronic technologies.
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High proton conductivity is reported for unhumidified ammonium borosulfate, NH4 [B(SO4 )2 ], a solid acid coordination polymer that contains 1D, hydrogen-bonded NH4 + ···1 ∞ [B(SO4 )4/2 ]- chains. NH4 [B(SO4 )2 ] is thermally stable to 320 °C and is amenable to sintering into monolithic, polycrystalline discs at 200 °C and about 300 MPa of uniaxial pressure. Impedance spectroscopy measurements reveal ionic conductivities for sintered ammonium borosulfate of 0.1 mS cm-1 at 25 °C and up to 10 mS cm-1 at 180 °C in ambient air. No superprotonic transition is observed in the temperature range of 25-180 °C. Ab initio molecular dynamics simulations show these high conductivities are aided by free rotation of the NH4 + units and significant gyrational mobility of the SO4 tetrahedra, which, in turn, provide facile pathways for proton locomotion. High conductivities, a wide operational temperature window, and tolerance to both ambient and anhydrous conditions make NH4 [B(SO4 )]2 an attractive candidate electrolyte for intermediate-temperature hydrogen fuel cells that may enable operation at temperatures as high as 300 °C without active humidification.
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BACKGROUND: Serum glial fibrillary acidic protein (GFAP) and ubiquitin carboxyl-terminal esterase L1 (UCH-L1) have recently received US Food and Drug Administration approval for prediction of abnormal computed tomography (CT) in mild traumatic brain injury patients (mTBI). However, their performance in elderly patients has not been characterized. METHODS: We performed a posthoc analysis using the A Prospective Clinical Evaluation of Biomarkers of Traumatic Brain Injury (ALERT-TBI) study data. Previously recorded patient variables and serum values of GFAP and UCH-L1 from mTBI patients were partitioned at 65 years of age (herein referred to as ≥65, high-risk; <65, low-risk). We sought to assess the influence of age on predictive performance, sensitivity, and negative predictive value (NPV) of serum UCH-L1 and GFAP to predict intracranial injury by CT. RESULTS: Elderly mTBI patients constituted 25.7% of the patient cohort (n = 504/1959). Sensitivity and NPV of GFAP/UCH-L1 were 100%, with no significant difference from younger patients (P = 0.5525 and P > 0.9999, respectively). Specificity was significantly lower in elderly patients (0.131 vs 0.442; P < 0.0001) and decreased stepwise with older age. Compared to younger patients, elderly mTBI patients without abnormal (i.e., normal) CT findings also had a significantly higher GFAP (38.6 vs 16.2 pg/mL; P < 0.0001) and UCH-L1 (347.4 vs 232.1 pg/mL; P < 0.0001). CONCLUSIONS: Sensitivity and NPV to predict intracranial injury by CT was nearly identical between younger and elderly mTBI patients. Decrements in specificity and increased serum values suggest that special deference may be warranted for elderly patients.
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Conmoción Encefálica , Proteína Ácida Fibrilar de la Glía/sangre , Tomografía Computarizada por Rayos X/métodos , Ubiquitina Tiolesterasa/sangre , Factores de Edad , Anciano de 80 o más Años , Biomarcadores/sangre , Encéfalo/diagnóstico por imagen , Conmoción Encefálica/sangre , Conmoción Encefálica/diagnóstico , Correlación de Datos , Femenino , Humanos , Masculino , Valor Predictivo de las Pruebas , Factores de Riesgo , Sensibilidad y EspecificidadRESUMEN
BACKGROUND: The aim of this study was to characterize the time-resolved progression of clinical laboratory disturbances days-following an exertional heat stroke (EHS). Currently, normalization of organ injury clinical biomarker values is the primary indicator of EHS recovery. However, an archetypical biochemical recovery profile following EHS has not been established. METHODS: We performed a retrospective analysis of EHS patient records in US military personnel from 2008-2014 using the Military Health System Data Repository (MDR). We focused on commonly reported clinical laboratory analytes measured on the day of injury and all proceeding follow-up visits. RESULTS: Over the prescribed period, there were 2,529 EHS episodes treated at 250 unique treatment locations. Laboratory results, including a standardized set of blood, serum and urine assays, were analyzed from 0-340 days following the initial injury. Indicators of acute kidney injury, including serum electrolyte disturbances and abnormal urinalysis findings, were most prevalent on the day of the injury but normalized within 24-48hours (creatinine, blood urea nitrogen, and blood and protein in urine). Muscle damage and liver function-associated markers peaked 0-4 days after injury and persisted outside their respective reference ranges for 2-16 days (alanine aminotransferase, aspartate aminotransferase, creatine phosphokinase, myoglobin, prothrombin time). CONCLUSION: Biochemical recovery from EHS spans a 16-day time course, and markers of end-organ damage exhibit distinct patterns over this period. This analysis underscores the prognostic value of each clinical laboratory analyte and will assist in evaluating EHS patient presentation, injury severity and physiological recovery.
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Golpe de Calor/sangre , Golpe de Calor/orina , Esfuerzo Físico/fisiología , Lesión Renal Aguda/sangre , Lesión Renal Aguda/etiología , Lesión Renal Aguda/orina , Adulto , Biomarcadores/sangre , Biomarcadores/orina , Nitrógeno de la Urea Sanguínea , Creatinina/sangre , Coagulación Intravascular Diseminada/sangre , Coagulación Intravascular Diseminada/etiología , Femenino , Insuficiencia Hepática/sangre , Insuficiencia Hepática/etiología , Insuficiencia Hepática/orina , Humanos , Masculino , Salud Militar , Personal Militar , Músculos/lesiones , Mioglobina/sangre , Estudios Retrospectivos , Factores de Tiempo , Estados Unidos , Adulto JovenRESUMEN
Si24 is a new, open-framework silicon allotrope that is metastable at ambient conditions. Unlike diamond cubic silicon, which is an indirect-gap semiconductor, Si24 has a quasidirect gap near 1.4 eV, presenting new opportunities for optoelectronic and solar energy conversion devices. Previous studies indicate that Na can diffuse from micron-sized grains of a high-pressure Na4Si24 precursor to create Si24 powders at ambient conditions. Remarkably, we demonstrate here that Na remains highly mobile within large (~100 µm) Na4Si24 single crystals. Na readily diffuses out of Na4Si24 crystals under vacuum with gentle heating (10-4 mbar at 125 °C) and can be further reacted with iodine to produce large Si24 crystals that are 99.9985 at% silicon, as measured by wavelength-dispersive x-ray spectroscopy. Si24 crystals display a sharp, direct optical absorption edge at 1.51(1) eV with an absorption coefficient near the band edge that is demonstrably greater than diamond cubic silicon. Temperature-dependent electrical transport measurements confirm the removal of Na from metallic Na4Si24 to render single-crystalline semiconducting samples of Si24. These optical and electrical measurements provide insights into key parameters such as the electron donor impurity level from residual Na, reduced electron mass, and electron relaxation time. Effective Na removal on bulk length scales and the high absorption coefficient of single-crystal Si24 indicate promise for use of this material in bulk and thin film forms with potential applications in optoelectronic technologies.
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Relative to the rich library of small-molecule organics, few examples of ordered extended (i.e., nonmolecular) hydrocarbon networks are known. In particular, sp3 bonded, diamond-like materials represent appealing targets because of their desirable mechanical, thermal, and optical properties. While many covalent organic frameworks (COFs)-extended, covalently bonded, and porous structures-have been realized through molecular architecture with exceptional control, the design and synthesis of dense, covalent extended solids has been a longstanding challenge. Here we report the preparation of a sp3-bonded, low-dimensional hydrocarbon synthesized via high-pressure, solid-state diradical polymerization of cubane (C8H8), which is a saturated, but immensely strained, cage-like molecule. Experimental measurements show that the obtained product is crystalline with three-dimensional order that appears to largely preserve the basic structural topology of the cubane molecular precursor and exhibits high hardness (comparable to fused quartz) and thermal stability up to 300 °C. Among the plausible theoretical candidate structures, one-dimensional carbon scaffolds comprising six- and four-membered rings that pack within a pseudosquare lattice provide the best agreement with experimental data. These diamond-like molecular rods with extraordinarily small thickness are among the smallest members in the carbon nanothread family, and calculations indicate one of the stiffest one-dimensional systems known. These results present opportunities for the synthesis of purely sp3-bonded extended solids formed through the strain release of saturated molecules, as opposed to only unsaturated precursors.
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Nanothreads are one-dimensional sp3 hydrocarbons that pack within pseudohexagonal crystalline lattices. They are believed to lack long-range order along the thread axis and also lack interthread registry. Here we investigate the phase behavior of thiophene up to 35 GPa and establish a pressure-induced phase transition sequence that mirrors previous observations in low-temperature studies. Slow compression to 35 GPa results in the formation of a recoverable saturated product with a 2D monoclinic diffraction pattern along (0001) that agrees closely with atomistic simulations for single crystals of thiophene-derived nanothreads. Paradoxically, this lower-symmetry packing signals a higher degree of structural order since it must arise from constituents with a consistent azimuthal orientation about their shared axis. The simplicity of thiophene reaction pathways (with only four carbon atoms per ring) apparently yields the first nanothreads with orientational order, a striking outcome considering that a single point defect in a 1D system can disrupt long-range structural order.
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INTRODUCTION: Precipitating factors that contribute to the severity of exertional heat stroke (EHS) are unclear. The purpose of this study was to determine the effect of prior illness (PI) on EHS severity. METHODS: We performed a retrospective clinical record review of 179 documented cases of EHS at the Marine Corps Base in Quantico, Virginia. RESULTS: Approximately 30% of EHS cases had a medically documented PI. Anthropometrics (height, weight, body mass index) and commonly associated risk factors for EHS (age, number of days in training, wet bulb globe temperature, sleep patterns) did not differ between PI and no illness (NI) groups. PI patients presented with higher maximal rectal core temperatures (40.6 ± 1.0°C vs. 40.3 ± 1.2°C; P = 0.0419), and elevated pulse rates (118.1 ± 16.7 bpm vs. 110.5 ± 24.2 bpm; P = 0.0397). At the point of care, biomarker values were similar between PI and NI groups, with the exception of a trend toward elevated monocytes in those with PI (7.9 ± 2.9% vs 6.7± 2.7%; P = 0.0521). Rate and duration of cooling were similar between PI and NI patients. CONCLUSION: This study indicates that PI has a minimal effect on the patient presentation, severity and treatment outcome of EHS. The results of this study have important implications for military, civilian, and occupational populations who are at risk for EHS.
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Golpe de Calor/diagnóstico , Hipotermia Inducida , Índice de Severidad de la Enfermedad , Adulto , Femenino , Golpe de Calor/etiología , Golpe de Calor/terapia , Calor/efectos adversos , Humanos , Masculino , Personal Militar , Factores Desencadenantes , Estudios Retrospectivos , Factores de Riesgo , Resultado del Tratamiento , Virginia , Adulto JovenRESUMEN
The chemical stability of solid cubane under high-pressure was examined with in situ Raman spectroscopy and synchrotron powder X-ray diffraction (PXRD) in a diamond anvil cell (DAC) up to 60 GPa. The Raman modes associated with solid cubane were assigned by comparing experimental data with calculations based on density functional perturbation theory, and low-frequency lattice modes are reported for the first time. The equation of state of solid cubane derived from the PXRD measurements taken during compression gives a bulk modulus of 14.5(2) GPa. In contrast with previous work and chemical intuition, PXRD and Raman data indicate that solid cubane exhibits anomalously large stability under extreme pressure, despite its immensely strained 90° C-C-C bond angles.
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Single crystals of a complex Zintl compound with the composition Na4Ge13 were synthesized for the first time using a high-pressure/high-temperature approach. Single-crystal diffraction of synchrotron radiation revealed a hexagonal crystal structure with P6/m space group symmetry that is composed of a three-dimensional sp3 Ge framework punctuated by small and large channels along the crystallographic c axis. Na atoms are inside hexagonal prism-based Ge cages along the small channels, while the larger channels are occupied by layers of disordered sixfold Na rings, which are in turn filled by disordered [Ge4]4- tetrahedra. This compound is the same as "Na1-xGe3+z" reported previously, but the availability of single crystals allowed for more complete structural determination with a formula unit best described as Na4Ge12(Ge4)0.25. The compound is the first known example of a guest-host structure where discrete Zintl polyanions are confined inside the channels of a three-dimensional covalent framework. These features give rise to temperature-dependent disorder, as confirmed by first-principles calculations and physical properties measurements. The availability of single-crystal specimens allowed for measurement of the intrinsic low-temperature transport properties of this material and revealed its semiconductor behavior, which was corroborated by theoretical calculations.
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The 1 : 1 acetylene-benzene cocrystal, C2H2·C6H6, was synthesized under pressure in a diamond anvil cell (DAC) and its evolution under pressure was studied with single-crystal X-ray diffraction and Raman spectroscopy. C2H2·C6H6 is stable up to 30 GPa, nearly 10× the observed polymerization pressure for molecular acetylene to polyacetylene. Upon mild heating at 30 GPa, the cocrystal was observed to undergo an irreversible transition to a mixture of amorphous hydrocarbon and a crystalline phase with similar diffraction to i-carbon, a nanodiamond polymorph currently lacking a definitive structure. Characterization of this i-carbon-like phase suggests that it remains hydrogenated and may help explain previous observations of nanodiamond polymorphs. Potential reaction pathways in C2H2·C6H6 are discussed and compared with other theoretical extended hydrocarbons that may be obtained through crystal engineering. The cocrystallization of benzene with other more inert gases may provide a novel pathway to selectively control the rich chemistry of these materials.