1.
J Asian Nat Prod Res
; 19(12): 1232-1238, 2017 Dec.
Article
En
| MEDLINE
| ID: mdl-28349726
A new α-pyrone, nocapyrone S (1), together with five known compounds (2-6), were isolated from the deep-sea actinomycete Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111(T). Their structures were determined by spectroscopic analyses. The absolute configuration of 1 was established by quantum approaches. Cytotoxic activity of 1 was evaluated against K562, MCF-7, SGC7901, A375, Hela, and HepG2 cell lines.
Actinomycetales/chemistry , Antineoplastic Agents/isolation & purification , Nocardia/chemistry , Pyrones/isolation & purification , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Drug Screening Assays, Antitumor , HeLa Cells , Hep G2 Cells , Humans , K562 Cells , MCF-7 Cells , Marine Biology , Molecular Structure , Pyrones/chemistry , Pyrones/pharmacology