How Scientists View Vaccine Hesitancy.

This paper examines possible causes, consequences, and potential solutions for addressing vaccine hesitancy in the United States, focusing on the perspectives of academic scientists. By examining the experiences of scientists, who are arguably a critical community in US society, we gain deeper insights into how they understand the complexities of vaccine hesitancy and whether their insights and opinions converge with or diverge from the current literature. We present findings from a national survey of a representative sample of academic scientists from the fields of biology and public health regarding vaccine hesitancy and related topics. Empirical analysis using descriptive, bivariate, and multivariate analyses covers multiple topics, including vaccine controversy, trust in science, causes of vaccine hesitancy, preferred policy and regulatory approaches, risk perceptions, and scientists' ethics and perceived communication roles. The results highlight a diversity of opinions within the scientific community regarding how to improve science-society communication in regard to vaccines, including the need to be transparent and candid to the public about the risk of vaccines and their research.

U.S. Visa and Immigration Policy Challenges: Explanations for Faculty Perceptions and Intent to Leave.

United States (US) immigration policies have increasingly focused on national security resulting in universities experiencing declines in international student applications, constraints on international scholar employment, and complications facilitating international research collaborations. The COVID-19 pandemic brought additional travel restrictions, embassy closures, and health and safety concerns that exacerbated these challenges. Science mobility is critical for science education, training, competitiveness, and innovation. Using a representative sample of US and foreign-born scientists in three STEM fields, we explore how recent visa and immigration policies have shaped research collaborations, work with students and postdoctoral scholars, and intentions to leave. We use descriptive statistics, analysis of variance, and logistic regression and find academic scientists report disruptions from visa and immigration policies; negative impacts of immigration policies on US higher education; negative effects on recruitment and retention of international trainees; and increased intentions to leave the US driven by negative perceptions of immigration policy. Supplementary Information: The online version contains supplementary material available at 10.1007/s11162-023-09731-0.

Pragmatic, Prospective Comparative Effectiveness Trial of Carbon Ion Therapy, Surgery, and Proton Therapy for the Management of Pelvic Sarcomas (Soft Tissue/Bone) Involving the Bone: The PROSPER Study Rationale and Design.

Surgical treatment of pelvic sarcoma involving the bone is the standard of care but is associated with several sequelae and reduced functional quality of life (QOL). Treatment with photon and proton radiotherapy is associated with relapse. Carbon ion radiotherapy (CIRT) may reduce both relapse rates and treatment sequelae. The PROSPER study is a tricontinental, nonrandomized, prospective, three-arm, pragmatic trial evaluating treatments of pelvic sarcoma involving the bone. Patients aged at least 15 years are eligible for inclusion. Participants must have an Eastern Cooperative Oncology Group Performance Status score of two or less, newly diagnosed disease, and histopathologic confirmation of pelvic chordoma, chondrosarcoma, osteosarcoma, Ewing sarcoma with bone involvement, rhabdomyosarcoma (RMS) with bone involvement, or non-RMS soft tissue sarcoma with bone involvement. Treatment arms include (1) CIRT (n = 30) delivered in Europe and Asia, (2) surgical treatment with or without adjuvant radiotherapy (n = 30), and (3) proton therapy (n = 30). Arms two and three will be conducted at Mayo Clinic campuses in Arizona, Florida, and Minnesota. The primary end point is to compare the 1-year change in functional QOL between CIRT and surgical treatment. Additional comparisons among the three arms will be made between treatment sequelae, local control, and other QOL measures.

Cross-polarized common-path temporal interferometry for high-sensitivity strong-field ionization measurements.

Absolute density measurements of low-ionization-degree or low-density plasmas ionized by lasers are very important for understanding strong-field physics, atmospheric propagation of intense laser pulses, Lidar etc. A cross-polarized common-path temporal interferometer using balanced detection was developed for measuring plasma density with a sensitivity of ∼0.6 mrad, equivalent to a plasma density-length product of ∼2.6 × 1013 cm-2 if using an 800 nm probe laser. By using this interferometer, we have investigated strong-field ionization yield versus intensity for various noble gases (Ar, Kr, and Xe) using 800 nm, 55 fs laser pulses with both linear (LP) and circular (CP) polarization. The experimental results were compared to the theoretical models of Ammosov-Delone-Krainov (ADK) and Perelomov-Popov-Terent'ev (PPT). We find that the measured phase change induced by plasma formation can be explained by the ADK theory in the adiabatic tunneling ionization regime, while PPT model can be applied to all different regimes. We have also measured the photoionization and fractional photodissociation of molecular (MO) hydrogen. By comparing our experimental results with PPT and MO-PPT models, we have determined the likely ionization pathways when using three different pump laser wavelengths of 800 nm, 400 nm, and 267 nm.

Number Concentration Measurements of Polystyrene Submicrometer Particles.

The number of techniques to measure number concentrations and size distributions of submicrometer particles has recently increased. Submicrometer particle standards are needed to improve the accuracy and reproducibility of these techniques. The number concentrations of fluorescently labeled polystyrene submicrometer sphere suspensions with nominal 100 nm, 200 nm and 500 nm diameters were measured using seven different techniques. Diameter values were also measured where possible. The diameter values were found to agree within 20%, but the number concentration values differed by as much as a factor of two. Accuracy and reproducibility related with the different techniques are discussed with the goal of using number concentration standards for instrument calibration. Three of the techniques were used to determine SI-traceable number concentration values, and the three independent values were averaged to give consensus values. This consensus approach is proposed as a protocol for certifying SI-traceable number concentration standards.

COVID-19 and gender inequity in science: Consistent harm over time.

Stay-at-home-orders, online learning, and work from home policies are some of the responses governments, universities, and other institutions adopted to slow the spread of COVID-19. However, research shows these measures have increased pre-existing gender disparities in the workplace. The working conditions for women during the pandemic worsened due to increased family care responsibilities and unequal distribution of domestic labor. In the academy, working from home has resulted in reduced research time and increased teaching and family care responsibilities, with a larger proportion of that burden falling to women. We investigate the persistence of gender inequity among academic scientists resulting from university COVID-19 responses over time. We draw on two surveys administered in May 2020 and May 2021 to university-based biologists, biochemists, and civil and environmental engineers, to analyze how the pandemic response has disproportionately impacted women in academia and the endurance of those inequities. Results show significantly greater negative impacts from the pandemic on women's research activities and work-life balance, compared to men. We conclude by discussing the implications of our results, and the need for the academy to better predict and adjust to the gender disparities its policies create.

Efficient second harmonic generation of a high-power picosecond CO2 laser.

A comparative analysis of AgGaSe2, GaSe, CdGeAs2, and Te for second harmonic generation (SHG) of a picosecond CO2 laser at intensities up to 50 GW/cm2 is presented. We demonstrate external energy conversion efficiency of >20% in AgGaSe2. Conversion efficiency >5% is measured in GaSe and CdGeAs2. Self-focusing and multifilamentation are found to severely limit the SHG process in CdGeAs2 and Te at such high fields. Demonstration of ≥150 MW SH pulses for a 10 µm picosecond pump, in combination with femtosecond CO2 laser development, will open new strong-field applications in the 4.5-5.5 µm range.

COVID-19 and the academy: opinions and experiences of university-based scientists in the U.S.

Much of the available evidence regarding COVID-19 effects on the scientific community in the U.S. is anecdotal and non-representative. We report findings from a based survey of university-based biologists, biochemists, and civil and environmental engineers regarding negative and positive COVID-19 impacts, respondent contributions to addressing the pandemic, and their opinions regarding COVID-19 research policies. The most common negative impact was university closures, cited by 93% of all scientists. Significant subgroup differences emerged, with higher proportions of women, assistant professors, and scientists at institutions located in COVID-19 "hotspot" counties reporting difficulties concentrating on research. Assistant professors additionally reported facing more unanticipated childcare responsibilities. Approximately half of the sample also reported one or more positive COVID-19 impacts, suggesting the importance of developing a better understanding of the complete range of impacts across all fields of science. Regarding COVID-19 relevant public policy, findings suggest divergence of opinion concerning surveillance technologies and the need to alter federal approval processes for new tests and vaccines.

Correction: COVID-19 and the academy: opinions and experiences of university-based scientists in the U.S.

[This corrects the article DOI: 10.1057/s41599-021-00823-9.].

The effects of electronic alert letters for internet surveys of academic scientists.

Survey alert letters improve response rates and assure potential respondents that the research is legitimate and of high quality. Pre-notification by mail increases response rates for web surveys because it represents a second mode of communication and contributes to increases in respondent trust and study legitimacy. Due to work-from-home orders in response to COVID-19, postal alert letters are unlikely to reach research participants at their place of employment. We conducted three experiments testing the effects of sending academic scientists a pre-notification email message on web survey response rates as compared to no alert email message and variation in the timing of the pre-notification. The data comes from three random national samples of university-based scientists that were conducted during the early months of the COVID-19 pandemic. Two of three experiments suggest that email alert pre-notifications can have a minor effect on improving response rates to web surveys of academic scientists. The timing of those pre-notification messages, though, had no effect on survey response. These findings indicate pre-notification messages remain useful when studying academic scientists. Future research should compare the effects of electronic as compared to postal pre-notification on survey response among scientists, as postal pre-notification requires extensive resources.

The Role of Genetic Resources in Breeding for Climate Change: The Case of Public Breeding Programmes in Eighteen Developing Countries.

The role of plant breeding in adapting crops to climate changes that affect food production in developing countries is recognized as extremely important and urgent, alongside other agronomic, socio-economic and policy adaptation pathways. To enhance plant breeders' capacity to respond to climate challenges, it is acknowledged that they need to be able to access and use as much genetic diversity as they can get. Through an analysis of data from a global survey, we explore if and how public breeders in selected developing countries are responding to climate challenges through a renewed or innovative use of plant genetic resources, particularly in terms of types of material incorporated into their breeding work as well as sources of such germplasm. It also looks at the possible limitations breeders encounter in their efforts towards exploring diversity for adaptation. Breeders are clearly considering climate challenges. In general, their efforts are aimed at intensifying their breeding work on traits that they were already working on before climate change was so widely discussed. Similarly, the kinds of germplasm they use, and the sources from which they obtain it, do not appear to have changed significantly over the course of recent years. The main challenges breeders faced in accessing germplasm were linked to administrative/legal factors, particularly related to obtaining genetic resources across national borders. They also underscore technical challenges such as a lack of appropriate technologies to exploit germplasm sets such as crop wild relatives and landraces. Addressing these limitations will be crucial to fully enhance the role of public sector breeders in helping to adapt vulnerable agricultural systems to the challenges of climate change.

Polarons in Halide Perovskites: A Perspective.

Metal halide perovskites (MHPs) have rapidly emerged as leading contenders in photovoltaic technology and other optoelectronic applications owing to their outstanding optoelectronic properties. After a decade of intense research, an in-depth understanding of the charge carrier transport in MHPs is still an active topic of debate. In this Perspective, we discuss the current state of the field by summarizing the most extensively studied carrier transport mechanisms, such as electron-phonon scattering limited dynamics, ferroelectric effects, Rashba-type band splitting, and polaronic transport. We further extensively discuss the emerging experimental and computational evidence for dominant polaronic carrier dynamics in MHPs. Focusing on both small and large polarons, we explore the fundamental aspects of their motion through the lattice, protecting the photogenerated charge carriers from the recombination process. Finally, we outline different physical and chemical approaches considered recently to study and exploit the polaron transport in MHPs.

What drives public transit organizations in the United States to adapt to extreme weather events?

Extreme weather events often disrupt the operation of public transit systems, and challenge the capacity of transit agencies to effectively respond to them. In this paper, we draw upon a recent nationwide survey of 273 public transit agencies in metropolitan regions across the United States to understand the factors that influence their scope of adaptation to anticipated climate risks. We find that a transit agency undertakes more adaptation measures when transit officials perceive greater risks and greater adaptive capacity of the agency, or when it experiences more severe extreme weather events. We also show that local institutional environment, in particular, political ideology, affects the scope of transit adaptation activities. Transit agencies that operate in more politically liberal counties tend to engage in more adaptation actions, while the effect of state-level ideology depends on the level of perceived influence from state governments.

Building Global Genomics Initiatives and Enabling Data Sharing: Insights from Multiple Case Studies.

This genomics global governance research study presents the dynamics and the evolving nature of salient challenges that global genomics initiatives encounter in designing new models for data management, exchange, and collaboration across disciplines, sectors, and countries. Using a multiple case study approach, we assessed and compared organizational responses across diverse genomics initiatives. The richness of a comparative qualitative analysis clearly shows the complexity addressed by genomics initiatives and, importantly, expands current studies by moving beyond an open versus property regime dichotomy. Although we identify some common themes, fundamental differences emerge in the way genomics initiatives set goals, manage heterogeneity, define resources, devise governance, and enable data sharing. Such differences demonstrate the ongoing processes of adapting governance structures, management processes, and organizational design solutions that are implemented in response to different social, technical, and policy environments. We find that genomics initiatives largely benefit from and are shaped by the engagement with large communities of scientists to rethink and design shared rules and guidelines for data exchange and use. Our study provides direct guidance to future global genomics initiatives, but it also offers a benchmark for research in the omics field broadly, both in terms of design and methodological approaches to understand the emerging forms of scientific governance and innovation ecosystems.

Plant genetic resources for food and agriculture: opportunities and challenges emerging from the science and information technology revolution.

Contents Summary 1407 I. Introduction 1408 II. Technological advances and their utility for gene banks and breeding, and longer-term contributions to SDGs 1408 III. The challenges that must be overcome to realise emerging R&D opportunities 1410 IV. Renewed governance structures for PGR (and related big data) 1413 V. Access and benefit sharing and big data 1416 VI. Conclusion 1417 Acknowledgements 1417 ORCID 1417 References 1417 SUMMARY: Over the last decade, there has been an ongoing revolution in the exploration, manipulation and synthesis of biological systems, through the development of new technologies that generate, analyse and exploit big data. Users of Plant Genetic Resources (PGR) can potentially leverage these capacities to significantly increase the efficiency and effectiveness of their efforts to conserve, discover and utilise novel qualities in PGR, and help achieve the Sustainable Development Goals (SDGs). This review advances the discussion on these emerging opportunities and discusses how taking advantage of them will require data integration and synthesis across disciplinary, organisational and international boundaries, and the formation of multi-disciplinary, international partnerships. We explore some of the institutional and policy challenges that these efforts will face, particularly how these new technologies may influence the structure and role of research for sustainable development, ownership of resources, and access and benefit sharing. We discuss potential responses to political and institutional challenges, ranging from options for enhanced structure and governance of research discovery platforms to internationally brokered benefit-sharing agreements, and identify a set of broad principles that could guide the global community as it seeks or considers solutions.

An integrative theory-driven framework for evaluating travel training programs.

Since the 1970s, travel training programs, which provide a short-term training to people with disabilities and older people to teach them independent travel skills required to use fixed-route transportation, have spread across the United States. But the authors note that currently, there is no integrative framework for evaluating the training programs, although it is crucial for improving program implementation and developing knowledge and theories related to travel training. Therefore, this research aims to build an integrative theory-driven evaluation framework of the programs on the basis of prior studies on travel training and the literature on program evaluation and learning and training theories. The framework considers (1) a wide range of key elements related to the delivery systems and outcomes of travel training; (2) diverse stakeholders that engage in designing, operating, and assessing travel training; and (3) the short-term, intermediate, and long-term outcomes of the programs. Based on the framework, the authors develop a flexible logic model for travel training programs to help scholars and practitioners design and conduct actual evaluation studies. Thus, this research is expected to make theoretical and practical contributions to theory-driven program evaluation and travel training programs.

Methods for identifying translational researchers.

There is currently no generally accepted method for identifying the community of translational researchers when evaluating Clinical and Translational Science Centers. We use data from the multiyear evaluation of the University of Illinois at Chicago Center for Clinical and Translational Science (CCTS) to investigate the complexities of reliably identifying translational researchers. We use three methods to identify translational researchers: (1) participating in CCTS services and programs; (2) self-identifying as a translational researcher; and (3) engaging in activities that are characteristic of translational science. We find little overlap of these differently defined research groups. We conclude with a discussion of how the findings suggest challenges for evaluating translational science programs and the need for better definition, communication, and demonstration of translational science for scientists and evaluators.

Addressing fear of crime in public space: gender differences in reaction to safety measures in train transit.

Research has identified several factors that affect fear of crime in public space. However, the extent to which gender moderates the effectiveness of fear-reducing measures has received little attention. Using data from the Chicago Transit Authority Customer Satisfaction Survey of 2003, this study aims to understand whether train transit security practices and service attributes affect men and women differently. Findings indicate that, while the presence of video cameras has a lower effect on women's feelings of safety compared with men, frequent and on-time service matters more to male passengers. Additionally, experience with safety-related problems affects women significantly more than men. Conclusions discuss the implications of the study for theory and gender-specific policies to improve perceptions of transit safety.